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Q6P1E1

- ZMIZ1_MOUSE

UniProt

Q6P1E1 - ZMIZ1_MOUSE

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Protein
Zinc finger MIZ domain-containing protein 1
Gene
Zmiz1, Rai17, Zimp10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri734 – 81178SP-RING-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. artery morphogenesis Source: MGI
  2. cell aging Source: MGI
  3. developmental growth Source: MGI
  4. heart morphogenesis Source: MGI
  5. in utero embryonic development Source: MGI
  6. positive regulation of fibroblast proliferation Source: MGI
  7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  8. transcription, DNA-templated Source: UniProtKB-KW
  9. vasculogenesis Source: MGI
  10. vitellogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MIZ domain-containing protein 1
Alternative name(s):
PIAS-like protein Zimp10
Retinoic acid-induced protein 17
Gene namesi
Name:Zmiz1
Synonyms:Rai17, Zimp10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:3040693. Zmiz1.

Subcellular locationi

Nucleus speckle By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nuclear speck Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Death between 9.5-10.5 dpc. Mice are approximately half the size of wild-type littermates and display vascular and cell viability defects. Some heterozygotes also do not survive but those that do have no apparent defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10721072Zinc finger MIZ domain-containing protein 1
PRO_0000218988Add
BLAST

Proteomic databases

PaxDbiQ6P1E1.
PRIDEiQ6P1E1.

PTM databases

PhosphoSiteiQ6P1E1.

Expressioni

Gene expression databases

ArrayExpressiQ6P1E1.
BgeeiQ6P1E1.
CleanExiMM_ZMIZ1.
GenevestigatoriQ6P1E1.

Interactioni

Subunit structurei

Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR By similarity.

Protein-protein interaction databases

IntActiQ6P1E1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6P1E1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 30526Ala-rich
Add
BLAST
Compositional biasi340 – 562223Pro-rich
Add
BLAST
Compositional biasi874 – 1007134Pro-rich
Add
BLAST

Domaini

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein By similarity.

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG237400.
GeneTreeiENSGT00550000074410.
HOGENOMiHOG000253014.
HOVERGENiHBG056252.
InParanoidiQ6P1E1.
OMAiDFMHGPQ.
OrthoDBiEOG715Q3Q.
PhylomeDBiQ6P1E1.
TreeFamiTF316952.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02891. zf-MIZ. 1 hit.
[Graphical view]
PROSITEiPS51044. ZF_SP_RING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6P1E1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE     50
QSLMGCLTVV SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC 100
EELGRLLLLR HQKSRQNDPP GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS 150
VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ VLGNPMANAN NPMNPGGNPM 200
ASGMSTSNPG INSPQFAGQQ QQFSTKAGPA QPYIQPNMYG RPGYPGSGGF 250
GASYPGGPSA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT 300
ATVAALQETQ NKDINQYGPV CSSFQMGPTQ AYNSQFMNQP GPRGPASMGG 350
SLNPAGMAAG MTPSGMSGPP MGMNQPRPPG ISPFGTHGQR MPQQTYPGPR 400
PQSLPIQSIK RPYPGEPNYG NQQYGPNSQF PTQPGQYPTP NPPRPLTSPN 450
YPGQRMPSQP STGQYPPPTV NMGQYYKPEQ FNGQNNTFSS GSSYSSYSQG 500
SVNRPPRPVP VANYPHSPVP GNPTPPMTPG SSIPPYLSPS QDVKPPFPPD 550
IKPNMSALPP PPANHNDELR LTFPVRDGVV LEPFRLEHNL AVSNHVFHLR 600
PTVHQTLMWR SDLELQFKCY HHEDRQMNTN WPASVQVSVN ATPLTIERGD 650
NKTSHKPLHL KHVCQPGRNT IQITVTACCC SHLFVLQLVH RPSVRSVLQG 700
LLKKRLLPAE HCITKIKRNF SSVAASSGNT TLNGEDGVEQ TAIKVSLKCP 750
ITFRRIQLPA RGHDCKHVQC FDLESYLQLN CERGTWRCPV CNKTALLEGL 800
EVDQYMWGIL NAIQHSEFEE VTIDPTCSWR PVPIKSDLHI KDDPDGIPSK 850
RFKTMSPSQM IMPNVMEMIA ALGPGPSPYP LPPPPGGTSS NDYSSQGNNY 900
QGHGNFDFPH GNPGGTSMND FMHGPPQLSH PPDMPNNMAA LEKPLSHPMQ 950
ETMPHAGSSD QPHPSIQQGL HVPHPSSQAG PPLHHSGAPP PSQPPRQPPQ 1000
AAPGNHPHSD LTFNPSSALE GQAGAQGASD MPEPSLDLLP ELTNPDELLS 1050
YLDPPDLPSN SNDDLLSLFE NN 1072

Note: No experimental confirmation available.

