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Protein

39S ribosomal protein L14, mitochondrial

Gene

MRPL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L14, mitochondrial
Short name:
L14mt
Short name:
MRP-L14
Alternative name(s):
39S ribosomal protein L32, mitochondrial
Short name:
L32mt
Short name:
MRP-L32
Mitochondrial large ribosomal subunit protein uL14m1 Publication
Gene namesi
Name:MRPL14
Synonyms:MRPL32, RPML32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000180992.6.
HGNCiHGNC:14279. MRPL14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180992.
PharmGKBiPA30943.

Polymorphism and mutation databases

BioMutaiMRPL14.
DMDMi74749064.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000026113431 – 14539S ribosomal protein L14, mitochondrialAdd BLAST115

Proteomic databases

EPDiQ6P1L8.
MaxQBiQ6P1L8.
PaxDbiQ6P1L8.
PeptideAtlasiQ6P1L8.
PRIDEiQ6P1L8.
TopDownProteomicsiQ6P1L8.

PTM databases

iPTMnetiQ6P1L8.
PhosphoSitePlusiQ6P1L8.
SwissPalmiQ6P1L8.

Expressioni

Gene expression databases

BgeeiENSG00000180992.
CleanExiHS_MRPL14.
HS_MRPL32.
ExpressionAtlasiQ6P1L8. baseline and differential.
GenevisibleiQ6P1L8. HS.

Organism-specific databases

HPAiHPA038769.
HPA076790.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with MALSU1 (PubMed:22829778).3 Publications

Protein-protein interaction databases

BioGridi122350. 49 interactors.
CORUMiQ6P1L8.
IntActiQ6P1L8. 13 interactors.
MINTiMINT-6776547.
STRINGi9606.ENSP00000361084.

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 48Combined sources4
Beta strandi56 – 65Combined sources10
Beta strandi72 – 77Combined sources6
Beta strandi80 – 86Combined sources7
Beta strandi94 – 102Combined sources9
Beta strandi104 – 107Combined sources4
Beta strandi110 – 112Combined sources3
Beta strandi119 – 123Combined sources5
Helixi125 – 127Combined sources3
Beta strandi130 – 133Combined sources4
Turni135 – 140Combined sources6
Beta strandi141 – 144Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40L1-145[»]
3J9Melectron microscopy3.50L1-145[»]
5OOLelectron microscopy3.06L1-145[»]
5OOMelectron microscopy3.03L1-145[»]
ProteinModelPortaliQ6P1L8.
SMRiQ6P1L8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3441. Eukaryota.
ENOG4111JDP. LUCA.
GeneTreeiENSGT00390000001121.
HOGENOMiHOG000183701.
HOVERGENiHBG088508.
InParanoidiQ6P1L8.
KOiK02874.
OMAiHRMPGPR.
OrthoDBiEOG091G1144.
PhylomeDBiQ6P1L8.
TreeFamiTF324586.

Family and domain databases

Gene3Di2.40.150.20. 1 hit.
HAMAPiMF_01367. Ribosomal_L14. 1 hit.
InterProiView protein in InterPro
IPR000218. Ribosomal_L14P.
IPR036853. Ribosomal_L14P_sf.
PfamiView protein in Pfam
PF00238. Ribosomal_L14. 1 hit.
SMARTiView protein in SMART
SM01374. Ribosomal_L14. 1 hit.
SUPFAMiSSF50193. SSF50193. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P1L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP
60 70 80 90 100
YHRAPRCIHV YKKNGVGKVG DQILLAIKGQ KKKALIVGHC MPGPRMTPRF
110 120 130 140
DSNNVVLIED NGNPVGTRIK TPIPTSLRKR EGEYSKVLAI AQNFV
Length:145
Mass (Da):15,948
Last modified:July 5, 2004 - v1
Checksum:i841360D2E84071A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312086 mRNA. Translation: BAG35022.1.
AL109615 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX04243.1.
BC065005 mRNA. Translation: AAH65005.1.
AB051339 Genomic DNA. Translation: BAB54929.2.
CCDSiCCDS34460.1.
RefSeqiNP_001305696.1. NM_001318767.1.
NP_001305697.1. NM_001318768.1.
NP_115487.2. NM_032111.3.
UniGeneiHs.311190.

Genome annotation databases

EnsembliENST00000372014; ENSP00000361084; ENSG00000180992.
GeneIDi64928.
KEGGihsa:64928.
UCSCiuc003owp.4. human.

Similar proteinsi

Entry informationi

Entry nameiRM14_HUMAN
AccessioniPrimary (citable) accession number: Q6P1L8
Secondary accession number(s): B2R575, Q96Q72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families