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Protein

General transcription factor IIH subunit 2-like protein

Gene

GTF2H2C

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri291 – 30818C4-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 2-like protein
Alternative name(s):
General transcription factor IIH polypeptide 2-like protein
Gene namesi
Name:GTF2H2C
AND
Name:GTF2H2C_2
Synonyms:GTF2H2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:31394. GTF2H2C.
HGNC:35418. GTF2H2C_2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720349.

Polymorphism and mutation databases

BioMutaiGTF2H2C.
DMDMi74737138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395General transcription factor IIH subunit 2-like proteinPRO_0000332132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P1K8.
MaxQBiQ6P1K8.
PaxDbiQ6P1K8.
PRIDEiQ6P1K8.

PTM databases

iPTMnetiQ6P1K8.
PhosphoSiteiQ6P1K8.

Expressioni

Gene expression databases

BgeeiQ6P1K8.
ExpressionAtlasiQ6P1K8. baseline and differential.
GenevisibleiQ6P1K8. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DZIP3Q86Y133EBI-8469755,EBI-948630
ERCC2P180743EBI-8469755,EBI-6380590
GTF2H3Q138893EBI-8469755,EBI-6380459

Protein-protein interaction databases

BioGridi608768. 6 interactions.
610778. 13 interactions.
IntActiQ6P1K8. 5 interactions.
MINTiMINT-4906733.
STRINGi9606.ENSP00000370105.

Structurei

3D structure databases

ProteinModelPortaliQ6P1K8.
SMRiQ6P1K8. Positions 56-240, 328-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 236177VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GTF2H2 family.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri291 – 30818C4-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2807. Eukaryota.
COG5151. LUCA.
GeneTreeiENSGT00490000043395.
HOGENOMiHOG000159415.
HOVERGENiHBG059468.
InParanoidiQ6P1K8.
KOiK03142.
OMAiHITIEAL.
PhylomeDBiQ6P1K8.
TreeFamiTF314037.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR007087. Znf_C2H2.
[Graphical view]
PANTHERiPTHR12695:SF2. PTHR12695:SF2. 1 hit.
PfamiPF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
[Graphical view]
PIRSFiPIRSF015919. TFIIH_SSL1. 1 hit.
SMARTiSM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00622. ssl1. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P1K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH
60 70 80 90 100
GQVRLGMMRH LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP
110 120 130 140 150
ISQIGIIVTK SKRAEKLTEL SGNPRKHITS LKEAVDMTCH GEPSLYNSLS
160 170 180 190 200
MAMQTLKHMP GHTSREVLII FSSLTTCDPS NIYDLIKTLK AAKIRVSVIG
210 220 230 240 250
LSAEVRVCTV LARETGGTYH VILDESHYKE LLTHHLSPPP ASSSSECSLI
260 270 280 290 300
RMGFPQHTIA SLSDQDAKPS FSMAHLDGNT EPGLTLGGYF CPQCRAKYCE
310 320 330 340 350
LPVECKICGL TLVSAPHLAR SYHHLFPLDA FQEIPLEEYN GERFCYGCQG
360 370 380 390
ELKDQHVYVC AVCQNVFCVD CDVFVHDSLH CCPGCIHKIP APSGV
Length:395
Mass (Da):44,452
Last modified:July 5, 2004 - v1
Checksum:i3BBD377500E04B9A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571M → I in BAF85050 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292361 mRNA. Translation: BAF85050.1.
AK315282 mRNA. Translation: BAG37691.1.
AC147575 Genomic DNA. No translation available.
BC064557 mRNA. Translation: AAH64557.1.
BC065021 mRNA. Translation: AAH65021.1.
BC105980 mRNA. Translation: AAI05981.1.
BC171860 mRNA. Translation: AAI71860.1.
CCDSiCCDS43325.1.
RefSeqiNP_001035955.1. NM_001042490.3.
NP_001092198.1. NM_001098728.1.
XP_005248645.1. XM_005248588.3.
XP_005248647.1. XM_005248590.2.
XP_006714751.1. XM_006714688.2.
XP_011545265.1. XM_011546963.1.
XP_011545266.1. XM_011546964.1.
XP_011545267.1. XM_011546965.1.
UniGeneiHs.191356.
Hs.422901.

Genome annotation databases

EnsembliENST00000380729; ENSP00000370105; ENSG00000183474.
ENST00000510979; ENSP00000422907; ENSG00000183474.
ENST00000619699; ENSP00000483148; ENSG00000274675.
ENST00000621406; ENSP00000480471; ENSG00000274675.
GeneIDi728340.
730394.
KEGGihsa:728340.
hsa:730394.
UCSCiuc003jwy.6. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292361 mRNA. Translation: BAF85050.1.
AK315282 mRNA. Translation: BAG37691.1.
AC147575 Genomic DNA. No translation available.
BC064557 mRNA. Translation: AAH64557.1.
BC065021 mRNA. Translation: AAH65021.1.
BC105980 mRNA. Translation: AAI05981.1.
BC171860 mRNA. Translation: AAI71860.1.
CCDSiCCDS43325.1.
RefSeqiNP_001035955.1. NM_001042490.3.
NP_001092198.1. NM_001098728.1.
XP_005248645.1. XM_005248588.3.
XP_005248647.1. XM_005248590.2.
XP_006714751.1. XM_006714688.2.
XP_011545265.1. XM_011546963.1.
XP_011545266.1. XM_011546964.1.
XP_011545267.1. XM_011546965.1.
UniGeneiHs.191356.
Hs.422901.

3D structure databases

ProteinModelPortaliQ6P1K8.
SMRiQ6P1K8. Positions 56-240, 328-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608768. 6 interactions.
610778. 13 interactions.
IntActiQ6P1K8. 5 interactions.
MINTiMINT-4906733.
STRINGi9606.ENSP00000370105.

PTM databases

iPTMnetiQ6P1K8.
PhosphoSiteiQ6P1K8.

Polymorphism and mutation databases

BioMutaiGTF2H2C.
DMDMi74737138.

Proteomic databases

EPDiQ6P1K8.
MaxQBiQ6P1K8.
PaxDbiQ6P1K8.
PRIDEiQ6P1K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380729; ENSP00000370105; ENSG00000183474.
ENST00000510979; ENSP00000422907; ENSG00000183474.
ENST00000619699; ENSP00000483148; ENSG00000274675.
ENST00000621406; ENSP00000480471; ENSG00000274675.
GeneIDi728340.
730394.
KEGGihsa:728340.
hsa:730394.
UCSCiuc003jwy.6. human.

Organism-specific databases

CTDi728340.
730394.
GeneCardsiGTF2H2C.
GTF2H2C_2.
HGNCiHGNC:31394. GTF2H2C.
HGNC:35418. GTF2H2C_2.
neXtProtiNX_Q6P1K8.
PharmGKBiPA164720349.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2807. Eukaryota.
COG5151. LUCA.
GeneTreeiENSGT00490000043395.
HOGENOMiHOG000159415.
HOVERGENiHBG059468.
InParanoidiQ6P1K8.
KOiK03142.
OMAiHITIEAL.
PhylomeDBiQ6P1K8.
TreeFamiTF314037.

Miscellaneous databases

PROiQ6P1K8.

Gene expression databases

BgeeiQ6P1K8.
ExpressionAtlasiQ6P1K8. baseline and differential.
GenevisibleiQ6P1K8. HS.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR007087. Znf_C2H2.
[Graphical view]
PANTHERiPTHR12695:SF2. PTHR12695:SF2. 1 hit.
PfamiPF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
[Graphical view]
PIRSFiPIRSF015919. TFIIH_SSL1. 1 hit.
SMARTiSM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00622. ssl1. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Stomach and Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver and Skin.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiT2H2L_HUMAN
AccessioniPrimary (citable) accession number: Q6P1K8
Secondary accession number(s): A6NED9
, A8K8J6, B2RCU4, B7ZW39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.