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Protein

Zinc finger protein 343

Gene

ZNF343

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri269 – 29123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 343
Gene namesi
Name:ZNF343
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16017. ZNF343.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38081.

Polymorphism and mutation databases

BioMutaiZNF343.
DMDMi74762346.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Zinc finger protein 343PRO_0000047543Add
BLAST

Proteomic databases

PaxDbiQ6P1L6.
PRIDEiQ6P1L6.

PTM databases

PhosphoSiteiQ6P1L6.

Expressioni

Gene expression databases

BgeeiQ6P1L6.
CleanExiHS_ZNF343.
ExpressionAtlasiQ6P1L6. baseline and differential.
GenevisibleiQ6P1L6. HS.

Organism-specific databases

HPAiHPA030587.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX03EBI-10252492,EBI-741480

Protein-protein interaction databases

BioGridi122592. 3 interactions.
IntActiQ6P1L6. 1 interaction.
STRINGi9606.ENSP00000278772.

Structurei

3D structure databases

ProteinModelPortaliQ6P1L6.
SMRiQ6P1L6. Positions 266-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 13978KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri269 – 29123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri297 – 31923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063157.
HOVERGENiHBG018163.
InParanoidiQ6P1L6.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6P1L6.
TreeFamiTF338096.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P1L6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLPYPSALG DQYWEEILLP KNGENVETMK KLTQNHKAKG LPSNDTDCPQ
60 70 80 90 100
KKEGKAQIVV PVTFRDVTVI FTEAEWKRLS PEQRNLYKEV MLENYRNLLS
110 120 130 140 150
LAEPKPEIYT CSSCLLAFSC QQFLSQHVLQ IFLGLCAENH FHPGNSSPGH
160 170 180 190 200
WKQQGQQYSH VSCWFENAEG QERGGGSKPW SARTEERETS RAFPSPLQRQ
210 220 230 240 250
SASPRKGNMV VETEPSSAQR PNPVQLDKGL KELETLRFGA INCREYEPDH
260 270 280 290 300
NLESNFITNP RTLLGKKPYI CSDCGRSFKD RSTLIRHHRI HSMEKPYVCS
310 320 330 340 350
ECGRGFSQKS NLSRHQRTHS EEKPYLCREC GQSFRSKSIL NRHQWTHSEE
360 370 380 390 400
KPYVCSECGR GFSEKSSFIR HQRTHSGEKP YVCLECGRSF CDKSTLRKHQ
410 420 430 440 450
RIHSGEKPYV CRECGRGFSQ NSDLIKHQRT HLDEKPYVCR ECGRGFCDKS
460 470 480 490 500
TLIIHERTHS GEKPYVCGEC GRGFSRKSLL LVHQRTHSGE KHYVCRECRR
510 520 530 540 550
GFSQKSNLIR HQRTHSNEKP YICRECGRGF CDKSTLIVHE RTHSGEKPYV
560 570 580 590
CSECGRGFSR KSLLLVHQRT HSGEKHYVCR ECGRGFSHKS NLIRHQRTH
Length:599
Mass (Da):69,220
Last modified:July 5, 2004 - v1
Checksum:i121CC71CBA462DF9
GO
Isoform 2 (identifier: Q6P1L6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Note: No experimental confirmation available.
Show »
Length:509
Mass (Da):58,847
Checksum:iFE51D2E7F647D016
GO
Isoform 3 (identifier: Q6P1L6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-118: AEPKPEIYTCSSCLLAF → GQEIETILANIVKSHLY
     119-599: Missing.

Note: No experimental confirmation available.
Show »
Length:118
Mass (Da):13,649
Checksum:i361A4F2B2F9C98A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti418 – 4181F → S in BAC04892 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti520 – 5201P → L.
Corresponds to variant rs6049415 [ dbSNP | Ensembl ].
VAR_059912

