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Q6P1N0

- C2D1A_HUMAN

UniProt

Q6P1N0 - C2D1A_HUMAN

Protein

Coiled-coil and C2 domain-containing protein 1A

Gene

CC2D1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses By similarity. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.By similarity1 Publication

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
    3. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    2. signal transduction Source: GOC

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil and C2 domain-containing protein 1A
    Alternative name(s):
    Akt kinase-interacting protein 1
    Five prime repressor element under dual repression-binding protein 1
    Short name:
    FRE under dual repression-binding protein 1
    Short name:
    Freud-1
    Putative NF-kappa-B-activating protein 023N
    Gene namesi
    Name:CC2D1A
    Synonyms:AKI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30237. CC2D1A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB
    4. microtubule organizing center Source: UniProtKB-SubCell
    5. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Mental retardation, autosomal recessive 3 (MRT3) [MIM:608443]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Mental retardation

    Organism-specific databases

    MIMi608443. phenotype.
    Orphaneti88616. Autosomal recessive nonsyndromic intellectual disability.
    PharmGKBiPA142672197.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 951951Coiled-coil and C2 domain-containing protein 1APRO_0000239609Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei204 – 2041Phosphothreonine1 Publication
    Modified residuei208 – 2081Phosphoserine; by CDK14 Publications
    Modified residuei253 – 2531Phosphoserine1 Publication
    Modified residuei455 – 4551Phosphoserine3 Publications

    Post-translational modificationi

    Phosphorylation on Ser-208 by CDK1 promotes spindle pole localization and association with SCC1/RAD21.5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6P1N0.
    PaxDbiQ6P1N0.
    PRIDEiQ6P1N0.

    PTM databases

    PhosphoSiteiQ6P1N0.

    Expressioni

    Gene expression databases

    BgeeiQ6P1N0.
    CleanExiHS_CC2D1A.
    GenevestigatoriQ6P1N0.

    Organism-specific databases

    HPAiCAB015220.
    HPA005436.

    Interactioni

    Protein-protein interaction databases

    BioGridi120212. 8 interactions.
    IntActiQ6P1N0. 3 interactions.
    MINTiMINT-4827481.
    STRINGi9606.ENSP00000313601.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P1N0.
    SMRiQ6P1N0. Positions 656-790.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini642 – 755114C2Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili346 – 39247Sequence AnalysisAdd
    BLAST
    Coiled coili484 – 51734Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi192 – 345154Pro-richAdd
    BLAST

    Domaini

    The C2 domain is required for the repression.By similarity

    Sequence similaritiesi

    Belongs to the CC2D1 family.Curated
    Contains 1 C2 domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG297234.
    HOGENOMiHOG000285993.
    HOVERGENiHBG100866.
    InParanoidiQ6P1N0.
    KOiK18260.
    OMAiMERYHVA.
    OrthoDBiEOG71G9TB.
    PhylomeDBiQ6P1N0.
    TreeFamiTF314229.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR006608. DM14.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    SM00685. DM14. 4 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P1N0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHKRKGPPGP PGRGAAAARQ LGLLVDLSPD GLMIPEDGAN DEELEAEFLA    50
    LVGGQPPALE KLKGKGPLPM EAIEKMASLC MRDPDEDEEE GTDEDDLEAD 100
    DDLLAELNEV LGEEQKASET PPPVAQPKPE APHPGLETTL QERLALYQTA 150
    IESARQAGDS AKMRRYDRGL KTLENLLASI RKGNAIDEAD IPPPVAIGKG 200
    PASTPTYSPA PTQPAPRIAS APEPRVTLEG PSATAPASSP GLAKPQMPPG 250
    PCSPGPLAQL QSRQRDYKLA ALHAKQQGDT TAAARHFRVA KSFDAVLEAL 300
    SRGEPVDLSC LPPPPDQLPP DPPSPPSQPP TPATAPSTTE VPPPPRTLLE 350
    ALEQRMERYQ VAAAQAKSKG DQRKARMHER IVKQYQDAIR AHKAGRAVDV 400
    AELPVPPGFP PIQGLEATKP TQQSLVGVLE TAMKLANQDE GPEDEEDEVP 450
    KKQNSPVAPT AQPKAPPSRT PQSGSAPTAK APPKATSTRA QQQLAFLEGR 500
    KKQLLQAALR AKQKNDVEGA KMHLRQAKGL EPMLEASRNG LPVDITKVPP 550
    APVNKDDFAL VQRPGPGLSQ EAARRYGELT KLIRQQHEMC LNHSNQFTQL 600
    GNITETTKFE KLAEDCKRSM DILKQAFVRG LPTPTARFEQ RTFSVIKIFP 650
    DLSSNDMLLF IVKGINLPTP PGLSPGDLDV FVRFDFPYPN VEEAQKDKTS 700
    VIKNTDSPEF KEQFKLCINR SHRGFRRAIQ TKGIKFEVVH KGGLFKTDRV 750
    LGTAQLKLDA LEIACEVREI LEVLDGRRPT GGRLEVMVRI REPLTAQQLE 800
    TTTERWLVID PVPAAVPTQV AGPKGKAPPV PAPARESGNR SARPLHSLSV 850
    LAFDQERLER KILALRQARR PVPPEVAQQY QDIMQRSQWQ RAQLEQGGVG 900
    IRREYAAQLE RQLQFYTEAA RRLGNDGSRD AAKEALYRRN LVESELQRLR 950
    R 951
    Length:951
    Mass (Da):104,062
    Last modified:July 5, 2004 - v1
    Checksum:i04D80124FC47729A
    GO
    Isoform 2 (identifier: Q6P1N0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         819-819: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:950
    Mass (Da):103,934
    Checksum:i4A6B9FF39DECF316
    GO

    Sequence cautioni

    The sequence BAA91029.1 differs from that shown. Reason: Aberrant splicing.
    The sequence BAB15464.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti646 – 6461I → V in AAN04488. 1 PublicationCurated
    Sequence conflicti824 – 8241K → E in BAC77355. (PubMed:12761501)Curated
    Sequence conflicti837 – 8371S → P in BAC77355. (PubMed:12761501)Curated
    Sequence conflicti906 – 9061A → T in BAC77355. (PubMed:12761501)Curated
    Sequence conflicti943 – 9431E → G in BAC77355. (PubMed:12761501)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti339 – 3391T → P.
    Corresponds to variant rs11883041 [ dbSNP | Ensembl ].
    VAR_026670
    Natural varianti635 – 6351T → S.
    Corresponds to variant rs2290663 [ dbSNP | Ensembl ].
    VAR_026671
    Natural varianti801 – 8011T → M.
    Corresponds to variant rs2305777 [ dbSNP | Ensembl ].
    VAR_026672

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei819 – 8191Missing in isoform 2. 1 PublicationVSP_019242

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF536205 mRNA. Translation: AAN04488.1.
    AB097002 mRNA. Translation: BAC77355.1.
    AK000248 mRNA. Translation: BAA91029.1. Sequence problems.
    AK026371 mRNA. Translation: BAB15464.1. Different initiation.
    BC048345 mRNA. Translation: AAH48345.1.
    BC064981 mRNA. Translation: AAH64981.1.
    CCDSiCCDS42512.1. [Q6P1N0-1]
    RefSeqiNP_060191.3. NM_017721.4. [Q6P1N0-1]
    XP_005260030.1. XM_005259973.1. [Q6P1N0-2]
    UniGeneiHs.269592.

