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Q6P1F6 (2ABA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Alternative name(s):
PP2A subunit B isoform B55-alpha
PP2A subunit B isoform PR55-alpha
PP2A subunit B isoform R2-alpha
PP2A subunit B isoform alpha
Gene names
Name:Ppp2r2a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment By similarity.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD By similarity.

Sequence similarities

Belongs to the phosphatase 2A regulatory subunit B family.

Contains 7 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 447446Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
PRO_0000071417

Regions

Repeat26 – 6540WD 1
Repeat91 – 13242WD 2
Repeat175 – 21339WD 3
Repeat224 – 26441WD 4
Repeat283 – 32139WD 5
Repeat338 – 37942WD 6
Repeat414 – 44633WD 7

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6P1F6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: F4D407FF7ADA4ED6

FASTA44751,692
        10         20         30         40         50         60 
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE 

        70         80         90        100        110        120 
NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK 

       130        140        150        160        170        180 
LWKISERDKR PEGYNLKEED GRYRDPTTVT TLRVPVFRPM DLMVEASPRR IFANAHTYHI 

       190        200        210        220        230        240 
NSISINSDYE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN 

       250        260        270        280        290        300 
TFVYSSSKGT IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM 

       310        320        330        340        350        360 
MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSVVMTG 

       370        380        390        400        410        420 
SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS GKRKKDEISV DSLDFNKKIL 

       430        440 
HTAWHPKENI IAVATTNNLY IFQDKVN 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and C57BL/6J.
Tissue: Brain and Embryo.
[2]Lubec G., Klug S.
Submitted (MAR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 200-210, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC065100 mRNA. Translation: AAH65100.1.
BC080692 mRNA. Translation: AAH80692.1.
CCDSCCDS56967.1.
RefSeqNP_001192117.1. NM_001205188.1.
NP_082308.1. NM_028032.3.
UniGeneMm.273997.

3D structure databases

ProteinModelPortalQ6P1F6.
SMRQ6P1F6. Positions 8-446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid215068. 1 interaction.
IntActQ6P1F6. 2 interactions.
MINTMINT-4086260.

Chemistry

BindingDBQ6P1F6.

PTM databases

PhosphoSiteQ6P1F6.

Proteomic databases

MaxQBQ6P1F6.
PaxDbQ6P1F6.
PRIDEQ6P1F6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000089230; ENSMUSP00000086640; ENSMUSG00000022052.
GeneID71978.
KEGGmmu:71978.
UCSCuc007uku.3. mouse.

Organism-specific databases

CTD5520.
MGIMGI:1919228. Ppp2r2a.

Phylogenomic databases

eggNOGCOG5170.
GeneTreeENSGT00390000006311.
HOVERGENHBG000012.
InParanoidQ6P1F6.
KOK04354.
OMAQRNMAGA.
OrthoDBEOG7Q5HCZ.
TreeFamTF105553.

Gene expression databases

ArrayExpressQ6P1F6.
BgeeQ6P1F6.
GenevestigatorQ6P1F6.

Family and domain databases

Gene3D2.130.10.10. 3 hits.
InterProIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERPTHR11871. PTHR11871. 1 hit.
PIRSFPIRSF037309. PP2A_PR55. 1 hit.
PRINTSPR00600. PP2APR55.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 3 hits.
PROSITEPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPPP2R2A. mouse.
NextBio335106.
PROQ6P1F6.
SOURCESearch...

Entry information

Entry name2ABA_MOUSE
AccessionPrimary (citable) accession number: Q6P1F6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot