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Q6P1E1 (ZMIZ1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger MIZ domain-containing protein 1
Alternative name(s):
PIAS-like protein Zimp10
Retinoic acid-induced protein 17
Gene names
Name:Zmiz1
Synonyms:Rai17, Zimp10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1072 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation By similarity.

Subunit structure

Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR By similarity.

Subcellular location

Nucleus speckle By similarity. Cytoplasm By similarity.

Domain

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein By similarity.

Disruption phenotype

Death between 9.5-10.5 dpc. Mice are approximately half the size of wild-type littermates and display vascular and cell viability defects. Some heterozygotes also do not survive but those that do have no apparent defects. Ref.3

Sequence similarities

Contains 1 SP-RING-type zinc finger.

Sequence caution

The sequence AAH57691.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC35753.1 differs from that shown. Reason: Frameshift at position 350.

The sequence BAC35753.1 differs from that shown. Reason: Intron retention.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6P1E1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q6P1E1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     320-325: Missing.
Note: May be due to a competing acceptor splice site.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10721072Zinc finger MIZ domain-containing protein 1
PRO_0000218988

Regions

Zinc finger734 – 81178SP-RING-type
Compositional bias280 – 30526Ala-rich
Compositional bias340 – 562223Pro-rich
Compositional bias874 – 1007134Pro-rich

Natural variations

Alternative sequence320 – 3256Missing in isoform 2.
VSP_012187

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 53B1AF1338EBDB17

FASTA1,072115,851
        10         20         30         40         50         60 
MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE QSLMGCLTVV 

        70         80         90        100        110        120 
SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC EELGRLLLLR HQKSRQNDPP 

       130        140        150        160        170        180 
GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ 

       190        200        210        220        230        240 
VLGNPMANAN NPMNPGGNPM ASGMSTSNPG INSPQFAGQQ QQFSTKAGPA QPYIQPNMYG 

       250        260        270        280        290        300 
RPGYPGSGGF GASYPGGPSA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT 

       310        320        330        340        350        360 
ATVAALQETQ NKDINQYGPV CSSFQMGPTQ AYNSQFMNQP GPRGPASMGG SLNPAGMAAG 

       370        380        390        400        410        420 
MTPSGMSGPP MGMNQPRPPG ISPFGTHGQR MPQQTYPGPR PQSLPIQSIK RPYPGEPNYG 

       430        440        450        460        470        480 
NQQYGPNSQF PTQPGQYPTP NPPRPLTSPN YPGQRMPSQP STGQYPPPTV NMGQYYKPEQ 

       490        500        510        520        530        540 
FNGQNNTFSS GSSYSSYSQG SVNRPPRPVP VANYPHSPVP GNPTPPMTPG SSIPPYLSPS 

       550        560        570        580        590        600 
QDVKPPFPPD IKPNMSALPP PPANHNDELR LTFPVRDGVV LEPFRLEHNL AVSNHVFHLR 

       610        620        630        640        650        660 
PTVHQTLMWR SDLELQFKCY HHEDRQMNTN WPASVQVSVN ATPLTIERGD NKTSHKPLHL 

       670        680        690        700        710        720 
KHVCQPGRNT IQITVTACCC SHLFVLQLVH RPSVRSVLQG LLKKRLLPAE HCITKIKRNF 

       730        740        750        760        770        780 
SSVAASSGNT TLNGEDGVEQ TAIKVSLKCP ITFRRIQLPA RGHDCKHVQC FDLESYLQLN 

       790        800        810        820        830        840 
CERGTWRCPV CNKTALLEGL EVDQYMWGIL NAIQHSEFEE VTIDPTCSWR PVPIKSDLHI 

       850        860        870        880        890        900 
KDDPDGIPSK RFKTMSPSQM IMPNVMEMIA ALGPGPSPYP LPPPPGGTSS NDYSSQGNNY 

       910        920        930        940        950        960 
QGHGNFDFPH GNPGGTSMND FMHGPPQLSH PPDMPNNMAA LEKPLSHPMQ ETMPHAGSSD 

       970        980        990       1000       1010       1020 
QPHPSIQQGL HVPHPSSQAG PPLHHSGAPP PSQPPRQPPQ AAPGNHPHSD LTFNPSSALE 

      1030       1040       1050       1060       1070 
GQAGAQGASD MPEPSLDLLP ELTNPDELLS YLDPPDLPSN SNDDLLSLFE NN 

« Hide

Isoform 2 [UniParc].

Checksum: 761BA804BFE025B4
Show »

FASTA1,066115,199

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6 and Czech II.
Tissue: Brain and Mammary tumor.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-416 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Ovary.
[3]"Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators."
Beliakoff J., Sun Z.
Nucl. Recept. Signal. 4:17-17(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC057691 mRNA. Translation: AAH57691.1. Different initiation.
BC058646 mRNA. Translation: AAH58646.1.
BC065120 mRNA. Translation: AAH65120.1.
AK054366 mRNA. Translation: BAC35753.1. Sequence problems.
CCDSCCDS26873.1. [Q6P1E1-1]
RefSeqNP_899031.2. NM_183208.3. [Q6P1E1-1]
XP_006519196.1. XM_006519133.1. [Q6P1E1-2]
UniGeneMm.227484.
Mm.486339.

3D structure databases

ProteinModelPortalQ6P1E1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6P1E1. 1 interaction.

PTM databases

PhosphoSiteQ6P1E1.

Proteomic databases

PaxDbQ6P1E1.
PRIDEQ6P1E1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000007961; ENSMUSP00000007961; ENSMUSG00000007817. [Q6P1E1-2]
ENSMUST00000162645; ENSMUSP00000124863; ENSMUSG00000007817. [Q6P1E1-1]
GeneID328365.
KEGGmmu:328365.
UCSCuc007srn.2. mouse. [Q6P1E1-1]
uc007sro.2. mouse. [Q6P1E1-2]

Organism-specific databases

CTD57178.
MGIMGI:3040693. Zmiz1.

Phylogenomic databases

eggNOGNOG237400.
GeneTreeENSGT00550000074410.
HOGENOMHOG000253014.
HOVERGENHBG056252.
InParanoidQ6P1E1.
OMADFMHGPQ.
OrthoDBEOG715Q3Q.
PhylomeDBQ6P1E1.
TreeFamTF316952.

Gene expression databases

ArrayExpressQ6P1E1.
BgeeQ6P1E1.
CleanExMM_ZMIZ1.
GenevestigatorQ6P1E1.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF02891. zf-MIZ. 1 hit.
[Graphical view]
PROSITEPS51044. ZF_SP_RING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZMIZ1. mouse.
NextBio398259.
PROQ6P1E1.
SOURCESearch...

Entry information

Entry nameZMIZ1_MOUSE
AccessionPrimary (citable) accession number: Q6P1E1
Secondary accession number(s): Q6PDK9, Q6PF85, Q8BW47
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot