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Q6P1E8 (EFCB6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
EF-hand calcium-binding domain-containing protein 6
Alternative name(s):
DJ-1-binding protein
Short name=DJBP
Gene names
Name:Efcab6
Synonyms:Djbp, Kiaa1672
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1516 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex By similarity.

Subunit structure

Binds PARK7. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 15 EF-hand domains.

Sequence caution

The sequence AAH56955.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH65111.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
   LigandCalcium
Metal-binding
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6P1E8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6P1E8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.
Isoform 3 (identifier: Q6P1E8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-838: Missing.
     839-844: PQRLIR → MSKKHG
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15161516EF-hand calcium-binding domain-containing protein 6
PRO_0000246026

Regions

Domain96 – 13136EF-hand 1
Domain197 – 23236EF-hand 2
Domain321 – 35636EF-hand 3
Domain427 – 46236EF-hand 4
Domain528 – 56336EF-hand 5
Domain655 – 69036EF-hand 6
Domain763 – 79836EF-hand 7
Domain905 – 94036EF-hand 8
Domain1086 – 112136EF-hand 9
Domain1193 – 122836EF-hand 10
Domain1229 – 126436EF-hand 11
Domain1338 – 137336EF-hand 12
Domain1374 – 140936EF-hand 13
Domain1449 – 148436EF-hand 14
Domain1485 – 151632EF-hand 15
Calcium binding109 – 120121 Potential
Calcium binding210 – 221122 Potential
Calcium binding776 – 787127 Potential
Calcium binding1462 – 14731214 Potential
Region1318 – 1516199Interaction with PARK7 By similarity
Region1422 – 151695Interaction with AR By similarity

Natural variations

Alternative sequence1 – 838838Missing in isoform 3.
VSP_029427
Alternative sequence1 – 688688Missing in isoform 2.
VSP_019814
Alternative sequence839 – 8446PQRLIR → MSKKHG in isoform 3.
VSP_029428

Experimental info

Sequence conflict6321E → K in AAH65111. Ref.4
Sequence conflict11011E → V in BAD90458. Ref.2
Sequence conflict11811R → K in BAD90458. Ref.2
Sequence conflict13911Missing in AAH56955. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 786C634E6CFA5CFD

FASTA1,516175,771
        10         20         30         40         50         60 
MKRNGTRLNF AKANSTKSGS TRARDLMNKM SIIPEWHSLY SNTRKLPCSR PHSSPCKMQR 

        70         80         90        100        110        120 
TIFQDLCRPS SSTTAIANPV LSYLDIERIL AQKISSRRDD IKKVFQILDR NHNQMVTKGD 

       130        140        150        160        170        180 
LKRVITAFLI PLTKDQFQDL LAQIPISSLG NVPYLEFLSR FGGGIDININ GIKRVNENEV 

       190        200        210        220        230        240 
DNRRTVKEVQ LTEKIFRNMR SIRKVFQVMD VNNTGLVQPQ ELRRVLETFC LRMQDGDYEK 

       250        260        270        280        290        300 
FLEQYNIDKT TAVDYNAFLK NLSVKNDASF KYLLSNAAEL SRETQQGKNG KRLLDTGSSE 

       310        320        330        340        350        360 
DVWKNYSLDD LEKTFCQEFS KSYEKIEKAL SAGDPSKGGY ISLNYLKVVL DTFIYRLPRR 

       370        380        390        400        410        420 
IFIQLIRRFG LKTSTKINWK QFLTAIYERQ KLEVSKTLPL KKRSSTEARN RSRKENIIKK 

       430        440        450        460        470        480 
LFKYSEDRYT ALKKTLLIIS STPSGHITWE ELRHILNCMV AKLNDSEFSE LKQTFDPEGT 

       490        500        510        520        530        540 
GAVRVNSLLD VLDDSTKVRK MSPSTDTKTP LPVAWDSVEE LVLDSITRNL QAFYSMLQSY 

       550        560        570        580        590        600 
DLRDTGTIGK NNFRKVMRVF CPYLSNEHLV RFSSKFQEAG SGRILYKKFL LSIGVGIPPP 

       610        620        630        640        650        660 
TPPLSSPKVQ LSDQFQIEEP GQQDERTQPS GEKTSEINNM TKEEVIDGLK HRIQQKDPVF 

       670        680        690        700        710        720 
RKQFLSISKE PDVKINQEEF RKVLERSGMP MNDCQYAMLA SKLGFKNEEG MSYQDFTMGF 

       730        740        750        760        770        780 
EDCMLSGLET VPLQSRTASR TNMDEHFISA EECLRIFPKK LKESFRDVYS AFFRIDLDRD 

       790        800        810        820        830        840 
GIISMHDFHR LLQYLQLNMV DLEFERFLSL LGLRLSVTLN FREFQNLCEK RPWKSDEAPQ 

       850        860        870        880        890        900 
RLIRCKQKVA DSELACEQAH QYLIMKAKTR WADLSKNFIE TDNEGNGILR RRDIKNSLYG 

