Reviewed,
UniProtKB/Swiss-Prot Q6P1M0 (S27A4_HUMAN)
Last modified
November 24, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Long-chain fatty acid transport protein 4 Short name=Fatty acid transport protein 4 Short name=FATP-4 EC=6.2.1.- Alternative name(s): Solute carrier family 27 member 4 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 643 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids By similarity. |
| Subcellular location | Membrane; Multi-pass membrane protein Probable. |
| Tissue specificity | Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue. Ref.1 |
| Miscellaneous | SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with aquired obesity. |
| Sequence similarities | Belongs to the ATP-dependent AMP-binding enzyme family. |
| Sequence caution | The sequence AAD11623.1 differs from that shown. Reason: Frameshift at positions 362, 387, 612 and 619. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid metabolism Lipid metabolism Lipid transport Transport |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Ligand | Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW fatty acid transport Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | fatty acid transporter activity Ref.1 Traceable author statement. Source: ProtInc ligase activityInferred from electronic annotation. Source: UniProtKB-KW nucleotide bindingInferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 643 | 643 | Long-chain fatty acid transport protein 4 | PRO_0000193209 | |||||
Regions | |||||||||
| Transmembrane | 20 – 42 | 23 | Potential | ||||||
| Transmembrane | 139 – 156 | 18 | Potential | ||||||
| Nucleotide binding | 243 – 254 | 12 | AMP Potential | ||||||
Natural variations | |||||||||
| Natural variant | 209 | 1 | G → S Correlates with lower body mass index, triglyceride concentrations, systolic blood pressure, insulin concentrations and homeostasis model assessment index. dbSNP rs2240953. Ref.7 | VAR_023783 | |||||
Experimental info | |||||||||
| Sequence conflict | 194 | 1 | L → P in AAD11623. Ref.1 | ||||||
| Sequence conflict | 605 | 1 | G → A in AAD11623. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)." Fitscher B.A., Riedel H.D., Young K.C., Stremmel W. Biochim. Biophys. Acta 1443:381-385(1998) [PubMed: 9878842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Heart. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus. |
| [3] | "DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. Dunham I.Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [6] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [7] | "Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome." Gertow K., Bellanda M., Eriksson P., Boquist S., Hamsten A., Sunnerhagen M., Fisher R.M. J. Clin. Endocrinol. Metab. 89:392-399(2004) [PubMed: 14715877] [Abstract] Cited for: VARIANT SER-209. |
Cross-references
Sequence databases | |
|---|---|
| AF055899 mRNA. Translation: AAD11623.1. Frameshift. AK290222 mRNA. Translation: BAF82911.1. AL359091 Genomic DNA. Translation: CAI13490.1. CH471090 Genomic DNA. Translation: EAW87779.1. BC065003 mRNA. Translation: AAH65003.1. | |
| IPI | IPI00412147. |
| RefSeq | NP_005085.2. |
| UniGene | Hs.656699 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q6P1M0. 1 interaction. |
| STRING | Q6P1M0. |
Proteomic databases | |
| PRIDE | Q6P1M0. |
Genome annotation databases | |
| Ensembl | ENST00000300456; ENSP00000300456; ENSG00000167114; Homo sapiens. [Genome view] |
| GeneID | 10999. |
| KEGG | hsa:10999. |
| UCSC | uc004but.1. human. |
Organism-specific databases | |
| CTD | 10999. |
| GeneCards | GC09P130142. |
| H-InvDB | HIX0008427. |
| HGNC | HGNC:10998. SLC27A4. |
| HPA | CAB009771. HPA007293. |
| MIM | 604194. gene. |
| Orphanet | 88621. Ichthyosis prematurity syndrome. |
| PharmGKB | PA35872. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q6P1M0. |
| HOVERGEN | Q6P1M0. |
| OMA | HWTFRQL |
| OrthoDB | EOG9GQSQQ |
Enzyme and pathway databases | |
| BRENDA | 6.2.1.3. 247. |
Gene expression databases | |
| ArrayExpress | Q6P1M0. |
| Bgee | Q6P1M0. |
| CleanEx | HS_SLC27A4. |
| Genevestigator | Q6P1M0. |
Family and domain databases | |
| InterPro | IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR002345. Lipocalin. [Graphical view] |
| Pfam | PF00501. AMP-binding. 1 hit. [Graphical view] |
| PROSITE | PS00455. AMP_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 41787. |
| SOURCE | Search... |
Entry information
| Entry name | S27A4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6P1M0 Secondary accession number(s): A8K2F7, O95186 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


