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Q6P1F6

- 2ABA_MOUSE

UniProt

Q6P1F6 - 2ABA_MOUSE

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Protein
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Gene
Ppp2r2a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment By similarity.

GO - Molecular functioni

  1. protein phosphatase type 2A regulator activity Source: InterPro
  2. protein serine/threonine phosphatase activity Source: Ensembl

GO - Biological processi

  1. protein dephosphorylation Source: Ensembl
  2. response to morphine Source: MGI
  3. signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_210180. Initiation of Nuclear Envelope Reformation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Alternative name(s):
PP2A subunit B isoform B55-alpha
PP2A subunit B isoform PR55-alpha
PP2A subunit B isoform R2-alpha
PP2A subunit B isoform alpha
Gene namesi
Name:Ppp2r2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1919228. Ppp2r2a.

Subcellular locationi

GO - Cellular componenti

  1. protein phosphatase type 2A complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 447446Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
PRO_0000071417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6P1F6.
PaxDbiQ6P1F6.
PRIDEiQ6P1F6.

PTM databases

PhosphoSiteiQ6P1F6.

Expressioni

Gene expression databases

ArrayExpressiQ6P1F6.
BgeeiQ6P1F6.
GenevestigatoriQ6P1F6.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD By similarity.

Protein-protein interaction databases

BioGridi215068. 3 interactions.
IntActiQ6P1F6. 2 interactions.
MINTiMINT-4086260.

Structurei

3D structure databases

ProteinModelPortaliQ6P1F6.
SMRiQ6P1F6. Positions 8-446.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 6540WD 1
Add
BLAST
Repeati91 – 13242WD 2
Add
BLAST
Repeati175 – 21339WD 3
Add
BLAST
Repeati224 – 26441WD 4
Add
BLAST
Repeati283 – 32139WD 5
Add
BLAST
Repeati338 – 37942WD 6
Add
BLAST
Repeati414 – 44633WD 7
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG5170.
GeneTreeiENSGT00390000006311.
HOVERGENiHBG000012.
InParanoidiQ6P1F6.
KOiK04354.
OMAiQRNMAGA.
OrthoDBiEOG7Q5HCZ.
TreeFamiTF105553.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P1F6-1 [UniParc]FASTAAdd to Basket

« Hide

MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG    50
RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR 100
WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT 150
TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI 200
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT 250
IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM 300
MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW 350
NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS 400
GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN 447
Length:447
Mass (Da):51,692
Last modified:July 5, 2004 - v1
Checksum:iF4D407FF7ADA4ED6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC065100 mRNA. Translation: AAH65100.1.
BC080692 mRNA. Translation: AAH80692.1.
CCDSiCCDS56967.1.
RefSeqiNP_001192117.1. NM_001205188.1.
NP_082308.1. NM_028032.3.
UniGeneiMm.273997.

Genome annotation databases

EnsembliENSMUST00000089230; ENSMUSP00000086640; ENSMUSG00000022052.
GeneIDi71978.
KEGGimmu:71978.
UCSCiuc007uku.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC065100 mRNA. Translation: AAH65100.1 .
BC080692 mRNA. Translation: AAH80692.1 .
CCDSi CCDS56967.1.
RefSeqi NP_001192117.1. NM_001205188.1.
NP_082308.1. NM_028032.3.
UniGenei Mm.273997.

3D structure databases

ProteinModelPortali Q6P1F6.
SMRi Q6P1F6. Positions 8-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 215068. 3 interactions.
IntActi Q6P1F6. 2 interactions.
MINTi MINT-4086260.

Chemistry

BindingDBi Q6P1F6.

PTM databases

PhosphoSitei Q6P1F6.

Proteomic databases

MaxQBi Q6P1F6.
PaxDbi Q6P1F6.
PRIDEi Q6P1F6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089230 ; ENSMUSP00000086640 ; ENSMUSG00000022052 .
GeneIDi 71978.
KEGGi mmu:71978.
UCSCi uc007uku.3. mouse.

Organism-specific databases

CTDi 5520.
MGIi MGI:1919228. Ppp2r2a.

Phylogenomic databases

eggNOGi COG5170.
GeneTreei ENSGT00390000006311.
HOVERGENi HBG000012.
InParanoidi Q6P1F6.
KOi K04354.
OMAi QRNMAGA.
OrthoDBi EOG7Q5HCZ.
TreeFami TF105553.

Enzyme and pathway databases

Reactomei REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_210180. Initiation of Nuclear Envelope Reformation.

Miscellaneous databases

ChiTaRSi PPP2R2A. mouse.
NextBioi 335106.
PROi Q6P1F6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6P1F6.
Bgeei Q6P1F6.
Genevestigatori Q6P1F6.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
InterProi IPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR11871. PTHR11871. 1 hit.
PIRSFi PIRSF037309. PP2A_PR55. 1 hit.
PRINTSi PR00600. PP2APR55.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 3 hits.
PROSITEi PS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and C57BL/6J.
    Tissue: Brain and Embryo.
  2. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 200-210, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.

Entry informationi

Entry namei2ABA_MOUSE
AccessioniPrimary (citable) accession number: Q6P1F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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