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Q6P1M0

- S27A4_HUMAN

UniProt

Q6P1M0 - S27A4_HUMAN

Protein

Long-chain fatty acid transport protein 4

Gene

SLC27A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi243 – 25412AMPSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. fatty acid transporter activity Source: ProtInc
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB
    3. nucleotide binding Source: UniProtKB-KW
    4. very long-chain fatty acid-CoA ligase activity Source: Ensembl

    GO - Biological processi

    1. fatty acid transport Source: ProtInc
    2. lipid metabolic process Source: ProtInc
    3. long-chain fatty acid import Source: UniProtKB
    4. long-chain fatty acid metabolic process Source: UniProtKB
    5. long-chain fatty acid transport Source: Reactome
    6. medium-chain fatty acid transport Source: Ensembl
    7. response to nutrient Source: Ensembl
    8. skin development Source: Ensembl
    9. transmembrane transport Source: Reactome
    10. transport Source: ProtInc
    11. very long-chain fatty acid catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport

    Keywords - Ligandi

    Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi6.2.1.3. 2681.
    ReactomeiREACT_23892. Transport of fatty acids.

    Protein family/group databases

    TCDBi4.C.1.1.10. the proposed fatty acid transporter (fat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain fatty acid transport protein 4 (EC:6.2.1.-)
    Short name:
    FATP-4
    Short name:
    Fatty acid transport protein 4
    Alternative name(s):
    Solute carrier family 27 member 4
    Gene namesi
    Name:SLC27A4
    Synonyms:ACSVL4, FATP4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:10998. SLC27A4.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: Ensembl
    2. endoplasmic reticulum membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: UniProtKB
    5. microvillus Source: Ensembl
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Ichthyosis prematurity syndrome (IPS) [MIM:608649]: A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921A → T in IPS. 1 Publication
    VAR_063192
    Natural varianti247 – 2471S → P in IPS. 1 Publication
    VAR_063193
    Natural varianti300 – 3001Q → R in IPS. 1 Publication
    VAR_063194
    Natural varianti374 – 3741R → C in IPS. 1 Publication
    VAR_064500
    Natural varianti583 – 5831R → H in IPS. 1 Publication
    VAR_063195

    Keywords - Diseasei

    Disease mutation, Ichthyosis

    Organism-specific databases

    MIMi608649. phenotype.
    Orphaneti88621. Ichthyosis prematurity syndrome.
    PharmGKBiPA35872.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 643643Long-chain fatty acid transport protein 4PRO_0000193209Add
    BLAST

    Proteomic databases

    MaxQBiQ6P1M0.
    PaxDbiQ6P1M0.
    PRIDEiQ6P1M0.

    PTM databases

    PhosphoSiteiQ6P1M0.

    Expressioni

    Tissue specificityi

    Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.1 Publication

    Gene expression databases

    ArrayExpressiQ6P1M0.
    BgeeiQ6P1M0.
    CleanExiHS_SLC27A4.
    GenevestigatoriQ6P1M0.

    Organism-specific databases

    HPAiCAB009771.
    HPA007293.

    Interactioni

    Protein-protein interaction databases

    BioGridi116192. 5 interactions.
    IntActiQ6P1M0. 5 interactions.
    MINTiMINT-8376036.
    STRINGi9606.ENSP00000300456.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P1M0.
    SMRiQ6P1M0. Positions 79-615.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15618HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000044189.
    HOVERGENiHBG005642.
    InParanoidiQ6P1M0.
    KOiK08745.
    OMAiNDIVYDC.
    OrthoDBiEOG7W6WKB.
    PhylomeDBiQ6P1M0.
    TreeFamiTF313430.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR022272. Lipocalin_CS.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P1M0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLGASLVGV LLFSKLVLKL PWTQVGFSLL FLYLGSGGWR FIRVFIKTIR    50
    RDIFGGLVLL KVKAKVRQCL QERRTVPILF ASTVRRHPDK TALIFEGTDT 100
    HWTFRQLDEY SSSVANFLQA RGLASGDVAA IFMENRNEFV GLWLGMAKLG 150
    VEAALINTNL RRDALLHCLT TSRARALVFG SEMASAICEV HASLDPSLSL 200
    FCSGSWEPGA VPPSTEHLDP LLKDAPKHLP SCPDKGFTDK LFYIYTSGTT 250
    GLPKAAIVVH SRYYRMAALV YYGFRMRPND IVYDCLPLYH SAGNIVGIGQ 300
    CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE 350
    NQHQVRMALG NGLRQSIWTN FSSRFHIPQV AEFYGATECN CSLGNFDSQV 400
    GACGFNSRIL SFVYPIRLVR VNEDTMELIR GPDGVCIPCQ PGEPGQLVGR 450
    IIQKDPLRRF DGYLNQGANN KKIAKDVFKK GDQAYLTGDV LVMDELGYLY 500
    FRDRTGDTFR WKGENVSTTE VEGTLSRLLD MADVAVYGVE VPGTEGRAGM 550
    AAVASPTGNC DLERFAQVLE KELPLYARPI FLRLLPELHK TGTYKFQKTE 600
    LRKEGFDPAI VKDPLFYLDA QKGRYVPLDQ EAYSRIQAGE EKL 643
    Length:643
    Mass (Da):72,064
    Last modified:July 5, 2004 - v1
    Checksum:i95E677DB3CEB9A14
    GO
    Isoform 2 (identifier: Q6P1M0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-76: MLLGASLVGV...RQCLQERRTV → MPLTLSTLLQ...ALHPGLHQDH
         77-482: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:237
    Mass (Da):26,001
    Checksum:i28E743004702E708
    GO

    Sequence cautioni

    The sequence AAD11623.1 differs from that shown. Reason: Frameshift at positions 362, 387, 612 and 619.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti194 – 1941L → P in AAD11623. (PubMed:9878842)Curated
    Sequence conflicti605 – 6051G → A in AAD11623. (PubMed:9878842)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921A → T in IPS. 1 Publication
    VAR_063192
    Natural varianti209 – 2091G → S Correlates with lower body mass index, triglyceride concentrations, systolic blood pressure, insulin concentrations and homeostasis model assessment index. 1 Publication
    Corresponds to variant rs2240953 [ dbSNP | Ensembl ].
    VAR_023783
    Natural varianti247 – 2471S → P in IPS. 1 Publication
    VAR_063193
    Natural varianti300 – 3001Q → R in IPS. 1 Publication
    VAR_063194
    Natural varianti374 – 3741R → C in IPS. 1 Publication
    VAR_064500
    Natural varianti583 – 5831R → H in IPS. 1 Publication
    VAR_063195

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7676MLLGA…ERRTV → MPLTLSTLLQPGRIWTGRRA AEPTPGHNAAWSLSGGGAAV LQAGAETALDPGGILPVVPL LGIWRLALHPGLHQDH in isoform 2. 1 PublicationVSP_055808Add
    BLAST
    Alternative sequencei77 – 482406Missing in isoform 2. 1 PublicationVSP_055809Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055899 mRNA. Translation: AAD11623.1. Frameshift.
    AK290222 mRNA. Translation: BAF82911.1.
    AL359091 Genomic DNA. Translation: CAI13490.1.
    CH471090 Genomic DNA. Translation: EAW87779.1.
    BC009959 mRNA. Translation: AAH09959.1.
    BC065003 mRNA. Translation: AAH65003.1.
    CCDSiCCDS6899.1.
    RefSeqiNP_005085.2. NM_005094.3.
    UniGeneiHs.656699.

    Genome annotation databases

    EnsembliENST00000300456; ENSP00000300456; ENSG00000167114. [Q6P1M0-1]
    ENST00000372870; ENSP00000361961; ENSG00000167114. [Q6P1M0-2]
    GeneIDi10999.
    KEGGihsa:10999.
    UCSCiuc004but.3. human.

