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Protein

Putative deoxyribonuclease TATDN1

Gene

TATDN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative deoxyribonuclease.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi112Divalent metal cation 1By similarity1
Metal bindingi112Divalent metal cation 2By similarity1
Metal bindingi149Divalent metal cation 2By similarity1
Metal bindingi174Divalent metal cation 2By similarity1
Metal bindingi222Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative deoxyribonuclease TATDN1 (EC:3.1.21.-)
Alternative name(s):
Hepatocarcinoma high expression protein
Gene namesi
Name:TATDN1
ORF Names:CDA11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24220. TATDN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83940.
OpenTargetsiENSG00000147687.
PharmGKBiPA134971804.

Polymorphism and mutation databases

BioMutaiTATDN1.
DMDMi166227295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003135901 – 297Putative deoxyribonuclease TATDN1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27N6-succinyllysineBy similarity1
Modified residuei46N6-succinyllysineBy similarity1

Proteomic databases

EPDiQ6P1N9.
MaxQBiQ6P1N9.
PaxDbiQ6P1N9.
PeptideAtlasiQ6P1N9.
PRIDEiQ6P1N9.

PTM databases

iPTMnetiQ6P1N9.
PhosphoSitePlusiQ6P1N9.

Expressioni

Gene expression databases

BgeeiENSG00000147687.
CleanExiHS_TATDN1.
ExpressionAtlasiQ6P1N9. baseline and differential.
GenevisibleiQ6P1N9. HS.

Organism-specific databases

HPAiHPA023634.
HPA053045.

Interactioni

Protein-protein interaction databases

BioGridi123823. 37 interactors.
IntActiQ6P1N9. 1 interactor.
STRINGi9606.ENSP00000276692.

Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Helixi16 – 19Combined sources4
Helixi32 – 42Combined sources11
Beta strandi44 – 49Combined sources6
Helixi54 – 64Combined sources11
Beta strandi70 – 74Combined sources5
Helixi78 – 82Combined sources5
Helixi83 – 87Combined sources5
Helixi89 – 101Combined sources13
Turni104 – 106Combined sources3
Beta strandi107 – 116Combined sources10
Turni120 – 122Combined sources3
Helixi125 – 134Combined sources10
Helixi136 – 142Combined sources7
Beta strandi146 – 152Combined sources7
Helixi154 – 163Combined sources10
Helixi165 – 167Combined sources3
Beta strandi171 – 173Combined sources3
Helixi180 – 188Combined sources9
Beta strandi192 – 195Combined sources4
Helixi197 – 199Combined sources3
Beta strandi200 – 202Combined sources3
Helixi203 – 210Combined sources8
Helixi214 – 216Combined sources3
Beta strandi217 – 219Combined sources3
Helixi235 – 237Combined sources3
Beta strandi244 – 247Combined sources4
Beta strandi252 – 254Combined sources3
Helixi260 – 262Combined sources3
Helixi263 – 274Combined sources12
Helixi278 – 293Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XIOX-ray1.19A5-295[»]
ProteinModelPortaliQ6P1N9.
SMRiQ6P1N9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6P1N9.

Family & Domainsi

Sequence similaritiesi

Belongs to the TatD-type hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG3020. Eukaryota.
COG0084. LUCA.
GeneTreeiENSGT00720000108776.
HOGENOMiHOG000201523.
HOVERGENiHBG097580.
InParanoidiQ6P1N9.
KOiK03424.
PhylomeDBiQ6P1N9.
TreeFamiTF324192.

Family and domain databases

InterProiIPR018228. DNase_TatD-rel_CS.
IPR032466. Metal_Hydrolase.
IPR001130. TatD_family.
[Graphical view]
PANTHERiPTHR10060. PTHR10060. 2 hits.
PfamiPF01026. TatD_DNase. 1 hit.
[Graphical view]
PIRSFiPIRSF005902. DNase_TatD. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS01091. TATD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P1N9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRFKFIDIG INLTDPMFRG IYRGVQKHQD DLQDVIGRAV EIGVKKFMIT
60 70 80 90 100
GGNLQDSKDA LHLAQTNGMF FSTVGCHPTR CGEFEKNNPD LYLKELLNLA
110 120 130 140 150
ENNKGKVVAI GECGLDFDRL QFCPKDTQLK YFEKQFELSE QTKLPMFLHC
160 170 180 190 200
RNSHAEFLDI MKRNRDRCVG GVVHSFDGTK EAAAALIDLD LYIGFNGCSL
210 220 230 240 250
KTEANLEVLK SIPSEKLMIE TDAPWCGVKS THAGSKYIRT AFPTKKKWES
260 270 280 290
GHCLKDRNEP CHIIQILEIM SAVRDEDPLE LANTLYNNTI KVFFPGI
Length:297
Mass (Da):33,602
Last modified:January 15, 2008 - v2
Checksum:iD8671A4A50E5D9B5
GO
Isoform 2 (identifier: Q6P1N9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.
Show »
Length:250
Mass (Da):28,166
Checksum:i9A5D90E84F43426C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161M → T in AAH64964 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0300451 – 47Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212250 mRNA. Translation: AAK14933.1.
AY071865 mRNA. Translation: AAL61823.1.
AK312204 mRNA. Translation: BAG35137.1.
CH471060 Genomic DNA. Translation: EAW92066.1.
CH471060 Genomic DNA. Translation: EAW92067.1.
BC064964 mRNA. Translation: AAH64964.1.
CCDSiCCDS55273.1. [Q6P1N9-2]
CCDS6351.1. [Q6P1N9-1]
RefSeqiNP_001139632.1. NM_001146160.1. [Q6P1N9-2]
NP_001304819.1. NM_001317890.1.
NP_001304820.1. NM_001317891.1.
NP_114415.1. NM_032026.3. [Q6P1N9-1]
XP_016869387.1. XM_017013898.1. [Q6P1N9-2]
UniGeneiHs.170568.

Genome annotation databases

EnsembliENST00000276692; ENSP00000276692; ENSG00000147687. [Q6P1N9-1]
ENST00000519548; ENSP00000428336; ENSG00000147687. [Q6P1N9-2]
GeneIDi83940.
KEGGihsa:83940.
UCSCiuc003yrd.4. human. [Q6P1N9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212250 mRNA. Translation: AAK14933.1.
AY071865 mRNA. Translation: AAL61823.1.
AK312204 mRNA. Translation: BAG35137.1.
CH471060 Genomic DNA. Translation: EAW92066.1.
CH471060 Genomic DNA. Translation: EAW92067.1.
BC064964 mRNA. Translation: AAH64964.1.
CCDSiCCDS55273.1. [Q6P1N9-2]
CCDS6351.1. [Q6P1N9-1]
RefSeqiNP_001139632.1. NM_001146160.1. [Q6P1N9-2]
NP_001304819.1. NM_001317890.1.
NP_001304820.1. NM_001317891.1.
NP_114415.1. NM_032026.3. [Q6P1N9-1]
XP_016869387.1. XM_017013898.1. [Q6P1N9-2]
UniGeneiHs.170568.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XIOX-ray1.19A5-295[»]
ProteinModelPortaliQ6P1N9.
SMRiQ6P1N9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123823. 37 interactors.
IntActiQ6P1N9. 1 interactor.
STRINGi9606.ENSP00000276692.

PTM databases

iPTMnetiQ6P1N9.
PhosphoSitePlusiQ6P1N9.

Polymorphism and mutation databases

BioMutaiTATDN1.
DMDMi166227295.

Proteomic databases

EPDiQ6P1N9.
MaxQBiQ6P1N9.
PaxDbiQ6P1N9.
PeptideAtlasiQ6P1N9.
PRIDEiQ6P1N9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276692; ENSP00000276692; ENSG00000147687. [Q6P1N9-1]
ENST00000519548; ENSP00000428336; ENSG00000147687. [Q6P1N9-2]
GeneIDi83940.
KEGGihsa:83940.
UCSCiuc003yrd.4. human. [Q6P1N9-1]

Organism-specific databases

CTDi83940.
DisGeNETi83940.
GeneCardsiTATDN1.
HGNCiHGNC:24220. TATDN1.
HPAiHPA023634.
HPA053045.
neXtProtiNX_Q6P1N9.
OpenTargetsiENSG00000147687.
PharmGKBiPA134971804.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3020. Eukaryota.
COG0084. LUCA.
GeneTreeiENSGT00720000108776.
HOGENOMiHOG000201523.
HOVERGENiHBG097580.
InParanoidiQ6P1N9.
KOiK03424.
PhylomeDBiQ6P1N9.
TreeFamiTF324192.

Miscellaneous databases

EvolutionaryTraceiQ6P1N9.
GenomeRNAii83940.
PROiQ6P1N9.

Gene expression databases

BgeeiENSG00000147687.
CleanExiHS_TATDN1.
ExpressionAtlasiQ6P1N9. baseline and differential.
GenevisibleiQ6P1N9. HS.

Family and domain databases

InterProiIPR018228. DNase_TatD-rel_CS.
IPR032466. Metal_Hydrolase.
IPR001130. TatD_family.
[Graphical view]
PANTHERiPTHR10060. PTHR10060. 2 hits.
PfamiPF01026. TatD_DNase. 1 hit.
[Graphical view]
PIRSFiPIRSF005902. DNase_TatD. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS01091. TATD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTATD1_HUMAN
AccessioniPrimary (citable) accession number: Q6P1N9
Secondary accession number(s): B2R5J0, Q8TD02, Q9BY40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.