Length:1,072
Mass (Da):115,851
Last modified:July 5, 2004 - v1
Checksum:i53B1AF1338EBDB17
GO
Isoform 2 (identifier: Q6P1E1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-325: Missing.

Note: May be due to a competing acceptor splice site.

Show »
Length:1,066
Mass (Da):115,199
Checksum:i761BA804BFE025B4
GO

Sequence cautioni

The sequence BAC35753.1 differs from that shown. Reason: Intron retention.
The sequence BAC35753.1 differs from that shown. Reason: Frameshift at position 350.
The sequence AAH57691.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei320 – 3256Missing in isoform 2.
VSP_012187

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC057691 mRNA. Translation: AAH57691.1. Different initiation.
BC058646 mRNA. Translation: AAH58646.1.
BC065120 mRNA. Translation: AAH65120.1.
AK054366 mRNA. Translation: BAC35753.1. Sequence problems.
CCDSiCCDS26873.1. [Q6P1E1-1]
RefSeqiNP_899031.2. NM_183208.3. [Q6P1E1-1]
XP_006519196.1. XM_006519133.1. [Q6P1E1-2]
UniGeneiMm.227484.
Mm.486339.

Genome annotation databases

EnsembliENSMUST00000007961; ENSMUSP00000007961; ENSMUSG00000007817. [Q6P1E1-2]
ENSMUST00000162645; ENSMUSP00000124863; ENSMUSG00000007817. [Q6P1E1-1]
GeneIDi328365.
KEGGimmu:328365.
UCSCiuc007srn.2. mouse. [Q6P1E1-1]
uc007sro.2. mouse. [Q6P1E1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC057691 mRNA. Translation: AAH57691.1 . Different initiation.
BC058646 mRNA. Translation: AAH58646.1 .
BC065120 mRNA. Translation: AAH65120.1 .
AK054366 mRNA. Translation: BAC35753.1 . Sequence problems.
CCDSi CCDS26873.1. [Q6P1E1-1 ]
RefSeqi NP_899031.2. NM_183208.3. [Q6P1E1-1 ]
XP_006519196.1. XM_006519133.1. [Q6P1E1-2 ]
UniGenei Mm.227484.
Mm.486339.

3D structure databases

ProteinModelPortali Q6P1E1.
ModBasei Search...

Protein-protein interaction databases

IntActi Q6P1E1. 1 interaction.

PTM databases

PhosphoSitei Q6P1E1.

Proteomic databases

PaxDbi Q6P1E1.
PRIDEi Q6P1E1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007961 ; ENSMUSP00000007961 ; ENSMUSG00000007817 . [Q6P1E1-2 ]
ENSMUST00000162645 ; ENSMUSP00000124863 ; ENSMUSG00000007817 . [Q6P1E1-1 ]
GeneIDi 328365.
KEGGi mmu:328365.
UCSCi uc007srn.2. mouse. [Q6P1E1-1 ]
uc007sro.2. mouse. [Q6P1E1-2 ]

Organism-specific databases

CTDi 57178.
MGIi MGI:3040693. Zmiz1.

Phylogenomic databases

eggNOGi NOG237400.
GeneTreei ENSGT00550000074410.
HOGENOMi HOG000253014.
HOVERGENi HBG056252.
InParanoidi Q6P1E1.
OMAi DFMHGPQ.
OrthoDBi EOG715Q3Q.
PhylomeDBi Q6P1E1.
TreeFami TF316952.

Miscellaneous databases

ChiTaRSi ZMIZ1. mouse.
NextBioi 398259.
PROi Q6P1E1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6P1E1.
Bgeei Q6P1E1.
CleanExi MM_ZMIZ1.
Genevestigatori Q6P1E1.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF02891. zf-MIZ. 1 hit.
[Graphical view ]
PROSITEi PS51044. ZF_SP_RING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6 and Czech II.
    Tissue: Brain and Mammary tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-416 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Ovary.
  3. "Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators."
    Beliakoff J., Sun Z.
    Nucl. Recept. Signal. 4:17-17(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiZMIZ1_MOUSE
AccessioniPrimary (citable) accession number: Q6P1E1
Secondary accession number(s): Q6PDK9, Q6PF85, Q8BW47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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