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Q6P158 (DHX57_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative ATP-dependent RNA helicase DHX57

EC=3.6.4.13
Alternative name(s):
DEAH box protein 57
Gene names
Name:DHX57
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1386 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable ATP-binding RNA helicase.

Catalytic activity

ATP + H2O = ADP + phosphate.

Sequence similarities

Belongs to the DEAD box helicase family. DEAH subfamily.

Contains 1 C3H1-type zinc finger.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Contains 1 UBA domain.

Sequence caution

The sequence AAM73547.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAY24256.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6P158-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6P158-2)

The sequence of this isoform differs from the canonical sequence as follows:
     636-658: SSATRLLYCTTGVLLRRLEGDTA → VCMLCLFPGNRNLWFLGIKSFGG
     659-1386: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6P158-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     530-535: ASRQFQ → VLNSHM
     536-1386: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13861386Putative ATP-dependent RNA helicase DHX57
PRO_0000233151

Regions

Domain180 – 22041UBA
Domain554 – 721168Helicase ATP-binding
Domain830 – 1010181Helicase C-terminal
Zinc finger299 – 32628C3H1-type
Nucleotide binding567 – 5748ATP By similarity
Coiled coil101 – 12525 Potential
Motif668 – 6714DEVH box
Compositional bias9 – 4941Gly-rich

Amino acid modifications

Modified residue1271Phosphoserine Ref.5 Ref.8 Ref.10
Modified residue4751Phosphoserine Ref.6
Modified residue4771Phosphoserine Ref.6
Modified residue4801Phosphoserine Ref.5 Ref.6

Natural variations

Alternative sequence1 – 102102Missing in isoform 3.
VSP_018056
Alternative sequence530 – 5356ASRQFQ → VLNSHM in isoform 3.
VSP_018057
Alternative sequence536 – 1386851Missing in isoform 3.
VSP_018058
Alternative sequence636 – 65823SSATR…EGDTA → VCMLCLFPGNRNLWFLGIKS FGG in isoform 2.
VSP_018059
Alternative sequence659 – 1386728Missing in isoform 2.
VSP_018060
Natural variant4101S → F.
Corresponds to variant rs11893062 [ dbSNP | Ensembl ].
VAR_052190
Natural variant4331S → G.
Corresponds to variant rs35371077 [ dbSNP | Ensembl ].
VAR_033861
Natural variant5871N → S. Ref.3 Ref.4
Corresponds to variant rs7598922 [ dbSNP | Ensembl ].
VAR_052191

Experimental info

Sequence conflict4741A → T in BAB71479. Ref.1
Sequence conflict9761L → V in AAM73547. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: FFF62BD4BF4C1F4D

FASTA1,386155,604
        10         20         30         40         50         60 
MSSSVRRKGK PGKGGGKGSS RGGRGGRSHA SKSHGSGGGG GGGGGGGGGN RKASSRIWDD 

        70         80         90        100        110        120 
GDDFCIFSES RRPSRPSNSN ISKGESRPKW KPKAKVPLQT LHMTSENQEK VKALLRDLQE 

       130        140        150        160        170        180 
QDADAGSERG LSGEEEDDEP DCCNDERYWP AGQEPSLVPD LDPLEYAGLA SVEPYVPEFT 

       190        200        210        220        230        240 
VSPFAVQKLS RYGFNTERCQ AVLRMCDGDV GASLEHLLTQ CFSETFGERM KISEAVNQIS 

       250        260        270        280        290        300 
LDECMEQRQE EAFALKSICG EKFIERIQNR VWTIGLELEY LTSRFRKSKP KESTKNVQEN 

       310        320        330        340        350        360 
SLEICKFYLK GNCKFGSKCR FKHEVPPNQI VGRIERSVDD SHLNAIEDAS FLYELEIRFS 

       370        380        390        400        410        420 
KDHKYPYQAP LVAFYSTNEN LPLACRLHIS EFLYDKALTF AETSEPVVYS LITLLEEESE 

       430        440        450        460        470        480 
IVKLLTNTHH KYSDPPVNFL PVPSRTRINN PACHKTVIPN NSFVSNQIPE VEKASESEES 

       490        500        510        520        530        540 
DEDDGPAPVI VENESYVNLK KKISKRYDWQ AKSVHAENGK ICKQFRMKQA SRQFQSILQE 

       550        560        570        580        590        600 
RQSLPAWEER ETILNLLRKH QVVVISGMTG CGKTTQIPQF ILDDSLNGPP EKVANIICTQ 

       610        620        630        640        650        660 
PRRISAISVA ERVAKERAER VGLTVGYQIR LESVKSSATR LLYCTTGVLL RRLEGDTALQ 

       670        680        690        700        710        720 
GVSHIIVDEV HERTEESDFL LLVLKDIVSQ RPGLQVILMS ATLNAELFSD YFNSCPVITI 

       730        740        750        760        770        780 
PGRTFPVDQF FLEDAIAVTR YVLQDGSPYM RSMKQISKEK LKARRNRTAF EEVEEDLRLS 

