Reviewed, UniProtKB/Swiss-Prot Q6P1M9 (ARMX5_HUMAN)

Names and origin

Protein names

Recommended name:
    Armadillo repeat-containing X-linked protein 5

Gene names

Name:

ARMCX5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 3 ARM repeats.

Ontologies

Keywords
Domain	Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 558	558	Armadillo repeat-containing X-linked protein 5		PRO_0000191371
Regions
	Repeat	300 – 339	40	ARM 1
	Repeat	422 – 461	40	ARM 2
	Repeat	463 – 503	41	ARM 3
Experimental info
	Sequence conflict	337	1	I → V in BAB14367. Ref.2
	Sequence conflict	376	1	V → A in CAH18306. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6P1M9-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 5783D6A62445BF5C	FASTA	558	62,346
	10 20 30 40 50 60 MVDSGTEARA RGKAEAGLQD GISGPATARV NGKTQAEAVA EAELKTESVT QAKAGDGAMT 70 80 90 100 110 120 RTHTVTYREA MAVTREVIKV EDTTKTRVMV ETKTKPLAER SIVPQTKSKA MPMSRVSTVT 130 140 150 160 170 180 KSEVKVVAVI EANIRSYAKS HDKANTGSRP DRREETSIGM KSSDEDEENI CSWFWTGEEP 190 200 210 220 230 240 SVGSWFWPEE ETSLQVYKPL PKIQEKPKPT HKPTLTIKQK VIAWSRARYI VLVPVEGGEQ 250 260 270 280 290 300 SLPPEGNWTL VETLIETPLG IRPLTKIPPY HGPYYQTLAE IKKQIRQREK YGPNPKACHC 310 320 330 340 350 360 KSRGFSLEPK EFDKLVALLK LTKDPFIHEI ATMIMGISPA YPFTQDIIHD VGITVMIENL 370 380 390 400 410 420 VNNPNVKEHP GALSMVDDSS ESSEEPKSGE SYIHQVCKGI ISCPLNSPVQ LAGLKLLGHL 430 440 450 460 470 480 SIKFEDHYVI TSYIPDFLTL LNKGSVKTKF YVLKVFSCLS KNHANTRELI SAKVLSSLVA 490 500 510 520 530 540 PFNKNESKAN ILNIIEIFEN INFQFKTKAK LFTKEKFTKS ELISIFQEAK QFGQKLQDLA 550 EHSDPEVRDK VIRLILKL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Oesophageal carcinoma.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle, Placenta and Uterus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK023031 mRNA. Translation: BAB14367.1. AK096692 mRNA. Translation: BAG53350.1. CR749476 mRNA. Translation: CAH18306.1. AL035551 Genomic DNA. Translation: CAI42194.1. CH471190 Genomic DNA. Translation: EAW54733.1. BC000792 mRNA. Translation: AAH00792.1. BC058904 mRNA. Translation: AAH58904.1. BC064983 mRNA. Translation: AAH64983.1.
IPI	IPI00549673.
RefSeq	NP_073749.2.
UniGene	Hs.522729
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q6P1M9.
Genome annotation databases
Ensembl	ENST00000246174; ENSP00000246174; ENSG00000125962; Homo sapiens. [Genome view] ENST00000372742; ENSP00000361827; ENSG00000125962; Homo sapiens. [Genome view] ENST00000395085; ENSP00000378520; ENSG00000125962; Homo sapiens. [Genome view]
GeneID	64860.
KEGG	hsa:64860.
UCSC	uc004ejg.1. human.
Organism-specific databases
CTD	64860.
GeneCards	GC0XP101660.
HGNC	HGNC:25772. ARMCX5.
HPA	HPA000996.
PharmGKB	PA134910322.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG127441.
HOVERGEN	Q6P1M9.
InParanoid	Q6P1M9.
OMA	PSVGSWF.
OrthoDB	EOG9GMXGB.
Gene expression databases
ArrayExpress	Q6P1M9.
Bgee	Q6P1M9.
CleanEx	HS_ARMCX5.
Genevestigator	Q6P1M9.
GermOnline	ENSG00000125962. Homo sapiens.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR006911. DUF634. [Graphical view]
Pfam	PF04826. DUF634. 1 hit. [Graphical view]
PROSITE	PS50176. ARM_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	67015.

Entry information

Entry name

ARMX5_HUMAN

Accession

Primary (citable) accession number: Q6P1M9
Secondary accession number(s): B3KU88 , Q68DB4, Q9BVZ3, Q9H969

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 5, 2004
Last modified:	December 15, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.