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Protein

UPF0536 protein C12orf66 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0536 protein C12orf66 homolog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2670984. BC048403.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445UPF0536 protein C12orf66 homologPRO_0000321903Add
BLAST

Proteomic databases

MaxQBiQ6P1I3.
PaxDbiQ6P1I3.
PRIDEiQ6P1I3.

PTM databases

PhosphoSiteiQ6P1I3.

Expressioni

Gene expression databases

BgeeiQ6P1I3.
CleanExiMM_BC048403.
ExpressionAtlasiQ6P1I3. baseline and differential.
GenevisibleiQ6P1I3. MM.

Structurei

Secondary structure

1
445
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi132 – 14817Combined sources
Helixi149 – 1513Combined sources
Beta strandi152 – 1543Combined sources
Helixi157 – 1648Combined sources
Turni166 – 1683Combined sources
Helixi169 – 1713Combined sources
Helixi183 – 20422Combined sources
Turni205 – 2073Combined sources
Helixi209 – 23123Combined sources
Helixi253 – 27220Combined sources
Helixi274 – 2796Combined sources
Helixi283 – 29210Combined sources
Helixi297 – 30812Combined sources
Beta strandi311 – 3177Combined sources
Beta strandi348 – 3558Combined sources
Helixi358 – 3603Combined sources
Helixi361 – 37010Combined sources
Helixi372 – 3765Combined sources
Beta strandi381 – 3866Combined sources
Turni387 – 3904Combined sources
Beta strandi391 – 3999Combined sources
Beta strandi402 – 4109Combined sources
Helixi417 – 42812Combined sources
Helixi432 – 4376Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GNXX-ray2.45A123-445[»]
ProteinModelPortaliQ6P1I3.
SMRiQ6P1I3. Positions 123-440.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6P1I3.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0536 family.Curated

Phylogenomic databases

eggNOGiENOG410IIK7. Eukaryota.
ENOG41109T1. LUCA.
GeneTreeiENSGT00390000009583.
HOGENOMiHOG000082532.
HOVERGENiHBG107712.
InParanoidiQ6P1I3.
OMAiPEPHFTL.
OrthoDBiEOG783MVB.
PhylomeDBiQ6P1I3.
TreeFamiTF329125.

Family and domain databases

InterProiIPR018544. DUF2003.
[Graphical view]
PfamiPF09404. DUF2003. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P1I3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGESIPLAAP VPVEQAVLET FFSHLGIFSY DKAKDNVEKE REANKSAGGS
60 70 80 90 100
WLSLLAALAH LAAAEKVYHS LTYLGQKLGG QSFFSRKDSI RTIYTSLHNE
110 120 130 140 150
LKKVVAGRGA PGGTAPHVEE LLPHLSEQLC FFVQARMEIA DFYEKMYALS
160 170 180 190 200
TQKFINTEEL VSTLDTILRK YSSRFHHPIL SPLESSFQLE VGVLSHLLKA
210 220 230 240 250
QAQISEWKFL PSLVTLHNAH TKLQSWGQTF EKQRETKKHL FGGQSQKAVQ
260 270 280 290 300
PPHLFLWLMK LKTMLLAKFS FYFHEALSRQ TTASEMKALT AKANPDLFGK
310 320 330 340 350
ISSFIRKYDA ANVSLIFDNR GSESFQGHGY HHPHSYREAP KGVDQYPAVV
360 370 380 390 400
SLPSDRPVMH WPNVIMIMTD RASDLNSLEK VVHFYDDKVQ STYFLTRPEP
410 420 430 440
HFTIVVIFES KKSERDSHFI SFLNELSLAL KNPKVFASLK PGSKG
Length:445
Mass (Da):50,256
Last modified:July 5, 2004 - v1
Checksum:i163F1C08E0CE5B27
GO
Isoform 2 (identifier: Q6P1I3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-169: GQSFFSRKDS...LVSTLDTILR → TSAPPLPLRR...FAPCMDWFHK
     170-445: Missing.

