Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6P1E1

- ZMIZ1_MOUSE

UniProt

Q6P1E1 - ZMIZ1_MOUSE

Protein

Zinc finger MIZ domain-containing protein 1

Gene

Zmiz1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri734 – 81178SP-RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. artery morphogenesis Source: MGI
    2. cell aging Source: MGI
    3. developmental growth Source: MGI
    4. heart morphogenesis Source: MGI
    5. in utero embryonic development Source: MGI
    6. positive regulation of fibroblast proliferation Source: MGI
    7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    8. transcription, DNA-templated Source: UniProtKB-KW
    9. vasculogenesis Source: MGI
    10. vitellogenesis Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger MIZ domain-containing protein 1
    Alternative name(s):
    PIAS-like protein Zimp10
    Retinoic acid-induced protein 17
    Gene namesi
    Name:Zmiz1
    Synonyms:Rai17, Zimp10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:3040693. Zmiz1.

    Subcellular locationi

    Nucleus speckle By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear speck Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Death between 9.5-10.5 dpc. Mice are approximately half the size of wild-type littermates and display vascular and cell viability defects. Some heterozygotes also do not survive but those that do have no apparent defects.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10721072Zinc finger MIZ domain-containing protein 1PRO_0000218988Add
    BLAST

    Proteomic databases

    PaxDbiQ6P1E1.
    PRIDEiQ6P1E1.

    PTM databases

    PhosphoSiteiQ6P1E1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P1E1.
    BgeeiQ6P1E1.
    CleanExiMM_ZMIZ1.
    GenevestigatoriQ6P1E1.

    Interactioni

    Subunit structurei

    Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR.By similarity

    Protein-protein interaction databases

    IntActiQ6P1E1. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P1E1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi280 – 30526Ala-richAdd
    BLAST
    Compositional biasi340 – 562223Pro-richAdd
    BLAST
    Compositional biasi874 – 1007134Pro-richAdd
    BLAST

    Domaini

    The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein By similarity.By similarity

    Sequence similaritiesi

    Contains 1 SP-RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri734 – 81178SP-RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG237400.
    GeneTreeiENSGT00550000074410.
    HOGENOMiHOG000253014.
    HOVERGENiHBG056252.
    InParanoidiQ6P1E1.
    OMAiDFMHGPQ.
    OrthoDBiEOG715Q3Q.
    PhylomeDBiQ6P1E1.
    TreeFamiTF316952.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR004181. Znf_MIZ.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF02891. zf-MIZ. 1 hit.
    [Graphical view]
    PROSITEiPS51044. ZF_SP_RING. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P1E1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE     50
    QSLMGCLTVV SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC 100
    EELGRLLLLR HQKSRQNDPP GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS 150
    VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ VLGNPMANAN NPMNPGGNPM 200
    ASGMSTSNPG INSPQFAGQQ QQFSTKAGPA QPYIQPNMYG RPGYPGSGGF 250
    GASYPGGPSA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT 300
    ATVAALQETQ NKDINQYGPV CSSFQMGPTQ AYNSQFMNQP GPRGPASMGG 350
    SLNPAGMAAG MTPSGMSGPP MGMNQPRPPG ISPFGTHGQR MPQQTYPGPR 400
    PQSLPIQSIK RPYPGEPNYG NQQYGPNSQF PTQPGQYPTP NPPRPLTSPN 450
    YPGQRMPSQP STGQYPPPTV NMGQYYKPEQ FNGQNNTFSS GSSYSSYSQG 500
    SVNRPPRPVP VANYPHSPVP GNPTPPMTPG SSIPPYLSPS QDVKPPFPPD 550
    IKPNMSALPP PPANHNDELR LTFPVRDGVV LEPFRLEHNL AVSNHVFHLR 600
    PTVHQTLMWR SDLELQFKCY HHEDRQMNTN WPASVQVSVN ATPLTIERGD 650
    NKTSHKPLHL KHVCQPGRNT IQITVTACCC SHLFVLQLVH RPSVRSVLQG 700
    LLKKRLLPAE HCITKIKRNF SSVAASSGNT TLNGEDGVEQ TAIKVSLKCP 750
    ITFRRIQLPA RGHDCKHVQC FDLESYLQLN CERGTWRCPV CNKTALLEGL 800
    EVDQYMWGIL NAIQHSEFEE VTIDPTCSWR PVPIKSDLHI KDDPDGIPSK 850
    RFKTMSPSQM IMPNVMEMIA ALGPGPSPYP LPPPPGGTSS NDYSSQGNNY 900
    QGHGNFDFPH GNPGGTSMND FMHGPPQLSH PPDMPNNMAA LEKPLSHPMQ 950
    ETMPHAGSSD QPHPSIQQGL HVPHPSSQAG PPLHHSGAPP PSQPPRQPPQ 1000
    AAPGNHPHSD LTFNPSSALE GQAGAQGASD MPEPSLDLLP ELTNPDELLS 1050
    YLDPPDLPSN SNDDLLSLFE NN 1072

    Note: No experimental confirmation available.

