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Q6P1L8

- RM14_HUMAN

UniProt

Q6P1L8 - RM14_HUMAN

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Protein

39S ribosomal protein L14, mitochondrial

Gene
MRPL14, MRPL32, RPML32
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation Inferred.1 Publication

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L14, mitochondrial
Short name:
L14mt
Short name:
MRP-L14
Alternative name(s):
39S ribosomal protein L32, mitochondrial
Short name:
L32mt
Short name:
MRP-L32
Gene namesi
Name:MRPL14
Synonyms:MRPL32, RPML32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:14279. MRPL14.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030Mitochondrion By similarityAdd
BLAST
Chaini31 – 14511539S ribosomal protein L14, mitochondrialUniRule annotationPRO_0000261134Add
BLAST

Proteomic databases

MaxQBiQ6P1L8.
PaxDbiQ6P1L8.
PeptideAtlasiQ6P1L8.
PRIDEiQ6P1L8.

PTM databases

PhosphoSiteiQ6P1L8.

Expressioni

Gene expression databases

BgeeiQ6P1L8.
CleanExiHS_MRPL14.
HS_MRPL32.
GenevestigatoriQ6P1L8.

Organism-specific databases

HPAiHPA038769.

Interactioni

Subunit structurei

Part of the mitochondrial ribosome large subunit (39S) By similarity; associates with MALSU1.

Protein-protein interaction databases

BioGridi122350. 28 interactions.
IntActiQ6P1L8. 3 interactions.
MINTiMINT-6776547.
STRINGi9606.ENSP00000361084.

Structurei

3D structure databases

ProteinModelPortaliQ6P1L8.
SMRiQ6P1L8. Positions 32-145.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG331407.
HOGENOMiHOG000183701.
HOVERGENiHBG088508.
InParanoidiQ6P1L8.
KOiK02874.
OMAiALGNTPY.
OrthoDBiEOG78D7MS.
PhylomeDBiQ6P1L8.
TreeFamiTF324586.

Family and domain databases

Gene3Di2.40.150.20. 1 hit.
HAMAPiMF_01367. Ribosomal_L14.
InterProiIPR023571. Ribosomal_L14_dom.
IPR000218. Ribosomal_L14b/L23e.
[Graphical view]
PfamiPF00238. Ribosomal_L14. 1 hit.
[Graphical view]
SUPFAMiSSF50193. SSF50193. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P1L8-1 [UniParc]FASTAAdd to Basket

« Hide

MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP    50
YHRAPRCIHV YKKNGVGKVG DQILLAIKGQ KKKALIVGHC MPGPRMTPRF 100
DSNNVVLIED NGNPVGTRIK TPIPTSLRKR EGEYSKVLAI AQNFV 145
Length:145
Mass (Da):15,948
Last modified:July 5, 2004 - v1
Checksum:i841360D2E84071A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312086 mRNA. Translation: BAG35022.1.
AL109615 Genomic DNA. Translation: CAI19245.1.
CH471081 Genomic DNA. Translation: EAX04243.1.
BC065005 mRNA. Translation: AAH65005.1.
AB051339 Genomic DNA. Translation: BAB54929.2.
CCDSiCCDS34460.1.
RefSeqiNP_115487.2. NM_032111.2.
XP_005249357.1. XM_005249300.1.
XP_005249358.1. XM_005249301.2.
UniGeneiHs.311190.

Genome annotation databases

EnsembliENST00000372014; ENSP00000361084; ENSG00000180992.
GeneIDi64928.
KEGGihsa:64928.
UCSCiuc003owp.3. human.

Polymorphism databases

DMDMi74749064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK312086 mRNA. Translation: BAG35022.1 .
AL109615 Genomic DNA. Translation: CAI19245.1 .
CH471081 Genomic DNA. Translation: EAX04243.1 .
BC065005 mRNA. Translation: AAH65005.1 .
AB051339 Genomic DNA. Translation: BAB54929.2 .
CCDSi CCDS34460.1.
RefSeqi NP_115487.2. NM_032111.2.
XP_005249357.1. XM_005249300.1.
XP_005249358.1. XM_005249301.2.
UniGenei Hs.311190.

3D structure databases

ProteinModelPortali Q6P1L8.
SMRi Q6P1L8. Positions 32-145.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122350. 28 interactions.
IntActi Q6P1L8. 3 interactions.
MINTi MINT-6776547.
STRINGi 9606.ENSP00000361084.

PTM databases

PhosphoSitei Q6P1L8.

Polymorphism databases

DMDMi 74749064.

Proteomic databases

MaxQBi Q6P1L8.
PaxDbi Q6P1L8.
PeptideAtlasi Q6P1L8.
PRIDEi Q6P1L8.

Protocols and materials databases

DNASUi 64928.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372014 ; ENSP00000361084 ; ENSG00000180992 .
GeneIDi 64928.
KEGGi hsa:64928.
UCSCi uc003owp.3. human.

Organism-specific databases

CTDi 64928.
GeneCardsi GC06M044128.
HGNCi HGNC:14279. MRPL14.
HPAi HPA038769.
MIMi 611827. gene.
neXtProti NX_Q6P1L8.
PharmGKBi PA30943.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331407.
HOGENOMi HOG000183701.
HOVERGENi HBG088508.
InParanoidi Q6P1L8.
KOi K02874.
OMAi ALGNTPY.
OrthoDBi EOG78D7MS.
PhylomeDBi Q6P1L8.
TreeFami TF324586.

Miscellaneous databases

ChiTaRSi MRPL14. human.
GenomeRNAii 64928.
NextBioi 67102.
PROi Q6P1L8.
SOURCEi Search...

Gene expression databases

Bgeei Q6P1L8.
CleanExi HS_MRPL14.
HS_MRPL32.
Genevestigatori Q6P1L8.

Family and domain databases

Gene3Di 2.40.150.20. 1 hit.
HAMAPi MF_01367. Ribosomal_L14.
InterProi IPR023571. Ribosomal_L14_dom.
IPR000218. Ribosomal_L14b/L23e.
[Graphical view ]
Pfami PF00238. Ribosomal_L14. 1 hit.
[Graphical view ]
SUPFAMi SSF50193. SSF50193. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-76, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MALSU1.

Entry informationi

Entry nameiRM14_HUMAN
AccessioniPrimary (citable) accession number: Q6P1L8
Secondary accession number(s): B2R575, Q96Q72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi