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Protein

Ral guanine nucleotide dissociation stimulator-like 1

Gene

rgl1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable guanine nucleotide exchange factor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Ral guanine nucleotide dissociation stimulator-like 1
Short name:
RalGDS-like 1
Gene namesi
Name:rgl1
ORF Names:zgc:77299
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1816. rgl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Ral guanine nucleotide dissociation stimulator-like 1PRO_0000306798Add
BLAST

Proteomic databases

PaxDbiQ6P112.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000120417.

Structurei

3D structure databases

ProteinModelPortaliQ6P112.
SMRiQ6P112. Positions 683-767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 231131N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini270 – 539270Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini684 – 77188Ras-associatingPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi566 – 64782Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3629. Eukaryota.
ENOG410ZUT5. LUCA.
HOGENOMiHOG000231592.
HOVERGENiHBG005864.
InParanoidiQ6P112.
PhylomeDBiQ6P112.

Family and domain databases

CDDicd06224. REM. 1 hit.
Gene3Di1.10.840.10. 2 hits.
InterProiIPR000159. RA_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030748. RGL1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23113:SF199. PTHR23113:SF199. 2 hits.
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISHYPLASL LPWPPVPQLL DIDGDGGVAL QRYQPRSPET GPRYWSSVQD
60 70 80 90 100
WGEEVEEGAI YNVTLKRVQI QQAANKGARW LGAEGDRLPP GHTVSQLETC
110 120 130 140 150
KIRSIRAGTL ERLVETLLTA FGDNDLTYTS IFLSTYRAFA STQSVLELLL
160 170 180 190 200
DRYGSFEDCE GERSQCQTGE SRKAVRKALA SILRAWLDQC PEDFQEPPSY
210 220 230 240 250
PSLHRVLGFL QKAMPGSEPM RRAQSLLEQL RVQASLENET EGGFQCINPF
260 270 280 290 300
CLGEDEEVEI DLQEDFFSFE VDLVAEQLTY MDALLFKKVV PHHCLGSIWS
310 320 330 340 350
QRDKKDGKQS APTIRATITQ FNAVTACVVS TILRQRQIRP HLCARIIQRW
360 370 380 390 400
IDIAQECRIR KNFSSLRAIV SALQSNPLYR LKRTWASVAK DSMQMFEELS
410 420 430 440 450
DIFSDQNNYL TSRELLMREG TSKFASLDSC AKDHQKRSQK RLQLQKDMGA
460 470 480 490 500
MQGTIPYLGT FLTDLTMLDT ALPDQVEGGL INFEKRRREF EVIAQIKLLQ
510 520 530 540 550
SACNSYCLTP DPAFFRWFKS QPQYSEEESY VLSCEVEGLG DNSPTSPKPR
560 570 580 590 600
KSMVKRLSLL FLGNDSTNTS SPVRESPRSP PTGSSGESMD SVSVSSSDSS
610 620 630 640 650
PSESDGMTPT HSIDAHLKKL SESSSCNSLH SMDTSSSTAS ASISLASPTL
660 670 680 690 700
PGPPCNHRRS ISLTPLMSPT SPGFPPAYNT QAQDACIIRV SLEQGNGNLY
710 720 730 740 750
KSIMLTSQDK TPAVISRAMT KHNLEGEQAA DYELVQVISE ERELVIPDNA
760 770 780 790 800
NVFYAMSTSA NFDFLLRLRG SEGRPVQLRS RCSSTLPRTQ QRSSLSLRLS

KVTL
Length:804
Mass (Da):89,690
Last modified:July 5, 2004 - v1
Checksum:i623607589ED40182
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065335 mRNA. Translation: AAH65335.1.
UniGeneiDr.106940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065335 mRNA. Translation: AAH65335.1.
UniGeneiDr.106940.

3D structure databases

ProteinModelPortaliQ6P112.
SMRiQ6P112. Positions 683-767.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000120417.

Proteomic databases

PaxDbiQ6P112.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-040426-1816. rgl1.

Phylogenomic databases

eggNOGiKOG3629. Eukaryota.
ENOG410ZUT5. LUCA.
HOGENOMiHOG000231592.
HOVERGENiHBG005864.
InParanoidiQ6P112.
PhylomeDBiQ6P112.

Miscellaneous databases

PROiQ6P112.

Family and domain databases

CDDicd06224. REM. 1 hit.
Gene3Di1.10.840.10. 2 hits.
InterProiIPR000159. RA_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030748. RGL1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23113:SF199. PTHR23113:SF199. 2 hits.
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGL1_DANRE
AccessioniPrimary (citable) accession number: Q6P112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.