Tiam1

Functionⁱ

GO - Molecular functionⁱ

guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processⁱ

activation of GTPase activity Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Tiam1 proteinImported
Gene namesⁱ	Name:Tiam1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:103306. Tiam1.

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P1D6.
PaxDbⁱ	Q6P1D6.
PeptideAtlas More...PeptideAtlasⁱ	Q6P1D6.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q6P1D6. MM.

Genevisibleⁱ

Q6P1D6. MM.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P1D6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	439 – 547	PHInterPro annotationAdd BLAST		109

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	553 – 580	Sequence analysisAdd BLAST		28

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410ITS1. Eukaryota. ENOG410XPCM. LUCA.
HOGENOMⁱ	HOG000143385.
HOVERGENⁱ	HBG062357.
KEGG Orthology (KO) More...KOⁱ	K05731.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR011993. PH_dom-like. IPR001849. PH_domain. IPR033360. TIAM1.
PANTHERⁱ	PTHR22826:SF183. PTHR22826:SF183. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169. PH. 1 hit.
SMARTⁱ	View protein in SMART SM00233. PH. 1 hit.
SUPFAMⁱ	SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50003. PH_DOMAIN. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6P1D6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNAESQNVD HEFYGEKHAS LGRKHTSRSL RLSHKTRRTR HASSGKAIHR 
        60         70         80         90        100
NSEVSTRSSS TPSIPQSLAE NGLEPFSQEG ALDDFGDPIW VDRVDMGLRP 
       110        120        130        140        150
VSYTDSSVTP SVDGSIVLTA ASVQSMPDSE ESRLYGDDAT YLAEGGRRQC 
       160        170        180        190        200
PYTSNGPTFM ETASFKKKRS KSADIWREDS LEFSLSDLSQ EHLTSNEEIL 
       210        220        230        240        250
GSAEEKDCEE ARGMETEASP RQLSTCQRAN SLGDLYAQKN SGVKANGGPR 
       260        270        280        290        300
NRFSSYCRNL VSDIPDLAKH KMPPAAAEET PPYSNYNTLP CRKSHCLSEG 
       310        320        330        340        350
ATNPQISLSK SMQGRRAKTT QDVNTGEGSE FADSGIEGAT TDTDLLSRRS 
       360        370        380        390        400
NATNSSYSPP TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTTNSES 
       410        420        430        440        450
LEEAGSAHSD EQSSGTLSSP GQSDILLTAA QGTVRKAGAL AVKNFLVHKK 
       460        470        480        490        500
NKKVESATRR KWKHYWVSLK GCTLFFYETD GRSGIDHNSV PKHAVWVENS 
       510        520        530        540        550
IVQAVPEHPK KDFVFCLSNS LGDAFLFQTT SQTELENWIT AIHSACAAAV 
       560        570        580        590        600
ARHHHKEDTL RLLKSEIKKL EQKIDMDEKM KKMGEMQLSS VTDSKKKKTI 
       610        620        630        640        650
LDQIFVWEQN LEQFQMDLFR FRCYLASLQG GELPNPKRLL AFASRPTKVA 
       660        670        680        690        700
MGRLGIFSVS SFHALVAART GEIGVRRRTQ AMSRSASKRR SRKDFLKSVH 
       710        720        730        740        750
SILRDKHRRQ LLKTESLPSA QQYVPFGGKR LCALKGARPA MSRAVSAPSK 
       760        770        780        790        800
SLGRRRRRLA RNRFTIDSDA ISASSPEKEP QQPAGGGDTD RWVEEQFDLA 
       810        820        830        840        850
QYEEQDDIKE TDILSDDDEF CESLKGASVD RDLQEQLQAA SISQRARGRR 
       860        870        880        890        900
TLDSHASRMT QLKKQAALSG INGGLESASE EVIWVRREDF APSRKLNTEI

Length:900

Mass (Da):99,653

Last modified:July 5, 2004 - v1

Checksum:ⁱ989A5DF2440ABA50

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC065126 mRNA. Translation: AAH65126.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001139358.1. NM_001145886.1. NP_001139359.1. NM_001145887.1. NP_033410.2. NM_009384.3.
UniGeneⁱ	Mm.310902.

Genome annotation databases

GeneIDⁱ	21844.
KEGGⁱ	mmu:21844.
UCSC genome browser More...UCSCⁱ	uc007zvw.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC065126 mRNA. Translation: AAH65126.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001139358.1. NM_001145886.1. NP_001139359.1. NM_001145887.1. NP_033410.2. NM_009384.3.
UniGeneⁱ	Mm.310902.

3D structure databases

ProteinModelPortalⁱ	Q6P1D6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P1D6.
PaxDbⁱ	Q6P1D6.
PeptideAtlas More...PeptideAtlasⁱ	Q6P1D6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	21844.
KEGGⁱ	mmu:21844.
UCSC genome browser More...UCSCⁱ	uc007zvw.2. mouse.

Organism-specific databases

CTDⁱ	7074.
MGIⁱ	MGI:103306. Tiam1.

Phylogenomic databases

eggNOGⁱ	ENOG410ITS1. Eukaryota. ENOG410XPCM. LUCA.
HOGENOMⁱ	HOG000143385.
HOVERGENⁱ	HBG062357.
KEGG Orthology (KO) More...KOⁱ	K05731.

Miscellaneous databases

ChiTaRSⁱ	Tiam1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Genevisibleⁱ	Q6P1D6. MM.

Genevisibleⁱ

Q6P1D6. MM.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR011993. PH_dom-like. IPR001849. PH_domain. IPR033360. TIAM1.
PANTHERⁱ	PTHR22826:SF183. PTHR22826:SF183. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169. PH. 1 hit.
SMARTⁱ	View protein in SMART SM00233. PH. 1 hit.
SUPFAMⁱ	SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50003. PH_DOMAIN. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q6P1D6_MOUSE
Accessionⁱ	Q6P1D6Primary (citable) accession number: Q6P1D6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 5, 2004
	Last sequence update:	July 5, 2004
	Last modified:	July 5, 2017
	This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q6P1D6 (Q6P1D6_MOUSE)

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Tiam1 protein

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6P1D6 (Q6P1D6_MOUSE)

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Tiam1 protein

Tiam1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