Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

39S ribosomal protein L54, mitochondrial

Gene

MRPL54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L54, mitochondrial
Short name:
L54mt
Short name:
MRP-L54
Gene namesi
Name:MRPL54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16685. MRPL54.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30987.

Polymorphism and mutation databases

BioMutaiMRPL54.
DMDMi74737109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1414MitochondrionSequence analysisAdd
BLAST
Chaini15 – 13812439S ribosomal protein L54, mitochondrialPRO_0000278280Add
BLAST

Proteomic databases

EPDiQ6P161.
MaxQBiQ6P161.
PaxDbiQ6P161.
PeptideAtlasiQ6P161.
PRIDEiQ6P161.
TopDownProteomicsiQ6P161.

PTM databases

PhosphoSiteiQ6P161.

Expressioni

Gene expression databases

BgeeiQ6P161.
CleanExiHS_MRPL54.
ExpressionAtlasiQ6P161. baseline and differential.
GenevisibleiQ6P161. HS.

Organism-specific databases

HPAiHPA042117.
HPA046767.

Interactioni

Protein-protein interaction databases

BioGridi125522. 11 interactions.
IntActiQ6P161. 8 interactions.
STRINGi9606.ENSP00000331849.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50l1-138[»]
ProteinModelPortaliQ6P161.
SMRiQ6P161. Positions 102-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3435. Eukaryota.
ENOG411244M. LUCA.
GeneTreeiENSGT00390000001201.
HOGENOMiHOG000068097.
HOVERGENiHBG093903.
InParanoidiQ6P161.
KOiK17435.
OMAiRLTTYAM.
OrthoDBiEOG7DJSQ4.
PhylomeDBiQ6P161.
TreeFamiTF314007.

Family and domain databases

InterProiIPR013870. Ribosomal_L37_mit.
[Graphical view]
PfamiPF08561. Ribosomal_L37. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKRLFGAT RTWAGWGAWE LLNPATSGRL LARDYAKKPV MKGAKSGKGA
60 70 80 90 100
VTSEALKDPD VCTDPVQLTT YAMGVNIYKE GQDVPLKPDA EYPEWLFEMN
110 120 130
LGPPKTLEEL DPESREYWRR LRKQNIWRHN RLSKNKRL
Length:138
Mass (Da):15,819
Last modified:July 5, 2004 - v1
Checksum:i98E0FCA10592B064
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065273 mRNA. Translation: AAH65273.1.
CCDSiCCDS12111.1.
RefSeqiNP_758455.1. NM_172251.2.
UniGeneiHs.356578.

Genome annotation databases

EnsembliENST00000330133; ENSP00000331849; ENSG00000183617.
GeneIDi116541.
KEGGihsa:116541.
UCSCiuc002lyq.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065273 mRNA. Translation: AAH65273.1.
CCDSiCCDS12111.1.
RefSeqiNP_758455.1. NM_172251.2.
UniGeneiHs.356578.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50l1-138[»]
ProteinModelPortaliQ6P161.
SMRiQ6P161. Positions 102-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125522. 11 interactions.
IntActiQ6P161. 8 interactions.
STRINGi9606.ENSP00000331849.

PTM databases

PhosphoSiteiQ6P161.

Polymorphism and mutation databases

BioMutaiMRPL54.
DMDMi74737109.

Proteomic databases

EPDiQ6P161.
MaxQBiQ6P161.
PaxDbiQ6P161.
PeptideAtlasiQ6P161.
PRIDEiQ6P161.
TopDownProteomicsiQ6P161.

Protocols and materials databases

DNASUi116541.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330133; ENSP00000331849; ENSG00000183617.
GeneIDi116541.
KEGGihsa:116541.
UCSCiuc002lyq.5. human.

Organism-specific databases

CTDi116541.
GeneCardsiMRPL54.
HGNCiHGNC:16685. MRPL54.
HPAiHPA042117.
HPA046767.
MIMi611858. gene.
neXtProtiNX_Q6P161.
PharmGKBiPA30987.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3435. Eukaryota.
ENOG411244M. LUCA.
GeneTreeiENSGT00390000001201.
HOGENOMiHOG000068097.
HOVERGENiHBG093903.
InParanoidiQ6P161.
KOiK17435.
OMAiRLTTYAM.
OrthoDBiEOG7DJSQ4.
PhylomeDBiQ6P161.
TreeFamiTF314007.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

GenomeRNAii116541.
PROiQ6P161.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P161.
CleanExiHS_MRPL54.
ExpressionAtlasiQ6P161. baseline and differential.
GenevisibleiQ6P161. HS.

Family and domain databases

InterProiIPR013870. Ribosomal_L37_mit.
[Graphical view]
PfamiPF08561. Ribosomal_L37. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM54_HUMAN
AccessioniPrimary (citable) accession number: Q6P161
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.