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Protein

EF-hand calcium-binding domain-containing protein 6

Gene

Efcab6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi109 – 120121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi210 – 221122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi776 – 787127PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi1462 – 14731214PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 6
Alternative name(s):
DJ-1-binding protein
Short name:
DJBP
Gene namesi
Name:Efcab6
Synonyms:Djbp, Kiaa1672
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1924877. Efcab6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15161516EF-hand calcium-binding domain-containing protein 6PRO_0000246026Add
BLAST

Proteomic databases

MaxQBiQ6P1E8.
PaxDbiQ6P1E8.
PRIDEiQ6P1E8.

PTM databases

PhosphoSiteiQ6P1E8.

Expressioni

Gene expression databases

BgeeiQ6P1E8.
CleanExiMM_EFCAB6.
GenevisibleiQ6P1E8. MM.

Interactioni

Subunit structurei

Binds PARK7. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114909.

Structurei

3D structure databases

ProteinModelPortaliQ6P1E8.
SMRiQ6P1E8. Positions 1178-1259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 13136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini197 – 23236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini321 – 35636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini427 – 46236EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini528 – 56336EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini655 – 69036EF-hand 6PROSITE-ProRule annotationAdd
BLAST
Domaini763 – 79836EF-hand 7PROSITE-ProRule annotationAdd
BLAST
Domaini905 – 94036EF-hand 8PROSITE-ProRule annotationAdd
BLAST
Domaini1086 – 112136EF-hand 9PROSITE-ProRule annotationAdd
BLAST
Domaini1193 – 122836EF-hand 10PROSITE-ProRule annotationAdd
BLAST
Domaini1229 – 126436EF-hand 11PROSITE-ProRule annotationAdd
BLAST
Domaini1338 – 137336EF-hand 12PROSITE-ProRule annotationAdd
BLAST
Domaini1374 – 140936EF-hand 13PROSITE-ProRule annotationAdd
BLAST
Domaini1449 – 148436EF-hand 14PROSITE-ProRule annotationAdd
BLAST
Domaini1485 – 151632EF-hand 15PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1318 – 1516199Interaction with PARK7By similarityAdd
BLAST
Regioni1422 – 151695Interaction with ARBy similarityAdd
BLAST

Sequence similaritiesi

Contains 15 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG46752.
GeneTreeiENSGT00390000013629.
HOVERGENiHBG095997.
InParanoidiQ6P1E8.
OMAiVLKDFCY.
OrthoDBiEOG7SV0TX.
PhylomeDBiQ6P1E8.
TreeFamiTF329179.