    Genome annotation databases

    EnsembliENST00000318003; ENSP00000313601; ENSG00000132024. [Q6P1N0-1]
    ENST00000589606; ENSP00000467526; ENSG00000132024. [Q6P1N0-2]
    GeneIDi54862.
    KEGGihsa:54862.
    UCSCiuc002mxo.2. human. [Q6P1N0-1]
    uc002mxp.2. human. [Q6P1N0-2]

    Polymorphism databases

    DMDMi74737148.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF536205 mRNA. Translation: AAN04488.1 .
    AB097002 mRNA. Translation: BAC77355.1 .
    AK000248 mRNA. Translation: BAA91029.1 . Sequence problems.
    AK026371 mRNA. Translation: BAB15464.1 . Different initiation.
    BC048345 mRNA. Translation: AAH48345.1 .
    BC064981 mRNA. Translation: AAH64981.1 .
    CCDSi CCDS42512.1. [Q6P1N0-1 ]
    RefSeqi NP_060191.3. NM_017721.4. [Q6P1N0-1 ]
    XP_005260030.1. XM_005259973.1. [Q6P1N0-2 ]
    UniGenei Hs.269592.

    3D structure databases

    ProteinModelPortali Q6P1N0.
    SMRi Q6P1N0. Positions 656-790.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120212. 8 interactions.
    IntActi Q6P1N0. 3 interactions.
    MINTi MINT-4827481.
    STRINGi 9606.ENSP00000313601.

    PTM databases

    PhosphoSitei Q6P1N0.

    Polymorphism databases

    DMDMi 74737148.

    Proteomic databases

    MaxQBi Q6P1N0.
    PaxDbi Q6P1N0.
    PRIDEi Q6P1N0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318003 ; ENSP00000313601 ; ENSG00000132024 . [Q6P1N0-1 ]
    ENST00000589606 ; ENSP00000467526 ; ENSG00000132024 . [Q6P1N0-2 ]
    GeneIDi 54862.
    KEGGi hsa:54862.
    UCSCi uc002mxo.2. human. [Q6P1N0-1 ]
    uc002mxp.2. human. [Q6P1N0-2 ]

    Organism-specific databases

    CTDi 54862.
    GeneCardsi GC19P014016.
    HGNCi HGNC:30237. CC2D1A.
    HPAi CAB015220.
    HPA005436.
    MIMi 608443. phenotype.
    610055. gene.
    neXtProti NX_Q6P1N0.
    Orphaneti 88616. Autosomal recessive nonsyndromic intellectual disability.
    PharmGKBi PA142672197.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297234.
    HOGENOMi HOG000285993.
    HOVERGENi HBG100866.
    InParanoidi Q6P1N0.
    KOi K18260.
    OMAi MERYHVA.
    OrthoDBi EOG71G9TB.
    PhylomeDBi Q6P1N0.
    TreeFami TF314229.

    Miscellaneous databases

    ChiTaRSi CC2D1A. human.
    GeneWikii CC2D1A.
    GenomeRNAii 54862.
    NextBioi 57750.
    PROi Q6P1N0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P1N0.
    CleanExi HS_CC2D1A.
    Genevestigatori Q6P1N0.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR006608. DM14.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    SM00685. DM14. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Guo J.H., Chen L., Yu L.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    2. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
      Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung fibroblast.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-606 AND 622-951 (ISOFORM 1).
      Tissue: Ovary.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Ovary.
    5. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation."
      Basel-Vanagaite L., Attia R., Yahav M., Ferland R.J., Anteki L., Walsh C.A., Olender T., Straussberg R., Magal N., Taub E., Drasinover V., Alkelai A., Bercovich D., Rechavi G., Simon A.J., Shohat M.
      J. Med. Genet. 43:203-210(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INVOLVEMENT IN MRT3.
    7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-204; SER-208; SER-253 AND SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Mitotic phosphorylation of Aki1 at Ser208 by cyclin B1-Cdk1 complex."
      Nakamura A., Naito M., Arai H., Fujita N.
      Biochem. Biophys. Res. Commun. 393:872-876(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-208 BY CDK1, SUBCELLULAR LOCATION.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208 AND SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiC2D1A_HUMAN
    AccessioniPrimary (citable) accession number: Q6P1N0
    Secondary accession number(s): Q7Z435
    , Q86XV0, Q8NF89, Q9H603, Q9NXI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3