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Q6P1L8

- RM14_HUMAN

UniProt

Q6P1L8 - RM14_HUMAN

Protein

39S ribosomal protein L14, mitochondrial

Gene

MRPL14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation Probable.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L14, mitochondrial
    Short name:
    L14mt
    Short name:
    MRP-L14
    Alternative name(s):
    39S ribosomal protein L32, mitochondrial
    Short name:
    L32mt
    Short name:
    MRP-L32
    Gene namesi
    Name:MRPL14
    Synonyms:MRPL32, RPML32
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:14279. MRPL14.

    Subcellular locationi

    Mitochondrion 2 Publications

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30943.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030MitochondrionBy similarityAdd
    BLAST
    Chaini31 – 14511539S ribosomal protein L14, mitochondrialPRO_0000261134Add
    BLAST

    Proteomic databases

    MaxQBiQ6P1L8.
    PaxDbiQ6P1L8.
    PeptideAtlasiQ6P1L8.
    PRIDEiQ6P1L8.

    PTM databases

    PhosphoSiteiQ6P1L8.

    Expressioni

    Gene expression databases

    BgeeiQ6P1L8.
    CleanExiHS_MRPL14.
    HS_MRPL32.
    GenevestigatoriQ6P1L8.

    Organism-specific databases

    HPAiHPA038769.

    Interactioni

    Subunit structurei

    Part of the mitochondrial ribosome large subunit (39S) By similarity; associates with MALSU1.

    Protein-protein interaction databases

    BioGridi122350. 28 interactions.
    IntActiQ6P1L8. 3 interactions.
    MINTiMINT-6776547.
    STRINGi9606.ENSP00000361084.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P1L8.
    SMRiQ6P1L8. Positions 32-145.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L14P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG331407.
    HOGENOMiHOG000183701.
    HOVERGENiHBG088508.
    InParanoidiQ6P1L8.
    KOiK02874.
    OMAiALGNTPY.
    OrthoDBiEOG78D7MS.
    PhylomeDBiQ6P1L8.
    TreeFamiTF324586.

    Family and domain databases

    Gene3Di2.40.150.20. 1 hit.
    HAMAPiMF_01367. Ribosomal_L14.
    InterProiIPR023571. Ribosomal_L14_dom.
    IPR000218. Ribosomal_L14b/L23e.
    [Graphical view]
    PfamiPF00238. Ribosomal_L14. 1 hit.
    [Graphical view]
    SUPFAMiSSF50193. SSF50193. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P1L8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP    50
    YHRAPRCIHV YKKNGVGKVG DQILLAIKGQ KKKALIVGHC MPGPRMTPRF 100
    DSNNVVLIED NGNPVGTRIK TPIPTSLRKR EGEYSKVLAI AQNFV 145
    Length:145
    Mass (Da):15,948
    Last modified:July 5, 2004 - v1
    Checksum:i841360D2E84071A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312086 mRNA. Translation: BAG35022.1.
    AL109615 Genomic DNA. Translation: CAI19245.1.
    CH471081 Genomic DNA. Translation: EAX04243.1.
    BC065005 mRNA. Translation: AAH65005.1.
    AB051339 Genomic DNA. Translation: BAB54929.2.
    CCDSiCCDS34460.1.
    RefSeqiNP_115487.2. NM_032111.2.
    XP_005249357.1. XM_005249300.1.
    XP_005249358.1. XM_005249301.2.
    UniGeneiHs.311190.

    Genome annotation databases

    EnsembliENST00000372014; ENSP00000361084; ENSG00000180992.
    GeneIDi64928.
    KEGGihsa:64928.
    UCSCiuc003owp.3. human.

    Polymorphism databases

    DMDMi74749064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK312086 mRNA. Translation: BAG35022.1 .
    AL109615 Genomic DNA. Translation: CAI19245.1 .
    CH471081 Genomic DNA. Translation: EAX04243.1 .
    BC065005 mRNA. Translation: AAH65005.1 .
    AB051339 Genomic DNA. Translation: BAB54929.2 .
    CCDSi CCDS34460.1.
    RefSeqi NP_115487.2. NM_032111.2.
    XP_005249357.1. XM_005249300.1.
    XP_005249358.1. XM_005249301.2.
    UniGenei Hs.311190.

    3D structure databases

    ProteinModelPortali Q6P1L8.
    SMRi Q6P1L8. Positions 32-145.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122350. 28 interactions.
    IntActi Q6P1L8. 3 interactions.
    MINTi MINT-6776547.
    STRINGi 9606.ENSP00000361084.

    PTM databases

    PhosphoSitei Q6P1L8.

    Polymorphism databases

    DMDMi 74749064.

    Proteomic databases

    MaxQBi Q6P1L8.
    PaxDbi Q6P1L8.
    PeptideAtlasi Q6P1L8.
    PRIDEi Q6P1L8.

    Protocols and materials databases

    DNASUi 64928.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372014 ; ENSP00000361084 ; ENSG00000180992 .
    GeneIDi 64928.
    KEGGi hsa:64928.
    UCSCi uc003owp.3. human.

    Organism-specific databases

    CTDi 64928.
    GeneCardsi GC06M044128.
    HGNCi HGNC:14279. MRPL14.
    HPAi HPA038769.
    MIMi 611827. gene.
    neXtProti NX_Q6P1L8.
    PharmGKBi PA30943.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331407.
    HOGENOMi HOG000183701.
    HOVERGENi HBG088508.
    InParanoidi Q6P1L8.
    KOi K02874.
    OMAi ALGNTPY.
    OrthoDBi EOG78D7MS.
    PhylomeDBi Q6P1L8.
    TreeFami TF324586.

    Miscellaneous databases

    ChiTaRSi MRPL14. human.
    GenomeRNAii 64928.
    NextBioi 67102.
    PROi Q6P1L8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P1L8.
    CleanExi HS_MRPL14.
    HS_MRPL32.
    Genevestigatori Q6P1L8.

    Family and domain databases

    Gene3Di 2.40.150.20. 1 hit.
    HAMAPi MF_01367. Ribosomal_L14.
    InterProi IPR023571. Ribosomal_L14_dom.
    IPR000218. Ribosomal_L14b/L23e.
    [Graphical view ]
    Pfami PF00238. Ribosomal_L14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50193. SSF50193. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-76, SUBCELLULAR LOCATION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MALSU1.

    Entry informationi

    Entry nameiRM14_HUMAN
    AccessioniPrimary (citable) accession number: Q6P1L8
    Secondary accession number(s): B2R575, Q96Q72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3