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Q6P1E1

- ZMIZ1_MOUSE

UniProt

Q6P1E1 - ZMIZ1_MOUSE

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Protein

Zinc finger MIZ domain-containing protein 1

Gene

Zmiz1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri734 – 81178SP-RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. artery morphogenesis Source: MGI
  2. cell aging Source: MGI
  3. developmental growth Source: MGI
  4. heart morphogenesis Source: MGI
  5. in utero embryonic development Source: MGI
  6. positive regulation of fibroblast proliferation Source: MGI
  7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  8. transcription, DNA-templated Source: UniProtKB-KW
  9. vasculogenesis Source: MGI
  10. vitellogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MIZ domain-containing protein 1
Alternative name(s):
PIAS-like protein Zimp10
Retinoic acid-induced protein 17
Gene namesi
Name:Zmiz1
Synonyms:Rai17, Zimp10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:3040693. Zmiz1.

Subcellular locationi

Nucleus speckle By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Death between 9.5-10.5 dpc. Mice are approximately half the size of wild-type littermates and display vascular and cell viability defects. Some heterozygotes also do not survive but those that do have no apparent defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10721072Zinc finger MIZ domain-containing protein 1PRO_0000218988Add
BLAST

Proteomic databases

MaxQBiQ6P1E1.
PaxDbiQ6P1E1.
PRIDEiQ6P1E1.

PTM databases

PhosphoSiteiQ6P1E1.

Expressioni

Gene expression databases

BgeeiQ6P1E1.
CleanExiMM_ZMIZ1.
ExpressionAtlasiQ6P1E1. baseline and differential.
GenevestigatoriQ6P1E1.

Interactioni

Subunit structurei

Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR.By similarity

Protein-protein interaction databases

IntActiQ6P1E1. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6P1E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 30526Ala-richAdd
BLAST
Compositional biasi340 – 562223Pro-richAdd
BLAST
Compositional biasi874 – 1007134Pro-richAdd
BLAST

Domaini

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein By similarity.By similarity

Sequence similaritiesi

Contains 1 SP-RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri734 – 81178SP-RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG237400.
GeneTreeiENSGT00550000074410.
HOGENOMiHOG000253014.
HOVERGENiHBG056252.
InParanoidiQ6P1E1.
OMAiDFMHGPQ.
OrthoDBiEOG715Q3Q.
PhylomeDBiQ6P1E1.
TreeFamiTF316952.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02891. zf-MIZ. 1 hit.
[Graphical view]
PROSITEiPS51044. ZF_SP_RING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6P1E1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE
60 70 80 90 100
QSLMGCLTVV SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC
110 120 130 140 150
EELGRLLLLR HQKSRQNDPP GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS
160 170 180 190 200
VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ VLGNPMANAN NPMNPGGNPM
210 220 230 240 250
ASGMSTSNPG INSPQFAGQQ QQFSTKAGPA QPYIQPNMYG RPGYPGSGGF
260 270 280 290 300
GASYPGGPSA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT
310 320 330 340 350
ATVAALQETQ NKDINQYGPV CSSFQMGPTQ AYNSQFMNQP GPRGPASMGG
360 370 380 390 400
SLNPAGMAAG MTPSGMSGPP MGMNQPRPPG ISPFGTHGQR MPQQTYPGPR
410 420 430 440 450
PQSLPIQSIK RPYPGEPNYG NQQYGPNSQF PTQPGQYPTP NPPRPLTSPN
460 470 480 490 500
YPGQRMPSQP STGQYPPPTV NMGQYYKPEQ FNGQNNTFSS GSSYSSYSQG
510 520 530 540 550
SVNRPPRPVP VANYPHSPVP GNPTPPMTPG SSIPPYLSPS QDVKPPFPPD
560 570 580 590 600
IKPNMSALPP PPANHNDELR LTFPVRDGVV LEPFRLEHNL AVSNHVFHLR
610 620 630 640 650
PTVHQTLMWR SDLELQFKCY HHEDRQMNTN WPASVQVSVN ATPLTIERGD
660 670 680 690 700
NKTSHKPLHL KHVCQPGRNT IQITVTACCC SHLFVLQLVH RPSVRSVLQG
710 720 730 740 750
LLKKRLLPAE HCITKIKRNF SSVAASSGNT TLNGEDGVEQ TAIKVSLKCP
760 770 780 790 800
ITFRRIQLPA RGHDCKHVQC FDLESYLQLN CERGTWRCPV CNKTALLEGL
810 820 830 840 850
EVDQYMWGIL NAIQHSEFEE VTIDPTCSWR PVPIKSDLHI KDDPDGIPSK
860 870 880 890 900
RFKTMSPSQM IMPNVMEMIA ALGPGPSPYP LPPPPGGTSS NDYSSQGNNY
910 920 930 940 950
QGHGNFDFPH GNPGGTSMND FMHGPPQLSH PPDMPNNMAA LEKPLSHPMQ
960 970 980 990 1000
ETMPHAGSSD QPHPSIQQGL HVPHPSSQAG PPLHHSGAPP PSQPPRQPPQ
1010 1020 1030 1040 1050
AAPGNHPHSD LTFNPSSALE GQAGAQGASD MPEPSLDLLP ELTNPDELLS
1060 1070
YLDPPDLPSN SNDDLLSLFE NN

Note: No experimental confirmation available.

Length:1,072
Mass (Da):115,851
Last modified:July 5, 2004 - v1
Checksum:i53B1AF1338EBDB17
GO
Isoform 2 (identifier: Q6P1E1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-325: Missing.

Note: May be due to a competing acceptor splice site.

Show »
Length:1,066
Mass (Da):115,199
Checksum:i761BA804BFE025B4
GO

Sequence cautioni

The sequence BAC35753.1 differs from that shown. Reason: Intron retention.
The sequence BAC35753.1 differs from that shown. Reason: Frameshift at position 350.
The sequence AAH57691.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei320 – 3256Missing in isoform 2. 1 PublicationVSP_012187

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC057691 mRNA. Translation: AAH57691.1. Different initiation.
BC058646 mRNA. Translation: AAH58646.1.
BC065120 mRNA. Translation: AAH65120.1.
AK054366 mRNA. Translation: BAC35753.1. Sequence problems.
CCDSiCCDS26873.1. [Q6P1E1-1]
RefSeqiNP_899031.2. NM_183208.3. [Q6P1E1-1]
XP_006519196.1. XM_006519133.1. [Q6P1E1-2]
UniGeneiMm.227484.
Mm.486339.

Genome annotation databases

EnsembliENSMUST00000007961; ENSMUSP00000007961; ENSMUSG00000007817. [Q6P1E1-2]
ENSMUST00000162645; ENSMUSP00000124863; ENSMUSG00000007817. [Q6P1E1-1]
GeneIDi328365.
KEGGimmu:328365.
UCSCiuc007srn.2. mouse. [Q6P1E1-1]
uc007sro.2. mouse. [Q6P1E1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC057691 mRNA. Translation: AAH57691.1 . Different initiation.
BC058646 mRNA. Translation: AAH58646.1 .
BC065120 mRNA. Translation: AAH65120.1 .
AK054366 mRNA. Translation: BAC35753.1 . Sequence problems.
CCDSi CCDS26873.1. [Q6P1E1-1 ]
RefSeqi NP_899031.2. NM_183208.3. [Q6P1E1-1 ]
XP_006519196.1. XM_006519133.1. [Q6P1E1-2 ]
UniGenei Mm.227484.
Mm.486339.

3D structure databases

ProteinModelPortali Q6P1E1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6P1E1. 1 interaction.

PTM databases

PhosphoSitei Q6P1E1.

Proteomic databases

MaxQBi Q6P1E1.
PaxDbi Q6P1E1.
PRIDEi Q6P1E1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007961 ; ENSMUSP00000007961 ; ENSMUSG00000007817 . [Q6P1E1-2 ]
ENSMUST00000162645 ; ENSMUSP00000124863 ; ENSMUSG00000007817 . [Q6P1E1-1 ]
GeneIDi 328365.
KEGGi mmu:328365.
UCSCi uc007srn.2. mouse. [Q6P1E1-1 ]
uc007sro.2. mouse. [Q6P1E1-2 ]

Organism-specific databases

CTDi 57178.
MGIi MGI:3040693. Zmiz1.

Phylogenomic databases

eggNOGi NOG237400.
GeneTreei ENSGT00550000074410.
HOGENOMi HOG000253014.
HOVERGENi HBG056252.
InParanoidi Q6P1E1.
OMAi DFMHGPQ.
OrthoDBi EOG715Q3Q.
PhylomeDBi Q6P1E1.
TreeFami TF316952.

Miscellaneous databases

ChiTaRSi ZMIZ1. mouse.
NextBioi 398259.
PROi Q6P1E1.
SOURCEi Search...

Gene expression databases

Bgeei Q6P1E1.
CleanExi MM_ZMIZ1.
ExpressionAtlasi Q6P1E1. baseline and differential.
Genevestigatori Q6P1E1.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF02891. zf-MIZ. 1 hit.
[Graphical view ]
PROSITEi PS51044. ZF_SP_RING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6 and Czech II.
    Tissue: Brain and Mammary tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-416 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Ovary.
  3. "Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators."
    Beliakoff J., Sun Z.
    Nucl. Recept. Signal. 4:17-17(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiZMIZ1_MOUSE
AccessioniPrimary (citable) accession number: Q6P1E1
Secondary accession number(s): Q6PDK9, Q6PF85, Q8BW47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3