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9090Missing in isoform 2. 1 PublicationVSP_016028Add
BLAST
Alternative sequencei102 – 11817AEPKP…CLLAF → GQEIETILANIVKSHLY in isoform 3. 1 PublicationVSP_016029Add
BLAST
Alternative sequencei119 – 599481Missing in isoform 3. 1 PublicationVSP_016030Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055734 mRNA. Translation: BAB71000.1.
AK096911 mRNA. Translation: BAC04892.1.
AL049650 Genomic DNA. Translation: CAB46713.2.
AL049650 Genomic DNA. Translation: CAI22572.1.
AL049650 Genomic DNA. Translation: CAI22573.1.
AL049650 Genomic DNA. Translation: CAI22574.1.
BC002897 mRNA. Translation: AAH02897.1.
BC011862 mRNA. Translation: AAH11862.2.
BC065009 mRNA. Translation: AAH65009.1.
CCDSiCCDS13028.1. [Q6P1L6-1]
CCDS74692.1. [Q6P1L6-2]
CCDS74694.1. [Q6P1L6-3]
RefSeqiNP_001269424.1. NM_001282495.1. [Q6P1L6-1]
NP_001269425.1. NM_001282496.1. [Q6P1L6-1]
NP_001269426.1. NM_001282497.1.
NP_001269427.1. NM_001282498.1. [Q6P1L6-2]
NP_001269428.1. NM_001282499.1. [Q6P1L6-3]
NP_077301.4. NM_024325.5. [Q6P1L6-1]
UniGeneiHs.516846.

Genome annotation databases

EnsembliENST00000278772; ENSP00000278772; ENSG00000088876. [Q6P1L6-1]
ENST00000358413; ENSP00000351188; ENSG00000088876. [Q6P1L6-3]
ENST00000381253; ENSP00000370652; ENSG00000088876. [Q6P1L6-3]
ENST00000617391; ENSP00000483851; ENSG00000088876. [Q6P1L6-2]
GeneIDi79175.
KEGGihsa:79175.
UCSCiuc002wge.2. human. [Q6P1L6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055734 mRNA. Translation: BAB71000.1.
AK096911 mRNA. Translation: BAC04892.1.
AL049650 Genomic DNA. Translation: CAB46713.2.
AL049650 Genomic DNA. Translation: CAI22572.1.
AL049650 Genomic DNA. Translation: CAI22573.1.
AL049650 Genomic DNA. Translation: CAI22574.1.
BC002897 mRNA. Translation: AAH02897.1.
BC011862 mRNA. Translation: AAH11862.2.
BC065009 mRNA. Translation: AAH65009.1.
CCDSiCCDS13028.1. [Q6P1L6-1]
CCDS74692.1. [Q6P1L6-2]
CCDS74694.1. [Q6P1L6-3]
RefSeqiNP_001269424.1. NM_001282495.1. [Q6P1L6-1]
NP_001269425.1. NM_001282496.1. [Q6P1L6-1]
NP_001269426.1. NM_001282497.1.
NP_001269427.1. NM_001282498.1. [Q6P1L6-2]
NP_001269428.1. NM_001282499.1. [Q6P1L6-3]
NP_077301.4. NM_024325.5. [Q6P1L6-1]
UniGeneiHs.516846.

3D structure databases

ProteinModelPortaliQ6P1L6.
SMRiQ6P1L6. Positions 266-599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122592. 3 interactions.
IntActiQ6P1L6. 1 interaction.
STRINGi9606.ENSP00000278772.

PTM databases

PhosphoSiteiQ6P1L6.

Polymorphism and mutation databases

BioMutaiZNF343.
DMDMi74762346.

Proteomic databases

PaxDbiQ6P1L6.
PRIDEiQ6P1L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278772; ENSP00000278772; ENSG00000088876. [Q6P1L6-1]
ENST00000358413; ENSP00000351188; ENSG00000088876. [Q6P1L6-3]
ENST00000381253; ENSP00000370652; ENSG00000088876. [Q6P1L6-3]
ENST00000617391; ENSP00000483851; ENSG00000088876. [Q6P1L6-2]
GeneIDi79175.
KEGGihsa:79175.
UCSCiuc002wge.2. human. [Q6P1L6-1]

Organism-specific databases

CTDi79175.
GeneCardsiZNF343.
HGNCiHGNC:16017. ZNF343.
HPAiHPA030587.
neXtProtiNX_Q6P1L6.
PharmGKBiPA38081.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063157.
HOVERGENiHBG018163.
InParanoidiQ6P1L6.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6P1L6.
TreeFamiTF338096.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF343. human.
GenomeRNAii79175.
NextBioi68149.
PROiQ6P1L6.

Gene expression databases

BgeeiQ6P1L6.
CleanExiHS_ZNF343.
ExpressionAtlasiQ6P1L6. baseline and differential.
GenevisibleiQ6P1L6. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney and Neuroblastoma.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Lung, Skin and Uterus.

Entry informationi

Entry nameiZN343_HUMAN
AccessioniPrimary (citable) accession number: Q6P1L6
Secondary accession number(s): Q5JXU8
, Q5JXU9, Q8N8F2, Q96EX8, Q96NA5, Q9BQB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.