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Protein

Ras-like protein family member 11B

Gene

rasl11b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378GTPBy similarity
Nucleotide bindingi77 – 815GTPBy similarity
Nucleotide bindingi142 – 1454GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • mesendoderm development Source: ZFIN
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 11B
Gene namesi
Name:rasl11bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-040426-793. rasl11b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Ras-like protein family member 11BPRO_0000308368Add
BLAST

Proteomic databases

PaxDbiQ6P0U3.

Expressioni

Gene expression databases

BgeeiQ6P0U3.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003188.

Structurei

3D structure databases

ProteinModelPortaliQ6P0U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 242224Small GTPase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG108422.
InParanoidiQ6P0U3.
KOiK07853.
OMAiIQVHENG.
OrthoDBiEOG70W3F5.
PhylomeDBiQ6P0U3.
TreeFamiTF318030.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P0U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIQNMSTI AEYPSADCPS SRVIKIAVIG GSGVGKTALV VRFLTKRFIG
60 70 80 90 100
DYERNVGNLY SREVQIDGEQ VAIQVQDTPG VQVNANGLSC TDHVSRSIQW
110 120 130 140 150
ADAVVMVYSV TDRKSFDLIG QLHQLVTRTH SDRSIPIILV ANKADLLHVR
160 170 180 190 200
RVDAQEGPVL SSALSCSFYE VSASEDYNQV HSAFHRLCVD LAKLQPQTPI
210 220 230 240
NATSSVTEKK RSPLIPRPKS PNMQDLKRRF KQVLSAKVRT VTSV
Length:244
Mass (Da):26,974
Last modified:July 5, 2004 - v1
Checksum:iEDEFAA8FAC62C37F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031T → A in ABI97979 (Ref. 1) Curated
Sequence conflicti222 – 2221N → D in AAH44471 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ983377 mRNA. Translation: ABI97979.1.
BC044471 mRNA. Translation: AAH44471.1.
BC065446 mRNA. Translation: AAH65446.1.
BK001704 mRNA. Translation: DAA02246.1.
RefSeqiNP_956434.1. NM_200140.1.
UniGeneiDr.51739.

Genome annotation databases

EnsembliENSDART00000015755; ENSDARP00000003188; ENSDARG00000015611.
GeneIDi393109.
KEGGidre:393109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ983377 mRNA. Translation: ABI97979.1.
BC044471 mRNA. Translation: AAH44471.1.
BC065446 mRNA. Translation: AAH65446.1.
BK001704 mRNA. Translation: DAA02246.1.
RefSeqiNP_956434.1. NM_200140.1.
UniGeneiDr.51739.

3D structure databases

ProteinModelPortaliQ6P0U3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003188.

Proteomic databases

PaxDbiQ6P0U3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000015755; ENSDARP00000003188; ENSDARG00000015611.
GeneIDi393109.
KEGGidre:393109.

Organism-specific databases

CTDi65997.
ZFINiZDB-GENE-040426-793. rasl11b.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG108422.
InParanoidiQ6P0U3.
KOiK07853.
OMAiIQVHENG.
OrthoDBiEOG70W3F5.
PhylomeDBiQ6P0U3.
TreeFamiTF318030.

Miscellaneous databases

PROiQ6P0U3.

Gene expression databases

BgeeiQ6P0U3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Pezeron G., Lambert G., Dickmeis T., Strahle U., Rosa F., Mourrain P.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: ABImported.
  3. "Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors."
    Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M., Verjovski-Almeida S., Reis E.M.
    Biochem. Biophys. Res. Commun. 316:618-627(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiRSLBB_DANRE
AccessioniPrimary (citable) accession number: Q6P0U3
Secondary accession number(s): Q001T7, Q803I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.