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Q6P1J6

- PLB1_HUMAN

UniProt

Q6P1J6 - PLB1_HUMAN

Protein

Phospholipase B1, membrane-associated

Gene

PLB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Membrane-associated phospholipase. Exhibits a calcium-independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
    Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by diisopropyl fluorophosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei400 – 4001NucleophileBy similarity
    Binding sitei474 – 4741Substrate; via amide nitrogenBy similarity
    Binding sitei513 – 5131SubstrateBy similarity
    Active sitei1346 – 13461By similarity
    Active sitei1349 – 13491By similarity

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC
    2. phospholipase A2 activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerophospholipid biosynthetic process Source: Reactome
    2. lipid catabolic process Source: UniProtKB-KW
    3. phosphatidylcholine acyl-chain remodeling Source: Reactome
    4. phospholipid metabolic process Source: Reactome
    5. phototransduction, visible light Source: Reactome
    6. retinoid metabolic process Source: Reactome
    7. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_120829. Acyl chain remodelling of PC.
    REACT_24968. Retinoid metabolism and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipase B1, membrane-associated
    Short name:
    Phospholipase B
    Short name:
    hPLB
    Alternative name(s):
    Phospholipase B/lipase
    Short name:
    PLB/LIP
    Including the following 2 domains:
    Phospholipase A2 (EC:3.1.1.4)
    Lysophospholipase (EC:3.1.1.5)
    Gene namesi
    Name:PLB1
    Synonyms:PLB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:30041. PLB1.

    Subcellular locationi

    Apical cell membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Present in the intestinal brush border membranes.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134891309.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 14581437Phospholipase B1, membrane-associatedPRO_0000324383Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi529 – 5291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1055 – 10551N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Undergoes proteolytic cleavage in the ileum.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6P1J6.
    PRIDEiQ6P1J6.

    PTM databases

    PhosphoSiteiQ6P1J6.

    Expressioni

    Tissue specificityi

    Expressed in the epidermis (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ6P1J6.
    BgeeiQ6P1J6.
    CleanExiHS_PLB1.
    GenevestigatoriQ6P1J6.

    Organism-specific databases

    HPAiHPA014045.

    Interactioni

    Protein-protein interaction databases

    BioGridi127341. 1 interaction.
    STRINGi9606.ENSP00000330442.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P1J6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 14171396ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1439 – 145820CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1418 – 143821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati39 – 3473091Add
    BLAST
    Repeati362 – 7073462Add
    BLAST
    Repeati708 – 10543473Add
    BLAST
    Repeati1064 – 14023394Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni39 – 140213644 X 308-326 AA approximate repeatsAdd
    BLAST
    Regioni1403 – 144543Necessary for membrane localizationBy similarityAdd
    BLAST

    Domaini

    Repeat 2 contains the catalytic domain.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311176.
    HOGENOMiHOG000115574.
    HOVERGENiHBG108263.
    InParanoidiQ6P1J6.
    KOiK14621.
    OMAiCPDKDPS.
    OrthoDBiEOG7MPRD0.
    PhylomeDBiQ6P1J6.
    TreeFamiTF314942.

