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Protein

Phospholipase B1, membrane-associated

Gene

PLB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Membrane-associated phospholipase. Exhibits a calcium-independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by diisopropyl fluorophosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei400 – 4001NucleophileBy similarity
Binding sitei474 – 4741Substrate; via amide nitrogenBy similarity
Binding sitei513 – 5131SubstrateBy similarity
Active sitei1346 – 13461By similarity
Active sitei1349 – 13491By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_120829. Acyl chain remodelling of PC.
REACT_24968. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase B1, membrane-associated
Short name:
Phospholipase B
Short name:
hPLB
Alternative name(s):
Phospholipase B/lipase
Short name:
PLB/LIP
Including the following 2 domains:
Phospholipase A2 (EC:3.1.1.4)
Lysophospholipase (EC:3.1.1.5)
Gene namesi
Name:PLB1
Synonyms:PLB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30041. PLB1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 14171396ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1418 – 143821HelicalSequence AnalysisAdd
BLAST
Topological domaini1439 – 145820CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891309.

Polymorphism and mutation databases

BioMutaiPLB1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 14581437Phospholipase B1, membrane-associatedPRO_0000324383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi529 – 5291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1055 – 10551N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Undergoes proteolytic cleavage in the ileum.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6P1J6.
PRIDEiQ6P1J6.

PTM databases

PhosphoSiteiQ6P1J6.

Expressioni

Tissue specificityi

Expressed in the epidermis (at protein level).1 Publication

Gene expression databases

BgeeiQ6P1J6.
CleanExiHS_PLB1.
ExpressionAtlasiQ6P1J6. baseline and differential.
GenevisibleiQ6P1J6. HS.

Organism-specific databases

HPAiHPA014045.

Interactioni

Protein-protein interaction databases

BioGridi127341. 8 interactions.
IntActiQ6P1J6. 3 interactions.
STRINGi9606.ENSP00000330442.

Structurei

3D structure databases

ProteinModelPortaliQ6P1J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati39 – 3473091Add
BLAST
Repeati362 – 7073462Add
BLAST
Repeati708 – 10543473Add
BLAST
Repeati1064 – 14023394Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 140213644 X 308-326 AA approximate repeatsAdd
BLAST
Regioni1403 – 144543Necessary for membrane localizationBy similarityAdd
BLAST

Domaini

Repeat 2 contains the catalytic domain.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311176.
GeneTreeiENSGT00530000063883.
HOGENOMiHOG000115574.
HOVERGENiHBG108263.
InParanoidiQ6P1J6.
KOiK14621.
OMAiNDLCHYC.
OrthoDBiEOG7MPRD0.
PhylomeDBiQ6P1J6.
TreeFamiTF314942.

Family and domain databases

Gene3Di3.40.50.1110. 5 hits.
InterProiIPR001087. GDSL.
IPR008265. Lipase_GDSL_AS.
IPR013830. SGNH_hydro.
[Graphical view]
PfamiPF00657. Lipase_GDSL. 3 hits.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 7 hits.
PROSITEiPS01098. LIPASE_GDSL_SER. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P1J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLRPGIFLL ELLLLLGQGT PQIHTSPRKS TLEGQLWPET LKNSPFPCNP
60 70 80 90 100
NKLGVNMPSK SVHSLKPSDI KFVAAIGNLE IPPDPGTGDL EKQDWTERPQ
110 120 130 140 150
QVCMGVMTVL SDIIRYFSPS VPMPVCHTGK RVIPHDGAED LWIQAQELVR
160 170 180 190 200
NMKENLQLDF QFDWKLINVF FSNASQCYLC PSAQQNGLAA GGVDELMGVL
210 220 230 240 250
DYLQQEVPRA FVNLVDLSEV AEVSRQYHGT WLSPAPEPCN CSEETTRLAK
260 270 280 290 300
VVMQWSYQEA WNSLLASSRY SEQESFTVVF QPFFYETTPS LHSEDPRLQD
310 320 330 340 350
STTLAWHLWN RMMEPAGEKD EPLSVKHGRP MKCPSQESPY LFSYRNSNYL
360 370 380 390 400
TRLQKPQDKL EVREGAEIRC PDKDPSDTVP TSVHRLKPAD INVIGALGDS
410 420 430 440 450
LTAGNGAGST PGNVLDVLTQ YRGLSWSVGG DENIGTVTTL ANILREFNPS
460 470 480 490 500
LKGFSVGTGK ETSPNAFLNQ AVAGGRAEDL PVQARRLVDL MKNDTRIHFQ
510 520 530 540 550
EDWKIITLFI GGNDLCDFCN DLVHYSPQNF TDNIGKALDI LHAEVPRAFV
560 570 580 590 600
NLVTVLEIVN LRELYQEKKV YCPRMILRSL CPCVLKFDDN STELATLIEF
610 620 630 640 650
NKKFQEKTHQ LIESGRYDTR EDFTVVVQPF FENVDMPKTS EGLPDNSFFA
660 670 680 690 700
PDCFHFSSKS HSRAASALWN NMLEPVGQKT TRHKFENKIN ITCPNQVQPF
710 720 730 740 750
LRTYKNSMQG HGTWLPCRDR APSALHPTSV HALRPADIQV VAALGDSLTA
760 770 780 790 800
GNGIGSKPDD LPDVTTQYRG LSYSAGGDGS LENVTTLPNI LREFNRNLTG
810 820 830 840 850
YAVGTGDAND TNAFLNQAVP GAKAEDLMSQ VQTLMQKMKD DHRVNFHEDW
860 870 880 890 900
KVITVLIGGS DLCDYCTDSN LYSAANFVHH LRNALDVLHR EVPRVLVNLV
910 920 930 940 950
DFLNPTIMRQ VFLGNPDKCP VQQASVLCNC VLTLRENSQE LARLEAFSRA
960 970 980 990 1000
YRSSMRELVG SGRYDTQEDF SVVLQPFFQN IQLPVLADGL PDTSFFAPDC
1010 1020 1030 1040 1050
IHPNQKFHSQ LARALWTNML EPLGSKTETL DLRAEMPITC PTQNEPFLRT
1060 1070 1080 1090 1100
PRNSNYTYPI KPAIENWGSD FLCTEWKASN SVPTSVHQLR PADIKVVAAL
1110 1120 1130 1140 1150
GDSLTTAVGA RPNNSSDLPT SWRGLSWSIG GDGNLETHTT LPNILKKFNP
1160 1170 1180 1190 1200
YLLGFSTSTW EGTAGLNVAA EGARARDMPA QAWDLVERMK NSPDINLEKD
1210 1220 1230 1240 1250
WKLVTLFIGV NDLCHYCENP EAHLATEYVQ HIQQALDILS EELPRAFVNV
1260 1270 1280 1290 1300
VEVMELASLY QGQGGKCAML AAQNNCTCLR HSQSSLEKQE LKKVNWNLQH
1310 1320 1330 1340 1350
GISSFSYWHQ YTQREDFAVV VQPFFQNTLT PLNERGDTDL TFFSEDCFHF
1360 1370 1380 1390 1400
SDRGHAEMAI ALWNNMLEPV GRKTTSNNFT HSRAKLKCPS PESPYLYTLR
1410 1420 1430 1440 1450
NSRLLPDQAE EAPEVLYWAV PVAAGVGLVV GIIGTVVWRC RRGGRREDPP

MSLRTVAL
Length:1,458
Mass (Da):163,081
Last modified:May 18, 2010 - v3
Checksum:i0B260E1489D8137B
GO
Isoform 2 (identifier: Q6P1J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.
     774-800: SAGGDGSLENVTTLPNILREFNRNLTG → RESKPGFLSDSWVSKSNRKCTRKAPNP
     801-1458: Missing.

Show »
Length:488
Mass (Da):54,341
Checksum:i6BE12FF5CB0AC9C5
GO
Isoform 3 (identifier: Q6P1J6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-184: Q → QQAPSLSTVLLS
     523-544: Missing.

Show »
Length:1,447
Mass (Da):161,713
Checksum:i463E147644AF72B7
GO
Isoform 4 (identifier: Q6P1J6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-760: AGNGIGSKPDD → VRTLGPQVVWG
     761-1458: Missing.

Note: No experimental confirmation available.
Show »
Length:760
Mass (Da):85,191
Checksum:i6910E87C50726761
GO
Isoform 5 (identifier: Q6P1J6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1035: Missing.

Show »
Length:423
Mass (Da):47,341
Checksum:iA66F32D49AC1A20C
GO

Sequence cautioni

The sequence BAB70920.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti426 – 4261W → Y in BAB70920 (PubMed:14702039).Curated
Sequence conflicti1186 – 11861V → L in AAH42674 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti212 – 2121V → L.
Corresponds to variant rs6753929 [ dbSNP | Ensembl ].
VAR_039793
Natural varianti708 – 7081M → V.
Corresponds to variant rs11681826 [ dbSNP | Ensembl ].
VAR_039794
Natural varianti821 – 8211G → R.
Corresponds to variant rs10201128 [ dbSNP | Ensembl ].
VAR_039795
Natural varianti879 – 8791H → D.
Corresponds to variant rs7601771 [ dbSNP | Ensembl ].
VAR_039796
Natural varianti987 – 9871A → V.
Corresponds to variant rs34289907 [ dbSNP | Ensembl ].
VAR_061358
Natural varianti1318 – 13181A → V.
Corresponds to variant rs2199619 [ dbSNP | Ensembl ].
VAR_039797

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10351035Missing in isoform 5. 1 PublicationVSP_032225Add
BLAST
Alternative sequencei1 – 312312Missing in isoform 2. 1 PublicationVSP_032226Add
BLAST
Alternative sequencei184 – 1841Q → QQAPSLSTVLLS in isoform 3. 1 PublicationVSP_032227
Alternative sequencei523 – 54422Missing in isoform 3. 1 PublicationVSP_032228Add
BLAST
Alternative sequencei750 – 76011AGNGIGSKPDD → VRTLGPQVVWG in isoform 4. 1 PublicationVSP_032229Add
BLAST
Alternative sequencei761 – 1458698Missing in isoform 4. 1 PublicationVSP_032230Add
BLAST
Alternative sequencei774 – 80027SAGGD…RNLTG → RESKPGFLSDSWVSKSNRKC TRKAPNP in isoform 2. 1 PublicationVSP_032231Add
BLAST
Alternative sequencei801 – 1458658Missing in isoform 2. 1 PublicationVSP_032232Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074011 Genomic DNA. Translation: AAY24081.1.
AC074011 Genomic DNA. Translation: AAY24082.1.
AC093164 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00532.1.
CH471053 Genomic DNA. Translation: EAX00533.1.
BC042674 mRNA. Translation: AAH42674.1.
BC065041 mRNA. Translation: AAH65041.1.
BC153864 mRNA. Translation: AAI53865.1.
AK055428 mRNA. Translation: BAB70920.1. Different initiation.
CCDSiCCDS33168.1. [Q6P1J6-1]
CCDS54340.1. [Q6P1J6-3]
RefSeqiNP_001164056.1. NM_001170585.1. [Q6P1J6-3]
NP_694566.4. NM_153021.4. [Q6P1J6-1]
UniGeneiHs.444933.

Genome annotation databases

EnsembliENST00000327757; ENSP00000330442; ENSG00000163803.
ENST00000422425; ENSP00000416440; ENSG00000163803. [Q6P1J6-3]
GeneIDi151056.
KEGGihsa:151056.
UCSCiuc002rmb.2. human. [Q6P1J6-1]
uc002rmc.3. human. [Q6P1J6-2]
uc002rme.2. human. [Q6P1J6-5]
uc010ezj.2. human. [Q6P1J6-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074011 Genomic DNA. Translation: AAY24081.1.
AC074011 Genomic DNA. Translation: AAY24082.1.
AC093164 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00532.1.
CH471053 Genomic DNA. Translation: EAX00533.1.
BC042674 mRNA. Translation: AAH42674.1.
BC065041 mRNA. Translation: AAH65041.1.
BC153864 mRNA. Translation: AAI53865.1.
AK055428 mRNA. Translation: BAB70920.1. Different initiation.
CCDSiCCDS33168.1. [Q6P1J6-1]
CCDS54340.1. [Q6P1J6-3]
RefSeqiNP_001164056.1. NM_001170585.1. [Q6P1J6-3]
NP_694566.4. NM_153021.4. [Q6P1J6-1]
UniGeneiHs.444933.

3D structure databases

ProteinModelPortaliQ6P1J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127341. 8 interactions.
IntActiQ6P1J6. 3 interactions.
STRINGi9606.ENSP00000330442.

PTM databases

PhosphoSiteiQ6P1J6.

Polymorphism and mutation databases

BioMutaiPLB1.

Proteomic databases

PaxDbiQ6P1J6.
PRIDEiQ6P1J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327757; ENSP00000330442; ENSG00000163803.
ENST00000422425; ENSP00000416440; ENSG00000163803. [Q6P1J6-3]
GeneIDi151056.
KEGGihsa:151056.
UCSCiuc002rmb.2. human. [Q6P1J6-1]
uc002rmc.3. human. [Q6P1J6-2]
uc002rme.2. human. [Q6P1J6-5]
uc010ezj.2. human. [Q6P1J6-3]

Organism-specific databases

CTDi151056.
GeneCardsiGC02P028732.
H-InvDBHIX0024210.
HGNCiHGNC:30041. PLB1.
HPAiHPA014045.
MIMi610179. gene.
neXtProtiNX_Q6P1J6.
PharmGKBiPA134891309.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG311176.
GeneTreeiENSGT00530000063883.
HOGENOMiHOG000115574.
HOVERGENiHBG108263.
InParanoidiQ6P1J6.
KOiK14621.
OMAiNDLCHYC.
OrthoDBiEOG7MPRD0.
PhylomeDBiQ6P1J6.
TreeFamiTF314942.

Enzyme and pathway databases

ReactomeiREACT_120829. Acyl chain remodelling of PC.
REACT_24968. Retinoid metabolism and transport.

Miscellaneous databases

GenomeRNAii151056.
NextBioi86583.
PROiQ6P1J6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P1J6.
CleanExiHS_PLB1.
ExpressionAtlasiQ6P1J6. baseline and differential.
GenevisibleiQ6P1J6. HS.

Family and domain databases

Gene3Di3.40.50.1110. 5 hits.
InterProiIPR001087. GDSL.
IPR008265. Lipase_GDSL_AS.
IPR013830. SGNH_hydro.
[Graphical view]
PfamiPF00657. Lipase_GDSL. 3 hits.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 7 hits.
PROSITEiPS01098. LIPASE_GDSL_SER. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1458 (ISOFORM 3).
    Tissue: Brain and Skin.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 426-1458 (ISOFORM 4).
    Tissue: Brain.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPLB1_HUMAN
AccessioniPrimary (citable) accession number: Q6P1J6
Secondary accession number(s): A8KAX2
, Q53S03, Q8IUP7, Q96DP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: July 22, 2015
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.