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Protein

N-acetylglucosamine-6-phosphate deacetylase

Gene

amdhd2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.By similarity

Catalytic activityi

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi143Divalent metal cationBy similarity1
Metal bindingi211Divalent metal cation; via tele nitrogenBy similarity1
Metal bindingi232Divalent metal cation; via tele nitrogenBy similarity1
Binding sitei243SubstrateBy similarity1
Active sitei294Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-DRE-446210 Synthesis of UDP-N-acetyl-glucosamine
UniPathwayiUPA00629

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosamine-6-phosphate deacetylaseBy similarity (EC:3.5.1.25By similarity)
Short name:
GlcNAc 6-P deacetylaseBy similarity
Alternative name(s):
Amidohydrolase domain-containing protein 2By similarity
Gene namesi
Name:amdhd2
ORF Names:zgc:77775
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-040426-1871 amdhd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157791 – 404N-acetylglucosamine-6-phosphate deacetylaseAdd BLAST404

Proteomic databases

PaxDbiQ6P0U0

Expressioni

Gene expression databases

BgeeiENSDARG00000100376

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011842

Structurei

3D structure databases

ProteinModelPortaliQ6P0U0
SMRiQ6P0U0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 155Substrate bindingBy similarity2
Regioni235 – 236Substrate bindingBy similarity2
Regioni269 – 272Substrate bindingBy similarity4
Regioni328 – 330Substrate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3892 Eukaryota
COG1820 LUCA
GeneTreeiENSGT00390000012605
HOGENOMiHOG000275010
HOVERGENiHBG108170
InParanoidiQ6P0U0
KOiK01443
OMAiHAFNAMP
OrthoDBiEOG091G08JG
PhylomeDBiQ6P0U0
TreeFamiTF315036

Family and domain databases

CDDicd00854 NagA, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR003764 GlcNAc_6-P_deAcase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PIRSFiPIRSF038994 NagA, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR00221 nagA, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P0U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSNKSVSDA PITQFVNCRI LKNHKLQWED LWVREGKILN PEKLFFDEQG
60 70 80 90 100
FADHRVDCEN KIIAPGFIDV QLNGGYGIDF SQASSDIRGG VALVAKKILE
110 120 130 140 150
HGVTSFCPTL VTSPPHIYHK VIPELRVQDG GPEGAGVLGI HLEGPFISEE
160 170 180 190 200
KRGAHPPKFL RTFQSGGVAD LMETYGQLEN VAMVTLAPEL TNSAAAIHEL
210 220 230 240 250
SSRGITVSVG HSMADLSQAE EAVQNGATFI THLFNAMLPF HHRDPGIVGL
260 270 280 290 300
LTSDRIPPGR TVYYGMIADG IHTHPAALRI AHRAHPAGLV LVTDAVTAMG
310 320 330 340 350
LPPGRHTLGQ QQIDIQGLHA YVAGTTTLSG SIATMDMCVR HFREASGCTV
360 370 380 390 400
EAALEAASLH PAQLLGISHR KGTLEFGADA DFIVLDDMLT VRETYIAGQQ

VWRK
Length:404
Mass (Da):43,686
Last modified:July 5, 2004 - v1
Checksum:iBCF27EA3F4D1226F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065449 mRNA Translation: AAH65449.1
RefSeqiNP_991244.1, NM_205681.1
XP_005163800.1, XM_005163743.3
XP_005163801.1, XM_005163744.3
UniGeneiDr.84266

Genome annotation databases

EnsembliENSDART00000159647; ENSDARP00000133871; ENSDARG00000100376
ENSDART00000168070; ENSDARP00000135101; ENSDARG00000100376
GeneIDi402981
KEGGidre:402981

Similar proteinsi

Entry informationi

Entry nameiNAGA_DANRE
AccessioniPrimary (citable) accession number: Q6P0U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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