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Q6P1E8

- EFCB6_MOUSE

UniProt

Q6P1E8 - EFCB6_MOUSE

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Protein
EF-hand calcium-binding domain-containing protein 6
Gene
Efcab6, Djbp, Kiaa1672
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi109 – 120121 Reviewed prediction
Add
BLAST
Calcium bindingi210 – 221122 Reviewed prediction
Add
BLAST
Calcium bindingi776 – 787127 Reviewed prediction
Add
BLAST
Calcium bindingi1462 – 14731214 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 6
Alternative name(s):
DJ-1-binding protein
Short name:
DJBP
Gene namesi
Name:Efcab6
Synonyms:Djbp, Kiaa1672
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1924877. Efcab6.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15161516EF-hand calcium-binding domain-containing protein 6
PRO_0000246026Add
BLAST

Proteomic databases

MaxQBiQ6P1E8.
PaxDbiQ6P1E8.
PRIDEiQ6P1E8.

PTM databases

PhosphoSiteiQ6P1E8.

Expressioni

Gene expression databases

BgeeiQ6P1E8.
CleanExiMM_EFCAB6.
GenevestigatoriQ6P1E8.

Interactioni

Subunit structurei

Binds PARK7. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6P1E8.
SMRiQ6P1E8. Positions 100-271, 328-384, 432-489, 533-591, 663-718, 776-827, 874-932, 1093-1149, 1178-1259, 1343-1401, 1453-1513.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 13136EF-hand 1
Add
BLAST
Domaini197 – 23236EF-hand 2
Add
BLAST
Domaini321 – 35636EF-hand 3
Add
BLAST
Domaini427 – 46236EF-hand 4
Add
BLAST
Domaini528 – 56336EF-hand 5
Add
BLAST
Domaini655 – 69036EF-hand 6
Add
BLAST
Domaini763 – 79836EF-hand 7
Add
BLAST
Domaini905 – 94036EF-hand 8
Add
BLAST
Domaini1086 – 112136EF-hand 9
Add
BLAST
Domaini1193 – 122836EF-hand 10
Add
BLAST
Domaini1229 – 126436EF-hand 11
Add
BLAST
Domaini1338 – 137336EF-hand 12
Add
BLAST
Domaini1374 – 140936EF-hand 13
Add
BLAST
Domaini1449 – 148436EF-hand 14
Add
BLAST
Domaini1485 – 151632EF-hand 15
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1318 – 1516199Interaction with PARK7 By similarity
Add
BLAST
Regioni1422 – 151695Interaction with AR By similarity
Add
BLAST

Sequence similaritiesi

Contains 15 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG46752.
GeneTreeiENSGT00390000013629.
HOVERGENiHBG095997.
InParanoidiQ6P1E8.
OMAiGMPMDDD.
OrthoDBiEOG7SV0TX.
PhylomeDBiQ6P1E8.
TreeFamiTF329179.

Family and domain databases

Gene3Di1.10.238.10. 9 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR015070. EF_hand_Ca-bd_contain_6.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF08976. DUF1880. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 11 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 15 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6P1E8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKRNGTRLNF AKANSTKSGS TRARDLMNKM SIIPEWHSLY SNTRKLPCSR     50
PHSSPCKMQR TIFQDLCRPS SSTTAIANPV LSYLDIERIL AQKISSRRDD 100
IKKVFQILDR NHNQMVTKGD LKRVITAFLI PLTKDQFQDL LAQIPISSLG 150
NVPYLEFLSR FGGGIDININ GIKRVNENEV DNRRTVKEVQ LTEKIFRNMR 200
SIRKVFQVMD VNNTGLVQPQ ELRRVLETFC LRMQDGDYEK FLEQYNIDKT 250
TAVDYNAFLK NLSVKNDASF KYLLSNAAEL SRETQQGKNG KRLLDTGSSE 300
DVWKNYSLDD LEKTFCQEFS KSYEKIEKAL SAGDPSKGGY ISLNYLKVVL 350
DTFIYRLPRR IFIQLIRRFG LKTSTKINWK QFLTAIYERQ KLEVSKTLPL 400
KKRSSTEARN RSRKENIIKK LFKYSEDRYT ALKKTLLIIS STPSGHITWE 450
ELRHILNCMV AKLNDSEFSE LKQTFDPEGT GAVRVNSLLD VLDDSTKVRK 500
MSPSTDTKTP LPVAWDSVEE LVLDSITRNL QAFYSMLQSY DLRDTGTIGK 550
NNFRKVMRVF CPYLSNEHLV RFSSKFQEAG SGRILYKKFL LSIGVGIPPP 600
TPPLSSPKVQ LSDQFQIEEP GQQDERTQPS GEKTSEINNM TKEEVIDGLK 650
HRIQQKDPVF RKQFLSISKE PDVKINQEEF RKVLERSGMP MNDCQYAMLA 700
SKLGFKNEEG MSYQDFTMGF EDCMLSGLET VPLQSRTASR TNMDEHFISA 750
EECLRIFPKK LKESFRDVYS AFFRIDLDRD GIISMHDFHR LLQYLQLNMV 800
DLEFERFLSL LGLRLSVTLN FREFQNLCEK RPWKSDEAPQ RLIRCKQKVA 850
DSELACEQAH QYLIMKAKTR WADLSKNFIE TDNEGNGILR RRDIKNSLYG 900
FDIPLTPREF EKLWQNYDTE GRGYITYQEF LHRLGIRYSP KVHRPYKEDY 950
FNFLGHFTKP KQVQEEIQEL QQISEREKLM NHYEEISKAF NAMEKSKPVA 1000
LCRVQKVLQE CGCPLKEEEL ISLLKSLDVS VHNNHIDPVE FLRALEISWA 1050
SKARPKEKEE SSPPPISFSK VTPDEVIKTM QEVVESSQPA LVEAFSALDK 1100
EDTGFVKAME FGDVLRSVCQ KLTDNQYHYF LRRLRLHLTP NIHWKYFLEN 1150
FSTFQDETAD DWAENMPKAP PPMSPKETAH RDIVARVQKA VASHYHTIVQ 1200
EFENFDTLKS NTVSRDEFRS ICTRHIQILT DEQFDRLWSE LPVNAKGRLK 1250
YQDFLSKLSI ERVPSPPMAA GDSGESTMAQ RGSSAPEFSQ GTRSNLYSPP 1300
RDSRVGLKSR SHPCTPVGTP PLQNCEPIES RLRKQIQGCW RELLRECKEK 1350
DTDKQGTISA AEFLALVEKF KLDISREESQ QLIVKYDLKN NGKFAYCDFI 1400
QSCVLLLKAK ETSLMRRMRI QNADKMKEAG METPSFYSAL LRIQPKIVHC 1450
WRPMRRSFKT YDKNGTGLLS VADFRKVLRQ YSINLSEEEF FHVLEYYDKS 1500
LSSKISYNDF LRAFLQ 1516
Length:1,516
Mass (Da):175,771
Last modified:November 13, 2007 - v2
Checksum:i786C634E6CFA5CFD
GO
Isoform 2 (identifier: Q6P1E8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.

Show »
Length:828
Mass (Da):96,577
Checksum:i945F0D4BC0AEB37F
GO
Isoform 3 (identifier: Q6P1E8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-838: Missing.
     839-844: PQRLIR → MSKKHG

Note: Gene prediction based on EST data.

Show »
Length:678
Mass (Da):78,779
Checksum:i180AD60E21442E83
GO

Sequence cautioni

The sequence AAH56955.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH65111.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 838838Missing in isoform 3.
VSP_029427Add
BLAST
Alternative sequencei1 – 688688Missing in isoform 2.
VSP_019814Add
BLAST
Alternative sequencei839 – 8446PQRLIR → MSKKHG in isoform 3.
VSP_029428