       790        800        810        820        830        840 
LHLQDQDSVK DAVPDQQLDF KQLLARYKGV SKSVIKTMSI MDFEKVNLEL IEALLEWIVD 

       850        860        870        880        890        900 
GKHSYPPGAI LVFLPGLAEI KMLYEQLQSN SLFNNRRSNR CVIHPLHSSL SSEEQQAVFV 

       910        920        930        940        950        960 
KPPAGVTKII ISTNIAETSI TIDDVVYVID SGKMKEKRYD ASKGMESLED TFVSQANALQ 

       970        980        990       1000       1010       1020 
RKGRAGRVAS GVCFHLFTSH HYNHQLLKQQ LPEIQRVPLE QLCLRIKILE MFSAHNLQSV 

      1030       1040       1050       1060       1070       1080 
FSRLIEPPHT DSLRASKIRL RDLGALTPDE RLTPLGYHLA SLPVDVRIGK LMLFGSIFRC 

      1090       1100       1110       1120       1130       1140 
LDPALTIAAS LAFKSPFVSP WDKKEEANQK KLEFAFANSD YLALLQAYKG WQLSTKEGVR 

      1150       1160       1170       1180       1190       1200 
ASYNYCRQNF LSGRVLQEMA SLKRQFTELL SDIGFAREGL RAREIEKRAQ GGDGVLDATG 

      1210       1220       1230       1240       1250       1260 
EEANSNAENP KLISAMLCAA LYPNVVQVKS PEGKFQKTST GAVRMQPKSA ELKFVTKNDG 

      1270       1280       1290       1300       1310       1320 
YVHIHPSSVN YQVRHFDSPY LLYHEKIKTS RVFIRDCSMV SVYPLVLFGG GQVNVQLQRG 

      1330       1340       1350       1360       1370       1380 
EFVVSLDDGW IRFVAASHQV AELVKELRCE LDQLLQDKIK NPSIDLCTCP RGSRIISTIV 


KLVTTQ 

« Hide

Isoform 2 [UniParc].

Checksum: 570E49695D5B05A3
Show »

FASTA65873,602
Isoform 3 [UniParc].

Checksum: 1B83D88C94570046
Show »

FASTA43349,508

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Testis.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-587.
Tissue: Skin.
[4]"Molecular cloning of a new member of DEAH-box RNA/DNA helicase gene family."
Lin S., Ying K., Wang Z., Xie Y., Mao Y.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 405-1386 (ISOFORM 1), VARIANT SER-587.
Tissue: Brain.
[5]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127 AND SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475; SER-477 AND SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057423 mRNA. Translation: BAB71479.1.
AC018693 Genomic DNA. Translation: AAY24256.1. Sequence problems.
BC053623 mRNA. Translation: AAH53623.1.
BC060778 mRNA. Translation: AAH60778.2.
BC065278 mRNA. Translation: AAH65278.1.
BC131534 mRNA. Translation: AAI31535.1.
AF283512 mRNA. Translation: AAM73547.1. Different initiation.
CCDSCCDS1800.1. [Q6P158-1]
RefSeqNP_945314.1. NM_198963.1. [Q6P158-1]
UniGeneHs.468226.

3D structure databases

ProteinModelPortalQ6P158.
SMRQ6P158. Positions 464-804, 1031-1309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124783. 9 interactions.
IntActQ6P158. 2 interactions.
MINTMINT-4774949.
STRING9606.ENSP00000295373.

PTM databases

PhosphoSiteQ6P158.

Polymorphism databases

DMDM94710252.

Proteomic databases

MaxQBQ6P158.
PaxDbQ6P158.
PeptideAtlasQ6P158.
PRIDEQ6P158.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295373; ENSP00000295373; ENSG00000163214. [Q6P158-1]
GeneID90957.
KEGGhsa:90957.
UCSCuc002rre.3. human. [Q6P158-1]
uc002rrg.3. human. [Q6P158-2]

Organism-specific databases

CTD90957.
GeneCardsGC02M039025.
HGNCHGNC:20086. DHX57.
HPAHPA036160.
neXtProtNX_Q6P158.
PharmGKBPA134919698.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1643.
HOVERGENHBG080658.
InParanoidQ6P158.
KOK13026.
OMATQCFSET.
OrthoDBEOG7SV0TS.
PhylomeDBQ6P158.
TreeFamTF324744.

Gene expression databases

ArrayExpressQ6P158.
BgeeQ6P158.
CleanExHS_DHX57.
GenevestigatorQ6P158.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR006575. RWD-domain.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000571. Znf_CCCH.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
PF05773. RWD. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMSSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50030. UBA. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDHX57. human.
GeneWikiDHX57.
GenomeRNAi90957.
NextBio77048.
PROQ6P158.

Entry information

Entry nameDHX57_HUMAN
AccessionPrimary (citable) accession number: Q6P158
Secondary accession number(s): A2RRC7 expand/collapse secondary AC list , Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM