Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6P1E8

- EFCB6_MOUSE

UniProt

Q6P1E8 - EFCB6_MOUSE

Protein

EF-hand calcium-binding domain-containing protein 6

Gene

Efcab6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi109 – 120121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi210 – 221122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi776 – 787127PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi1462 – 14731214PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EF-hand calcium-binding domain-containing protein 6
    Alternative name(s):
    DJ-1-binding protein
    Short name:
    DJBP
    Gene namesi
    Name:Efcab6
    Synonyms:Djbp, Kiaa1672
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1924877. Efcab6.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15161516EF-hand calcium-binding domain-containing protein 6PRO_0000246026Add
    BLAST

    Proteomic databases

    MaxQBiQ6P1E8.
    PaxDbiQ6P1E8.
    PRIDEiQ6P1E8.

    PTM databases

    PhosphoSiteiQ6P1E8.

    Expressioni

    Gene expression databases

    BgeeiQ6P1E8.
    CleanExiMM_EFCAB6.
    GenevestigatoriQ6P1E8.

    Interactioni

    Subunit structurei

    Binds PARK7. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P1E8.
    SMRiQ6P1E8. Positions 100-271, 328-384, 432-489, 533-591, 663-718, 776-827, 874-932, 1093-1149, 1178-1259, 1343-1401, 1453-1513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini96 – 13136EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini197 – 23236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini321 – 35636EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini427 – 46236EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini528 – 56336EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini655 – 69036EF-hand 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini763 – 79836EF-hand 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini905 – 94036EF-hand 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1086 – 112136EF-hand 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1193 – 122836EF-hand 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1229 – 126436EF-hand 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1338 – 137336EF-hand 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1374 – 140936EF-hand 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1449 – 148436EF-hand 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1485 – 151632EF-hand 15PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1318 – 1516199Interaction with PARK7By similarityAdd
    BLAST
    Regioni1422 – 151695Interaction with ARBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 15 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG46752.
    GeneTreeiENSGT00390000013629.
    HOVERGENiHBG095997.
    InParanoidiQ6P1E8.
    OMAiGMPMDDD.
    OrthoDBiEOG7SV0TX.
    PhylomeDBiQ6P1E8.
    TreeFamiTF329179.

