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Protein

HEAT repeat-containing protein 6

Gene

Heatr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
HEAT repeat-containing protein 6
Gene namesi
Name:Heatr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919790. Heatr6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11841184HEAT repeat-containing protein 6PRO_0000337174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei621 – 6211PhosphothreonineBy similarity
Modified residuei646 – 6461PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P1G0.
MaxQBiQ6P1G0.
PaxDbiQ6P1G0.
PRIDEiQ6P1G0.

PTM databases

iPTMnetiQ6P1G0.
PhosphoSiteiQ6P1G0.

Expressioni

Gene expression databases

BgeeiQ6P1G0.
GenevisibleiQ6P1G0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ6P1G0. 1 interaction.
STRINGi10090.ENSMUSP00000001002.

Structurei

3D structure databases

ProteinModelPortaliQ6P1G0.
SMRiQ6P1G0. Positions 822-887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati159 – 19840HEAT 1Add
BLAST
Repeati455 – 49339HEAT 2Add
BLAST
Repeati517 – 55539HEAT 3Add
BLAST
Repeati561 – 59838HEAT 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi315 – 32511Poly-LysAdd
BLAST
Compositional biasi333 – 3386Poly-Glu

Sequence similaritiesi

Contains 4 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4535. Eukaryota.
ENOG410XNWJ. LUCA.
GeneTreeiENSGT00390000016675.
HOGENOMiHOG000112878.
HOVERGENiHBG057052.
InParanoidiQ6P1G0.
OMAiQQCSSWT.
OrthoDBiEOG771269.
PhylomeDBiQ6P1G0.
TreeFamiTF324244.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR025283. DUF4042.
[Graphical view]
PfamiPF13251. DUF4042. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6P1G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVQVAASL PCGQPREAPR ELSPEQDDGF RRLSARLRAL QPDDSTVSRM
60 70 80 90 100
EIHLLFDQLI SENYSEGGGV APEDVSALLV RACQLVPLNQ NHLVSKVCQL
110 120 130 140 150
IHRLLNRLQV VVDEPNLDFL LTYTISALQQ CSSWTHMEIL QALAALVYCN
160 170 180 190 200
GSKCQKHLPD LLGKSGLLMK LSDLSHSDPE VRRAAVHCMA NLCLSVPGQP
210 220 230 240 250
YLEEPYQHVC FQAFLTILQS PKSSDMDDIT FCMLLQNALK GIQSLLNGGK
260 270 280 290 300
MRLTQTEHLG ALLAVLKKAM FHGLPGLNIE MPAVLYPTPL PQYDGRSPVK
310 320 330 340 350
PQQPESTTAR SSANKKKKHK VKTKKTQQGE KAEEEEEEPC GEVEAAPGLS
360 370 380 390 400
MDQANVSGES AWCSSPWGSQ GLPVDGGRAA GREQASLPFA SSSWKRVSSS
410 420 430 440 450
ESDYSDAEGG MQGKMRSYQA KVRQGALACF LSTIKSIEKK VLYGYWSAFV
460 470 480 490 500
PDTPELGSPQ SVSLMTLTLK DPSPKTRACA LQVLSAILEG SKQFLSVAED
510 520 530 540 550
TSDHKRAFTP FSVTIASSIR ELHRCLLLAL VAESSSQTLT QIIKCLANLV
560 570 580 590 600
SNAPYNRLKL SLLTKVWNHI KPYIRHKDVN VRVSSLTLLG AIVSTHAPLP
610 620 630 640 650
EVQLLLQQPC SSGLSSSSSA TPHLSTPDGW KTFPAGSSLE EASLSSPKGS
660 670 680 690 700
SEPCWLIRLC ISTVVLPKED SCSGSDAGSA LGSTYEPSPM RLEALQVLAH
710 720 730 740 750
LARGYFSTAQ LYLMELGEVI CKCMCEANPS IQLHGVKLLE ELGAGLIQQY
760 770 780 790 800
KPDSNIAPEQ RVPVHLVVVF WTAMLSGPLP RALQSAEHPT LQASACDALS
810 820 830 840 850
SILPEAFSSL PNDKQILCIT VLLGLNDSKN HLVKAATSRA LGVYVLFPCL
860 870 880 890 900
RQDVIFVADT ANAILMSLQD KSLNVRAKAA WSLGNLTDTL IVNMDTPDPS
910 920 930 940 950
FQDEFSGLLL LKMLQCAIQA STDKDKVKSN AVRALGNLLH FLQPSHVERP
960 970 980 990 1000
RFAEIIEESI QALISTVVNE AAMKVRWNAC YAMGNVFKNP ALPLGTAPWT
1010 1020 1030 1040 1050
SQAYKALTSV VMSCKNFKVR IRSAAALSVP SKRGQYGSLE QFIQIWSALV
1060 1070 1080 1090 1100
TALQKSEDTT DFLEFKYCAS LRTHICQALL HLLSLASASD LPGIQETLKL
1110 1120 1130 1140 1150
HGDMIRSYIL QFLKSGAEGD DPGAVHTPQE RVQMVRVALK HIHRVQTLAG
1160 1170 1180
DTARGAIMGF LEDILTVHCD SSGEQVMLRG PSDQ
Length:1,184
Mass (Da):128,922
Last modified:July 5, 2004 - v1
Checksum:i64A78EB3ADE61CA7
GO

