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Q6P1F6

- 2ABA_MOUSE

UniProt

Q6P1F6 - 2ABA_MOUSE

Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Gene

Ppp2r2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.By similarity

    GO - Molecular functioni

    1. protein phosphatase type 2A regulator activity Source: InterPro
    2. protein serine/threonine phosphatase activity Source: Ensembl

    GO - Biological processi

    1. protein dephosphorylation Source: Ensembl
    2. response to morphine Source: MGI
    3. signal transduction Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_206803. Cyclin A/B1 associated events during G2/M transition.
    REACT_210180. Initiation of Nuclear Envelope Reformation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    Alternative name(s):
    PP2A subunit B isoform B55-alpha
    PP2A subunit B isoform PR55-alpha
    PP2A subunit B isoform R2-alpha
    PP2A subunit B isoform alpha
    Gene namesi
    Name:Ppp2r2a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1919228. Ppp2r2a.

    Subcellular locationi

    GO - Cellular componenti

    1. protein phosphatase type 2A complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 447446Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformPRO_0000071417Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ6P1F6.
    PaxDbiQ6P1F6.
    PRIDEiQ6P1F6.

    PTM databases

    PhosphoSiteiQ6P1F6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P1F6.
    BgeeiQ6P1F6.
    GenevestigatoriQ6P1F6.

    Interactioni

    Subunit structurei

    PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with TP53. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD By similarity.By similarity

    Protein-protein interaction databases

    BioGridi215068. 3 interactions.
    IntActiQ6P1F6. 2 interactions.
    MINTiMINT-4086260.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P1F6.
    SMRiQ6P1F6. Positions 8-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati26 – 6540WD 1Add
    BLAST
    Repeati91 – 13242WD 2Add
    BLAST
    Repeati175 – 21339WD 3Add
    BLAST
    Repeati224 – 26441WD 4Add
    BLAST
    Repeati283 – 32139WD 5Add
    BLAST
    Repeati338 – 37942WD 6Add
    BLAST
    Repeati414 – 44633WD 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 WD repeats.Curated

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG5170.
    GeneTreeiENSGT00390000006311.
    HOVERGENiHBG000012.
    InParanoidiQ6P1F6.
    KOiK04354.
    OMAiQRNMAGA.
    OrthoDBiEOG7Q5HCZ.
    TreeFamiTF105553.

    Family and domain databases

    Gene3Di2.130.10.10. 3 hits.
    InterProiIPR000009. PP2A_PR55.
    IPR018067. PP2A_PR55_CS.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PANTHERiPTHR11871. PTHR11871. 1 hit.
    PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
    PRINTSiPR00600. PP2APR55.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 3 hits.
    PROSITEiPS01024. PR55_1. 1 hit.
    PS01025. PR55_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P1F6-1 [UniParc]FASTAAdd to Basket

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    MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG    50
    RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR 100
    WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT 150
    TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI 200
    NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT 250
    IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM 300
    MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW 350
    NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS 400
    GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN 447
    Length:447
    Mass (Da):51,692
    Last modified:July 5, 2004 - v1
    Checksum:iF4D407FF7ADA4ED6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC065100 mRNA. Translation: AAH65100.1.
    BC080692 mRNA. Translation: AAH80692.1.
    CCDSiCCDS56967.1.
    RefSeqiNP_001192117.1. NM_001205188.1.
    NP_082308.1. NM_028032.3.
    UniGeneiMm.273997.

    Genome annotation databases

    EnsembliENSMUST00000089230; ENSMUSP00000086640; ENSMUSG00000022052.
    GeneIDi71978.
    KEGGimmu:71978.
    UCSCiuc007uku.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC065100 mRNA. Translation: AAH65100.1 .
    BC080692 mRNA. Translation: AAH80692.1 .
    CCDSi CCDS56967.1.
    RefSeqi NP_001192117.1. NM_001205188.1.
    NP_082308.1. NM_028032.3.
    UniGenei Mm.273997.

    3D structure databases

    ProteinModelPortali Q6P1F6.
    SMRi Q6P1F6. Positions 8-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 215068. 3 interactions.
    IntActi Q6P1F6. 2 interactions.
    MINTi MINT-4086260.

    Chemistry

    BindingDBi Q6P1F6.

    PTM databases

    PhosphoSitei Q6P1F6.

    Proteomic databases

    MaxQBi Q6P1F6.
    PaxDbi Q6P1F6.
    PRIDEi Q6P1F6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089230 ; ENSMUSP00000086640 ; ENSMUSG00000022052 .
    GeneIDi 71978.
    KEGGi mmu:71978.
    UCSCi uc007uku.3. mouse.

    Organism-specific databases

    CTDi 5520.
    MGIi MGI:1919228. Ppp2r2a.

    Phylogenomic databases

    eggNOGi COG5170.
    GeneTreei ENSGT00390000006311.
    HOVERGENi HBG000012.
    InParanoidi Q6P1F6.
    KOi K04354.
    OMAi QRNMAGA.
    OrthoDBi EOG7Q5HCZ.
    TreeFami TF105553.

    Enzyme and pathway databases

    Reactomei REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_206803. Cyclin A/B1 associated events during G2/M transition.
    REACT_210180. Initiation of Nuclear Envelope Reformation.

    Miscellaneous databases

    ChiTaRSi PPP2R2A. mouse.
    NextBioi 335106.
    PROi Q6P1F6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P1F6.
    Bgeei Q6P1F6.
    Genevestigatori Q6P1F6.

    Family and domain databases

    Gene3Di 2.130.10.10. 3 hits.
    InterProi IPR000009. PP2A_PR55.
    IPR018067. PP2A_PR55_CS.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    PANTHERi PTHR11871. PTHR11871. 1 hit.
    PIRSFi PIRSF037309. PP2A_PR55. 1 hit.
    PRINTSi PR00600. PP2APR55.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 3 hits.
    PROSITEi PS01024. PR55_1. 1 hit.
    PS01025. PR55_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and C57BL/6J.
      Tissue: Brain and Embryo.
    2. Lubec G., Klug S.
      Submitted (MAR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 200-210, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Hippocampus.

    Entry informationi

    Entry namei2ABA_MOUSE
    AccessioniPrimary (citable) accession number: Q6P1F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3