Q6P1J6 (PLB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholipase B1, membrane-associated
Short name=Phospholipase B
Short name=hPLB

Alternative name(s):
Phospholipase B/lipase
Short name=PLB/LIP

Including the following 2 domains:

1. Phospholipase A2
   EC=3.1.1.4
2. Lysophospholipase
   EC=3.1.1.5

Gene names

Name:	PLB1
Synonyms:	PLB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1458 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Membrane-associated phospholipase. Exhibits a calcium-independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids By similarity.
Catalytic activity	2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
Enzyme regulation	Inhibited by diisopropyl fluorophosphate By similarity.
Subcellular location	Apical cell membrane; Single-pass type I membrane protein By similarity. Note: Present in the intestinal brush border membranes By similarity.
Tissue specificity	Expressed in the epidermis (at protein level). Ref.5
Domain	Repeat 2 contains the catalytic domain By similarity.
Post-translational modification	Undergoes proteolytic cleavage in the ileum By similarity.
Sequence similarities	Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.
Sequence caution	The sequence BAB70920.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycerophospholipid biosynthetic process Traceable author statement. Source: Reactome lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylcholine acyl-chain remodeling Traceable author statement. Source: Reactome retinoid metabolic process Traceable author statement. Source: Reactome steroid metabolic process Traceable author statement. Source: Reactome
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	lysophospholipase activity Inferred from electronic annotation. Source: EC phospholipase A2 activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P1J6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P1J6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.
     774-800: SAGGDGSLENVTTLPNILREFNRNLTG → RESKPGFLSDSWVSKSNRKCTRKAPNP
     801-1458: Missing.

Isoform 3 (identifier: Q6P1J6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     184-184: Q → QQAPSLSTVLLS
     523-544: Missing.