    Family and domain databases

    Gene3Di1.10.238.10. 9 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR015070. EF_hand_Ca-bd_contain_6.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF08976. DUF1880. 1 hit.
    PF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 11 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 15 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P1E8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKRNGTRLNF AKANSTKSGS TRARDLMNKM SIIPEWHSLY SNTRKLPCSR     50
    PHSSPCKMQR TIFQDLCRPS SSTTAIANPV LSYLDIERIL AQKISSRRDD 100
    IKKVFQILDR NHNQMVTKGD LKRVITAFLI PLTKDQFQDL LAQIPISSLG 150
    NVPYLEFLSR FGGGIDININ GIKRVNENEV DNRRTVKEVQ LTEKIFRNMR 200
    SIRKVFQVMD VNNTGLVQPQ ELRRVLETFC LRMQDGDYEK FLEQYNIDKT 250
    TAVDYNAFLK NLSVKNDASF KYLLSNAAEL SRETQQGKNG KRLLDTGSSE 300
    DVWKNYSLDD LEKTFCQEFS KSYEKIEKAL SAGDPSKGGY ISLNYLKVVL 350
    DTFIYRLPRR IFIQLIRRFG LKTSTKINWK QFLTAIYERQ KLEVSKTLPL 400
    KKRSSTEARN RSRKENIIKK LFKYSEDRYT ALKKTLLIIS STPSGHITWE 450
    ELRHILNCMV AKLNDSEFSE LKQTFDPEGT GAVRVNSLLD VLDDSTKVRK 500
    MSPSTDTKTP LPVAWDSVEE LVLDSITRNL QAFYSMLQSY DLRDTGTIGK 550
    NNFRKVMRVF CPYLSNEHLV RFSSKFQEAG SGRILYKKFL LSIGVGIPPP 600
    TPPLSSPKVQ LSDQFQIEEP GQQDERTQPS GEKTSEINNM TKEEVIDGLK 650
    HRIQQKDPVF RKQFLSISKE PDVKINQEEF RKVLERSGMP MNDCQYAMLA 700
    SKLGFKNEEG MSYQDFTMGF EDCMLSGLET VPLQSRTASR TNMDEHFISA 750
    EECLRIFPKK LKESFRDVYS AFFRIDLDRD GIISMHDFHR LLQYLQLNMV 800
    DLEFERFLSL LGLRLSVTLN FREFQNLCEK RPWKSDEAPQ RLIRCKQKVA 850
    DSELACEQAH QYLIMKAKTR WADLSKNFIE TDNEGNGILR RRDIKNSLYG 900
    FDIPLTPREF EKLWQNYDTE GRGYITYQEF LHRLGIRYSP KVHRPYKEDY 950
    FNFLGHFTKP KQVQEEIQEL QQISEREKLM NHYEEISKAF NAMEKSKPVA 1000
    LCRVQKVLQE CGCPLKEEEL ISLLKSLDVS VHNNHIDPVE FLRALEISWA 1050
    SKARPKEKEE SSPPPISFSK VTPDEVIKTM QEVVESSQPA LVEAFSALDK 1100
    EDTGFVKAME FGDVLRSVCQ KLTDNQYHYF LRRLRLHLTP NIHWKYFLEN 1150
    FSTFQDETAD DWAENMPKAP PPMSPKETAH RDIVARVQKA VASHYHTIVQ 1200
    EFENFDTLKS NTVSRDEFRS ICTRHIQILT DEQFDRLWSE LPVNAKGRLK 1250
    YQDFLSKLSI ERVPSPPMAA GDSGESTMAQ RGSSAPEFSQ GTRSNLYSPP 1300
    RDSRVGLKSR SHPCTPVGTP PLQNCEPIES RLRKQIQGCW RELLRECKEK 1350
    DTDKQGTISA AEFLALVEKF KLDISREESQ QLIVKYDLKN NGKFAYCDFI 1400
    QSCVLLLKAK ETSLMRRMRI QNADKMKEAG METPSFYSAL LRIQPKIVHC 1450
    WRPMRRSFKT YDKNGTGLLS VADFRKVLRQ YSINLSEEEF FHVLEYYDKS 1500
    LSSKISYNDF LRAFLQ 1516
    Length:1,516
    Mass (Da):175,771
    Last modified:November 13, 2007 - v2
    Checksum:i786C634E6CFA5CFD
    GO
    Isoform 2 (identifier: Q6P1E8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-688: Missing.

    Show »
    Length:828
    Mass (Da):96,577
    Checksum:i945F0D4BC0AEB37F
    GO
    Isoform 3 (identifier: Q6P1E8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-838: Missing.
         839-844: PQRLIR → MSKKHG

    Note: Gene prediction based on EST data.

    Show »
    Length:678
    Mass (Da):78,779
    Checksum:i180AD60E21442E83
    GO

    Sequence cautioni

    The sequence AAH56955.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH65111.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti632 – 6321E → K in AAH65111. (PubMed:15489334)Curated
    Sequence conflicti1101 – 11011E → V in BAD90458. 1 PublicationCurated
    Sequence conflicti1181 – 11811R → K in BAD90458. 1 PublicationCurated
    Sequence conflicti1391 – 13911Missing in AAH56955. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 838838Missing in isoform 3. CuratedVSP_029427Add
    BLAST
    Alternative sequencei1 – 688688Missing in isoform 2. 2 PublicationsVSP_019814Add
    BLAST
    Alternative sequencei839 – 8446PQRLIR → MSKKHG in isoform 3. CuratedVSP_029428