Family and domain databases

Gene3Di1.10.238.10. 9 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR015070. EF_hand_Ca-bd_contain_6.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF08976. DUF1880. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 11 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 15 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P1E8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRNGTRLNF AKANSTKSGS TRARDLMNKM SIIPEWHSLY SNTRKLPCSR
60 70 80 90 100
PHSSPCKMQR TIFQDLCRPS SSTTAIANPV LSYLDIERIL AQKISSRRDD
110 120 130 140 150
IKKVFQILDR NHNQMVTKGD LKRVITAFLI PLTKDQFQDL LAQIPISSLG
160 170 180 190 200
NVPYLEFLSR FGGGIDININ GIKRVNENEV DNRRTVKEVQ LTEKIFRNMR
210 220 230 240 250
SIRKVFQVMD VNNTGLVQPQ ELRRVLETFC LRMQDGDYEK FLEQYNIDKT
260 270 280 290 300
TAVDYNAFLK NLSVKNDASF KYLLSNAAEL SRETQQGKNG KRLLDTGSSE
310 320 330 340 350
DVWKNYSLDD LEKTFCQEFS KSYEKIEKAL SAGDPSKGGY ISLNYLKVVL
360 370 380 390 400
DTFIYRLPRR IFIQLIRRFG LKTSTKINWK QFLTAIYERQ KLEVSKTLPL
410 420 430 440 450
KKRSSTEARN RSRKENIIKK LFKYSEDRYT ALKKTLLIIS STPSGHITWE
460 470 480 490 500
ELRHILNCMV AKLNDSEFSE LKQTFDPEGT GAVRVNSLLD VLDDSTKVRK
510 520 530 540 550
MSPSTDTKTP LPVAWDSVEE LVLDSITRNL QAFYSMLQSY DLRDTGTIGK
560 570 580 590 600
NNFRKVMRVF CPYLSNEHLV RFSSKFQEAG SGRILYKKFL LSIGVGIPPP
610 620 630 640 650
TPPLSSPKVQ LSDQFQIEEP GQQDERTQPS GEKTSEINNM TKEEVIDGLK
660 670 680 690 700
HRIQQKDPVF RKQFLSISKE PDVKINQEEF RKVLERSGMP MNDCQYAMLA
710 720 730 740 750
SKLGFKNEEG MSYQDFTMGF EDCMLSGLET VPLQSRTASR TNMDEHFISA
760 770 780 790 800
EECLRIFPKK LKESFRDVYS AFFRIDLDRD GIISMHDFHR LLQYLQLNMV
810 820 830 840 850
DLEFERFLSL LGLRLSVTLN FREFQNLCEK RPWKSDEAPQ RLIRCKQKVA
860 870 880 890 900
DSELACEQAH QYLIMKAKTR WADLSKNFIE TDNEGNGILR RRDIKNSLYG
910 920 930 940 950
FDIPLTPREF EKLWQNYDTE GRGYITYQEF LHRLGIRYSP KVHRPYKEDY
960 970 980 990 1000
FNFLGHFTKP KQVQEEIQEL QQISEREKLM NHYEEISKAF NAMEKSKPVA
1010 1020 1030 1040 1050
LCRVQKVLQE CGCPLKEEEL ISLLKSLDVS VHNNHIDPVE FLRALEISWA
1060 1070 1080 1090 1100
SKARPKEKEE SSPPPISFSK VTPDEVIKTM QEVVESSQPA LVEAFSALDK
1110 1120 1130 1140 1150
EDTGFVKAME FGDVLRSVCQ KLTDNQYHYF LRRLRLHLTP NIHWKYFLEN
1160 1170 1180 1190 1200
FSTFQDETAD DWAENMPKAP PPMSPKETAH RDIVARVQKA VASHYHTIVQ
1210 1220 1230 1240 1250
EFENFDTLKS NTVSRDEFRS ICTRHIQILT DEQFDRLWSE LPVNAKGRLK
1260 1270 1280 1290 1300
YQDFLSKLSI ERVPSPPMAA GDSGESTMAQ RGSSAPEFSQ GTRSNLYSPP
1310 1320 1330 1340 1350
RDSRVGLKSR SHPCTPVGTP PLQNCEPIES RLRKQIQGCW RELLRECKEK
1360 1370 1380 1390 1400
DTDKQGTISA AEFLALVEKF KLDISREESQ QLIVKYDLKN NGKFAYCDFI
1410 1420 1430 1440 1450
QSCVLLLKAK ETSLMRRMRI QNADKMKEAG METPSFYSAL LRIQPKIVHC
1460 1470 1480 1490 1500
WRPMRRSFKT YDKNGTGLLS VADFRKVLRQ YSINLSEEEF FHVLEYYDKS
1510
LSSKISYNDF LRAFLQ
Length:1,516
Mass (Da):175,771
Last modified:November 13, 2007 - v2
Checksum:i786C634E6CFA5CFD
GO
Isoform 2 (identifier: Q6P1E8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.

Show »
Length:828
Mass (Da):96,577
Checksum:i945F0D4BC0AEB37F
GO
Isoform 3 (identifier: Q6P1E8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-838: Missing.
     839-844: PQRLIR → MSKKHG

Note: Gene prediction based on EST data.
Show »
Length:678
Mass (Da):78,779
Checksum:i180AD60E21442E83
GO

