ID   ARMX5_HUMAN             Reviewed;         558 AA.
AC   Q6P1M9; B3KU88; D3DX99; Q68DB4; Q9BVZ3; Q9H969;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 148.
DE   RecName: Full=Armadillo repeat-containing X-linked protein 5;
GN   Name=ARMCX5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Esophageal carcinoma;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle, Placenta, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q6P1M9; Q92624: APPBP2; NbExp=6; IntAct=EBI-10252512, EBI-743771;
CC       Q6P1M9; P42858: HTT; NbExp=6; IntAct=EBI-10252512, EBI-466029;
CC   -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC       family. {ECO:0000305}.
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DR   EMBL; AK023031; BAB14367.1; -; mRNA.
DR   EMBL; AK096692; BAG53350.1; -; mRNA.
DR   EMBL; CR749476; CAH18306.1; -; mRNA.
DR   EMBL; AL035551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471190; EAW54733.1; -; Genomic_DNA.
DR   EMBL; CH471190; EAW54734.1; -; Genomic_DNA.
DR   EMBL; BC000792; AAH00792.1; -; mRNA.
DR   EMBL; BC058904; AAH58904.1; -; mRNA.
DR   EMBL; BC064983; AAH64983.1; -; mRNA.
DR   CCDS; CCDS14500.1; -.
DR   RefSeq; NP_001161950.1; NM_001168478.1.
DR   RefSeq; NP_001161951.1; NM_001168479.1.
DR   RefSeq; NP_001161952.1; NM_001168480.1.
DR   RefSeq; NP_001161954.1; NM_001168482.1.
DR   RefSeq; NP_001161957.1; NM_001168485.1.
DR   RefSeq; NP_073749.2; NM_022838.3.
DR   AlphaFoldDB; Q6P1M9; -.
DR   SMR; Q6P1M9; -.
DR   BioGRID; 122333; 31.
DR   IntAct; Q6P1M9; 7.
DR   STRING; 9606.ENSP00000474720; -.
DR   GlyCosmos; Q6P1M9; 4 sites, 1 glycan.
DR   GlyGen; Q6P1M9; 4 sites, 1 O-linked glycan (4 sites).
DR   iPTMnet; Q6P1M9; -.
DR   PhosphoSitePlus; Q6P1M9; -.
DR   BioMuta; ARMCX5; -.
DR   DMDM; 74749066; -.
DR   EPD; Q6P1M9; -.
DR   MassIVE; Q6P1M9; -.
DR   MaxQB; Q6P1M9; -.
DR   PaxDb; 9606-ENSP00000474720; -.
DR   PeptideAtlas; Q6P1M9; -.
DR   ProteomicsDB; 66854; -.
DR   Pumba; Q6P1M9; -.
DR   Antibodypedia; 384; 47 antibodies from 14 providers.
DR   DNASU; 64860; -.
DR   Ensembl; ENST00000246174.6; ENSP00000246174.2; ENSG00000125962.16.
DR   Ensembl; ENST00000372742.1; ENSP00000361827.1; ENSG00000125962.16.
DR   Ensembl; ENST00000473968.7; ENSP00000473737.2; ENSG00000125962.16.
DR   Ensembl; ENST00000477663.6; ENSP00000474484.2; ENSG00000125962.16.
DR   Ensembl; ENST00000479502.2; ENSP00000474470.2; ENSG00000125962.16.
DR   Ensembl; ENST00000604957.1; ENSP00000474720.1; ENSG00000125962.16.
DR   GeneID; 64860; -.
DR   KEGG; hsa:64860; -.
DR   MANE-Select; ENST00000473968.7; ENSP00000473737.2; NM_001168478.2; NP_001161950.1.
DR   UCSC; uc004ejg.4; human.
DR   AGR; HGNC:25772; -.
DR   CTD; 64860; -.
DR   GeneCards; ARMCX5; -.
DR   HGNC; HGNC:25772; ARMCX5.
DR   HPA; ENSG00000125962; Low tissue specificity.
DR   MIM; 301047; gene.
DR   neXtProt; NX_Q6P1M9; -.
DR   OpenTargets; ENSG00000125962; -.
DR   PharmGKB; PA134910322; -.
DR   VEuPathDB; HostDB:ENSG00000125962; -.
DR   eggNOG; ENOG502RK9I; Eukaryota.
DR   GeneTree; ENSGT00940000163081; -.
DR   HOGENOM; CLU_037187_2_0_1; -.
DR   InParanoid; Q6P1M9; -.
DR   OMA; PKACRCK; -.
DR   OrthoDB; 2912889at2759; -.
DR   PhylomeDB; Q6P1M9; -.
DR   TreeFam; TF335652; -.
DR   PathwayCommons; Q6P1M9; -.
DR   SignaLink; Q6P1M9; -.
DR   BioGRID-ORCS; 64860; 9 hits in 774 CRISPR screens.
DR   GenomeRNAi; 64860; -.
DR   Pharos; Q6P1M9; Tdark.
DR   PRO; PR:Q6P1M9; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q6P1M9; Protein.
DR   Bgee; ENSG00000125962; Expressed in islet of Langerhans and 183 other cell types or tissues.
DR   ExpressionAtlas; Q6P1M9; baseline and differential.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR006911; ARM-rpt_dom.
DR   InterPro; IPR016024; ARM-type_fold.
DR   PANTHER; PTHR47081; -; 1.
DR   PANTHER; PTHR47081:SF2; ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 5; 1.
DR   Pfam; PF04826; Arm_2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   Genevisible; Q6P1M9; HS.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..558
FT                   /note="Armadillo repeat-containing X-linked protein 5"
FT                   /id="PRO_0000191371"
FT   REPEAT          300..339
FT                   /note="ARM 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          422..461
FT                   /note="ARM 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          463..503
FT                   /note="ARM 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          520..558
FT                   /note="ARM 4"
FT                   /evidence="ECO:0000255"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          369..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        337
FT                   /note="I -> V (in Ref. 2; BAB14367)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        376
FT                   /note="V -> A (in Ref. 1; CAH18306)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   558 AA;  62346 MW;  5783D6A62445BF5C CRC64;
     MVDSGTEARA RGKAEAGLQD GISGPATARV NGKTQAEAVA EAELKTESVT QAKAGDGAMT
     RTHTVTYREA MAVTREVIKV EDTTKTRVMV ETKTKPLAER SIVPQTKSKA MPMSRVSTVT
     KSEVKVVAVI EANIRSYAKS HDKANTGSRP DRREETSIGM KSSDEDEENI CSWFWTGEEP
     SVGSWFWPEE ETSLQVYKPL PKIQEKPKPT HKPTLTIKQK VIAWSRARYI VLVPVEGGEQ
     SLPPEGNWTL VETLIETPLG IRPLTKIPPY HGPYYQTLAE IKKQIRQREK YGPNPKACHC
     KSRGFSLEPK EFDKLVALLK LTKDPFIHEI ATMIMGISPA YPFTQDIIHD VGITVMIENL
     VNNPNVKEHP GALSMVDDSS ESSEEPKSGE SYIHQVCKGI ISCPLNSPVQ LAGLKLLGHL
     SIKFEDHYVI TSYIPDFLTL LNKGSVKTKF YVLKVFSCLS KNHANTRELI SAKVLSSLVA
     PFNKNESKAN ILNIIEIFEN INFQFKTKAK LFTKEKFTKS ELISIFQEAK QFGQKLQDLA
     EHSDPEVRDK VIRLILKL
//