Q6P1F6 (2ABA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Alternative name(s):
PP2A subunit B isoform B55-alpha
PP2A subunit B isoform PR55-alpha
PP2A subunit B isoform R2-alpha
PP2A subunit B isoform alpha

Gene names

Name:

Ppp2r2a

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment By similarity.
Subunit structure	PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD By similarity.
Sequence similarities	Belongs to the phosphatase 2A regulatory subunit B family. Contains 7 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: Compara response to morphine Inferred from mutant phenotype PubMed 16102737. Source: MGI signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	protein phosphatase type 2A complex Inferred from electronic annotation. Source: InterPro
Molecular_function	protein phosphatase type 2A regulator activity Inferred from electronic annotation. Source: InterPro protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform		PRO_0000071417
Regions
	Repeat	26 – 65	40	WD 1
	Repeat	91 – 132	42	WD 2
	Repeat	175 – 213	39	WD 3
	Repeat	224 – 264	41	WD 4
	Repeat	283 – 321	39	WD 5
	Repeat	338 – 379	42	WD 6
	Repeat	414 – 446	33	WD 7

Sequences

	Sequence		Length	Mass (Da)
	Q6P1F6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F4D407FF7ADA4ED6	FASTA	447	51,692
	10 20 30 40 50 60 MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE 70 80 90 100 110 120 NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK 130 140 150 160 170 180 LWKISERDKR PEGYNLKEED GRYRDPTTVT TLRVPVFRPM DLMVEASPRR IFANAHTYHI 190 200 210 220 230 240 NSISINSDYE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN 250 260 270 280 290 300 TFVYSSSKGT IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM 310 320 330 340 350 360 MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSVVMTG 370 380 390 400 410 420 SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS GKRKKDEISV DSLDFNKKIL 430 440 HTAWHPKENI IAVATTNNLY IFQDKVN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and C57BL/6J. Tissue: Brain and Embryo.
[2]	Lubec G., Klug S. Submitted (MAR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 200-210, MASS SPECTROMETRY. Tissue: Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC065100 mRNA. Translation: AAH65100.1. BC080692 mRNA. Translation: AAH80692.1.
IPI	IPI00667471.
RefSeq	NP_001192117.1. NM_001205188.1. NP_082308.1. NM_028032.3.
UniGene	Mm.273997.
3D structure databases
ProteinModelPortal	Q6P1F6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6P1F6. 1 interaction.
PTM databases
PhosphoSite	Q6P1F6.
Proteomic databases
PaxDb	Q6P1F6.
PRIDE	Q6P1F6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000089230; ENSMUSP00000086640; ENSMUSG00000022052.
GeneID	71978.
KEGG	mmu:71978.
Organism-specific databases
CTD	5520.
MGI	MGI:1919228. Ppp2r2a.
Phylogenomic databases
eggNOG	COG5170.
GeneTree	ENSGT00390000006311.
HOVERGEN	HBG000012.
InParanoid	Q6P1F6.
KO	K04354.
OMA	EFHPTEC.
OrthoDB	EOG4M0F1K.
Gene expression databases
ArrayExpress	Q6P1F6.
Bgee	Q6P1F6.
Genevestigator	Q6P1F6.
GermOnline	ENSMUSG00000022052. Mus musculus.
Family and domain databases
Gene3D	2.130.10.10. 3 hits.
InterPro	IPR000009. PP2A_PR55. IPR018067. PP2A_PR55_CS. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
PANTHER	PTHR11871. PTHR11871. 1 hit.
PIRSF	PIRSF037309. PP2A_PR55. 1 hit.
PRINTS	PR00600. PP2APR55.
SMART	SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS01024. PR55_1. 1 hit. PS01025. PR55_2. 1 hit. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q6P1F6.
ChiTaRS	PPP2R2A. mouse.
NextBio	335106.
SOURCE	Search...

Entry information

Entry name

2ABA_MOUSE

Accession

Primary (citable) accession number: Q6P1F6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program