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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 3

Gene

Lrig3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.2 Publications

GO - Biological processi

  • otolith morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 3
Short name:
LIG-3
Gene namesi
Name:Lrig3
Synonyms:Kiaa3016
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2443955. Lrig3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei810 – 830HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display circling and head tossing behavior, due to a defect in inner ear morphogenesis. In mutants, fusion of the canal pouches starts earlier than normal and involves an abnormally large region, leading to truncation of the lateral semicircular canal in the inner ear. Nevertheless, hearing seems to be normal. Mutant mice also display craniofacial deformities, and especially a dramatically shortened snout.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001483225 – 1117Leucine-rich repeats and immunoglobulin-like domains protein 3Add BLAST1093

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi442N-linked (GlcNAc...)Sequence analysis1
Glycosylationi469N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi520 ↔ 581PROSITE-ProRule annotation
Disulfide bondi624 ↔ 676PROSITE-ProRule annotation
Glycosylationi688N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi718 ↔ 767PROSITE-ProRule annotation
Glycosylationi729N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1014N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6P1C6.
PRIDEiQ6P1C6.

PTM databases

iPTMnetiQ6P1C6.
PhosphoSitePlusiQ6P1C6.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Detected in the lateral wall of the otic vesicle at 10.5 dpc. Enriched in lateral pouch epithelium at 12.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000020105.
GenevisibleiQ6P1C6. MM.

Interactioni

Subunit structurei

Interacts with EGFR, ERBB2 and ERBB4 (in vitro).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074360.

Structurei

Secondary structure

11117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni491 – 494Combined sources4
Beta strandi500 – 503Combined sources4
Beta strandi508 – 511Combined sources4
Beta strandi516 – 525Combined sources10
Beta strandi531 – 536Combined sources6
Beta strandi545 – 551Combined sources7
Helixi554 – 556Combined sources3
Beta strandi560 – 568Combined sources9
Helixi573 – 575Combined sources3
Beta strandi577 – 585Combined sources9
Beta strandi588 – 591Combined sources4
Beta strandi595 – 600Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SO5X-ray1.70A/B490-600[»]
ProteinModelPortaliQ6P1C6.
SMRiQ6P1C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 74LRRNTAdd BLAST37
Repeati75 – 98LRR 1Add BLAST24
Repeati99 – 120LRR 2Add BLAST22
Repeati122 – 143LRR 3Add BLAST22
Repeati146 – 168LRR 4Add BLAST23
Repeati169 – 189LRR 5Add BLAST21
Repeati193 – 214LRR 6Add BLAST22
Repeati216 – 237LRR 7Add BLAST22
Repeati240 – 261LRR 8Add BLAST22
Repeati264 – 285LRR 9Add BLAST22
Repeati288 – 309LRR 10Add BLAST22
Repeati312 – 333LRR 11Add BLAST22
Repeati336 – 357LRR 12Add BLAST22
Repeati360 – 382LRR 13Add BLAST23
Repeati387 – 408LRR 14Add BLAST22
Repeati411 – 432LRR 15Add BLAST22
Domaini444 – 495LRRCTAdd BLAST52
Domaini499 – 598Ig-like C2-type 1Add BLAST100
Domaini603 – 692Ig-like C2-type 2Add BLAST90
Domaini697 – 783Ig-like C2-type 3Add BLAST87

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG4194. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiQ6P1C6.
OMAiMEPGYFD.
OrthoDBiEOG091G04H0.
PhylomeDBiQ6P1C6.
TreeFamiTF325380.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52058. SSF52058. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P1C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPGLRAAT AALGLLLCAG LGRAGPAGSG GHGAPGQLLD DDAQRPCPAA
60 70 80 90 100
CHCLGDLLDC SRRRLVRLPD PLPAWVTRLD LSHNRLSFIQ TSSLSHLQSL
110 120 130 140 150
QEVKLNNNEL ETIPNLGSIS ANIRQLSLAG NAIDKILPEQ LEAFQSLETL
160 170 180 190 200
DLSNNNISEL RTAFPPLQLK YLYINNNRVS SMEPGYFDNL ASTLLVLKLN
210 220 230 240 250
RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA LKSLKMQRNG
260 270 280 290 300
VTKLMDGAFW GLSNMEVLQL DHNNLTEITK GWLYGLLMLR ELHLSQNAIN
310 320 330 340 350
RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNAL HIGNNKVSYI
360 370 380 390 400
ADCAFRGLTS LKTLDLRNNE ISWTIEDMSG AFSGLDRLRQ LILQGNRIRS
410 420 430 440 450
ITKKAFAGLD TLEHLDLSGN AIMSLQSNAF SQMKKLQQLH LNTSSLLCDC
460 470 480 490 500
QLRWLPQWVA ENNFQSFVNA SCAHPQLLKG RSIFTVSPDG FVCDDFPKPQ
510 520 530 540 550
ITVQPETQSA IKGSDVSFTC SAASSSDSPM TFAWKKDNEA LQDAEMENYA
560 570 580 590 600
HLRAQGGELM EYTTILRLRN VEFTSEGKYQ CVISNHFGSS YSVKAKLTIN
610 620 630 640 650
MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER
660 670 680 690 700
RMHVMPEDDV FFIVDVKIED IGVYSCTAQN SAGSVSANAT LTVLETPSFL
710 720 730 740 750
RPLLDRTVTK GETAVLQCIA GGSPPPRLNW TKDDSPLVVT ERHFFAAGNQ
760 770 780 790 800
LLIIVDSDVS DAGKYTCEMS NTLGTERGNV RLSVIPTPTC DSPHMTAPSL
810 820 830 840 850
DGDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC SITNTDETNL
860 870 880 890 900
PADIPSYLSS QGTLADRQDG YISSESGSHH QFVTSSGGGF FLPQHDGAGT
910 920 930 940 950
CHFDDSSEAD VEAASDPFLC PFVGSTGPVY LQGNLYSPDP FEVYLPGCSS
960 970 980 990 1000
DPRTALMDHC ESSYVKQDRF SCARPSEEPC ERSLKSIPWP HSRKLTDSTY
1010 1020 1030 1040 1050
PPNEGHTVQT LCLNKSSVDF STGPEPGSAT SSNSFMGTFG KPLRRPHLDA
1060 1070 1080 1090 1100
FSSSAQPPDC QPRPCHGKSL SSPELDSESE ENDKERTDFR EENHRCTYQQ
1110
IFHTYRTPDC QPCDSDT
Length:1,117
Mass (Da):122,688
Last modified:July 5, 2004 - v1
Checksum:i107A1B6960BF6A37
GO

Sequence cautioni

The sequence BAC32175 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC98291 differs from that shown. Reason: Frameshift at position 410.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti467F → L in AAR98630 (PubMed:15203213).Curated1
Sequence conflicti561 – 571Missing in BAC98291 (PubMed:12693553).CuratedAdd BLAST11
Sequence conflicti1054S → F in BAC98291 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY505341 mRNA. Translation: AAR98630.1.
BC065142 mRNA. Translation: AAH65142.1.
AK044994 mRNA. Translation: BAC32175.1. Different initiation.
AK078783 mRNA. Translation: BAC37394.1.
AK129481 mRNA. Translation: BAC98291.1. Frameshift.
CCDSiCCDS24219.1.
RefSeqiNP_796126.4. NM_177152.5.
UniGeneiMm.275586.

Genome annotation databases

EnsembliENSMUST00000074807; ENSMUSP00000074360; ENSMUSG00000020105.
GeneIDi320398.
KEGGimmu:320398.
UCSCiuc007hhc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY505341 mRNA. Translation: AAR98630.1.
BC065142 mRNA. Translation: AAH65142.1.
AK044994 mRNA. Translation: BAC32175.1. Different initiation.
AK078783 mRNA. Translation: BAC37394.1.
AK129481 mRNA. Translation: BAC98291.1. Frameshift.
CCDSiCCDS24219.1.
RefSeqiNP_796126.4. NM_177152.5.
UniGeneiMm.275586.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SO5X-ray1.70A/B490-600[»]
ProteinModelPortaliQ6P1C6.
SMRiQ6P1C6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074360.

PTM databases

iPTMnetiQ6P1C6.
PhosphoSitePlusiQ6P1C6.

Proteomic databases

PaxDbiQ6P1C6.
PRIDEiQ6P1C6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074807; ENSMUSP00000074360; ENSMUSG00000020105.
GeneIDi320398.
KEGGimmu:320398.
UCSCiuc007hhc.2. mouse.

Organism-specific databases

CTDi121227.
MGIiMGI:2443955. Lrig3.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG4194. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiQ6P1C6.
OMAiMEPGYFD.
OrthoDBiEOG091G04H0.
PhylomeDBiQ6P1C6.
TreeFamiTF325380.

Miscellaneous databases

PROiQ6P1C6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020105.
GenevisibleiQ6P1C6. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52058. SSF52058. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRIG3_MOUSE
AccessioniPrimary (citable) accession number: Q6P1C6
Secondary accession number(s): Q6ZPE6
, Q8BRF0, Q8BS51, Q8C5E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.