Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UPF0536 protein C12orf66 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0536 protein C12orf66 homolog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2670984. BC048403.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219031 – 445UPF0536 protein C12orf66 homologAdd BLAST445

Proteomic databases

PaxDbiQ6P1I3.
PRIDEiQ6P1I3.

PTM databases

iPTMnetiQ6P1I3.
PhosphoSitePlusiQ6P1I3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053684.
CleanExiMM_BC048403.
ExpressionAtlasiQ6P1I3. baseline and differential.
GenevisibleiQ6P1I3. MM.

Structurei

Secondary structure

1445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi132 – 148Combined sources17
Helixi149 – 151Combined sources3
Beta strandi152 – 154Combined sources3
Helixi157 – 164Combined sources8
Turni166 – 168Combined sources3
Helixi169 – 171Combined sources3
Helixi183 – 204Combined sources22
Turni205 – 207Combined sources3
Helixi209 – 231Combined sources23
Helixi253 – 272Combined sources20
Helixi274 – 279Combined sources6
Helixi283 – 292Combined sources10
Helixi297 – 308Combined sources12
Beta strandi311 – 317Combined sources7
Beta strandi348 – 355Combined sources8
Helixi358 – 360Combined sources3
Helixi361 – 370Combined sources10
Helixi372 – 376Combined sources5
Beta strandi381 – 386Combined sources6
Turni387 – 390Combined sources4
Beta strandi391 – 399Combined sources9
Beta strandi402 – 410Combined sources9
Helixi417 – 428Combined sources12
Helixi432 – 437Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GNXX-ray2.45A123-445[»]
ProteinModelPortaliQ6P1I3.
SMRiQ6P1I3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6P1I3.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0536 family.Curated

Phylogenomic databases

eggNOGiENOG410IIK7. Eukaryota.
ENOG41109T1. LUCA.
GeneTreeiENSGT00390000009583.
HOGENOMiHOG000082532.
HOVERGENiHBG107712.
InParanoidiQ6P1I3.
OMAiPEPHFTL.
OrthoDBiEOG091G0G65.
PhylomeDBiQ6P1I3.
TreeFamiTF329125.

Family and domain databases

InterProiIPR018544. DUF2003.
[Graphical view]
PfamiPF09404. DUF2003. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P1I3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGESIPLAAP VPVEQAVLET FFSHLGIFSY DKAKDNVEKE REANKSAGGS
60 70 80 90 100
WLSLLAALAH LAAAEKVYHS LTYLGQKLGG QSFFSRKDSI RTIYTSLHNE
110 120 130 140 150
LKKVVAGRGA PGGTAPHVEE LLPHLSEQLC FFVQARMEIA DFYEKMYALS
160 170 180 190 200
TQKFINTEEL VSTLDTILRK YSSRFHHPIL SPLESSFQLE VGVLSHLLKA
210 220 230 240 250
QAQISEWKFL PSLVTLHNAH TKLQSWGQTF EKQRETKKHL FGGQSQKAVQ
260 270 280 290 300
PPHLFLWLMK LKTMLLAKFS FYFHEALSRQ TTASEMKALT AKANPDLFGK
310 320 330 340 350
ISSFIRKYDA ANVSLIFDNR GSESFQGHGY HHPHSYREAP KGVDQYPAVV
360 370 380 390 400
SLPSDRPVMH WPNVIMIMTD RASDLNSLEK VVHFYDDKVQ STYFLTRPEP
410 420 430 440
HFTIVVIFES KKSERDSHFI SFLNELSLAL KNPKVFASLK PGSKG
Length:445
Mass (Da):50,256
Last modified:July 5, 2004 - v1
Checksum:i163F1C08E0CE5B27
GO
Isoform 2 (identifier: Q6P1I3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-169: GQSFFSRKDS...LVSTLDTILR → TSAPPLPLRR...FAPCMDWFHK
     170-445: Missing.

Show »
Length:169
Mass (Da):18,191
Checksum:i2342C329E0390956
GO

Sequence cautioni

The sequence BAC39804 differs from that shown. Reason: Frameshift at position 422.Curated
The sequence BAE41440 differs from that shown. Reason: Frameshift at positions 294 and 322.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti368M → V in BAC39804 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03181980 – 169GQSFF…DTILR → TSAPPLPLRRKERGCAAWSA WLGCLVTPSGRLHSAQVSSH RCPFFPSVPQAPPTGLCHRC LGGLGGCSSLGMLQTPWVYG FAPCMDWFHK in isoform 2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_031820170 – 445Missing in isoform 2. 1 PublicationAdd BLAST276

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087110 mRNA. Translation: BAC39804.1. Frameshift.
AK138662 mRNA. Translation: BAE23738.1.
AK162911 mRNA. Translation: BAE37112.1.
AK169891 mRNA. Translation: BAE41440.1. Frameshift.
BC065058 mRNA. Translation: AAH65058.1.
CCDSiCCDS24213.1. [Q6P1I3-1]
RefSeqiNP_766610.2. NM_173022.2. [Q6P1I3-1]
UniGeneiMm.209172.

Genome annotation databases

EnsembliENSMUST00000065600; ENSMUSP00000070834; ENSMUSG00000053684. [Q6P1I3-1]
GeneIDi270802.
KEGGimmu:270802.
UCSCiuc007hfx.1. mouse. [Q6P1I3-1]
uc007hfz.1. mouse. [Q6P1I3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087110 mRNA. Translation: BAC39804.1. Frameshift.
AK138662 mRNA. Translation: BAE23738.1.
AK162911 mRNA. Translation: BAE37112.1.
AK169891 mRNA. Translation: BAE41440.1. Frameshift.
BC065058 mRNA. Translation: AAH65058.1.
CCDSiCCDS24213.1. [Q6P1I3-1]
RefSeqiNP_766610.2. NM_173022.2. [Q6P1I3-1]
UniGeneiMm.209172.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GNXX-ray2.45A123-445[»]
ProteinModelPortaliQ6P1I3.
SMRiQ6P1I3.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6P1I3.
PhosphoSitePlusiQ6P1I3.

Proteomic databases

PaxDbiQ6P1I3.
PRIDEiQ6P1I3.

Protocols and materials databases

DNASUi270802.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065600; ENSMUSP00000070834; ENSMUSG00000053684. [Q6P1I3-1]
GeneIDi270802.
KEGGimmu:270802.
UCSCiuc007hfx.1. mouse. [Q6P1I3-1]
uc007hfz.1. mouse. [Q6P1I3-2]

Organism-specific databases

MGIiMGI:2670984. BC048403.

Phylogenomic databases

eggNOGiENOG410IIK7. Eukaryota.
ENOG41109T1. LUCA.
GeneTreeiENSGT00390000009583.
HOGENOMiHOG000082532.
HOVERGENiHBG107712.
InParanoidiQ6P1I3.
OMAiPEPHFTL.
OrthoDBiEOG091G0G65.
PhylomeDBiQ6P1I3.
TreeFamiTF329125.

Miscellaneous databases

EvolutionaryTraceiQ6P1I3.
PROiQ6P1I3.

Gene expression databases

BgeeiENSMUSG00000053684.
CleanExiMM_BC048403.
ExpressionAtlasiQ6P1I3. baseline and differential.
GenevisibleiQ6P1I3. MM.

Family and domain databases

InterProiIPR018544. DUF2003.
[Graphical view]
PfamiPF09404. DUF2003. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCL066_MOUSE
AccessioniPrimary (citable) accession number: Q6P1I3
Secondary accession number(s): Q3TE08, Q3TRB8, Q8C334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.