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti632 – 6321E → K in AAH65111. 1 Publication
Sequence conflicti1101 – 11011E → V in BAD90458. 1 Publication
Sequence conflicti1181 – 11811R → K in BAD90458. 1 Publication
Sequence conflicti1391 – 13911Missing in AAH56955. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK019850 mRNA. Translation: BAB31880.1.
AK220412 mRNA. Translation: BAD90458.1.
AL513354, AL603867 Genomic DNA. Translation: CAO78062.1.
AL513354 Genomic DNA. Translation: CAO78063.1.
AL513354 Genomic DNA. Translation: CAO78064.1.
AL603867, AL513354 Genomic DNA. Translation: CAO77882.1.
BC056955 mRNA. Translation: AAH56955.1. Different initiation.
BC065111 mRNA. Translation: AAH65111.1. Different initiation.
CCDSiCCDS27707.2. [Q6P1E8-1]
RefSeqiNP_001155100.1. NM_001161628.1. [Q6P1E8-3]
NP_001155101.1. NM_001161629.1. [Q6P1E8-4]
NP_084222.4. NM_029946.4. [Q6P1E8-1]
XP_006521596.1. XM_006521533.1. [Q6P1E8-1]
UniGeneiMm.196288.

Genome annotation databases

EnsembliENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441. [Q6P1E8-1]
GeneIDi77627.
KEGGimmu:77627.
UCSCiuc007xbo.1. mouse. [Q6P1E8-4]
uc007xbq.1. mouse. [Q6P1E8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK019850 mRNA. Translation: BAB31880.1 .
AK220412 mRNA. Translation: BAD90458.1 .
AL513354 , AL603867 Genomic DNA. Translation: CAO78062.1 .
AL513354 Genomic DNA. Translation: CAO78063.1 .
AL513354 Genomic DNA. Translation: CAO78064.1 .
AL603867 , AL513354 Genomic DNA. Translation: CAO77882.1 .
BC056955 mRNA. Translation: AAH56955.1 . Different initiation.
BC065111 mRNA. Translation: AAH65111.1 . Different initiation.
CCDSi CCDS27707.2. [Q6P1E8-1 ]
RefSeqi NP_001155100.1. NM_001161628.1. [Q6P1E8-3 ]
NP_001155101.1. NM_001161629.1. [Q6P1E8-4 ]
NP_084222.4. NM_029946.4. [Q6P1E8-1 ]
XP_006521596.1. XM_006521533.1. [Q6P1E8-1 ]
UniGenei Mm.196288.

3D structure databases

ProteinModelPortali Q6P1E8.
SMRi Q6P1E8. Positions 100-271, 328-384, 432-489, 533-591, 663-718, 776-827, 874-932, 1093-1149, 1178-1259, 1343-1401, 1453-1513.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6P1E8.

Proteomic databases

MaxQBi Q6P1E8.
PaxDbi Q6P1E8.
PRIDEi Q6P1E8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000156187 ; ENSMUSP00000114909 ; ENSMUSG00000022441 . [Q6P1E8-1 ]
GeneIDi 77627.
KEGGi mmu:77627.
UCSCi uc007xbo.1. mouse. [Q6P1E8-4 ]
uc007xbq.1. mouse. [Q6P1E8-1 ]

Organism-specific databases

CTDi 64800.
MGIi MGI:1924877. Efcab6.
Rougei Search...

Phylogenomic databases

eggNOGi NOG46752.
GeneTreei ENSGT00390000013629.
HOVERGENi HBG095997.
InParanoidi Q6P1E8.
OMAi GMPMDDD.
OrthoDBi EOG7SV0TX.
PhylomeDBi Q6P1E8.
TreeFami TF329179.

Miscellaneous databases

NextBioi 347254.
PROi Q6P1E8.
SOURCEi Search...

Gene expression databases

Bgeei Q6P1E8.
CleanExi MM_EFCAB6.
Genevestigatori Q6P1E8.

Family and domain databases

Gene3Di 1.10.238.10. 9 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR015070. EF_hand_Ca-bd_contain_6.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF08976. DUF1880. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 11 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 15 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiEFCB6_MOUSE
AccessioniPrimary (citable) accession number: Q6P1E8
Secondary accession number(s): A6PW10
, A6PW11, A6PW12, Q5DTV8, Q6PGK8, Q9D2D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi