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Protein

General transcription factor IIH subunit 2-like protein

Gene

GTF2H2C

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri291 – 308C4-typeAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 2-like protein
Alternative name(s):
General transcription factor IIH polypeptide 2-like protein
Gene namesi
Name:GTF2H2C
AND
Name:GTF2H2C_2
Synonyms:GTF2H2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000183474.15.
HGNCiHGNC:31394. GTF2H2C.
HGNC:35418. GTF2H2C_2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183474.
PharmGKBiPA164720349.

Polymorphism and mutation databases

BioMutaiGTF2H2C.
DMDMi74737138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003321321 – 395General transcription factor IIH subunit 2-like proteinAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P1K8.
MaxQBiQ6P1K8.
PaxDbiQ6P1K8.
PeptideAtlasiQ6P1K8.
PRIDEiQ6P1K8.

PTM databases

iPTMnetiQ6P1K8.
PhosphoSitePlusiQ6P1K8.

Expressioni

Gene expression databases

BgeeiENSG00000183474.
ExpressionAtlasiQ6P1K8. baseline and differential.
GenevisibleiQ6P1K8. HS.

Organism-specific databases

HPAiHPA047001.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi608768. 9 interactors.
610778. 14 interactors.
IntActiQ6P1K8. 8 interactors.
MINTiMINT-4906733.
STRINGi9606.ENSP00000370105.

Structurei

3D structure databases

ProteinModelPortaliQ6P1K8.
SMRiQ6P1K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 236VWFAPROSITE-ProRule annotationAdd BLAST177

Sequence similaritiesi

Belongs to the GTF2H2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri291 – 308C4-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2807. Eukaryota.
COG5151. LUCA.
GeneTreeiENSGT00490000043395.
HOGENOMiHOG000159415.
HOVERGENiHBG059468.
InParanoidiQ6P1K8.
KOiK03142.
OMAiANSQMAY.
OrthoDBiEOG091G08ZR.
PhylomeDBiQ6P1K8.
TreeFamiTF314037.

Family and domain databases

CDDicd01453. vWA_transcription_factor_IIH_t. 1 hit.
Gene3Di3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR036465. vWFA_dom_sf.
IPR013087. Znf_C2H2_type.
PANTHERiPTHR12695. PTHR12695. 1 hit.
PfamiView protein in Pfam
PF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
PIRSFiPIRSF015919. TFIIH_SSL1. 1 hit.
SMARTiView protein in SMART
SM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00622. ssl1. 1 hit.
PROSITEiView protein in PROSITE
PS50234. VWFA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P1K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH
60 70 80 90 100
GQVRLGMMRH LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP
110 120 130 140 150
ISQIGIIVTK SKRAEKLTEL SGNPRKHITS LKEAVDMTCH GEPSLYNSLS
160 170 180 190 200
MAMQTLKHMP GHTSREVLII FSSLTTCDPS NIYDLIKTLK AAKIRVSVIG
210 220 230 240 250
LSAEVRVCTV LARETGGTYH VILDESHYKE LLTHHLSPPP ASSSSECSLI
260 270 280 290 300
RMGFPQHTIA SLSDQDAKPS FSMAHLDGNT EPGLTLGGYF CPQCRAKYCE
310 320 330 340 350
LPVECKICGL TLVSAPHLAR SYHHLFPLDA FQEIPLEEYN GERFCYGCQG
360 370 380 390
ELKDQHVYVC AVCQNVFCVD CDVFVHDSLH CCPGCIHKIP APSGV
Length:395
Mass (Da):44,452
Last modified:July 5, 2004 - v1
Checksum:i3BBD377500E04B9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57M → I in BAF85050 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292361 mRNA. Translation: BAF85050.1.
AK315282 mRNA. Translation: BAG37691.1.
AC147575 Genomic DNA. No translation available.
BC064557 mRNA. Translation: AAH64557.1.
BC065021 mRNA. Translation: AAH65021.1.
BC105980 mRNA. Translation: AAI05981.1.
BC171860 mRNA. Translation: AAI71860.1.
CCDSiCCDS43325.1.
RefSeqiNP_001035955.1. NM_001042490.3.
NP_001092198.1. NM_001098728.1.
XP_005248645.1. XM_005248588.4.
XP_005248647.1. XM_005248590.3.
XP_006714751.1. XM_006714688.3.
UniGeneiHs.191356.
Hs.422901.

Genome annotation databases

EnsembliENST00000380729; ENSP00000370105; ENSG00000183474.
ENST00000510979; ENSP00000422907; ENSG00000183474.
ENST00000619699; ENSP00000483148; ENSG00000274675.
ENST00000621406; ENSP00000480471; ENSG00000274675.
GeneIDi728340.
730394.
KEGGihsa:728340.
hsa:730394.
UCSCiuc003jwy.6. human.

Similar proteinsi

Entry informationi

Entry nameiT2H2L_HUMAN
AccessioniPrimary (citable) accession number: Q6P1K8
Secondary accession number(s): A6NED9
, A8K8J6, B2RCU4, B7ZW39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families