Show »
Length:169
Mass (Da):18,191
Checksum:i2342C329E0390956
GO

Sequence cautioni

The sequence BAC39804.1 differs from that shown. Reason: Frameshift at position 422. Curated
The sequence BAE41440.1 differs from that shown. Reason: Frameshift at positions 294 and 322. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti368 – 3681M → V in BAC39804 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei80 – 16990GQSFF…DTILR → TSAPPLPLRRKERGCAAWSA WLGCLVTPSGRLHSAQVSSH RCPFFPSVPQAPPTGLCHRC LGGLGGCSSLGMLQTPWVYG FAPCMDWFHK in isoform 2. 1 PublicationVSP_031819Add
BLAST
Alternative sequencei170 – 445276Missing in isoform 2. 1 PublicationVSP_031820Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087110 mRNA. Translation: BAC39804.1. Frameshift.
AK138662 mRNA. Translation: BAE23738.1.
AK162911 mRNA. Translation: BAE37112.1.
AK169891 mRNA. Translation: BAE41440.1. Frameshift.
BC065058 mRNA. Translation: AAH65058.1.
CCDSiCCDS24213.1. [Q6P1I3-1]
RefSeqiNP_766610.2. NM_173022.2. [Q6P1I3-1]
UniGeneiMm.209172.

Genome annotation databases

EnsembliENSMUST00000065600; ENSMUSP00000070834; ENSMUSG00000053684. [Q6P1I3-1]
GeneIDi270802.
KEGGimmu:270802.
UCSCiuc007hfx.1. mouse. [Q6P1I3-1]
uc007hfz.1. mouse. [Q6P1I3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087110 mRNA. Translation: BAC39804.1. Frameshift.
AK138662 mRNA. Translation: BAE23738.1.
AK162911 mRNA. Translation: BAE37112.1.
AK169891 mRNA. Translation: BAE41440.1. Frameshift.
BC065058 mRNA. Translation: AAH65058.1.
CCDSiCCDS24213.1. [Q6P1I3-1]
RefSeqiNP_766610.2. NM_173022.2. [Q6P1I3-1]
UniGeneiMm.209172.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GNXX-ray2.45A123-445[»]
ProteinModelPortaliQ6P1I3.
SMRiQ6P1I3. Positions 123-440.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ6P1I3.

Proteomic databases

MaxQBiQ6P1I3.
PaxDbiQ6P1I3.
PRIDEiQ6P1I3.

Protocols and materials databases

DNASUi270802.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065600; ENSMUSP00000070834; ENSMUSG00000053684. [Q6P1I3-1]
GeneIDi270802.
KEGGimmu:270802.
UCSCiuc007hfx.1. mouse. [Q6P1I3-1]
uc007hfz.1. mouse. [Q6P1I3-2]

Organism-specific databases

MGIiMGI:2670984. BC048403.

Phylogenomic databases

eggNOGiENOG410IIK7. Eukaryota.
ENOG41109T1. LUCA.
GeneTreeiENSGT00390000009583.
HOGENOMiHOG000082532.
HOVERGENiHBG107712.
InParanoidiQ6P1I3.
OMAiPEPHFTL.
OrthoDBiEOG783MVB.
PhylomeDBiQ6P1I3.
TreeFamiTF329125.

Miscellaneous databases

EvolutionaryTraceiQ6P1I3.
NextBioi393387.
PROiQ6P1I3.

Gene expression databases

BgeeiQ6P1I3.
CleanExiMM_BC048403.
ExpressionAtlasiQ6P1I3. baseline and differential.
GenevisibleiQ6P1I3. MM.

Family and domain databases

InterProiIPR018544. DUF2003.
[Graphical view]
PfamiPF09404. DUF2003. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Lung and Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  3. "X-ray structure of a hypothetical protein from mouse mm.209172."
    Center for eukaryotic structural genomics (CESG)
    Submitted (MAY-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 123-445.

Entry informationi

Entry nameiCL066_MOUSE
AccessioniPrimary (citable) accession number: Q6P1I3
Secondary accession number(s): Q3TE08, Q3TRB8, Q8C334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.