       910        920        930        940        950        960 
FDIPLTPREF EKLWQNYDTE GRGYITYQEF LHRLGIRYSP KVHRPYKEDY FNFLGHFTKP 

       970        980        990       1000       1010       1020 
KQVQEEIQEL QQISEREKLM NHYEEISKAF NAMEKSKPVA LCRVQKVLQE CGCPLKEEEL 

      1030       1040       1050       1060       1070       1080 
ISLLKSLDVS VHNNHIDPVE FLRALEISWA SKARPKEKEE SSPPPISFSK VTPDEVIKTM 

      1090       1100       1110       1120       1130       1140 
QEVVESSQPA LVEAFSALDK EDTGFVKAME FGDVLRSVCQ KLTDNQYHYF LRRLRLHLTP 

      1150       1160       1170       1180       1190       1200 
NIHWKYFLEN FSTFQDETAD DWAENMPKAP PPMSPKETAH RDIVARVQKA VASHYHTIVQ 

      1210       1220       1230       1240       1250       1260 
EFENFDTLKS NTVSRDEFRS ICTRHIQILT DEQFDRLWSE LPVNAKGRLK YQDFLSKLSI 

      1270       1280       1290       1300       1310       1320 
ERVPSPPMAA GDSGESTMAQ RGSSAPEFSQ GTRSNLYSPP RDSRVGLKSR SHPCTPVGTP 

      1330       1340       1350       1360       1370       1380 
PLQNCEPIES RLRKQIQGCW RELLRECKEK DTDKQGTISA AEFLALVEKF KLDISREESQ 

      1390       1400       1410       1420       1430       1440 
QLIVKYDLKN NGKFAYCDFI QSCVLLLKAK ETSLMRRMRI QNADKMKEAG METPSFYSAL 

      1450       1460       1470       1480       1490       1500 
LRIQPKIVHC WRPMRRSFKT YDKNGTGLLS VADFRKVLRQ YSINLSEEEF FHVLEYYDKS 

      1510 
LSSKISYNDF LRAFLQ 

« Hide

Isoform 2 [UniParc].

Checksum: 945F0D4BC0AEB37F
Show »

FASTA82896,577
Isoform 3 [UniParc].

Checksum: 180AD60E21442E83
Show »

FASTA67878,779

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Testis.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Fetal brain.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK019850 mRNA. Translation: BAB31880.1.
AK220412 mRNA. Translation: BAD90458.1.
AL513354, AL603867 Genomic DNA. Translation: CAO78062.1.
AL513354 Genomic DNA. Translation: CAO78063.1.
AL513354 Genomic DNA. Translation: CAO78064.1.
AL603867, AL513354 Genomic DNA. Translation: CAO77882.1.
BC056955 mRNA. Translation: AAH56955.1. Different initiation.
BC065111 mRNA. Translation: AAH65111.1. Different initiation.
CCDSCCDS27707.2. [Q6P1E8-1]
RefSeqNP_001155100.1. NM_001161628.1. [Q6P1E8-3]
NP_001155101.1. NM_001161629.1. [Q6P1E8-4]
NP_084222.4. NM_029946.4. [Q6P1E8-1]
XP_006521596.1. XM_006521533.1. [Q6P1E8-1]
UniGeneMm.196288.

3D structure databases

ProteinModelPortalQ6P1E8.
SMRQ6P1E8. Positions 100-271, 328-384, 432-489, 533-591, 663-718, 776-827, 874-932, 1093-1149, 1178-1259, 1343-1401, 1453-1513.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6P1E8.

Proteomic databases

MaxQBQ6P1E8.
PaxDbQ6P1E8.
PRIDEQ6P1E8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441. [Q6P1E8-1]
GeneID77627.
KEGGmmu:77627.
UCSCuc007xbo.1. mouse. [Q6P1E8-4]
uc007xbq.1. mouse. [Q6P1E8-1]

Organism-specific databases

CTD64800.
MGIMGI:1924877. Efcab6.
RougeSearch...

Phylogenomic databases

eggNOGNOG46752.
GeneTreeENSGT00390000013629.
HOVERGENHBG095997.
InParanoidQ6P1E8.
OMAGMPMDDD.
OrthoDBEOG7SV0TX.
PhylomeDBQ6P1E8.
TreeFamTF329179.

Gene expression databases

BgeeQ6P1E8.
CleanExMM_EFCAB6.
GenevestigatorQ6P1E8.

Family and domain databases

Gene3D1.10.238.10. 9 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR015070. EF_hand_Ca-bd_contain_6.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF08976. DUF1880. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 11 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 15 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio347254.
PROQ6P1E8.
SOURCESearch...

Entry information

Entry nameEFCB6_MOUSE
AccessionPrimary (citable) accession number: Q6P1E8
Secondary accession number(s): A6PW10 expand/collapse secondary AC list , A6PW11, A6PW12, Q5DTV8, Q6PGK8, Q9D2D8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot