SLC27A4

Functionⁱ

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).By similarity

Miscellaneous

SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with acquired obesity.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	243 – 254	AMPSequence analysisAdd BLAST		12

GO - Molecular functionⁱ

fatty acid transmembrane transporter activity Source: Reactome
long-chain fatty acid-CoA ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22022213
nucleotide binding Source: UniProtKB-KW
very long-chain fatty acid-CoA ligase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid transport
Source: ProtInc
Traceable author statementⁱ
- 9878842
lipid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 9878842
long-chain fatty acid import
Source: UniProtKB
Inferred from direct assayⁱ
- 22022213
long-chain fatty acid metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 22022213
long-chain fatty acid transport Source: Reactome
medium-chain fatty acid transport Source: Ensembl
response to nutrient Source: Ensembl
skin development Source: Ensembl
very long-chain fatty acid catabolic process Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ligase
Biological process	Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport
Ligand	Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	6.2.1.3 2681
Reactomeⁱ	R-HSA-5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) R-HSA-804914 Transport of fatty acids

Protein family/group databases

TCDBⁱ	4.C.1.1.10 the fatty acid transporter (fat) family

TCDBⁱ

4.C.1.1.10 the fatty acid transporter (fat) family

Chemistry databases

SwissLipidsⁱ	SLP:000000451

SwissLipidsⁱ

SLP:000000451

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Long-chain fatty acid transport protein 4 (EC:6.2.1.-) Short name: FATP-4 Short name: Fatty acid transport protein 4 Alternative name(s): Solute carrier family 27 member 4
Gene namesⁱ	Name:SLC27A4 Synonyms:ACSVL4, FATP4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167114.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10998 SLC27A4
MIMⁱ	604194 gene
neXtProtⁱ	NX_Q6P1M0

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	20 – 42	HelicalSequence analysisAdd BLAST		23
Transmembraneⁱ	139 – 156	HelicalSequence analysisAdd BLAST		18

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ichthyosis prematurity syndrome (IPS)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations.

Keywords - Diseaseⁱ

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10999
MalaCards human disease database More...MalaCardsⁱ	SLC27A4
MIMⁱ	608649 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000167114
Orphanetⁱ	88621 Ichthyosis prematurity syndrome
PharmGKBⁱ	PA35872

Chemistry databases

ChEMBLⁱ	CHEMBL4327
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1111

Polymorphism and mutation databases

BioMutaⁱ	SLC27A4
DMDMⁱ	74749065

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000193209	1 – 643	Long-chain fatty acid transport protein 4Add BLAST		643

Proteomic databases

EPDⁱ	Q6P1M0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P1M0
PaxDbⁱ	Q6P1M0
PeptideAtlas More...PeptideAtlasⁱ	Q6P1M0
PRIDEⁱ	Q6P1M0
ProteomicsDBⁱ	66849

PTM databases

iPTMnetⁱ	Q6P1M0
PhosphoSitePlusⁱ	Q6P1M0
SwissPalmⁱ	Q6P1M0

Expressionⁱ

Tissue specificityⁱ

Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000167114
CleanExⁱ	HS_SLC27A4
ExpressionAtlasⁱ	Q6P1M0 baseline and differential
Genevisibleⁱ	Q6P1M0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009771 HPA007293

HPAⁱ

CAB009771
HPA007293

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	116192, 25 interactors
IntActⁱ	Q6P1M0, 22 interactors
Molecular INTeraction database More...MINTⁱ	Q6P1M0
STRINGⁱ	9606.ENSP00000300456

Chemistry databases

BindingDBⁱ

Q6P1M0

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P1M0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1179 Eukaryota ENOG410XQ8T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074420
HOGENOMⁱ	HOG000044189
HOVERGENⁱ	HBG005642
InParanoidⁱ	Q6P1M0
KEGG Orthology (KO) More...KOⁱ	K08745
OMAⁱ	FQGYYGN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B76
PhylomeDBⁱ	Q6P1M0
TreeFamⁱ	TF313430