Sequence cautioni

The sequence AAH03942.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663075 Genomic DNA. Translation: CAI25674.1.
BC003942 mRNA. Translation: AAH03942.1. Different initiation.
BC065092 mRNA. Translation: AAH65092.1.
AK012216 mRNA. Translation: BAB28103.3.
AK138219 mRNA. Translation: BAE23587.1.
CCDSiCCDS36259.1.
RefSeqiNP_663407.2. NM_145432.3.
UniGeneiMm.117874.

Genome annotation databases

EnsembliENSMUST00000001002; ENSMUSP00000001002; ENSMUSG00000000976.
GeneIDi217026.
KEGGimmu:217026.
UCSCiuc007kpt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663075 Genomic DNA. Translation: CAI25674.1.
BC003942 mRNA. Translation: AAH03942.1. Different initiation.
BC065092 mRNA. Translation: AAH65092.1.
AK012216 mRNA. Translation: BAB28103.3.
AK138219 mRNA. Translation: BAE23587.1.
CCDSiCCDS36259.1.
RefSeqiNP_663407.2. NM_145432.3.
UniGeneiMm.117874.

3D structure databases

ProteinModelPortaliQ6P1G0.
SMRiQ6P1G0. Positions 822-887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P1G0. 1 interaction.
STRINGi10090.ENSMUSP00000001002.

PTM databases

iPTMnetiQ6P1G0.
PhosphoSiteiQ6P1G0.

Proteomic databases

EPDiQ6P1G0.
MaxQBiQ6P1G0.
PaxDbiQ6P1G0.
PRIDEiQ6P1G0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001002; ENSMUSP00000001002; ENSMUSG00000000976.
GeneIDi217026.
KEGGimmu:217026.
UCSCiuc007kpt.1. mouse.

Organism-specific databases

CTDi63897.
MGIiMGI:1919790. Heatr6.

Phylogenomic databases

eggNOGiKOG4535. Eukaryota.
ENOG410XNWJ. LUCA.
GeneTreeiENSGT00390000016675.
HOGENOMiHOG000112878.
HOVERGENiHBG057052.
InParanoidiQ6P1G0.
OMAiQQCSSWT.
OrthoDBiEOG771269.
PhylomeDBiQ6P1G0.
TreeFamiTF324244.

Miscellaneous databases

ChiTaRSiHeatr6. mouse.
PROiQ6P1G0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P1G0.
GenevisibleiQ6P1G0. MM.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR025283. DUF4042.
[Graphical view]
PfamiPF13251. DUF4042. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Mammary tumor.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-321 AND 887-1181.
    Strain: C57BL/6J.
    Tissue: Embryo and Hypothalamus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiHEAT6_MOUSE
AccessioniPrimary (citable) accession number: Q6P1G0
Secondary accession number(s): Q3UUN8, Q99KZ5, Q9CSQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.