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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Gene

Ppp2r2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.By similarity

GO - Molecular functioni

  1. protein phosphatase type 2A regulator activity Source: InterPro
  2. protein serine/threonine phosphatase activity Source: MGI

GO - Biological processi

  1. protein dephosphorylation Source: MGI
  2. response to morphine Source: MGI
  3. signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_279505. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_289448. Cyclin D associated events in G1.
REACT_320608. Initiation of Nuclear Envelope Reformation.
REACT_349749. Cyclin A/B1 associated events during G2/M transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Alternative name(s):
PP2A subunit B isoform B55-alpha
PP2A subunit B isoform PR55-alpha
PP2A subunit B isoform R2-alpha
PP2A subunit B isoform alpha
Gene namesi
Name:Ppp2r2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1919228. Ppp2r2a.

Subcellular locationi

GO - Cellular componenti

  1. protein phosphatase type 2A complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 447446Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformPRO_0000071417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6P1F6.
PaxDbiQ6P1F6.
PRIDEiQ6P1F6.

PTM databases

PhosphoSiteiQ6P1F6.

Expressioni

Gene expression databases

BgeeiQ6P1F6.
ExpressionAtlasiQ6P1F6. baseline and differential.
GenevestigatoriQ6P1F6.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity).By similarity

Protein-protein interaction databases

BioGridi215068. 3 interactions.
IntActiQ6P1F6. 2 interactions.
MINTiMINT-4086260.

Structurei

3D structure databases

ProteinModelPortaliQ6P1F6.
SMRiQ6P1F6. Positions 8-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 6540WD 1Add
BLAST
Repeati91 – 13242WD 2Add
BLAST
Repeati175 – 21339WD 3Add
BLAST
Repeati224 – 26441WD 4Add
BLAST
Repeati283 – 32139WD 5Add
BLAST
Repeati338 – 37942WD 6Add
BLAST
Repeati414 – 44633WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG5170.
GeneTreeiENSGT00390000006311.
HOVERGENiHBG000012.
InParanoidiQ6P1F6.
KOiK04354.
OMAiFLKFSLR.
OrthoDBiEOG7Q5HCZ.
TreeFamiTF105553.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P1F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG
60 70 80 90 100
RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR
110 120 130 140 150
WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT
160 170 180 190 200
TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI
210 220 230 240 250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT
260 270 280 290 300
IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM
310 320 330 340 350
MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW
360 370 380 390 400
NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS
410 420 430 440
GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN
Length:447
Mass (Da):51,692
Last modified:July 5, 2004 - v1
Checksum:iF4D407FF7ADA4ED6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065100 mRNA. Translation: AAH65100.1.
BC080692 mRNA. Translation: AAH80692.1.
CCDSiCCDS56967.1.
RefSeqiNP_001192117.1. NM_001205188.1.
NP_082308.1. NM_028032.3.
UniGeneiMm.273997.

Genome annotation databases

EnsembliENSMUST00000089230; ENSMUSP00000086640; ENSMUSG00000022052.
GeneIDi71978.
KEGGimmu:71978.
UCSCiuc007uku.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065100 mRNA. Translation: AAH65100.1.
BC080692 mRNA. Translation: AAH80692.1.
CCDSiCCDS56967.1.
RefSeqiNP_001192117.1. NM_001205188.1.
NP_082308.1. NM_028032.3.
UniGeneiMm.273997.

3D structure databases

ProteinModelPortaliQ6P1F6.
SMRiQ6P1F6. Positions 8-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215068. 3 interactions.
IntActiQ6P1F6. 2 interactions.
MINTiMINT-4086260.

Chemistry

BindingDBiQ6P1F6.

PTM databases

PhosphoSiteiQ6P1F6.

Proteomic databases

MaxQBiQ6P1F6.
PaxDbiQ6P1F6.
PRIDEiQ6P1F6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089230; ENSMUSP00000086640; ENSMUSG00000022052.
GeneIDi71978.
KEGGimmu:71978.
UCSCiuc007uku.3. mouse.

Organism-specific databases

CTDi5520.
MGIiMGI:1919228. Ppp2r2a.

Phylogenomic databases

eggNOGiCOG5170.
GeneTreeiENSGT00390000006311.
HOVERGENiHBG000012.
InParanoidiQ6P1F6.
KOiK04354.
OMAiFLKFSLR.
OrthoDBiEOG7Q5HCZ.
TreeFamiTF105553.

Enzyme and pathway databases

ReactomeiREACT_279505. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_289448. Cyclin D associated events in G1.
REACT_320608. Initiation of Nuclear Envelope Reformation.
REACT_349749. Cyclin A/B1 associated events during G2/M transition.

Miscellaneous databases

ChiTaRSiPpp2r2a. mouse.
NextBioi335106.
PROiQ6P1F6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P1F6.
ExpressionAtlasiQ6P1F6. baseline and differential.
GenevestigatoriQ6P1F6.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and C57BL/6J.
    Tissue: Brain and Embryo.
  2. Lubec G., Klug S.
    Submitted (FEB-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 200-210, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.

Entry informationi

Entry namei2ABA_MOUSE
AccessioniPrimary (citable) accession number: Q6P1F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.