    Polymorphism databases

    DMDMi74749065.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055899 mRNA. Translation: AAD11623.1 . Frameshift.
    AK290222 mRNA. Translation: BAF82911.1 .
    AL359091 Genomic DNA. Translation: CAI13490.1 .
    CH471090 Genomic DNA. Translation: EAW87779.1 .
    BC009959 mRNA. Translation: AAH09959.1 .
    BC065003 mRNA. Translation: AAH65003.1 .
    CCDSi CCDS6899.1.
    RefSeqi NP_005085.2. NM_005094.3.
    UniGenei Hs.656699.

    3D structure databases

    ProteinModelPortali Q6P1M0.
    SMRi Q6P1M0. Positions 79-615.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116192. 5 interactions.
    IntActi Q6P1M0. 5 interactions.
    MINTi MINT-8376036.
    STRINGi 9606.ENSP00000300456.

    Chemistry

    BindingDBi Q6P1M0.
    ChEMBLi CHEMBL4327.

    Protein family/group databases

    TCDBi 4.C.1.1.10. the proposed fatty acid transporter (fat) family.

    PTM databases

    PhosphoSitei Q6P1M0.

    Polymorphism databases

    DMDMi 74749065.

    Proteomic databases

    MaxQBi Q6P1M0.
    PaxDbi Q6P1M0.
    PRIDEi Q6P1M0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300456 ; ENSP00000300456 ; ENSG00000167114 . [Q6P1M0-1 ]
    ENST00000372870 ; ENSP00000361961 ; ENSG00000167114 . [Q6P1M0-2 ]
    GeneIDi 10999.
    KEGGi hsa:10999.
    UCSCi uc004but.3. human.

    Organism-specific databases

    CTDi 10999.
    GeneCardsi GC09P131102.
    HGNCi HGNC:10998. SLC27A4.
    HPAi CAB009771.
    HPA007293.
    MIMi 604194. gene.
    608649. phenotype.
    neXtProti NX_Q6P1M0.
    Orphaneti 88621. Ichthyosis prematurity syndrome.
    PharmGKBi PA35872.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000044189.
    HOVERGENi HBG005642.
    InParanoidi Q6P1M0.
    KOi K08745.
    OMAi NDIVYDC.
    OrthoDBi EOG7W6WKB.
    PhylomeDBi Q6P1M0.
    TreeFami TF313430.

    Enzyme and pathway databases

    BRENDAi 6.2.1.3. 2681.
    Reactomei REACT_23892. Transport of fatty acids.

    Miscellaneous databases

    GeneWikii SLC27A4.
    GenomeRNAii 10999.
    NextBioi 41787.
    PROi Q6P1M0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P1M0.
    Bgeei Q6P1M0.
    CleanExi HS_SLC27A4.
    Genevestigatori Q6P1M0.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR022272. Lipocalin_CS.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)."
      Fitscher B.A., Riedel H.D., Young K.C., Stremmel W.
      Biochim. Biophys. Acta 1443:381-385(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Heart.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thalamus.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Lung.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome."
      Gertow K., Bellanda M., Eriksson P., Boquist S., Hamsten A., Sunnerhagen M., Fisher R.M.
      J. Clin. Endocrinol. Metab. 89:392-399(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SER-209.
    8. "Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome."
      Klar J., Schweiger M., Zimmerman R., Zechner R., Li H., Torma H., Vahlquist A., Bouadjar B., Dahl N., Fischer J.
      Am. J. Hum. Genet. 85:248-253(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS IPS THR-92; PRO-247; ARG-300 AND HIS-583.
    9. "A novel mutation in the fatty acid transport protein 4 gene in a patient initially described as affected by self-healing congenital verruciform hyperkeratosis."
      Morice-Picard F., Leaute-Labreze C., Decor A., Boralevi F., Lacombe D., Taieb A., Fischer J.
      Am. J. Med. Genet. A 152:2664-2665(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT IPS CYS-374.

    Entry informationi

    Entry nameiS27A4_HUMAN
    AccessioniPrimary (citable) accession number: Q6P1M0
    Secondary accession number(s): A8K2F7, O95186, Q96G53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with acquired obesity.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3