Isoform 4 (identifier: Q6P1J6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     750-760: AGNGIGSKPDD → VRTLGPQVVWG
     761-1458: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q6P1J6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1035: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 1458	1437	Phospholipase B1, membrane-associated		PRO_0000324383
Regions
	Topological domain	22 – 1417	1396	Extracellular Potential
	Transmembrane	1418 – 1438	21	Helical; Potential
	Topological domain	1439 – 1458	20	Cytoplasmic Potential
	Repeat	39 – 347	309	1
	Repeat	362 – 707	346	2
	Repeat	708 – 1054	347	3
	Repeat	1064 – 1402	339	4
	Region	39 – 1402	1364	4 X 308-326 AA approximate repeats
	Region	1403 – 1445	43	Necessary for membrane localization By similarity
Sites
	Active site	400	1	Nucleophile By similarity
	Active site	1346	1	By similarity
	Active site	1349	1	By similarity
	Binding site	474	1	Substrate; via amide nitrogen By similarity
	Binding site	513	1	Substrate By similarity
Amino acid modifications
	Glycosylation	240	1	N-linked (GlcNAc...) Potential
	Glycosylation	493	1	N-linked (GlcNAc...) Potential
	Glycosylation	529	1	N-linked (GlcNAc...) Potential
	Glycosylation	797	1	N-linked (GlcNAc...) Potential
	Glycosylation	1055	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 1035	1035	Missing in isoform 5.		VSP_032225
	Alternative sequence	1 – 312	312	Missing in isoform 2.		VSP_032226
	Alternative sequence	184	1	Q → QQAPSLSTVLLS in isoform 3.		VSP_032227
	Alternative sequence	523 – 544	22	Missing in isoform 3.		VSP_032228
	Alternative sequence	750 – 760	11	AGNGIGSKPDD → VRTLGPQVVWG in isoform 4.		VSP_032229
	Alternative sequence	761 – 1458	698	Missing in isoform 4.		VSP_032230
	Alternative sequence	774 – 800	27	SAGGD…RNLTG → RESKPGFLSDSWVSKSNRKC TRKAPNP in isoform 2.		VSP_032231
	Alternative sequence	801 – 1458	658	Missing in isoform 2.		VSP_032232
	Natural variant	212	1	V → L. Corresponds to variant rs6753929 [ dbSNP | Ensembl ].		VAR_039793
	Natural variant	708	1	M → V. Corresponds to variant rs11681826 [ dbSNP | Ensembl ].		VAR_039794
	Natural variant	821	1	G → R. Corresponds to variant rs10201128 [ dbSNP | Ensembl ].		VAR_039795
	Natural variant	879	1	H → D. Corresponds to variant rs7601771 [ dbSNP | Ensembl ].		VAR_039796
	Natural variant	987	1	A → V. Corresponds to variant rs34289907 [ dbSNP | Ensembl ].		VAR_061358
	Natural variant	1318	1	A → V. Corresponds to variant rs2199619 [ dbSNP | Ensembl ].		VAR_039797
Experimental info
	Sequence conflict	426	1	W → Y in BAB70920. Ref.4
	Sequence conflict	1186	1	V → L in AAH42674. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 0B260E1489D8137B	FASTA	1,458	163,081
	10 20 30 40 50 60 MGLRPGIFLL ELLLLLGQGT PQIHTSPRKS TLEGQLWPET LKNSPFPCNP NKLGVNMPSK 70 80 90 100 110 120 SVHSLKPSDI KFVAAIGNLE IPPDPGTGDL EKQDWTERPQ QVCMGVMTVL SDIIRYFSPS 130 140 150 160 170 180 VPMPVCHTGK RVIPHDGAED LWIQAQELVR NMKENLQLDF QFDWKLINVF FSNASQCYLC 190 200 210 220 230 240 PSAQQNGLAA GGVDELMGVL DYLQQEVPRA FVNLVDLSEV AEVSRQYHGT WLSPAPEPCN 250 260 270 280 290 300 CSEETTRLAK VVMQWSYQEA WNSLLASSRY SEQESFTVVF QPFFYETTPS LHSEDPRLQD 310 320 330 340 350 360 STTLAWHLWN RMMEPAGEKD EPLSVKHGRP MKCPSQESPY LFSYRNSNYL TRLQKPQDKL 370 380 390 400 410 420 EVREGAEIRC PDKDPSDTVP TSVHRLKPAD INVIGALGDS LTAGNGAGST PGNVLDVLTQ 430 440 450 460 470 480 YRGLSWSVGG DENIGTVTTL ANILREFNPS LKGFSVGTGK ETSPNAFLNQ AVAGGRAEDL 490 500 510 520 530 540 PVQARRLVDL MKNDTRIHFQ EDWKIITLFI GGNDLCDFCN DLVHYSPQNF TDNIGKALDI 550 560 570 580 590 600 LHAEVPRAFV NLVTVLEIVN LRELYQEKKV YCPRMILRSL CPCVLKFDDN STELATLIEF 610 620 630 640 650 660 NKKFQEKTHQ LIESGRYDTR EDFTVVVQPF FENVDMPKTS EGLPDNSFFA PDCFHFSSKS 670 680 690 700 710 720 HSRAASALWN NMLEPVGQKT TRHKFENKIN ITCPNQVQPF LRTYKNSMQG HGTWLPCRDR 730 740 750 760 770 780 APSALHPTSV HALRPADIQV VAALGDSLTA GNGIGSKPDD LPDVTTQYRG LSYSAGGDGS 790 800 810 820 830 840 LENVTTLPNI LREFNRNLTG YAVGTGDAND TNAFLNQAVP GAKAEDLMSQ VQTLMQKMKD 850 860 870 880 890 900 DHRVNFHEDW KVITVLIGGS DLCDYCTDSN LYSAANFVHH LRNALDVLHR EVPRVLVNLV 910 920 930 940 950 960 DFLNPTIMRQ VFLGNPDKCP VQQASVLCNC VLTLRENSQE LARLEAFSRA YRSSMRELVG 970 980 990 1000 1010 1020 SGRYDTQEDF SVVLQPFFQN IQLPVLADGL PDTSFFAPDC IHPNQKFHSQ LARALWTNML 1030 1040 1050 1060 1070 1080 EPLGSKTETL DLRAEMPITC PTQNEPFLRT PRNSNYTYPI KPAIENWGSD FLCTEWKASN 1090 1100 1110 1120 1130 1140 SVPTSVHQLR PADIKVVAAL GDSLTTAVGA RPNNSSDLPT SWRGLSWSIG GDGNLETHTT 1150 1160 1170 1180 1190 1200 LPNILKKFNP YLLGFSTSTW EGTAGLNVAA EGARARDMPA QAWDLVERMK NSPDINLEKD 1210 1220 1230 1240 1250 1260 WKLVTLFIGV NDLCHYCENP EAHLATEYVQ HIQQALDILS EELPRAFVNV VEVMELASLY 1270 1280 1290 1300 1310 1320 QGQGGKCAML AAQNNCTCLR HSQSSLEKQE LKKVNWNLQH GISSFSYWHQ YTQREDFAVV 1330 1340 1350 1360 1370 1380 VQPFFQNTLT PLNERGDTDL TFFSEDCFHF SDRGHAEMAI ALWNNMLEPV GRKTTSNNFT 1390 1400 1410 1420 1430 1440 HSRAKLKCPS PESPYLYTLR NSRLLPDQAE EAPEVLYWAV PVAAGVGLVV GIIGTVVWRC 1450 RRGGRREDPP MSLRTVAL
	Isoform 2 [UniParc]. Checksum: 6BE12FF5CB0AC9C5	FASTA	488	54,341
	10 20 30 40 50 60 MEPAGEKDEP LSVKHGRPMK CPSQESPYLF SYRNSNYLTR LQKPQDKLEV REGAEIRCPD 70 80 90 100 110 120 KDPSDTVPTS VHRLKPADIN VIGALGDSLT AGNGAGSTPG NVLDVLTQYR GLSWSVGGDE 130 140 150 160 170 180 NIGTVTTLAN ILREFNPSLK GFSVGTGKET SPNAFLNQAV AGGRAEDLPV QARRLVDLMK 190 200 210 220 230 240 NDTRIHFQED WKIITLFIGG NDLCDFCNDL VHYSPQNFTD NIGKALDILH AEVPRAFVNL 250 260 270 280 290 300 VTVLEIVNLR ELYQEKKVYC PRMILRSLCP CVLKFDDNST ELATLIEFNK KFQEKTHQLI 310 320 330 340 350 360 ESGRYDTRED FTVVVQPFFE NVDMPKTSEG LPDNSFFAPD CFHFSSKSHS RAASALWNNM 370 380 390 400 410 420 LEPVGQKTTR HKFENKINIT CPNQVQPFLR TYKNSMQGHG TWLPCRDRAP SALHPTSVHA 430 440 450 460 470 480 LRPADIQVVA ALGDSLTAGN GIGSKPDDLP DVTTQYRGLS YRESKPGFLS DSWVSKSNRK CTRKAPNP
	Isoform 3 [UniParc]. Checksum: 463E147644AF72B7	FASTA	1,447	161,713
	10 20 30 40 50 60 MGLRPGIFLL ELLLLLGQGT PQIHTSPRKS TLEGQLWPET LKNSPFPCNP NKLGVNMPSK 70 80 90 100 110 120 SVHSLKPSDI KFVAAIGNLE IPPDPGTGDL EKQDWTERPQ QVCMGVMTVL SDIIRYFSPS 130 140 150 160 170 180 VPMPVCHTGK RVIPHDGAED LWIQAQELVR NMKENLQLDF QFDWKLINVF FSNASQCYLC 190 200 210 220 230 240 PSAQQAPSLS TVLLSQNGLA AGGVDELMGV LDYLQQEVPR AFVNLVDLSE VAEVSRQYHG 250 260 270 280 290 300 TWLSPAPEPC NCSEETTRLA KVVMQWSYQE AWNSLLASSR YSEQESFTVV FQPFFYETTP 310 320 330 340 350 360 SLHSEDPRLQ DSTTLAWHLW NRMMEPAGEK DEPLSVKHGR PMKCPSQESP YLFSYRNSNY 