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Q6P158

- DHX57_HUMAN

UniProt

Q6P158 - DHX57_HUMAN

Protein

Putative ATP-dependent RNA helicase DHX57

Gene

DHX57

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Functioni

    Probable ATP-binding RNA helicase.

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri299 – 32628C3H1-typePROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi567 – 5748ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent helicase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. poly(A) RNA binding Source: UniProtKB

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ATP-dependent RNA helicase DHX57 (EC:3.6.4.13)
    Alternative name(s):
    DEAH box protein 57
    Gene namesi
    Name:DHX57
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:20086. DHX57.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134919698.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13861386Putative ATP-dependent RNA helicase DHX57PRO_0000233151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei127 – 1271Phosphoserine3 Publications
    Modified residuei475 – 4751Phosphoserine1 Publication
    Modified residuei477 – 4771Phosphoserine1 Publication
    Modified residuei480 – 4801Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6P158.
    PaxDbiQ6P158.
    PeptideAtlasiQ6P158.
    PRIDEiQ6P158.

    PTM databases

    PhosphoSiteiQ6P158.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P158.
    BgeeiQ6P158.
    CleanExiHS_DHX57.
    GenevestigatoriQ6P158.

    Organism-specific databases

    HPAiHPA036160.

    Interactioni

    Protein-protein interaction databases

    BioGridi124783. 10 interactions.
    IntActiQ6P158. 3 interactions.
    MINTiMINT-4774949.
    STRINGi9606.ENSP00000295373.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P158.
    SMRiQ6P158. Positions 464-804, 1031-1309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini180 – 22041UBAPROSITE-ProRule annotationAdd
    BLAST
    Domaini554 – 721168Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini830 – 1010181Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili101 – 12525Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi668 – 6714DEVH box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi9 – 4941Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
    Contains 1 UBA domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri299 – 32628C3H1-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1643.
    HOVERGENiHBG080658.
    InParanoidiQ6P158.
    KOiK13026.
    OMAiTQCFSET.
    OrthoDBiEOG7SV0TS.
    PhylomeDBiQ6P158.
    TreeFamiTF324744.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    4.10.1000.10. 1 hit.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR002464. DNA/RNA_helicase_DEAH_CS.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR006575. RWD-domain.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    PF05773. RWD. 1 hit.
    PF00642. zf-CCCH. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00356. ZnF_C3H1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50030. UBA. 1 hit.
    PS50103. ZF_C3H1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P158-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSSVRRKGK PGKGGGKGSS RGGRGGRSHA SKSHGSGGGG GGGGGGGGGN     50
    RKASSRIWDD GDDFCIFSES RRPSRPSNSN ISKGESRPKW KPKAKVPLQT 100
    LHMTSENQEK VKALLRDLQE QDADAGSERG LSGEEEDDEP DCCNDERYWP 150
    AGQEPSLVPD LDPLEYAGLA SVEPYVPEFT VSPFAVQKLS RYGFNTERCQ 200
    AVLRMCDGDV GASLEHLLTQ CFSETFGERM KISEAVNQIS LDECMEQRQE 250
    EAFALKSICG EKFIERIQNR VWTIGLELEY LTSRFRKSKP KESTKNVQEN 300
    SLEICKFYLK GNCKFGSKCR FKHEVPPNQI VGRIERSVDD SHLNAIEDAS 350
    FLYELEIRFS KDHKYPYQAP LVAFYSTNEN LPLACRLHIS EFLYDKALTF 400
    AETSEPVVYS LITLLEEESE IVKLLTNTHH KYSDPPVNFL PVPSRTRINN 450
    PACHKTVIPN NSFVSNQIPE VEKASESEES DEDDGPAPVI VENESYVNLK 500
    KKISKRYDWQ AKSVHAENGK ICKQFRMKQA SRQFQSILQE RQSLPAWEER 550
    ETILNLLRKH QVVVISGMTG CGKTTQIPQF ILDDSLNGPP EKVANIICTQ 600
    PRRISAISVA ERVAKERAER VGLTVGYQIR LESVKSSATR LLYCTTGVLL 650
    RRLEGDTALQ GVSHIIVDEV HERTEESDFL LLVLKDIVSQ RPGLQVILMS 700
    ATLNAELFSD YFNSCPVITI PGRTFPVDQF FLEDAIAVTR YVLQDGSPYM 750
    RSMKQISKEK LKARRNRTAF EEVEEDLRLS LHLQDQDSVK DAVPDQQLDF 800
    KQLLARYKGV SKSVIKTMSI MDFEKVNLEL IEALLEWIVD GKHSYPPGAI 850
    LVFLPGLAEI KMLYEQLQSN SLFNNRRSNR CVIHPLHSSL SSEEQQAVFV 900
    KPPAGVTKII ISTNIAETSI TIDDVVYVID SGKMKEKRYD ASKGMESLED 950
    TFVSQANALQ RKGRAGRVAS GVCFHLFTSH HYNHQLLKQQ LPEIQRVPLE 1000
    QLCLRIKILE MFSAHNLQSV FSRLIEPPHT DSLRASKIRL RDLGALTPDE 1050
    RLTPLGYHLA SLPVDVRIGK LMLFGSIFRC LDPALTIAAS LAFKSPFVSP 1100
    WDKKEEANQK KLEFAFANSD YLALLQAYKG WQLSTKEGVR ASYNYCRQNF 1150
    LSGRVLQEMA SLKRQFTELL SDIGFAREGL RAREIEKRAQ GGDGVLDATG 1200
    EEANSNAENP KLISAMLCAA LYPNVVQVKS PEGKFQKTST GAVRMQPKSA 1250
    ELKFVTKNDG YVHIHPSSVN YQVRHFDSPY LLYHEKIKTS RVFIRDCSMV 1300
    SVYPLVLFGG GQVNVQLQRG EFVVSLDDGW IRFVAASHQV AELVKELRCE 1350
    LDQLLQDKIK NPSIDLCTCP RGSRIISTIV KLVTTQ 1386
    Length:1,386
    Mass (Da):155,604
    Last modified:May 2, 2006 - v2
    Checksum:iFFF62BD4BF4C1F4D
    GO
    Isoform 2 (identifier: Q6P158-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         636-658: SSATRLLYCTTGVLLRRLEGDTA → VCMLCLFPGNRNLWFLGIKSFGG
         659-1386: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:658
    Mass (Da):73,602
    Checksum:i570E49695D5B05A3
    GO
    Isoform 3 (identifier: Q6P158-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-102: Missing.
         530-535: ASRQFQ → VLNSHM
         536-1386: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:433
    Mass (Da):49,508
    Checksum:i1B83D88C94570046
    GO

    Sequence cautioni

    The sequence AAM73547.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAY24256.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti474 – 4741A → T in BAB71479. (PubMed:14702039)Curated
    Sequence conflicti976 – 9761L → V in AAM73547. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti410 – 4101S → F.
    Corresponds to variant rs11893062 [ dbSNP | Ensembl ].
    VAR_052190
    Natural varianti433 – 4331S → G.
    Corresponds to variant rs35371077 [ dbSNP | Ensembl ].
    VAR_033861
    Natural varianti587 – 5871N → S.2 Publications
    Corresponds to variant rs7598922 [ dbSNP | Ensembl ].
    VAR_052191

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 102102Missing in isoform 3. 1 PublicationVSP_018056Add
    BLAST
    Alternative sequencei530 – 5356ASRQFQ → VLNSHM in isoform 3. 1 PublicationVSP_018057
    Alternative sequencei536 – 1386851Missing in isoform 3. 1 PublicationVSP_018058Add
    BLAST
    Alternative sequencei636 – 65823SSATR…EGDTA → VCMLCLFPGNRNLWFLGIKS FGG in isoform 2. 1 PublicationVSP_018059Add
    BLAST
    Alternative sequencei659 – 1386728Missing in isoform 2. 1 PublicationVSP_018060Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057423 mRNA. Translation: BAB71479.1.
    AC018693 Genomic DNA. Translation: AAY24256.1. Sequence problems.
    BC053623 mRNA. Translation: AAH53623.1.
    BC060778 mRNA. Translation: AAH60778.2.
    BC065278 mRNA. Translation: AAH65278.1.
    BC131534 mRNA. Translation: AAI31535.1.
    AF283512 mRNA. Translation: AAM73547.1. Different initiation.
    CCDSiCCDS1800.1. [Q6P158-1]
    RefSeqiNP_945314.1. NM_198963.1. [Q6P158-1]
    UniGeneiHs.468226.

    Genome annotation databases

    EnsembliENST00000295373; ENSP00000295373; ENSG00000163214. [Q6P158-1]
    GeneIDi90957.
    KEGGihsa:90957.
    UCSCiuc002rre.3. human. [Q6P158-1]
    uc002rrg.3. human. [Q6P158-2]

    Polymorphism databases

    DMDMi94710252.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057423 mRNA. Translation: BAB71479.1 .
    AC018693 Genomic DNA. Translation: AAY24256.1 . Sequence problems.
    BC053623 mRNA. Translation: AAH53623.1 .
    BC060778 mRNA. Translation: AAH60778.2 .
    BC065278 mRNA. Translation: AAH65278.1 .
    BC131534 mRNA. Translation: AAI31535.1 .
    AF283512 mRNA. Translation: AAM73547.1 . Different initiation.
    CCDSi CCDS1800.1. [Q6P158-1 ]
    RefSeqi NP_945314.1. NM_198963.1. [Q6P158-1 ]
    UniGenei Hs.468226.

    3D structure databases

    ProteinModelPortali Q6P158.
    SMRi Q6P158. Positions 464-804, 1031-1309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124783. 10 interactions.
    IntActi Q6P158. 3 interactions.
    MINTi MINT-4774949.
    STRINGi 9606.ENSP00000295373.

    PTM databases

    PhosphoSitei Q6P158.

    Polymorphism databases

    DMDMi 94710252.

    Proteomic databases

    MaxQBi Q6P158.
    PaxDbi Q6P158.
    PeptideAtlasi Q6P158.
    PRIDEi Q6P158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295373 ; ENSP00000295373 ; ENSG00000163214 . [Q6P158-1 ]
    GeneIDi 90957.
    KEGGi hsa:90957.
    UCSCi uc002rre.3. human. [Q6P158-1 ]
    uc002rrg.3. human. [Q6P158-2 ]

    Organism-specific databases

    CTDi 90957.
    GeneCardsi GC02M039025.
    HGNCi HGNC:20086. DHX57.
    HPAi HPA036160.
    neXtProti NX_Q6P158.
    PharmGKBi PA134919698.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1643.
    HOVERGENi HBG080658.
    InParanoidi Q6P158.
    KOi K13026.
    OMAi TQCFSET.
    OrthoDBi EOG7SV0TS.
    PhylomeDBi Q6P158.
    TreeFami TF324744.

    Miscellaneous databases

    ChiTaRSi DHX57. human.
    GeneWikii DHX57.
    GenomeRNAii 90957.
    NextBioi 77048.
    PROi Q6P158.

    Gene expression databases

    ArrayExpressi Q6P158.
    Bgeei Q6P158.
    CleanExi HS_DHX57.
    Genevestigatori Q6P158.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    4.10.1000.10. 1 hit.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR002464. DNA/RNA_helicase_DEAH_CS.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR006575. RWD-domain.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    PF05773. RWD. 1 hit.
    PF00642. zf-CCCH. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    SM00356. ZnF_C3H1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50030. UBA. 1 hit.
    PS50103. ZF_C3H1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-587.
      Tissue: Skin.
    4. "Molecular cloning of a new member of DEAH-box RNA/DNA helicase gene family."
      Lin S., Ying K., Wang Z., Xie Y., Mao Y.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 405-1386 (ISOFORM 1), VARIANT SER-587.
      Tissue: Brain.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127 AND SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-475; SER-477 AND SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDHX57_HUMAN
    AccessioniPrimary (citable) accession number: Q6P158
    Secondary accession number(s): A2RRC7
    , Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3