    Family and domain databases

    Gene3Di3.40.50.1110. 5 hits.
    InterProiIPR001087. Lipase_GDSL.
    IPR008265. Lipase_GDSL_AS.
    IPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view]
    PfamiPF00657. Lipase_GDSL. 3 hits.
    [Graphical view]
    PROSITEiPS01098. LIPASE_GDSL_SER. 2 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P1J6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLRPGIFLL ELLLLLGQGT PQIHTSPRKS TLEGQLWPET LKNSPFPCNP     50
    NKLGVNMPSK SVHSLKPSDI KFVAAIGNLE IPPDPGTGDL EKQDWTERPQ 100
    QVCMGVMTVL SDIIRYFSPS VPMPVCHTGK RVIPHDGAED LWIQAQELVR 150
    NMKENLQLDF QFDWKLINVF FSNASQCYLC PSAQQNGLAA GGVDELMGVL 200
    DYLQQEVPRA FVNLVDLSEV AEVSRQYHGT WLSPAPEPCN CSEETTRLAK 250
    VVMQWSYQEA WNSLLASSRY SEQESFTVVF QPFFYETTPS LHSEDPRLQD 300
    STTLAWHLWN RMMEPAGEKD EPLSVKHGRP MKCPSQESPY LFSYRNSNYL 350
    TRLQKPQDKL EVREGAEIRC PDKDPSDTVP TSVHRLKPAD INVIGALGDS 400
    LTAGNGAGST PGNVLDVLTQ YRGLSWSVGG DENIGTVTTL ANILREFNPS 450
    LKGFSVGTGK ETSPNAFLNQ AVAGGRAEDL PVQARRLVDL MKNDTRIHFQ 500
    EDWKIITLFI GGNDLCDFCN DLVHYSPQNF TDNIGKALDI LHAEVPRAFV 550
    NLVTVLEIVN LRELYQEKKV YCPRMILRSL CPCVLKFDDN STELATLIEF 600
    NKKFQEKTHQ LIESGRYDTR EDFTVVVQPF FENVDMPKTS EGLPDNSFFA 650
    PDCFHFSSKS HSRAASALWN NMLEPVGQKT TRHKFENKIN ITCPNQVQPF 700
    LRTYKNSMQG HGTWLPCRDR APSALHPTSV HALRPADIQV VAALGDSLTA 750
    GNGIGSKPDD LPDVTTQYRG LSYSAGGDGS LENVTTLPNI LREFNRNLTG 800
    YAVGTGDAND TNAFLNQAVP GAKAEDLMSQ VQTLMQKMKD DHRVNFHEDW 850
    KVITVLIGGS DLCDYCTDSN LYSAANFVHH LRNALDVLHR EVPRVLVNLV 900
    DFLNPTIMRQ VFLGNPDKCP VQQASVLCNC VLTLRENSQE LARLEAFSRA 950
    YRSSMRELVG SGRYDTQEDF SVVLQPFFQN IQLPVLADGL PDTSFFAPDC 1000
    IHPNQKFHSQ LARALWTNML EPLGSKTETL DLRAEMPITC PTQNEPFLRT 1050
    PRNSNYTYPI KPAIENWGSD FLCTEWKASN SVPTSVHQLR PADIKVVAAL 1100
    GDSLTTAVGA RPNNSSDLPT SWRGLSWSIG GDGNLETHTT LPNILKKFNP 1150
    YLLGFSTSTW EGTAGLNVAA EGARARDMPA QAWDLVERMK NSPDINLEKD 1200
    WKLVTLFIGV NDLCHYCENP EAHLATEYVQ HIQQALDILS EELPRAFVNV 1250
    VEVMELASLY QGQGGKCAML AAQNNCTCLR HSQSSLEKQE LKKVNWNLQH 1300
    GISSFSYWHQ YTQREDFAVV VQPFFQNTLT PLNERGDTDL TFFSEDCFHF 1350
    SDRGHAEMAI ALWNNMLEPV GRKTTSNNFT HSRAKLKCPS PESPYLYTLR 1400
    NSRLLPDQAE EAPEVLYWAV PVAAGVGLVV GIIGTVVWRC RRGGRREDPP 1450
    MSLRTVAL 1458
    Length:1,458
    Mass (Da):163,081
    Last modified:May 18, 2010 - v3
    Checksum:i0B260E1489D8137B
    GO
    Isoform 2 (identifier: Q6P1J6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-312: Missing.
         774-800: SAGGDGSLENVTTLPNILREFNRNLTG → RESKPGFLSDSWVSKSNRKCTRKAPNP
         801-1458: Missing.

    Show »
    Length:488
    Mass (Da):54,341
    Checksum:i6BE12FF5CB0AC9C5
    GO
    Isoform 3 (identifier: Q6P1J6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         184-184: Q → QQAPSLSTVLLS
         523-544: Missing.

    Show »
    Length:1,447
    Mass (Da):161,713
    Checksum:i463E147644AF72B7
    GO
    Isoform 4 (identifier: Q6P1J6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         750-760: AGNGIGSKPDD → VRTLGPQVVWG
         761-1458: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:760
    Mass (Da):85,191
    Checksum:i6910E87C50726761
    GO
    Isoform 5 (identifier: Q6P1J6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1035: Missing.

    Show »
    Length:423
    Mass (Da):47,341
    Checksum:iA66F32D49AC1A20C
    GO

    Sequence cautioni

    The sequence BAB70920.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti426 – 4261W → Y in BAB70920. (PubMed:14702039)Curated
    Sequence conflicti1186 – 11861V → L in AAH42674. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti212 – 2121V → L.
    Corresponds to variant rs6753929 [ dbSNP | Ensembl ].
    VAR_039793
    Natural varianti708 – 7081M → V.
    Corresponds to variant rs11681826 [ dbSNP | Ensembl ].
    VAR_039794
    Natural varianti821 – 8211G → R.
    Corresponds to variant rs10201128 [ dbSNP | Ensembl ].
    VAR_039795
    Natural varianti879 – 8791H → D.
    Corresponds to variant rs7601771 [ dbSNP | Ensembl ].
    VAR_039796
    Natural varianti987 – 9871A → V.
    Corresponds to variant rs34289907 [ dbSNP | Ensembl ].
    VAR_061358
    Natural varianti1318 – 13181A → V.
    Corresponds to variant rs2199619 [ dbSNP | Ensembl ].
    VAR_039797

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 10351035Missing in isoform 5. 1 PublicationVSP_032225Add
    BLAST
    Alternative sequencei1 – 312312Missing in isoform 2. 1 PublicationVSP_032226Add
    BLAST
    Alternative sequencei184 – 1841Q → QQAPSLSTVLLS in isoform 3. 1 PublicationVSP_032227
    Alternative sequencei523 – 54422Missing in isoform 3. 1 PublicationVSP_032228Add
    BLAST
    Alternative sequencei750 – 76011AGNGIGSKPDD → VRTLGPQVVWG in isoform 4. 1 PublicationVSP_032229Add
    BLAST
    Alternative sequencei761 – 1458698Missing in isoform 4. 1 PublicationVSP_032230Add
    BLAST
    Alternative sequencei774 – 80027SAGGD…RNLTG → RESKPGFLSDSWVSKSNRKC TRKAPNP in isoform 2. 1 PublicationVSP_032231Add
    BLAST
    Alternative sequencei801 – 1458658Missing in isoform 2. 1 PublicationVSP_032232Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC074011 Genomic DNA. Translation: AAY24081.1.
    AC074011 Genomic DNA. Translation: AAY24082.1.
    AC093164 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00532.1.
    CH471053 Genomic DNA. Translation: EAX00533.1.
    BC042674 mRNA. Translation: AAH42674.1.
    BC065041 mRNA. Translation: AAH65041.1.
    BC153864 mRNA. Translation: AAI53865.1.
    AK055428 mRNA. Translation: BAB70920.1. Different initiation.
    CCDSiCCDS33168.1. [Q6P1J6-1]
    CCDS54340.1. [Q6P1J6-3]
    RefSeqiNP_001164056.1. NM_001170585.1. [Q6P1J6-3]
    NP_694566.4. NM_153021.4. [Q6P1J6-1]
    UniGeneiHs.444933.

    Genome annotation databases

    EnsembliENST00000327757; ENSP00000330442; ENSG00000163803. [Q6P1J6-1]
    ENST00000422425; ENSP00000416440; ENSG00000163803. [Q6P1J6-3]
    GeneIDi151056.
    KEGGihsa:151056.
    UCSCiuc002rmb.2. human. [Q6P1J6-1]
    uc002rmc.3. human. [Q6P1J6-2]
    uc002rme.2. human. [Q6P1J6-5]
    uc010ezj.2. human. [Q6P1J6-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC074011 Genomic DNA. Translation: AAY24081.1 .
    AC074011 Genomic DNA. Translation: AAY24082.1 .
    AC093164 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00532.1 .
    CH471053 Genomic DNA. Translation: EAX00533.1 .
    BC042674 mRNA. Translation: AAH42674.1 .
    BC065041 mRNA. Translation: AAH65041.1 .
    BC153864 mRNA. Translation: AAI53865.1 .
    AK055428 mRNA. Translation: BAB70920.1 . Different initiation.
    CCDSi CCDS33168.1. [Q6P1J6-1 ]
    CCDS54340.1. [Q6P1J6-3 ]
    RefSeqi NP_001164056.1. NM_001170585.1. [Q6P1J6-3 ]
    NP_694566.4. NM_153021.4. [Q6P1J6-1 ]
    UniGenei Hs.444933.

    3D structure databases

    ProteinModelPortali Q6P1J6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127341. 1 interaction.
    STRINGi 9606.ENSP00000330442.

    PTM databases

    PhosphoSitei Q6P1J6.

    Proteomic databases

    PaxDbi Q6P1J6.
    PRIDEi Q6P1J6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327757 ; ENSP00000330442 ; ENSG00000163803 . [Q6P1J6-1 ]
    ENST00000422425 ; ENSP00000416440 ; ENSG00000163803 . [Q6P1J6-3 ]
    GeneIDi 151056.
    KEGGi hsa:151056.
    UCSCi uc002rmb.2. human. [Q6P1J6-1 ]
    uc002rmc.3. human. [Q6P1J6-2 ]
    uc002rme.2. human. [Q6P1J6-5 ]
    uc010ezj.2. human. [Q6P1J6-3 ]

    Organism-specific databases

    CTDi 151056.
    GeneCardsi GC02P028732.
    H-InvDB HIX0024210.
    HGNCi HGNC:30041. PLB1.
    HPAi HPA014045.
    MIMi 610179. gene.
    neXtProti NX_Q6P1J6.
    PharmGKBi PA134891309.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311176.
    HOGENOMi HOG000115574.
    HOVERGENi HBG108263.
    InParanoidi Q6P1J6.
    KOi K14621.
    OMAi CPDKDPS.
    OrthoDBi EOG7MPRD0.
    PhylomeDBi Q6P1J6.
    TreeFami TF314942.

    Enzyme and pathway databases

    Reactomei REACT_120829. Acyl chain remodelling of PC.
    REACT_24968. Retinoid metabolism and transport.

    Miscellaneous databases

    GenomeRNAii 151056.
    NextBioi 86583.
    PROi Q6P1J6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P1J6.
    Bgeei Q6P1J6.
    CleanExi HS_PLB1.
    Genevestigatori Q6P1J6.

    Family and domain databases

    Gene3Di 3.40.50.1110. 5 hits.
    InterProi IPR001087. Lipase_GDSL.
    IPR008265. Lipase_GDSL_AS.
    IPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view ]
    Pfami PF00657. Lipase_GDSL. 3 hits.
    [Graphical view ]
    PROSITEi PS01098. LIPASE_GDSL_SER. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1458 (ISOFORM 3).
      Tissue: Brain and Skin.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 426-1458 (ISOFORM 4).
      Tissue: Brain.
    5. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPLB1_HUMAN
    AccessioniPrimary (citable) accession number: Q6P1J6
    Secondary accession number(s): A8KAX2
    , Q53S03, Q8IUP7, Q96DP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 94 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3