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Protein
Submitted name:

Alcohol dehydrogenase 8a

Gene

adh8a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+UniRule annotation

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: ZFIN
  • zinc ion binding Source: InterPro

GO - Biological processi

  • alcohol metabolic process Source: ZFIN
  • cellular response to xenobiotic stimulus Source: ZFIN
  • ethanol metabolic process Source: ZFIN
Complete GO annotation...

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-2161541. Abacavir metabolism.
R-DRE-5365859. RA biosynthesis pathway.
R-DRE-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Submitted name:
Alcohol dehydrogenase 8aImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:adh8aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-030529-3. adh8a.

Expressioni

Gene expression databases

BgeeiENSDARG00000091211.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024643.

Structurei

3D structure databases

SMRiQ6P0S5. Positions 2-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 373355PKS_ERInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the zinc-containing alcohol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOVERGENiHBG000195.
OMAiDGVPQMV.
OrthoDBiEOG091G08N3.
TreeFamiTF300429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P0S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAGKVIKC RAAVAWEPKA PLMMEEIEVA PPQEGEIRIK VIATGLCHTD
60 70 80 90 100
LYHLVDGDKR GFPVVLGHES AGVVESVGPG VTDYKPGDKV IPLFLSQCGK
110 120 130 140 150
CKFCKCPKTN LCESSWATKY HDIMAEPTSR FTCRGQTILQ FMGTSTFSEY
160 170 180 190 200
TVINQNAVAK IDENAPLDRV FLLGCGITTG YGAAVNTAGV TPGSVCAVFG
210 220 230 240 250
LGAVGLAAVM GCKNAGASRI FAVDINEKKF EKAKVFGATD FLNPKAYNKP
260 270 280 290 300
ISEVLIEMTN GGGVDFSIEC TGNTEVMRSA LESCAKGWGV SVVVGWTNVQ
310 320 330 340 350
DFSAKPIQLI YGKTWKGSLF GGFKCKDSVP KLVRDYMSGK IMLDEFITHK
360 370
MNLEQVNDAI NLMKTGQGIR TIMTVSK
Length:377
Mass (Da):40,572
Last modified:July 5, 2004 - v1
Checksum:i38F8C5D4D35FE418
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR559943 Genomic DNA. No translation available.
BC065464 mRNA. Translation: AAH65464.1.
RefSeqiNP_001001946.3. NM_001001946.4.
UniGeneiDr.159487.

Genome annotation databases

EnsembliENSDART00000008498; ENSDARP00000024643; ENSDARG00000091211.
GeneIDi322482.
KEGGidre:322482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR559943 Genomic DNA. No translation available.
BC065464 mRNA. Translation: AAH65464.1.
RefSeqiNP_001001946.3. NM_001001946.4.
UniGeneiDr.159487.

3D structure databases

SMRiQ6P0S5. Positions 2-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024643.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000008498; ENSDARP00000024643; ENSDARG00000091211.
GeneIDi322482.
KEGGidre:322482.

Organism-specific databases

CTDi322482.
ZFINiZDB-GENE-030529-3. adh8a.

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
GeneTreeiENSGT00430000030800.
HOVERGENiHBG000195.
OMAiDGVPQMV.
OrthoDBiEOG091G08N3.
TreeFamiTF300429.

Enzyme and pathway databases

ReactomeiR-DRE-2161541. Abacavir metabolism.
R-DRE-5365859. RA biosynthesis pathway.
R-DRE-71384. Ethanol oxidation.

Gene expression databases

BgeeiENSDARG00000091211.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6P0S5_DANRE
AccessioniPrimary (citable) accession number: Q6P0S5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.