Sequence cautioni

The sequence AAH56955.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH65111.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti632 – 6321E → K in AAH65111 (PubMed:15489334).Curated
Sequence conflicti1101 – 11011E → V in BAD90458 (Ref. 2) Curated
Sequence conflicti1181 – 11811R → K in BAD90458 (Ref. 2) Curated
Sequence conflicti1391 – 13911Missing in AAH56955 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 838838Missing in isoform 3. CuratedVSP_029427Add
BLAST
Alternative sequencei1 – 688688Missing in isoform 2. 2 PublicationsVSP_019814Add
BLAST
Alternative sequencei839 – 8446PQRLIR → MSKKHG in isoform 3. CuratedVSP_029428

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019850 mRNA. Translation: BAB31880.1.
AK220412 mRNA. Translation: BAD90458.1.
AL513354, AL603867 Genomic DNA. Translation: CAO78062.1.
AL513354 Genomic DNA. Translation: CAO78063.1.
AL513354 Genomic DNA. Translation: CAO78064.1.
AL603867, AL513354 Genomic DNA. Translation: CAO77882.1.
BC056955 mRNA. Translation: AAH56955.1. Different initiation.
BC065111 mRNA. Translation: AAH65111.1. Different initiation.
CCDSiCCDS27707.2. [Q6P1E8-1]
RefSeqiNP_001155100.1. NM_001161628.1. [Q6P1E8-3]
NP_001155101.1. NM_001161629.1. [Q6P1E8-4]
NP_084222.4. NM_029946.4. [Q6P1E8-1]
XP_006521596.1. XM_006521533.2. [Q6P1E8-1]
UniGeneiMm.196288.

Genome annotation databases

EnsembliENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441. [Q6P1E8-1]
GeneIDi77627.
KEGGimmu:77627.
UCSCiuc007xbo.1. mouse. [Q6P1E8-4]
uc007xbq.1. mouse. [Q6P1E8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019850 mRNA. Translation: BAB31880.1.
AK220412 mRNA. Translation: BAD90458.1.
AL513354, AL603867 Genomic DNA. Translation: CAO78062.1.
AL513354 Genomic DNA. Translation: CAO78063.1.
AL513354 Genomic DNA. Translation: CAO78064.1.
AL603867, AL513354 Genomic DNA. Translation: CAO77882.1.
BC056955 mRNA. Translation: AAH56955.1. Different initiation.
BC065111 mRNA. Translation: AAH65111.1. Different initiation.
CCDSiCCDS27707.2. [Q6P1E8-1]
RefSeqiNP_001155100.1. NM_001161628.1. [Q6P1E8-3]
NP_001155101.1. NM_001161629.1. [Q6P1E8-4]
NP_084222.4. NM_029946.4. [Q6P1E8-1]
XP_006521596.1. XM_006521533.2. [Q6P1E8-1]
UniGeneiMm.196288.

3D structure databases

ProteinModelPortaliQ6P1E8.
SMRiQ6P1E8. Positions 1178-1259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114909.

PTM databases

PhosphoSiteiQ6P1E8.

Proteomic databases

MaxQBiQ6P1E8.
PaxDbiQ6P1E8.
PRIDEiQ6P1E8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441. [Q6P1E8-1]
GeneIDi77627.
KEGGimmu:77627.
UCSCiuc007xbo.1. mouse. [Q6P1E8-4]
uc007xbq.1. mouse. [Q6P1E8-1]

Organism-specific databases

CTDi64800.
MGIiMGI:1924877. Efcab6.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG46752.
GeneTreeiENSGT00390000013629.
HOVERGENiHBG095997.
InParanoidiQ6P1E8.
OMAiVLKDFCY.
OrthoDBiEOG7SV0TX.
PhylomeDBiQ6P1E8.
TreeFamiTF329179.

Miscellaneous databases

NextBioi347254.
PROiQ6P1E8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P1E8.
CleanExiMM_EFCAB6.
GenevisibleiQ6P1E8. MM.

Family and domain databases

Gene3Di1.10.238.10. 9 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR015070. EF_hand_Ca-bd_contain_6.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF08976. DUF1880. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 11 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiEFCB6_MOUSE
AccessioniPrimary (citable) accession number: Q6P1E8
Secondary accession number(s): A6PW10
, A6PW11, A6PW12, Q5DTV8, Q6PGK8, Q9D2D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 13, 2007
Last modified: July 22, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.