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Protein

N-acetylglucosamine-6-phosphate deacetylase

Gene

amdhd2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.By similarity

Catalytic activityi

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi143Divalent metal cationBy similarity1
Metal bindingi211Divalent metal cation; via tele nitrogenBy similarity1
Metal bindingi232Divalent metal cation; via tele nitrogenBy similarity1
Binding sitei243SubstrateBy similarity1
Active sitei294Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

ReactomeiR-DRE-446210. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00629.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosamine-6-phosphate deacetylaseBy similarity (EC:3.5.1.25By similarity)
Short name:
GlcNAc 6-P deacetylaseBy similarity
Alternative name(s):
Amidohydrolase domain-containing protein 2By similarity
Gene namesi
Name:amdhd2
ORF Names:zgc:77775
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-040426-1871. amdhd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157791 – 404N-acetylglucosamine-6-phosphate deacetylaseAdd BLAST404

Proteomic databases

PaxDbiQ6P0U0.
PRIDEiQ6P0U0.

Expressioni

Gene expression databases

BgeeiENSDARG00000021293.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011842.

Structurei

3D structure databases

ProteinModelPortaliQ6P0U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 155Substrate bindingBy similarity2
Regioni235 – 236Substrate bindingBy similarity2
Regioni269 – 272Substrate bindingBy similarity4
Regioni328 – 330Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the NagA family.Curated

Phylogenomic databases

eggNOGiKOG3892. Eukaryota.
COG1820. LUCA.
GeneTreeiENSGT00390000012605.
HOGENOMiHOG000275010.
HOVERGENiHBG108170.
InParanoidiQ6P0U0.
KOiK01443.
OMAiGRHIFYG.
OrthoDBiEOG091G08JG.
PhylomeDBiQ6P0U0.
TreeFamiTF315036.

Family and domain databases

CDDicd00854. NagA. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR003764. GlcNAc_6-P_deAcase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038994. NagA. 1 hit.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR00221. nagA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P0U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSNKSVSDA PITQFVNCRI LKNHKLQWED LWVREGKILN PEKLFFDEQG
60 70 80 90 100
FADHRVDCEN KIIAPGFIDV QLNGGYGIDF SQASSDIRGG VALVAKKILE
110 120 130 140 150
HGVTSFCPTL VTSPPHIYHK VIPELRVQDG GPEGAGVLGI HLEGPFISEE
160 170 180 190 200
KRGAHPPKFL RTFQSGGVAD LMETYGQLEN VAMVTLAPEL TNSAAAIHEL
210 220 230 240 250
SSRGITVSVG HSMADLSQAE EAVQNGATFI THLFNAMLPF HHRDPGIVGL
260 270 280 290 300
LTSDRIPPGR TVYYGMIADG IHTHPAALRI AHRAHPAGLV LVTDAVTAMG
310 320 330 340 350
LPPGRHTLGQ QQIDIQGLHA YVAGTTTLSG SIATMDMCVR HFREASGCTV
360 370 380 390 400
EAALEAASLH PAQLLGISHR KGTLEFGADA DFIVLDDMLT VRETYIAGQQ

VWRK
Length:404
Mass (Da):43,686
Last modified:July 5, 2004 - v1
Checksum:iBCF27EA3F4D1226F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065449 mRNA. Translation: AAH65449.1.
RefSeqiNP_991244.1. NM_205681.1.
XP_005163800.1. XM_005163743.3.
XP_005163801.1. XM_005163744.3.
UniGeneiDr.84266.

Genome annotation databases

EnsembliENSDART00000159647; ENSDARP00000133871; ENSDARG00000100376.
ENSDART00000168070; ENSDARP00000135101; ENSDARG00000100376.
GeneIDi402981.
KEGGidre:402981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065449 mRNA. Translation: AAH65449.1.
RefSeqiNP_991244.1. NM_205681.1.
XP_005163800.1. XM_005163743.3.
XP_005163801.1. XM_005163744.3.
UniGeneiDr.84266.

3D structure databases

ProteinModelPortaliQ6P0U0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011842.

Proteomic databases

PaxDbiQ6P0U0.
PRIDEiQ6P0U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000159647; ENSDARP00000133871; ENSDARG00000100376.
ENSDART00000168070; ENSDARP00000135101; ENSDARG00000100376.
GeneIDi402981.
KEGGidre:402981.

Organism-specific databases

CTDi51005.
ZFINiZDB-GENE-040426-1871. amdhd2.

Phylogenomic databases

eggNOGiKOG3892. Eukaryota.
COG1820. LUCA.
GeneTreeiENSGT00390000012605.
HOGENOMiHOG000275010.
HOVERGENiHBG108170.
InParanoidiQ6P0U0.
KOiK01443.
OMAiGRHIFYG.
OrthoDBiEOG091G08JG.
PhylomeDBiQ6P0U0.
TreeFamiTF315036.

Enzyme and pathway databases

UniPathwayiUPA00629.
ReactomeiR-DRE-446210. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

PROiQ6P0U0.

Gene expression databases

BgeeiENSDARG00000021293.

Family and domain databases

CDDicd00854. NagA. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR003764. GlcNAc_6-P_deAcase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038994. NagA. 1 hit.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR00221. nagA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNAGA_DANRE
AccessioniPrimary (citable) accession number: Q6P0U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: October 5, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.