    Length:1,072
    Mass (Da):115,851
    Last modified:July 5, 2004 - v1
    Checksum:i53B1AF1338EBDB17
    GO
    Isoform 2 (identifier: Q6P1E1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         320-325: Missing.

    Note: May be due to a competing acceptor splice site.

    Show »
    Length:1,066
    Mass (Da):115,199
    Checksum:i761BA804BFE025B4
    GO

    Sequence cautioni

    The sequence BAC35753.1 differs from that shown. Reason: Intron retention.
    The sequence BAC35753.1 differs from that shown. Reason: Frameshift at position 350.
    The sequence AAH57691.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei320 – 3256Missing in isoform 2. 1 PublicationVSP_012187

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC057691 mRNA. Translation: AAH57691.1. Different initiation.
    BC058646 mRNA. Translation: AAH58646.1.
    BC065120 mRNA. Translation: AAH65120.1.
    AK054366 mRNA. Translation: BAC35753.1. Sequence problems.
    CCDSiCCDS26873.1. [Q6P1E1-1]
    RefSeqiNP_899031.2. NM_183208.3. [Q6P1E1-1]
    XP_006519196.1. XM_006519133.1. [Q6P1E1-2]
    UniGeneiMm.227484.
    Mm.486339.

    Genome annotation databases

    EnsembliENSMUST00000007961; ENSMUSP00000007961; ENSMUSG00000007817. [Q6P1E1-2]
    ENSMUST00000162645; ENSMUSP00000124863; ENSMUSG00000007817. [Q6P1E1-1]
    GeneIDi328365.
    KEGGimmu:328365.
    UCSCiuc007srn.2. mouse. [Q6P1E1-1]
    uc007sro.2. mouse. [Q6P1E1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC057691 mRNA. Translation: AAH57691.1 . Different initiation.
    BC058646 mRNA. Translation: AAH58646.1 .
    BC065120 mRNA. Translation: AAH65120.1 .
    AK054366 mRNA. Translation: BAC35753.1 . Sequence problems.
    CCDSi CCDS26873.1. [Q6P1E1-1 ]
    RefSeqi NP_899031.2. NM_183208.3. [Q6P1E1-1 ]
    XP_006519196.1. XM_006519133.1. [Q6P1E1-2 ]
    UniGenei Mm.227484.
    Mm.486339.

    3D structure databases

    ProteinModelPortali Q6P1E1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6P1E1. 1 interaction.

    PTM databases

    PhosphoSitei Q6P1E1.

    Proteomic databases

    PaxDbi Q6P1E1.
    PRIDEi Q6P1E1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000007961 ; ENSMUSP00000007961 ; ENSMUSG00000007817 . [Q6P1E1-2 ]
    ENSMUST00000162645 ; ENSMUSP00000124863 ; ENSMUSG00000007817 . [Q6P1E1-1 ]
    GeneIDi 328365.
    KEGGi mmu:328365.
    UCSCi uc007srn.2. mouse. [Q6P1E1-1 ]
    uc007sro.2. mouse. [Q6P1E1-2 ]

    Organism-specific databases

    CTDi 57178.
    MGIi MGI:3040693. Zmiz1.

    Phylogenomic databases

    eggNOGi NOG237400.
    GeneTreei ENSGT00550000074410.
    HOGENOMi HOG000253014.
    HOVERGENi HBG056252.
    InParanoidi Q6P1E1.
    OMAi DFMHGPQ.
    OrthoDBi EOG715Q3Q.
    PhylomeDBi Q6P1E1.
    TreeFami TF316952.

    Miscellaneous databases

    ChiTaRSi ZMIZ1. mouse.
    NextBioi 398259.
    PROi Q6P1E1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P1E1.
    Bgeei Q6P1E1.
    CleanExi MM_ZMIZ1.
    Genevestigatori Q6P1E1.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR004181. Znf_MIZ.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF02891. zf-MIZ. 1 hit.
    [Graphical view ]
    PROSITEi PS51044. ZF_SP_RING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6 and Czech II.
      Tissue: Brain and Mammary tumor.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-416 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Ovary.
    3. "Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators."
      Beliakoff J., Sun Z.
      Nucl. Recept. Signal. 4:17-17(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiZMIZ1_MOUSE
    AccessioniPrimary (citable) accession number: Q6P1E1
    Secondary accession number(s): Q6PDK9, Q6PF85, Q8BW47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3