370 380 390 400 410 420 LTRLQKPQDK LEVREGAEIR CPDKDPSDTV PTSVHRLKPA DINVIGALGD SLTAGNGAGS 430 440 450 460 470 480 TPGNVLDVLT QYRGLSWSVG GDENIGTVTT LANILREFNP SLKGFSVGTG KETSPNAFLN 490 500 510 520 530 540 QAVAGGRAED LPVQARRLVD LMKNDTRIHF QEDWKIITLF IGGNDLCDFC NDLVPRAFVN 550 560 570 580 590 600 LVTVLEIVNL RELYQEKKVY CPRMILRSLC PCVLKFDDNS TELATLIEFN KKFQEKTHQL 610 620 630 640 650 660 IESGRYDTRE DFTVVVQPFF ENVDMPKTSE GLPDNSFFAP DCFHFSSKSH SRAASALWNN 670 680 690 700 710 720 MLEPVGQKTT RHKFENKINI TCPNQVQPFL RTYKNSMQGH GTWLPCRDRA PSALHPTSVH 730 740 750 760 770 780 ALRPADIQVV AALGDSLTAG NGIGSKPDDL PDVTTQYRGL SYSAGGDGSL ENVTTLPNIL 790 800 810 820 830 840 REFNRNLTGY AVGTGDANDT NAFLNQAVPG AKAEDLMSQV QTLMQKMKDD HRVNFHEDWK 850 860 870 880 890 900 VITVLIGGSD LCDYCTDSNL YSAANFVHHL RNALDVLHRE VPRVLVNLVD FLNPTIMRQV 910 920 930 940 950 960 FLGNPDKCPV QQASVLCNCV LTLRENSQEL ARLEAFSRAY RSSMRELVGS GRYDTQEDFS 970 980 990 1000 1010 1020 VVLQPFFQNI QLPVLADGLP DTSFFAPDCI HPNQKFHSQL ARALWTNMLE PLGSKTETLD 1030 1040 1050 1060 1070 1080 LRAEMPITCP TQNEPFLRTP RNSNYTYPIK PAIENWGSDF LCTEWKASNS VPTSVHQLRP 1090 1100 1110 1120 1130 1140 ADIKVVAALG DSLTTAVGAR PNNSSDLPTS WRGLSWSIGG DGNLETHTTL PNILKKFNPY 1150 1160 1170 1180 1190 1200 LLGFSTSTWE GTAGLNVAAE GARARDMPAQ AWDLVERMKN SPDINLEKDW KLVTLFIGVN 1210 1220 1230 1240 1250 1260 DLCHYCENPE AHLATEYVQH IQQALDILSE ELPRAFVNVV EVMELASLYQ GQGGKCAMLA 1270 1280 1290 1300 1310 1320 AQNNCTCLRH SQSSLEKQEL KKVNWNLQHG ISSFSYWHQY TQREDFAVVV QPFFQNTLTP 1330 1340 1350 1360 1370 1380 LNERGDTDLT FFSEDCFHFS DRGHAEMAIA LWNNMLEPVG RKTTSNNFTH SRAKLKCPSP 1390 1400 1410 1420 1430 1440 ESPYLYTLRN SRLLPDQAEE APEVLYWAVP VAAGVGLVVG IIGTVVWRCR RGGRREDPPM SLRTVAL
	Isoform 4 [UniParc]. Checksum: 6910E87C50726761	FASTA	760	85,191
	10 20 30 40 50 60 MGLRPGIFLL ELLLLLGQGT PQIHTSPRKS TLEGQLWPET LKNSPFPCNP NKLGVNMPSK 70 80 90 100 110 120 SVHSLKPSDI KFVAAIGNLE IPPDPGTGDL EKQDWTERPQ QVCMGVMTVL SDIIRYFSPS 130 140 150 160 170 180 VPMPVCHTGK RVIPHDGAED LWIQAQELVR NMKENLQLDF QFDWKLINVF FSNASQCYLC 190 200 210 220 230 240 PSAQQNGLAA GGVDELMGVL DYLQQEVPRA FVNLVDLSEV AEVSRQYHGT WLSPAPEPCN 250 260 270 280 290 300 CSEETTRLAK VVMQWSYQEA WNSLLASSRY SEQESFTVVF QPFFYETTPS LHSEDPRLQD 310 320 330 340 350 360 STTLAWHLWN RMMEPAGEKD EPLSVKHGRP MKCPSQESPY LFSYRNSNYL TRLQKPQDKL 370 380 390 400 410 420 EVREGAEIRC PDKDPSDTVP TSVHRLKPAD INVIGALGDS LTAGNGAGST PGNVLDVLTQ 430 440 450 460 470 480 YRGLSWSVGG DENIGTVTTL ANILREFNPS LKGFSVGTGK ETSPNAFLNQ AVAGGRAEDL 490 500 510 520 530 540 PVQARRLVDL MKNDTRIHFQ EDWKIITLFI GGNDLCDFCN DLVHYSPQNF TDNIGKALDI 550 560 570 580 590 600 LHAEVPRAFV NLVTVLEIVN LRELYQEKKV YCPRMILRSL CPCVLKFDDN STELATLIEF 610 620 630 640 650 660 NKKFQEKTHQ LIESGRYDTR EDFTVVVQPF FENVDMPKTS EGLPDNSFFA PDCFHFSSKS 670 680 690 700 710 720 HSRAASALWN NMLEPVGQKT TRHKFENKIN ITCPNQVQPF LRTYKNSMQG HGTWLPCRDR 730 740 750 760 APSALHPTSV HALRPADIQV VAALGDSLTV RTLGPQVVWG
	Isoform 5 [UniParc]. Checksum: A66F32D49AC1A20C	FASTA	423	47,341
	10 20 30 40 50 60 MPITCPTQNE PFLRTPRNSN YTYPIKPAIE NWGSDFLCTE WKASNSVPTS VHQLRPADIK 70 80 90 100 110 120 VVAALGDSLT TAVGARPNNS SDLPTSWRGL SWSIGGDGNL ETHTTLPNIL KKFNPYLLGF 130 140 150 160 170 180 STSTWEGTAG LNVAAEGARA RDMPAQAWDL VERMKNSPDI NLEKDWKLVT LFIGVNDLCH 190 200 210 220 230 240 YCENPEAHLA TEYVQHIQQA LDILSEELPR AFVNVVEVME LASLYQGQGG KCAMLAAQNN 250 260 270 280 290 300 CTCLRHSQSS LEKQELKKVN WNLQHGISSF SYWHQYTQRE DFAVVVQPFF QNTLTPLNER 310 320 330 340 350 360 GDTDLTFFSE DCFHFSDRGH AEMAIALWNN MLEPVGRKTT SNNFTHSRAK LKCPSPESPY 370 380 390 400 410 420 LYTLRNSRLL PDQAEEAPEV LYWAVPVAAG VGLVVGIIGT VVWRCRRGGR REDPPMSLRT VAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1458 (ISOFORM 3). Tissue: Brain and Skin.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 426-1458 (ISOFORM 4). Tissue: Brain.
[5]	"Human epidermis is a novel site of phospholipase B expression." Maury E., Prevost M.-C., Nauze M., Redoules D., Tarroux R., Charveron M., Salles J.-P., Perret B., Chap H., Gassama-Diagne A. Biochem. Biophys. Res. Commun. 295:362-369(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC074011 Genomic DNA. Translation: AAY24081.1. AC074011 Genomic DNA. Translation: AAY24082.1. AC093164 Genomic DNA. No translation available. CH471053 Genomic DNA. Translation: EAX00532.1. CH471053 Genomic DNA. Translation: EAX00533.1. BC042674 mRNA. Translation: AAH42674.1. BC065041 mRNA. Translation: AAH65041.1. BC153864 mRNA. Translation: AAI53865.1. AK055428 mRNA. Translation: BAB70920.1. Different initiation.
IPI	IPI00397878. IPI00478604. IPI00886740. IPI00888210. IPI00888960.
RefSeq	NP_001164056.1. NM_001170585.1. NP_694566.4. NM_153021.4.
UniGene	Hs.444933.
3D structure databases
ProteinModelPortal	Q6P1J6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000330442.
PTM databases
PhosphoSite	Q6P1J6.
Polymorphism databases
DMDM	296452994.
Proteomic databases
PaxDb	Q6P1J6.
PRIDE	Q6P1J6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327757; ENSP00000330442; ENSG00000163803. ENST00000329020; ENSP00000330729; ENSG00000163803. ENST00000422425; ENSP00000416440; ENSG00000163803. ENST00000541605; ENSP00000437426; ENSG00000163803.
GeneID	151056.
KEGG	hsa:151056.
UCSC	uc002rmb.2. human. uc002rmc.3. human. uc002rme.2. human. uc010ezj.2. human.
Organism-specific databases
CTD	151056.
GeneCards	GC02P028732.
H-InvDB	HIX0024210.
HGNC	HGNC:30041. PLB1.
HPA	HPA014045.
MIM	610179. gene.
neXtProt	NX_Q6P1J6.
PharmGKB	PA134891309.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG311176.
HOGENOM	HOG000115574.
HOVERGEN	HBG108263.
InParanoid	Q6P1J6.
KO	K14621.
OMA	NDLCHYC.
OrthoDB	EOG46Q6T3.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q6P1J6.
Bgee	Q6P1J6.
CleanEx	HS_PLB1.
Genevestigator	Q6P1J6.
Family and domain databases
Gene3D	3.40.50.1110. 5 hits.
InterPro	IPR001087. Lipase_GDSL. IPR008265. Lipase_GDSL_AS. IPR013831. SGNH_hydro-type_esterase_dom. [Graphical view]
Pfam	PF00657. Lipase_GDSL. 3 hits. [Graphical view]
PROSITE	PS01098. LIPASE_GDSL_SER. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	151056.
NextBio	86583.
SOURCE	Search...

Entry information

Entry name

PLB1_HUMAN

Accession

Primary (citable) accession number: Q6P1J6
Secondary accession number(s): A8KAX2 , Q53S03, Q8IUP7, Q96DP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 80 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.