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05939 hsFATP4_like, 1 hit
InterProⁱ	View protein in InterPro IPR025110 AMP-bd_C IPR020845 AMP-binding_CS IPR000873 AMP-dep_Synth/Lig IPR030304 FATP4 IPR022272 Lipocalin_CS
PANTHERⁱ	PTHR43107:SF11 PTHR43107:SF11, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00501 AMP-binding, 1 hit PF13193 AMP-binding_C, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455 AMP_BINDING, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q6P1M0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLGASLVGV LLFSKLVLKL PWTQVGFSLL FLYLGSGGWR FIRVFIKTIR 
        60         70         80         90        100
RDIFGGLVLL KVKAKVRQCL QERRTVPILF ASTVRRHPDK TALIFEGTDT 
       110        120        130        140        150
HWTFRQLDEY SSSVANFLQA RGLASGDVAA IFMENRNEFV GLWLGMAKLG 
       160        170        180        190        200
VEAALINTNL RRDALLHCLT TSRARALVFG SEMASAICEV HASLDPSLSL 
       210        220        230        240        250
FCSGSWEPGA VPPSTEHLDP LLKDAPKHLP SCPDKGFTDK LFYIYTSGTT 
       260        270        280        290        300
GLPKAAIVVH SRYYRMAALV YYGFRMRPND IVYDCLPLYH SAGNIVGIGQ 
       310        320        330        340        350
CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE 
       360        370        380        390        400
NQHQVRMALG NGLRQSIWTN FSSRFHIPQV AEFYGATECN CSLGNFDSQV 
       410        420        430        440        450
GACGFNSRIL SFVYPIRLVR VNEDTMELIR GPDGVCIPCQ PGEPGQLVGR 
       460        470        480        490        500
IIQKDPLRRF DGYLNQGANN KKIAKDVFKK GDQAYLTGDV LVMDELGYLY 
       510        520        530        540        550
FRDRTGDTFR WKGENVSTTE VEGTLSRLLD MADVAVYGVE VPGTEGRAGM 
       560        570        580        590        600
AAVASPTGNC DLERFAQVLE KELPLYARPI FLRLLPELHK TGTYKFQKTE 
       610        620        630        640 
LRKEGFDPAI VKDPLFYLDA QKGRYVPLDQ EAYSRIQAGE EKL

Length:643

Mass (Da):72,064

Last modified:July 5, 2004 - v1

Checksum:ⁱ95E677DB3CEB9A14

GO

Isoform 2 (identifier: Q6P1M0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-76: MLLGASLVGV...RQCLQERRTV → MPLTLSTLLQ...ALHPGLHQDH
77-482: Missing.

« Hide

        10         20         30         40         50
MPLTLSTLLQ PGRIWTGRRA AEPTPGHNAA WSLSGGGAAV LQAGAETALD 
        60         70         80         90        100
PGGILPVVPL LGIWRLALHP GLHQDHQAYL TGDVLVMDEL GYLYFRDRTG 
       110        120        130        140        150
DTFRWKGENV STTEVEGTLS RLLDMADVAV YGVEVPGTEG RAGMAAVASP 
       160        170        180        190        200
TGNCDLERFA QVLEKELPLY ARPIFLRLLP ELHKTGTYKF QKTELRKEGF 
       210        220        230 
DPAIVKDPLF YLDAQKGRYV PLDQEAYSRI QAGEEKL

Note: No experimental confirmation available.

Show »

Length:237

Mass (Da):26,001

Checksum:ⁱ28E743004702E708

GO

Sequence cautionⁱ

The sequence AAD11623 differs from that shown. Reason: Frameshift at positions 362, 387, 612 and 619.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	194	L → P in AAD11623 (PubMed:9878842).Curated		1
Sequence conflictⁱ	605	G → A in AAD11623 (PubMed:9878842).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063192	92	A → T in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853132EnsemblClinVar.	1
Natural variantⁱVAR_023783	209	G → S Correlates with lower body mass index, triglyceride concentrations, systolic blood pressure, insulin concentrations and homeostasis model assessment index. 1 PublicationCorresponds to variant dbSNP:rs2240953Ensembl.	1
Natural variantⁱVAR_063193	247	S → P in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853133EnsemblClinVar.	1
Natural variantⁱVAR_063194	300	Q → R in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853134EnsemblClinVar.	1
Natural variantⁱVAR_064500	374	R → C in IPS. 1 PublicationCorresponds to variant dbSNP:rs768495407Ensembl.	1
Natural variantⁱVAR_063195	583	R → H in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853135EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055808	1 – 76	MLLGA…ERRTV → MPLTLSTLLQPGRIWTGRRA AEPTPGHNAAWSLSGGGAAV LQAGAETALDPGGILPVVPL LGIWRLALHPGLHQDH in isoform 2. 1 PublicationAdd BLAST		76
Alternative sequenceⁱVSP_055809	77 – 482	Missing in isoform 2. 1 PublicationAdd BLAST		406

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF055899 mRNA Translation: AAD11623.1 Frameshift. AK290222 mRNA Translation: BAF82911.1 AL359091 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87779.1 BC009959 mRNA Translation: AAH09959.1 BC065003 mRNA Translation: AAH65003.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6899.1 [Q6P1M0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_005085.2, NM_005094.3 [Q6P1M0-1] XP_016869711.1, XM_017014222.1 [Q6P1M0-1]
UniGeneⁱ	Hs.656699

Genome annotation databases

Ensemblⁱ	ENST00000300456; ENSP00000300456; ENSG00000167114 [Q6P1M0-1] ENST00000372870; ENSP00000361961; ENSG00000167114 [Q6P1M0-2]
GeneIDⁱ	10999
KEGGⁱ	hsa:10999
UCSC genome browser More...UCSCⁱ	uc004but.4 human [Q6P1M0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6P1M0	Long-chain fatty acid transport protein 4		MOUSE		643
Solute carrier family 27 member 4		MUSPF		651
Solute carrier family 27 member 4		AILME		644
UPI0004D09759		GALVR		644
Solute carrier family 27 member 4		ICTTR		643
+72
Q6P1M0-2	Solute carrier family 27 member 4		CALJA		238
Solute carrier family 27 member 4		AOTNA		238
SLC27A4 isoform 2		PANTR		237
Solute carrier family 27 member 4		MACMU		237
Long-chain fatty acid transport protein 4		MACFA		237
+8

Protein	Similar proteins		Species	Score	Length
Q6P1M0	Long-chain fatty acid transport protein 4		MOUSE		643
Solute carrier family 27 member 4		MUSPF		651
UPI0004D09759		GALVR		644
Solute carrier family 27 member 4		AILME		644
Long-chain fatty acid transport protein 4		MACMU		643
+302
Q6P1M0-2	Solute carrier family 27 member 4		AOTNA		238
Solute carrier family 27 member 4		CALJA		238
Solute carrier family 27 member 4		MACMU		237
Long-chain fatty acid transport protein 4		MACFA		237
Solute carrier family 27 member 4		MACNE		237
+10

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF055899 mRNA Translation: AAD11623.1 Frameshift. AK290222 mRNA Translation: BAF82911.1 AL359091 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87779.1 BC009959 mRNA Translation: AAH09959.1 BC065003 mRNA Translation: AAH65003.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6899.1 [Q6P1M0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_005085.2, NM_005094.3 [Q6P1M0-1] XP_016869711.1, XM_017014222.1 [Q6P1M0-1]
UniGeneⁱ	Hs.656699

3D structure databases

ProteinModelPortalⁱ	Q6P1M0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116192, 25 interactors
IntActⁱ	Q6P1M0, 22 interactors
Molecular INTeraction database More...MINTⁱ	Q6P1M0
STRINGⁱ	9606.ENSP00000300456

Chemistry databases

BindingDBⁱ	Q6P1M0
ChEMBLⁱ	CHEMBL4327
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1111
SwissLipidsⁱ	SLP:000000451

Protein family/group databases

TCDBⁱ	4.C.1.1.10 the fatty acid transporter (fat) family

TCDBⁱ

4.C.1.1.10 the fatty acid transporter (fat) family

PTM databases

iPTMnetⁱ	Q6P1M0
PhosphoSitePlusⁱ	Q6P1M0
SwissPalmⁱ	Q6P1M0

Polymorphism and mutation databases

BioMutaⁱ	SLC27A4
DMDMⁱ	74749065

Proteomic databases

EPDⁱ	Q6P1M0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P1M0
PaxDbⁱ	Q6P1M0
PeptideAtlas More...PeptideAtlasⁱ	Q6P1M0
PRIDEⁱ	Q6P1M0
ProteomicsDBⁱ	66849

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000300456; ENSP00000300456; ENSG00000167114 [Q6P1M0-1] ENST00000372870; ENSP00000361961; ENSG00000167114 [Q6P1M0-2]
GeneIDⁱ	10999
KEGGⁱ	hsa:10999
UCSC genome browser More...UCSCⁱ	uc004but.4 human [Q6P1M0-1]

Organism-specific databases

CTDⁱ	10999
DisGeNET More...DisGeNETⁱ	10999
EuPathDBⁱ	HostDB:ENSG00000167114.12
GeneCardsⁱ	SLC27A4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10998 SLC27A4
Human Protein Atlas More...HPAⁱ	CAB009771 HPA007293
MalaCards human disease database More...MalaCardsⁱ	SLC27A4
MIMⁱ	604194 gene 608649 phenotype
neXtProtⁱ	NX_Q6P1M0
Open Targets More...OpenTargetsⁱ	ENSG00000167114
Orphanetⁱ	88621 Ichthyosis prematurity syndrome
PharmGKBⁱ	PA35872
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1179 Eukaryota ENOG410XQ8T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074420
HOGENOMⁱ	HOG000044189
HOVERGENⁱ	HBG005642
InParanoidⁱ	Q6P1M0
KEGG Orthology (KO) More...KOⁱ	K08745
OMAⁱ	FQGYYGN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B76
PhylomeDBⁱ	Q6P1M0
TreeFamⁱ	TF313430

Enzyme and pathway databases

BRENDAⁱ	6.2.1.3 2681
Reactomeⁱ	R-HSA-5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) R-HSA-804914 Transport of fatty acids

Miscellaneous databases

ChiTaRSⁱ	SLC27A4 human
GeneWikiⁱ	SLC27A4
GenomeRNAiⁱ	10999
Protein Ontology More...PROⁱ	PR:Q6P1M0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167114
CleanExⁱ	HS_SLC27A4
ExpressionAtlasⁱ	Q6P1M0 baseline and differential
Genevisibleⁱ	Q6P1M0 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05939 hsFATP4_like, 1 hit
InterProⁱ	View protein in InterPro IPR025110 AMP-bd_C IPR020845 AMP-binding_CS IPR000873 AMP-dep_Synth/Lig IPR030304 FATP4 IPR022272 Lipocalin_CS
PANTHERⁱ	PTHR43107:SF11 PTHR43107:SF11, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00501 AMP-binding, 1 hit PF13193 AMP-binding_C, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455 AMP_BINDING, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S27A4_HUMAN
Accessionⁱ	Q6P1M0Primary (citable) accession number: Q6P1M0 Secondary accession number(s): A8K2F7, O95186, Q96G53
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
	Last sequence update:	July 5, 2004
	Last modified:	June 20, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniProtKB - Q6P1M0 (S27A4_HUMAN)

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Long-chain fatty acid transport protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