Q6P1L6 (ZN343_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 343

Gene names

Name:

ZNF343

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	599 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 12 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P1L6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P1L6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6P1L6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     102-118: AEPKPEIYTCSSCLLAF → GQEIETILANIVKSHLY
     119-599: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 599	599	Zinc finger protein 343		PRO_0000047543
Regions
	Domain	62 – 139	78	KRAB
	Zinc finger	269 – 291	23	C2H2-type 1
	Zinc finger	297 – 319	23	C2H2-type 2
	Zinc finger	325 – 347	23	C2H2-type 3
	Zinc finger	353 – 375	23	C2H2-type 4
	Zinc finger	381 – 403	23	C2H2-type 5
	Zinc finger	409 – 431	23	C2H2-type 6
	Zinc finger	437 – 459	23	C2H2-type 7
	Zinc finger	465 – 487	23	C2H2-type 8
	Zinc finger	493 – 515	23	C2H2-type 9
	Zinc finger	521 – 543	23	C2H2-type 10
	Zinc finger	549 – 571	23	C2H2-type 11
	Zinc finger	577 – 599	23	C2H2-type 12
Natural variations
	Alternative sequence	1 – 90	90	Missing in isoform 2.		VSP_016028
	Alternative sequence	102 – 118	17	AEPKP…CLLAF → GQEIETILANIVKSHLY in isoform 3.		VSP_016029
	Alternative sequence	119 – 599	481	Missing in isoform 3.		VSP_016030
	Natural variant	520	1	P → L. Corresponds to variant rs6049415 [ dbSNP | Ensembl ].		VAR_059912
Experimental info
	Sequence conflict	418	1	F → S in BAC04892. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 121CC71CBA462DF9	FASTA	599	69,220
	10 20 30 40 50 60 MMLPYPSALG DQYWEEILLP KNGENVETMK KLTQNHKAKG LPSNDTDCPQ KKEGKAQIVV 70 80 90 100 110 120 PVTFRDVTVI FTEAEWKRLS PEQRNLYKEV MLENYRNLLS LAEPKPEIYT CSSCLLAFSC 130 140 150 160 170 180 QQFLSQHVLQ IFLGLCAENH FHPGNSSPGH WKQQGQQYSH VSCWFENAEG QERGGGSKPW 190 200 210 220 230 240 SARTEERETS RAFPSPLQRQ SASPRKGNMV VETEPSSAQR PNPVQLDKGL KELETLRFGA 250 260 270 280 290 300 INCREYEPDH NLESNFITNP RTLLGKKPYI CSDCGRSFKD RSTLIRHHRI HSMEKPYVCS 310 320 330 340 350 360 ECGRGFSQKS NLSRHQRTHS EEKPYLCREC GQSFRSKSIL NRHQWTHSEE KPYVCSECGR 370 380 390 400 410 420 GFSEKSSFIR HQRTHSGEKP YVCLECGRSF CDKSTLRKHQ RIHSGEKPYV CRECGRGFSQ 430 440 450 460 470 480 NSDLIKHQRT HLDEKPYVCR ECGRGFCDKS TLIIHERTHS GEKPYVCGEC GRGFSRKSLL 490 500 510 520 530 540 LVHQRTHSGE KHYVCRECRR GFSQKSNLIR HQRTHSNEKP YICRECGRGF CDKSTLIVHE 550 560 570 580 590 RTHSGEKPYV CSECGRGFSR KSLLLVHQRT HSGEKHYVCR ECGRGFSHKS NLIRHQRTH
	Isoform 2 [UniParc]. Checksum: FE51D2E7F647D016	FASTA	509	58,847
	10 20 30 40 50 60 MLENYRNLLS LAEPKPEIYT CSSCLLAFSC QQFLSQHVLQ IFLGLCAENH FHPGNSSPGH 70 80 90 100 110 120 WKQQGQQYSH VSCWFENAEG QERGGGSKPW SARTEERETS RAFPSPLQRQ SASPRKGNMV 130 140 150 160 170 180 VETEPSSAQR PNPVQLDKGL KELETLRFGA INCREYEPDH NLESNFITNP RTLLGKKPYI 190 200 210 220 230 240 CSDCGRSFKD RSTLIRHHRI HSMEKPYVCS ECGRGFSQKS NLSRHQRTHS EEKPYLCREC 250 260 270 280 290 300 GQSFRSKSIL NRHQWTHSEE KPYVCSECGR GFSEKSSFIR HQRTHSGEKP YVCLECGRSF 310 320 330 340 350 360 CDKSTLRKHQ RIHSGEKPYV CRECGRGFSQ NSDLIKHQRT HLDEKPYVCR ECGRGFCDKS 370 380 390 400 410 420 TLIIHERTHS GEKPYVCGEC GRGFSRKSLL LVHQRTHSGE KHYVCRECRR GFSQKSNLIR 430 440 450 460 470 480 HQRTHSNEKP YICRECGRGF CDKSTLIVHE RTHSGEKPYV CSECGRGFSR KSLLLVHQRT 490 500 HSGEKHYVCR ECGRGFSHKS NLIRHQRTH
	Isoform 3 [UniParc]. Checksum: 361A4F2B2F9C98A6	FASTA	118	13,649
	10 20 30 40 50 60 MMLPYPSALG DQYWEEILLP KNGENVETMK KLTQNHKAKG LPSNDTDCPQ KKEGKAQIVV 70 80 90 100 110 PVTFRDVTVI FTEAEWKRLS PEQRNLYKEV MLENYRNLLS LGQEIETILA NIVKSHLY

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Kidney and Neuroblastoma.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Lung, Skin and Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK055734 mRNA. Translation: BAB71000.1. AK096911 mRNA. Translation: BAC04892.1. AL049650 Genomic DNA. Translation: CAB46713.2. AL049650 Genomic DNA. Translation: CAI22572.1. AL049650 Genomic DNA. Translation: CAI22573.1. AL049650 Genomic DNA. Translation: CAI22574.1. BC002897 mRNA. Translation: AAH02897.1. BC011862 mRNA. Translation: AAH11862.2. BC065009 mRNA. Translation: AAH65009.1.
IPI	IPI00013618. IPI00171188. IPI00654817.
RefSeq	NP_077301.4. NM_024325.4.
UniGene	Hs.516846.
3D structure databases
ProteinModelPortal	Q6P1L6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000278772.
PTM databases
PhosphoSite	Q6P1L6.
Polymorphism databases
DMDM	74762346.
Proteomic databases
PaxDb	Q6P1L6.
PRIDE	Q6P1L6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000278772; ENSP00000278772; ENSG00000088876. ENST00000358413; ENSP00000351188; ENSG00000088876. ENST00000381253; ENSP00000370652; ENSG00000088876. ENST00000421216; ENSP00000416488; ENSG00000088876. ENST00000445484; ENSP00000399682; ENSG00000088876.
GeneID	79175.
KEGG	hsa:79175.
UCSC	uc002wgd.1. human.
Organism-specific databases
CTD	79175.
GeneCards	GC20M002462.
HGNC	HGNC:16017. ZNF343.
HPA	HPA030587.
neXtProt	NX_Q6P1L6.
PharmGKB	PA38081.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOVERGEN	HBG018163.
InParanoid	Q6P1L6.
KO	K09228.
OMA	YTCSSCL.
OrthoDB	EOG4PRSQ7.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q6P1L6.
CleanEx	HS_ZNF343.
Genevestigator	Q6P1L6.
GermOnline	ENSG00000088876. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 12 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 3 hits. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 12 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 12 hits. PS50157. ZINC_FINGER_C2H2_2. 12 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79175.
NextBio	68149.

Entry information

Entry name

ZN343_HUMAN

Accession

Primary (citable) accession number: Q6P1L6
Secondary accession number(s): Q5JXU8 , Q5JXU9, Q8N8F2, Q96EX8, Q96NA5, Q9BQB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.