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Q6P1B1 (XPP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Xaa-Pro aminopeptidase 1
EC=3.4.11.9
Alternative name(s):
Aminoacylproline aminopeptidase
Cytosolic aminopeptidase P
Soluble aminopeptidase P
Short name=sAmp
X-Pro aminopeptidase 1
X-prolyl aminopeptidase 1, soluble
Gene names
Name:Xpnpep1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro By similarity.

Catalytic activity

Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. UniProtKB Q9NQW7

Cofactor

Binds 2 manganese ions per subunit By similarity.

Subunit structure

Homodimer By similarity. UniProtKB Q9NQW7

Subcellular location

Cytoplasm By similarity UniProtKB O54975.

Sequence similarities

Belongs to the peptidase M24B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 623622Xaa-Pro aminopeptidase 1
PRO_0000185084

Sites

Metal binding4151Manganese 1 By similarity
Metal binding4261Manganese 1 By similarity
Metal binding4261Manganese 2 By similarity
Metal binding4891Manganese 2 By similarity
Metal binding5231Manganese 1 By similarity
Metal binding5231Manganese 2 By similarity
Metal binding5371Manganese 1 By similarity
Metal binding5371Manganese 2 By similarity

Amino acid modifications

Modified residue3041N6-acetyllysine By similarity

Experimental info

Sequence conflict3471W → R in AAK48945. Ref.1
Sequence conflict4571A → T in AAK48945. Ref.1
Sequence conflict5441P → A in AAK48945. Ref.1
Sequence conflict5521N → T in AAK48945. Ref.1
Sequence conflict5561S → T in AAK48945. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6P1B1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3DACC2C5EDA74B9A

FASTA62369,591
        10         20         30         40         50         60 
MAPKVTSELL RQLRQAMRNS EYVAEPIQAY IIPSGDAHQS EYIAPCDCRR AFVSGFDGSA 

        70         80         90        100        110        120 
GTAIITEEHA AMWTDGRYFL QAAKQMDNNW TLMKMGLKDT PTQEDWLVSV LPEGSRVGVD 

       130        140        150        160        170        180 
PLIIPTDYWK KMAKVLRSAG HHLVPVKENL VDKIWTDRPE RPCKPLLTLG LDYTGISWKE 

       190        200        210        220        230        240 
KVADLRLKMA ERSIAWFVVT ALDEIAWLFN LRGSDVEHNP VFFSYAIVGL ETIMLFIDGD 

       250        260        270        280        290        300 
RVDAPGVKQH LLLDLGLEAE YRIQVLPYKS ILSELKALCA DLSPREKVWV SDKASYAVSE 

       310        320        330        340        350        360 
AIPKDHRCCM PYTPICIAKA VKNSAESDGM RRAHIKDAVA LCELFNWLEQ EVPKGGVTEI 

       370        380        390        400        410        420 
SAADKAEEFR RQQADFVDLS FPTISSTGPN GAIIHYAPVP ETNRTLSLDE VYLIDSGAQY 

       430        440        450        460        470        480 
KDGTTDVTRT MHFGTPTAYE KECFTYVLKG HIAVSAAVFP TGTKGHLLDS FARSALWDSG 

       490        500        510        520        530        540 
LDYLHGTGHG VGSFLNVHEG PCGISYKTFS DEPLEAGMIV TDEPGYYEDG AFGIRIENVV 

       550        560        570        580        590        600 
LVVPAKTKYN FNNRGSLTFE PLTLVPIQTK MIDVNALTDK ECDWLNSYHQ TCRDVVGKEL 

       610        620 
QSQGRQEALE WLIRETEPVS RQH

« Hide

References

« Hide 'large scale' references
[1]"Mouse soluble (cytosolic) aminopeptidase P."
Ryan J.W., Bondarev I.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF363970 mRNA. Translation: AAK48945.1.
BC065174 mRNA. Translation: AAH65174.1.
IPIIPI00420231.
RefSeqNP_573479.3. NM_133216.3.
UniGeneMm.99776.

3D structure databases

ProteinModelPortalQ6P1B1.
SMRQ6P1B1. Positions 3-619.
ModBaseSearch...

Protein family/group databases

MEROPSM24.009.

PTM databases

PhosphoSiteQ6P1B1.

Proteomic databases

PaxDbQ6P1B1.
PRIDEQ6P1B1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000069988; ENSMUSP00000070946; ENSMUSG00000025027.
GeneID170750.
KEGGmmu:170750.

Organism-specific databases

CTD7511.
MGIMGI:2180003. Xpnpep1.

Phylogenomic databases

eggNOGCOG0006.
GeneTreeENSGT00390000013970.
HOGENOMHOG000255713.
HOVERGENHBG002934.
InParanoidQ6P1B1.
KOK01262.
OMASRYWEQA.
OrthoDBEOG4BZN23.

Gene expression databases

ArrayExpressQ6P1B1.
BgeeQ6P1B1.
GenevestigatorQ6P1B1.
GermOnlineENSMUSG00000025027. Mus musculus.

Family and domain databases

Gene3D3.90.230.10. 1 hit.
InterProIPR000587. Creatinase.
IPR000994. Pept_M24_structural-domain.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamPF01321. Creatinase_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
SUPFAMSSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITEPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio370326.
SOURCESearch...

Entry information

Entry nameXPP1_MOUSE
AccessionPrimary (citable) accession number: Q6P1B1
Secondary accession number(s): Q91Y37
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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