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Protein

Inositol-pentakisphosphate 2-kinase

Gene

Ippk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1855167. Synthesis of pyrophosphates in the cytosol.
R-MMU-1855191. Synthesis of IPs in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-pentakisphosphate 2-kinase (EC:2.7.1.158)
Alternative name(s):
Inositol-1,3,4,5,6-pentakisphosphate 2-kinase
Ins(1,3,4,5,6)P5 2-kinase
Short name:
InsP5 2-kinase
Gene namesi
Name:Ippk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1922928. Ippk.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Death during ermbryogenesis before 8.5 dpc, suggesting that InsP6 is required for yolk sac function and development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105301 – 489Inositol-pentakisphosphate 2-kinaseAdd BLAST489

Proteomic databases

PaxDbiQ6P1C1.
PRIDEiQ6P1C1.

PTM databases

iPTMnetiQ6P1C1.
PhosphoSitePlusiQ6P1C1.

Expressioni

Tissue specificityi

In brain, it is expressed throughout the hippocampus (CA1, CA2, CA3 and dentate gyrus), inner layers of the cerebral cortex, and Purkinje cells of the cerebellum. In heart, it is expressed in cardiomyocytes but not in interstitial cells, blood vessels, or valves. Also expressed in testis.1 Publication

Developmental stagei

In E9 embryos it is expressed in regions corresponding to the neural tube, notochord and somites. Through the neural tube, it is expressed in the ventricular zone and in migrating neuroblasts. Also expressed in the notochord and specific regions of the somite. Strongly expressed in the myotome (future skeletal muscle) of the somite. In addition to the neural tube, it is also expressed in the ventricular zone and migrating neuroblasts throughout the embryonic brain. Prominent expression is detected in the yolk sac and embryonic heart. Within the yolk sac, it is expressed in both the epithelial and endothelial layers (blood vessels) but absent from the blood islands. In the heart, it is detected in both the atrial and ventricular chambers. In the ventricular myocardium it is present in both the endocardium and myocardium. Also expressed in the cardinal vein, aorta, digestive tract, and pharyngeal arches.

Gene expression databases

BgeeiENSMUSG00000021385.
CleanExiMM_IPPK.
GenevisibleiQ6P1C1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021817.

Structurei

3D structure databases

ProteinModelPortaliQ6P1C1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi136 – 140EXKPK motif5

Domaini

The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

Sequence similaritiesi

Belongs to the IPK1 type 2 family.Curated

Phylogenomic databases

eggNOGiKOG4749. Eukaryota.
ENOG410XSF2. LUCA.
GeneTreeiENSGT00390000010053.
HOGENOMiHOG000113092.
HOVERGENiHBG079461.
InParanoidiQ6P1C1.
KOiK10572.
OMAiTVMSTRF.
OrthoDBiEOG091G05DL.
PhylomeDBiQ6P1C1.
TreeFamiTF106142.

Family and domain databases

InterProiIPR009286. Ins_P5_2-kin.
[Graphical view]
PfamiPF06090. Ins_P5_2-kin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P1C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGKMDENE WSYHGEGNKS LVVAHAQRCV VLRFLKFPPN KKKTSEEILQ
60 70 80 90 100
HLQNIVDFGK NVMKDFLGEN YVHCGEVVQL PLEFVKQLCL KIQCERPESR
110 120 130 140 150
CDKDLDTFSG YAMCLPNLTR LQTFHFAEHR PILCVEIKPK CGFIPFSNDV
160 170 180 190 200
THEMKHKVCR YCMHQHLKVA TGKWKKISKY CPLDLYSGNK QRMHFALRSL
210 220 230 240 250
LQETQNNLRI FKNGELIYGC GDARSPVADL KELAHHLKPF FFPSNGLASG
260 270 280 290 300
PHCTKAVIRE LVHVITRVLL SSSEKARAGA LRLGLQGPRV CEASPFSRSL
310 320 330 340 350
HNQGKNTSEH SGLPKGCLLY KTLQVQMLDQ LDIEGLYPLY KRVEQYLEEF
360 370 380 390 400
PEERKTLQID GPYDEVFYQK LLDLSTEDDG TVAFALTKVQ QYRVAMTAKD
410 420 430 440 450
CSIMIALSPC LQGTSSDQRP VIPSSRSRLA FSVSVLDLDL KPYESIPHQY
460 470 480
KLDSKIVNYY SKTVHAKDDT VRSTRFKEHE DCTLVLHKV
Length:489
Mass (Da):55,928
Last modified:July 5, 2004 - v1
Checksum:i441839EA3F425D5A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83E → Q in BAE20447 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029085 mRNA. Translation: BAE20447.1.
AK160092 mRNA. Translation: BAE35623.1.
AK167467 mRNA. Translation: BAE39551.1.
BC062167 mRNA. Translation: AAH62167.1.
BC065157 mRNA. Translation: AAH65157.1.
CCDSiCCDS26500.1.
RefSeqiNP_951011.1. NM_199056.3.
UniGeneiMm.390586.

Genome annotation databases

EnsembliENSMUST00000021817; ENSMUSP00000021817; ENSMUSG00000021385.
GeneIDi75678.
KEGGimmu:75678.
UCSCiuc007qjj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029085 mRNA. Translation: BAE20447.1.
AK160092 mRNA. Translation: BAE35623.1.
AK167467 mRNA. Translation: BAE39551.1.
BC062167 mRNA. Translation: AAH62167.1.
BC065157 mRNA. Translation: AAH65157.1.
CCDSiCCDS26500.1.
RefSeqiNP_951011.1. NM_199056.3.
UniGeneiMm.390586.

3D structure databases

ProteinModelPortaliQ6P1C1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021817.

PTM databases

iPTMnetiQ6P1C1.
PhosphoSitePlusiQ6P1C1.

Proteomic databases

PaxDbiQ6P1C1.
PRIDEiQ6P1C1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021817; ENSMUSP00000021817; ENSMUSG00000021385.
GeneIDi75678.
KEGGimmu:75678.
UCSCiuc007qjj.2. mouse.

Organism-specific databases

CTDi64768.
MGIiMGI:1922928. Ippk.

Phylogenomic databases

eggNOGiKOG4749. Eukaryota.
ENOG410XSF2. LUCA.
GeneTreeiENSGT00390000010053.
HOGENOMiHOG000113092.
HOVERGENiHBG079461.
InParanoidiQ6P1C1.
KOiK10572.
OMAiTVMSTRF.
OrthoDBiEOG091G05DL.
PhylomeDBiQ6P1C1.
TreeFamiTF106142.

Enzyme and pathway databases

ReactomeiR-MMU-1855167. Synthesis of pyrophosphates in the cytosol.
R-MMU-1855191. Synthesis of IPs in the nucleus.

Miscellaneous databases

PROiQ6P1C1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021385.
CleanExiMM_IPPK.
GenevisibleiQ6P1C1. MM.

Family and domain databases

InterProiIPR009286. Ins_P5_2-kin.
[Graphical view]
PfamiPF06090. Ins_P5_2-kin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPPK_MOUSE
AccessioniPrimary (citable) accession number: Q6P1C1
Secondary accession number(s): Q3V3Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.