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Protein

39S ribosomal protein L54, mitochondrial

Gene

MRPL54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L54, mitochondrial
Short name:
L54mt
Short name:
MRP-L54
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL541 Publication
Gene namesi
Name:MRPL54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16685. MRPL54.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183617.
PharmGKBiPA30987.

Polymorphism and mutation databases

BioMutaiMRPL54.
DMDMi74737109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 14MitochondrionSequence analysisAdd BLAST14
ChainiPRO_000027828015 – 13839S ribosomal protein L54, mitochondrialAdd BLAST124

Proteomic databases

EPDiQ6P161.
MaxQBiQ6P161.
PaxDbiQ6P161.
PeptideAtlasiQ6P161.
PRIDEiQ6P161.
TopDownProteomicsiQ6P161.

Expressioni

Gene expression databases

BgeeiENSG00000183617.
CleanExiHS_MRPL54.
ExpressionAtlasiQ6P161. baseline and differential.
GenevisibleiQ6P161. HS.

Organism-specific databases

HPAiHPA042117.
HPA046767.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi125522. 13 interactors.
IntActiQ6P161. 8 interactors.
STRINGi9606.ENSP00000331849.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50l1-138[»]
ProteinModelPortaliQ6P161.
SMRiQ6P161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3435. Eukaryota.
ENOG411244M. LUCA.
GeneTreeiENSGT00390000001201.
HOGENOMiHOG000068097.
HOVERGENiHBG093903.
InParanoidiQ6P161.
KOiK17435.
OMAiRLTTYAM.
OrthoDBiEOG091G0TM2.
PhylomeDBiQ6P161.
TreeFamiTF314007.

Family and domain databases

InterProiView protein in InterPro
IPR013870. Ribosomal_L37_mit.
PfamiView protein in Pfam
PF08561. Ribosomal_L37. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKRLFGAT RTWAGWGAWE LLNPATSGRL LARDYAKKPV MKGAKSGKGA
60 70 80 90 100
VTSEALKDPD VCTDPVQLTT YAMGVNIYKE GQDVPLKPDA EYPEWLFEMN
110 120 130
LGPPKTLEEL DPESREYWRR LRKQNIWRHN RLSKNKRL
Length:138
Mass (Da):15,819
Last modified:July 5, 2004 - v1
Checksum:i98E0FCA10592B064
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065273 mRNA. Translation: AAH65273.1.
CCDSiCCDS12111.1.
RefSeqiNP_758455.1. NM_172251.2.
UniGeneiHs.356578.

Genome annotation databases

EnsembliENST00000330133; ENSP00000331849; ENSG00000183617.
GeneIDi116541.
KEGGihsa:116541.
UCSCiuc002lyq.5. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRM54_HUMAN
AccessioniPrimary (citable) accession number: Q6P161
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: April 12, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references