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Q6P1J6

- PLB1_HUMAN

UniProt

Q6P1J6 - PLB1_HUMAN

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Protein
Phospholipase B1, membrane-associated
Gene
PLB1, PLB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Membrane-associated phospholipase. Exhibits a calcium-independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by diisopropyl fluorophosphate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei400 – 4001Nucleophile By similarity
Binding sitei474 – 4741Substrate; via amide nitrogen By similarity
Binding sitei513 – 5131Substrate By similarity
Active sitei1346 – 13461 By similarity
Active sitei1349 – 13491 By similarity

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
  2. phospholipase A2 activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerophospholipid biosynthetic process Source: Reactome
  2. lipid catabolic process Source: UniProtKB-KW
  3. phosphatidylcholine acyl-chain remodeling Source: Reactome
  4. phospholipid metabolic process Source: Reactome
  5. phototransduction, visible light Source: Reactome
  6. retinoid metabolic process Source: Reactome
  7. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_120829. Acyl chain remodelling of PC.
REACT_24968. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase B1, membrane-associated
Short name:
Phospholipase B
Short name:
hPLB
Alternative name(s):
Phospholipase B/lipase
Short name:
PLB/LIP
Including the following 2 domains:
Phospholipase A2 (EC:3.1.1.4)
Lysophospholipase (EC:3.1.1.5)
Gene namesi
Name:PLB1
Synonyms:PLB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:30041. PLB1.

Subcellular locationi

Apical cell membrane; Single-pass type I membrane protein By similarity
Note: Present in the intestinal brush border membranes By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 14171396Extracellular Reviewed prediction
Add
BLAST
Transmembranei1418 – 143821Helical; Reviewed prediction
Add
BLAST
Topological domaini1439 – 145820Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 14581437Phospholipase B1, membrane-associated
PRO_0000324383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi240 – 2401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi493 – 4931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi529 – 5291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi797 – 7971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1055 – 10551N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Undergoes proteolytic cleavage in the ileum By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6P1J6.
PRIDEiQ6P1J6.

PTM databases

PhosphoSiteiQ6P1J6.

Expressioni

Tissue specificityi

Expressed in the epidermis (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ6P1J6.
BgeeiQ6P1J6.
CleanExiHS_PLB1.
GenevestigatoriQ6P1J6.

Organism-specific databases

HPAiHPA014045.

Interactioni

Protein-protein interaction databases

BioGridi127341. 1 interaction.
STRINGi9606.ENSP00000330442.

Structurei

3D structure databases

ProteinModelPortaliQ6P1J6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati39 – 3473091
Add
BLAST
Repeati362 – 7073462
Add
BLAST
Repeati708 – 10543473
Add
BLAST
Repeati1064 – 14023394
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 140213644 X 308-326 AA approximate repeats
Add
BLAST
Regioni1403 – 144543Necessary for membrane localization By similarity
Add
BLAST

Domaini

Repeat 2 contains the catalytic domain By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311176.
HOGENOMiHOG000115574.
HOVERGENiHBG108263.
InParanoidiQ6P1J6.
KOiK14621.
OMAiCPDKDPS.
OrthoDBiEOG7MPRD0.
PhylomeDBiQ6P1J6.
TreeFamiTF314942.

Family and domain databases

Gene3Di3.40.50.1110. 5 hits.
InterProiIPR001087. Lipase_GDSL.
IPR008265. Lipase_GDSL_AS.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]
PfamiPF00657. Lipase_GDSL. 3 hits.
[Graphical view]
PROSITEiPS01098. LIPASE_GDSL_SER. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6P1J6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLRPGIFLL ELLLLLGQGT PQIHTSPRKS TLEGQLWPET LKNSPFPCNP     50
NKLGVNMPSK SVHSLKPSDI KFVAAIGNLE IPPDPGTGDL EKQDWTERPQ 100
QVCMGVMTVL SDIIRYFSPS VPMPVCHTGK RVIPHDGAED LWIQAQELVR 150
NMKENLQLDF QFDWKLINVF FSNASQCYLC PSAQQNGLAA GGVDELMGVL 200
DYLQQEVPRA FVNLVDLSEV AEVSRQYHGT WLSPAPEPCN CSEETTRLAK 250
VVMQWSYQEA WNSLLASSRY SEQESFTVVF QPFFYETTPS LHSEDPRLQD 300
STTLAWHLWN RMMEPAGEKD EPLSVKHGRP MKCPSQESPY LFSYRNSNYL 350
TRLQKPQDKL EVREGAEIRC PDKDPSDTVP TSVHRLKPAD INVIGALGDS 400
LTAGNGAGST PGNVLDVLTQ YRGLSWSVGG DENIGTVTTL ANILREFNPS 450
LKGFSVGTGK ETSPNAFLNQ AVAGGRAEDL PVQARRLVDL MKNDTRIHFQ 500
EDWKIITLFI GGNDLCDFCN DLVHYSPQNF TDNIGKALDI LHAEVPRAFV 550
NLVTVLEIVN LRELYQEKKV YCPRMILRSL CPCVLKFDDN STELATLIEF 600
NKKFQEKTHQ LIESGRYDTR EDFTVVVQPF FENVDMPKTS EGLPDNSFFA 650
PDCFHFSSKS HSRAASALWN NMLEPVGQKT TRHKFENKIN ITCPNQVQPF 700
LRTYKNSMQG HGTWLPCRDR APSALHPTSV HALRPADIQV VAALGDSLTA 750
GNGIGSKPDD LPDVTTQYRG LSYSAGGDGS LENVTTLPNI LREFNRNLTG 800
YAVGTGDAND TNAFLNQAVP GAKAEDLMSQ VQTLMQKMKD DHRVNFHEDW 850
KVITVLIGGS DLCDYCTDSN LYSAANFVHH LRNALDVLHR EVPRVLVNLV 900
DFLNPTIMRQ VFLGNPDKCP VQQASVLCNC VLTLRENSQE LARLEAFSRA 950
YRSSMRELVG SGRYDTQEDF SVVLQPFFQN IQLPVLADGL PDTSFFAPDC 1000
IHPNQKFHSQ LARALWTNML EPLGSKTETL DLRAEMPITC PTQNEPFLRT 1050
PRNSNYTYPI KPAIENWGSD FLCTEWKASN SVPTSVHQLR PADIKVVAAL 1100
GDSLTTAVGA RPNNSSDLPT SWRGLSWSIG GDGNLETHTT LPNILKKFNP 1150
YLLGFSTSTW EGTAGLNVAA EGARARDMPA QAWDLVERMK NSPDINLEKD 1200
WKLVTLFIGV NDLCHYCENP EAHLATEYVQ HIQQALDILS EELPRAFVNV 1250
VEVMELASLY QGQGGKCAML AAQNNCTCLR HSQSSLEKQE LKKVNWNLQH 1300
GISSFSYWHQ YTQREDFAVV VQPFFQNTLT PLNERGDTDL TFFSEDCFHF 1350
SDRGHAEMAI ALWNNMLEPV GRKTTSNNFT HSRAKLKCPS PESPYLYTLR 1400
NSRLLPDQAE EAPEVLYWAV PVAAGVGLVV GIIGTVVWRC RRGGRREDPP 1450
MSLRTVAL 1458
Length:1,458
Mass (Da):163,081
Last modified:May 18, 2010 - v3
Checksum:i0B260E1489D8137B
GO
Isoform 2 (identifier: Q6P1J6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.
     774-800: SAGGDGSLENVTTLPNILREFNRNLTG → RESKPGFLSDSWVSKSNRKCTRKAPNP
     801-1458: Missing.

Show »
Length:488
Mass (Da):54,341
Checksum:i6BE12FF5CB0AC9C5
GO
Isoform 3 (identifier: Q6P1J6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-184: Q → QQAPSLSTVLLS
     523-544: Missing.

Show »
Length:1,447
Mass (Da):161,713
Checksum:i463E147644AF72B7
GO
Isoform 4 (identifier: Q6P1J6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-760: AGNGIGSKPDD → VRTLGPQVVWG
     761-1458: Missing.

Note: No experimental confirmation available.

Show »
Length:760
Mass (Da):85,191
Checksum:i6910E87C50726761
GO
Isoform 5 (identifier: Q6P1J6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1035: Missing.

Show »
Length:423
Mass (Da):47,341
Checksum:iA66F32D49AC1A20C
GO

Sequence cautioni

The sequence BAB70920.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti212 – 2121V → L.
Corresponds to variant rs6753929 [ dbSNP | Ensembl ].
VAR_039793
Natural varianti708 – 7081M → V.
Corresponds to variant rs11681826 [ dbSNP | Ensembl ].
VAR_039794
Natural varianti821 – 8211G → R.
Corresponds to variant rs10201128 [ dbSNP | Ensembl ].
VAR_039795
Natural varianti879 – 8791H → D.
Corresponds to variant rs7601771 [ dbSNP | Ensembl ].
VAR_039796
Natural varianti987 – 9871A → V.
Corresponds to variant rs34289907 [ dbSNP | Ensembl ].
VAR_061358
Natural varianti1318 – 13181A → V.
Corresponds to variant rs2199619 [ dbSNP | Ensembl ].
VAR_039797

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10351035Missing in isoform 5.
VSP_032225Add
BLAST
Alternative sequencei1 – 312312Missing in isoform 2.
VSP_032226Add
BLAST
Alternative sequencei184 – 1841Q → QQAPSLSTVLLS in isoform 3.
VSP_032227
Alternative sequencei523 – 54422Missing in isoform 3.
VSP_032228Add
BLAST
Alternative sequencei750 – 76011AGNGIGSKPDD → VRTLGPQVVWG in isoform 4.
VSP_032229Add
BLAST
Alternative sequencei761 – 1458698Missing in isoform 4.
VSP_032230Add
BLAST
Alternative sequencei774 – 80027SAGGD…RNLTG → RESKPGFLSDSWVSKSNRKC TRKAPNP in isoform 2.
VSP_032231Add
BLAST
Alternative sequencei801 – 1458658Missing in isoform 2.
VSP_032232Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti426 – 4261W → Y in BAB70920. 1 Publication
Sequence conflicti1186 – 11861V → L in AAH42674. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC074011 Genomic DNA. Translation: AAY24081.1.
AC074011 Genomic DNA. Translation: AAY24082.1.
AC093164 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00532.1.
CH471053 Genomic DNA. Translation: EAX00533.1.
BC042674 mRNA. Translation: AAH42674.1.
BC065041 mRNA. Translation: AAH65041.1.
BC153864 mRNA. Translation: AAI53865.1.
AK055428 mRNA. Translation: BAB70920.1. Different initiation.
CCDSiCCDS33168.1. [Q6P1J6-1]
CCDS54340.1. [Q6P1J6-3]
RefSeqiNP_001164056.1. NM_001170585.1. [Q6P1J6-3]
NP_694566.4. NM_153021.4. [Q6P1J6-1]
UniGeneiHs.444933.

Genome annotation databases

EnsembliENST00000327757; ENSP00000330442; ENSG00000163803. [Q6P1J6-1]
ENST00000329020; ENSP00000330729; ENSG00000163803. [Q6P1J6-2]
ENST00000422425; ENSP00000416440; ENSG00000163803. [Q6P1J6-3]
ENST00000541605; ENSP00000437426; ENSG00000163803. [Q6P1J6-5]
GeneIDi151056.
KEGGihsa:151056.
UCSCiuc002rmb.2. human. [Q6P1J6-1]
uc002rmc.3. human. [Q6P1J6-2]
uc002rme.2. human. [Q6P1J6-5]
uc010ezj.2. human. [Q6P1J6-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC074011 Genomic DNA. Translation: AAY24081.1 .
AC074011 Genomic DNA. Translation: AAY24082.1 .
AC093164 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00532.1 .
CH471053 Genomic DNA. Translation: EAX00533.1 .
BC042674 mRNA. Translation: AAH42674.1 .
BC065041 mRNA. Translation: AAH65041.1 .
BC153864 mRNA. Translation: AAI53865.1 .
AK055428 mRNA. Translation: BAB70920.1 . Different initiation.
CCDSi CCDS33168.1. [Q6P1J6-1 ]
CCDS54340.1. [Q6P1J6-3 ]
RefSeqi NP_001164056.1. NM_001170585.1. [Q6P1J6-3 ]
NP_694566.4. NM_153021.4. [Q6P1J6-1 ]
UniGenei Hs.444933.

3D structure databases

ProteinModelPortali Q6P1J6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127341. 1 interaction.
STRINGi 9606.ENSP00000330442.

PTM databases

PhosphoSitei Q6P1J6.

Proteomic databases

PaxDbi Q6P1J6.
PRIDEi Q6P1J6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327757 ; ENSP00000330442 ; ENSG00000163803 . [Q6P1J6-1 ]
ENST00000329020 ; ENSP00000330729 ; ENSG00000163803 . [Q6P1J6-2 ]
ENST00000422425 ; ENSP00000416440 ; ENSG00000163803 . [Q6P1J6-3 ]
ENST00000541605 ; ENSP00000437426 ; ENSG00000163803 . [Q6P1J6-5 ]
GeneIDi 151056.
KEGGi hsa:151056.
UCSCi uc002rmb.2. human. [Q6P1J6-1 ]
uc002rmc.3. human. [Q6P1J6-2 ]
uc002rme.2. human. [Q6P1J6-5 ]
uc010ezj.2. human. [Q6P1J6-3 ]

Organism-specific databases

CTDi 151056.
GeneCardsi GC02P028732.
H-InvDB HIX0024210.
HGNCi HGNC:30041. PLB1.
HPAi HPA014045.
MIMi 610179. gene.
neXtProti NX_Q6P1J6.
PharmGKBi PA134891309.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311176.
HOGENOMi HOG000115574.
HOVERGENi HBG108263.
InParanoidi Q6P1J6.
KOi K14621.
OMAi CPDKDPS.
OrthoDBi EOG7MPRD0.
PhylomeDBi Q6P1J6.
TreeFami TF314942.

Enzyme and pathway databases

Reactomei REACT_120829. Acyl chain remodelling of PC.
REACT_24968. Retinoid metabolism and transport.

Miscellaneous databases

GenomeRNAii 151056.
NextBioi 86583.
PROi Q6P1J6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6P1J6.
Bgeei Q6P1J6.
CleanExi HS_PLB1.
Genevestigatori Q6P1J6.

Family and domain databases

Gene3Di 3.40.50.1110. 5 hits.
InterProi IPR001087. Lipase_GDSL.
IPR008265. Lipase_GDSL_AS.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view ]
Pfami PF00657. Lipase_GDSL. 3 hits.
[Graphical view ]
PROSITEi PS01098. LIPASE_GDSL_SER. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1458 (ISOFORM 3).
    Tissue: Brain and Skin.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 426-1458 (ISOFORM 4).
    Tissue: Brain.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPLB1_HUMAN
AccessioniPrimary (citable) accession number: Q6P1J6
Secondary accession number(s): A8KAX2
, Q53S03, Q8IUP7, Q96DP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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