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK019850 mRNA. Translation: BAB31880.1.
    AK220412 mRNA. Translation: BAD90458.1.
    AL513354, AL603867 Genomic DNA. Translation: CAO78062.1.
    AL513354 Genomic DNA. Translation: CAO78063.1.
    AL513354 Genomic DNA. Translation: CAO78064.1.
    AL603867, AL513354 Genomic DNA. Translation: CAO77882.1.
    BC056955 mRNA. Translation: AAH56955.1. Different initiation.
    BC065111 mRNA. Translation: AAH65111.1. Different initiation.
    CCDSiCCDS27707.2. [Q6P1E8-1]
    RefSeqiNP_001155100.1. NM_001161628.1. [Q6P1E8-3]
    NP_001155101.1. NM_001161629.1. [Q6P1E8-4]
    NP_084222.4. NM_029946.4. [Q6P1E8-1]
    XP_006521596.1. XM_006521533.1. [Q6P1E8-1]
    UniGeneiMm.196288.

    Genome annotation databases

    EnsembliENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441. [Q6P1E8-1]
    GeneIDi77627.
    KEGGimmu:77627.
    UCSCiuc007xbo.1. mouse. [Q6P1E8-4]
    uc007xbq.1. mouse. [Q6P1E8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK019850 mRNA. Translation: BAB31880.1 .
    AK220412 mRNA. Translation: BAD90458.1 .
    AL513354 , AL603867 Genomic DNA. Translation: CAO78062.1 .
    AL513354 Genomic DNA. Translation: CAO78063.1 .
    AL513354 Genomic DNA. Translation: CAO78064.1 .
    AL603867 , AL513354 Genomic DNA. Translation: CAO77882.1 .
    BC056955 mRNA. Translation: AAH56955.1 . Different initiation.
    BC065111 mRNA. Translation: AAH65111.1 . Different initiation.
    CCDSi CCDS27707.2. [Q6P1E8-1 ]
    RefSeqi NP_001155100.1. NM_001161628.1. [Q6P1E8-3 ]
    NP_001155101.1. NM_001161629.1. [Q6P1E8-4 ]
    NP_084222.4. NM_029946.4. [Q6P1E8-1 ]
    XP_006521596.1. XM_006521533.1. [Q6P1E8-1 ]
    UniGenei Mm.196288.

    3D structure databases

    ProteinModelPortali Q6P1E8.
    SMRi Q6P1E8. Positions 100-271, 328-384, 432-489, 533-591, 663-718, 776-827, 874-932, 1093-1149, 1178-1259, 1343-1401, 1453-1513.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6P1E8.

    Proteomic databases

    MaxQBi Q6P1E8.
    PaxDbi Q6P1E8.
    PRIDEi Q6P1E8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000156187 ; ENSMUSP00000114909 ; ENSMUSG00000022441 . [Q6P1E8-1 ]
    GeneIDi 77627.
    KEGGi mmu:77627.
    UCSCi uc007xbo.1. mouse. [Q6P1E8-4 ]
    uc007xbq.1. mouse. [Q6P1E8-1 ]

    Organism-specific databases

    CTDi 64800.
    MGIi MGI:1924877. Efcab6.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG46752.
    GeneTreei ENSGT00390000013629.
    HOVERGENi HBG095997.
    InParanoidi Q6P1E8.
    OMAi GMPMDDD.
    OrthoDBi EOG7SV0TX.
    PhylomeDBi Q6P1E8.
    TreeFami TF329179.

    Miscellaneous databases

    NextBioi 347254.
    PROi Q6P1E8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P1E8.
    CleanExi MM_EFCAB6.
    Genevestigatori Q6P1E8.

    Family and domain databases

    Gene3Di 1.10.238.10. 9 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR015070. EF_hand_Ca-bd_contain_6.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF08976. DUF1880. 1 hit.
    PF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 11 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 15 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Fetal brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiEFCB6_MOUSE
    AccessioniPrimary (citable) accession number: Q6P1E8
    Secondary accession number(s): A6PW10
    , A6PW11, A6PW12, Q5DTV8, Q6PGK8, Q9D2D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3