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Protein

LETM1 domain-containing protein 1

Gene

LETMD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.1 Publication

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 domain-containing protein 1
Alternative name(s):
Cervical cancer 1 proto-oncogene protein p40
Cervical cancer proto-oncogene 2 protein
HCCR-1
HCRR-2
Gene namesi
Name:LETMD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24241. LETMD1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 137CytoplasmicSequence analysisAdd BLAST137
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 360Mitochondrial intermembraneSequence analysisAdd BLAST202

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi25875.
OpenTargetsiENSG00000050426.
PharmGKBiPA134914870.

Polymorphism and mutation databases

BioMutaiLETMD1.
DMDMi74737159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104191 – 360LETM1 domain-containing protein 1Add BLAST360

Proteomic databases

EPDiQ6P1Q0.
MaxQBiQ6P1Q0.
PaxDbiQ6P1Q0.
PeptideAtlasiQ6P1Q0.
PRIDEiQ6P1Q0.

PTM databases

iPTMnetiQ6P1Q0.
PhosphoSitePlusiQ6P1Q0.

Expressioni

Tissue specificityi

Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.1 Publication

Gene expression databases

BgeeiENSG00000050426.
CleanExiHS_LETMD1.
ExpressionAtlasiQ6P1Q0. baseline and differential.
GenevisibleiQ6P1Q0. HS.

Organism-specific databases

HPAiCAB008910.

Interactioni

Subunit structurei

Interacts with BRI3BP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
REEP5Q007653EBI-1549822,EBI-1549827

Protein-protein interaction databases

BioGridi117390. 34 interactors.
IntActiQ6P1Q0. 16 interactors.
STRINGi9606.ENSP00000262055.

Structurei

3D structure databases

ProteinModelPortaliQ6P1Q0.
SMRiQ6P1Q0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 360Letm1 RBDPROSITE-ProRule annotationAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 110Required and sufficient for mitochondrial importAdd BLAST110

Sequence similaritiesi

Contains 1 Letm1 RBD (ribosome-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4263. Eukaryota.
ENOG410ZXCM. LUCA.
GeneTreeiENSGT00390000018328.
HOGENOMiHOG000037443.
HOVERGENiHBG108107.
InParanoidiQ6P1Q0.
OMAiMVGYAFF.
OrthoDBiEOG091G0GD0.
PhylomeDBiQ6P1Q0.
TreeFamiTF314047.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P1Q0-1) [UniParc]FASTAAdd to basket
Also known as: HCCR-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSRVCWAR SAVWGSAVTP GHFVTRRLQL GRSGLAWGAP RSSKLHLSPK
60 70 80 90 100
ADVKNLMSYV VTKTKAINGK YHRFLGRHFP RFYVLYTIFM KGLQMLWADA
110 120 130 140 150
KKARRIKTNM WKHNIKFHQL PYREMEHLRQ FRQDVTKCLF LGIISIPPFA
160 170 180 190 200
NYLVFLLMYL FPRQLLIRHF WTPKQQTDFL DIYHAFRKQS HPEIISYLEK
210 220 230 240 250
VIPLISDAGL RWRLTDLCTK IQRGTHPAIH DILALRECFS NHPLGMNQLQ
260 270 280 290 300
ALHVKALSRA MLLTSYLPPP LLRHRLKTHT TVIHQLDKAL AKLGIGQLTA
310 320 330 340 350
QEVKSACYLR GLNSTHIGED RCRTWLGEWL QISCSLKEAE LSLLLHNVVL
360
LSTNYLGTRR
Length:360
Mass (Da):41,790
Last modified:July 5, 2004 - v1
Checksum:iEC50BEFB0E4A6DF5
GO
Isoform 2 (identifier: Q6P1Q0-2) [UniParc]FASTAAdd to basket
Also known as: HCRR-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:304
Mass (Da):35,723
Checksum:iE42CDAB0CEBAAA44
GO
Isoform 3 (identifier: Q6P1Q0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-155: GLQMLWADAK...IPPFANYLVF → ESLEPGHASH...SPWPEFYAYW
     156-360: Missing.

Show »
Length:155
Mass (Da):17,258
Checksum:iD059023F1D465080
GO
Isoform 4 (identifier: Q6P1Q0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Show »
Length:203
Mass (Da):23,429
Checksum:i8ED05540B421D63A
GO
Isoform 5 (identifier: Q6P1Q0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.

Show »
Length:100
Mass (Da):11,318
Checksum:i4C5179D6F75156C7
GO
Isoform 6 (identifier: Q6P1Q0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-99: LQMLWAD → TCFPGNY
     100-360: Missing.

Show »
Length:99
Mass (Da):11,221
Checksum:i3E00BF9104FCFCFF
GO
Isoform 7 (identifier: Q6P1Q0-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-130: Q → QVWARGRYPEVHGE

Show »
Length:373
Mass (Da):43,328
Checksum:i4DAF71CBE878FAAB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88I → T in AAP85625 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03703384V → I.3 PublicationsCorresponds to variant rs12379dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0292731 – 260Missing in isoform 5. 1 PublicationAdd BLAST260
Alternative sequenceiVSP_0292741 – 157Missing in isoform 4. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_0292751 – 56Missing in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_02927692 – 155GLQML…NYLVF → ESLEPGHASHILPASSLVET SFEDSYNCDSPTGQGFGKAG DWPADCSGSKIGLLSPWPEF YAYW in isoform 3. 2 PublicationsAdd BLAST64
Alternative sequenceiVSP_02927793 – 99LQMLWAD → TCFPGNY in isoform 6. 1 Publication7
Alternative sequenceiVSP_029278100 – 360Missing in isoform 6. 1 PublicationAdd BLAST261
Alternative sequenceiVSP_045299130Q → QVWARGRYPEVHGE in isoform 7. 1 Publication1
Alternative sequenceiVSP_029279156 – 360Missing in isoform 3. 2 PublicationsAdd BLAST205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195651 mRNA. Translation: AAK34885.1.
AF315598 mRNA. Translation: AAL26878.1.
AY259835 mRNA. Translation: AAP85624.1.
AY259836 mRNA. Translation: AAP85625.1.
AF329277 mRNA. Translation: AAL56993.1.
AK127540 mRNA. Translation: BAG54519.1.
AC087884 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58167.1.
CH471111 Genomic DNA. Translation: EAW58169.1.
CH471111 Genomic DNA. Translation: EAW58170.1.
BC000395 mRNA. Translation: AAH00395.2.
BC019274 mRNA. Translation: AAH19274.1.
BC064943 mRNA. Translation: AAH64943.1.
AL050286 mRNA. Translation: CAB43387.2.
CCDSiCCDS58231.1. [Q6P1Q0-7]
CCDS8806.1. [Q6P1Q0-1]
PIRiT08763.
RefSeqiNP_001230618.1. NM_001243689.1. [Q6P1Q0-7]
NP_056231.3. NM_015416.4. [Q6P1Q0-1]
XP_006719402.1. XM_006719339.1. [Q6P1Q0-4]
XP_006719403.1. XM_006719340.1. [Q6P1Q0-4]
UniGeneiHs.655272.

Genome annotation databases

EnsembliENST00000262055; ENSP00000262055; ENSG00000050426. [Q6P1Q0-1]
ENST00000418425; ENSP00000389903; ENSG00000050426. [Q6P1Q0-7]
ENST00000550100; ENSP00000447047; ENSG00000050426. [Q6P1Q0-3]
ENST00000550929; ENSP00000450163; ENSG00000050426. [Q6P1Q0-2]
GeneIDi25875.
KEGGihsa:25875.
UCSCiuc001rxl.4. human. [Q6P1Q0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195651 mRNA. Translation: AAK34885.1.
AF315598 mRNA. Translation: AAL26878.1.
AY259835 mRNA. Translation: AAP85624.1.
AY259836 mRNA. Translation: AAP85625.1.
AF329277 mRNA. Translation: AAL56993.1.
AK127540 mRNA. Translation: BAG54519.1.
AC087884 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58167.1.
CH471111 Genomic DNA. Translation: EAW58169.1.
CH471111 Genomic DNA. Translation: EAW58170.1.
BC000395 mRNA. Translation: AAH00395.2.
BC019274 mRNA. Translation: AAH19274.1.
BC064943 mRNA. Translation: AAH64943.1.
AL050286 mRNA. Translation: CAB43387.2.
CCDSiCCDS58231.1. [Q6P1Q0-7]
CCDS8806.1. [Q6P1Q0-1]
PIRiT08763.
RefSeqiNP_001230618.1. NM_001243689.1. [Q6P1Q0-7]
NP_056231.3. NM_015416.4. [Q6P1Q0-1]
XP_006719402.1. XM_006719339.1. [Q6P1Q0-4]
XP_006719403.1. XM_006719340.1. [Q6P1Q0-4]
UniGeneiHs.655272.

3D structure databases

ProteinModelPortaliQ6P1Q0.
SMRiQ6P1Q0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117390. 34 interactors.
IntActiQ6P1Q0. 16 interactors.
STRINGi9606.ENSP00000262055.

PTM databases

iPTMnetiQ6P1Q0.
PhosphoSitePlusiQ6P1Q0.

Polymorphism and mutation databases

BioMutaiLETMD1.
DMDMi74737159.

Proteomic databases

EPDiQ6P1Q0.
MaxQBiQ6P1Q0.
PaxDbiQ6P1Q0.
PeptideAtlasiQ6P1Q0.
PRIDEiQ6P1Q0.

Protocols and materials databases

DNASUi25875.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262055; ENSP00000262055; ENSG00000050426. [Q6P1Q0-1]
ENST00000418425; ENSP00000389903; ENSG00000050426. [Q6P1Q0-7]
ENST00000550100; ENSP00000447047; ENSG00000050426. [Q6P1Q0-3]
ENST00000550929; ENSP00000450163; ENSG00000050426. [Q6P1Q0-2]
GeneIDi25875.
KEGGihsa:25875.
UCSCiuc001rxl.4. human. [Q6P1Q0-1]

Organism-specific databases

CTDi25875.
DisGeNETi25875.
GeneCardsiLETMD1.
HGNCiHGNC:24241. LETMD1.
HPAiCAB008910.
neXtProtiNX_Q6P1Q0.
OpenTargetsiENSG00000050426.
PharmGKBiPA134914870.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4263. Eukaryota.
ENOG410ZXCM. LUCA.
GeneTreeiENSGT00390000018328.
HOGENOMiHOG000037443.
HOVERGENiHBG108107.
InParanoidiQ6P1Q0.
OMAiMVGYAFF.
OrthoDBiEOG091G0GD0.
PhylomeDBiQ6P1Q0.
TreeFamiTF314047.

Miscellaneous databases

ChiTaRSiLETMD1. human.
GeneWikiiLETMD1.
GenomeRNAii25875.
PROiQ6P1Q0.

Gene expression databases

BgeeiENSG00000050426.
CleanExiHS_LETMD1.
ExpressionAtlasiQ6P1Q0. baseline and differential.
GenevisibleiQ6P1Q0. HS.

Family and domain databases

InterProiIPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
PROSITEiPS51758. LETM1_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLTMD1_HUMAN
AccessioniPrimary (citable) accession number: Q6P1Q0
Secondary accession number(s): A6NER7
, B3KXK7, Q6X2E4, Q6X2E5, Q7L2G9, Q7L690, Q8WXW6, Q96PK7, Q9BY59, Q9Y3X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.