##gff-version 3 Q6P0Q8 UniProtKB Chain 1 1798 . . . ID=PRO_0000086312;Note=Microtubule-associated serine/threonine-protein kinase 2 Q6P0Q8 UniProtKB Domain 512 785 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Q6P0Q8 UniProtKB Domain 786 854 . . . Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618 Q6P0Q8 UniProtKB Domain 1104 1192 . . . Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 Q6P0Q8 UniProtKB Region 1 61 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Region 172 257 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Region 278 305 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Region 477 508 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Region 860 892 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Region 908 927 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Region 934 1013 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Region 1067 1097 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Region 1195 1725 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Region 1738 1798 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 7 24 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 39 54 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 172 188 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 197 211 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 230 257 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 278 292 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 860 889 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1068 1091 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1217 1231 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1234 1279 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1288 1314 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1346 1361 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1421 1445 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1481 1501 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1589 1604 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1624 1656 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1682 1705 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Compositional bias 1774 1798 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6P0Q8 UniProtKB Active site 635 635 . . . Note=Proton acceptor;Ontology_term=ECO:0000250,ECO:0000255,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q9BXM7,ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 Q6P0Q8 UniProtKB Binding site 518 526 . . . Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q9BXM7,ECO:0000255|PROSITE-ProRule:PRU00159 Q6P0Q8 UniProtKB Binding site 541 541 . . . Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:Q9BXM7,ECO:0000255|PROSITE-ProRule:PRU00159 Q6P0Q8 UniProtKB Modified residue 66 66 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6P0Q8 UniProtKB Modified residue 74 74 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19369195,PMID:19690332,PMID:20068231,PMID:23186163 Q6P0Q8 UniProtKB Modified residue 148 148 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163 Q6P0Q8 UniProtKB Modified residue 151 151 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60592 Q6P0Q8 UniProtKB Modified residue 209 209 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 Q6P0Q8 UniProtKB Modified residue 290 290 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6P0Q8 UniProtKB Modified residue 874 874 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q6P0Q8 UniProtKB Modified residue 876 876 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6P0Q8 UniProtKB Modified residue 895 895 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60592 Q6P0Q8 UniProtKB Modified residue 900 900 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q6P0Q8 UniProtKB Modified residue 1004 1004 . . . Note=Omega-N-methylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 Q6P0Q8 UniProtKB Modified residue 1032 1032 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163 Q6P0Q8 UniProtKB Modified residue 1256 1256 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6P0Q8 UniProtKB Modified residue 1337 1337 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q60592 Q6P0Q8 UniProtKB Modified residue 1364 1364 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6P0Q8 UniProtKB Modified residue 1447 1447 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6P0Q8 UniProtKB Modified residue 1508 1508 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17081983;Dbxref=PMID:17081983 Q6P0Q8 UniProtKB Alternative sequence 327 396 . . . ID=VSP_051698;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q6P0Q8 UniProtKB Alternative sequence 1091 1113 . . . ID=VSP_051699;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q6P0Q8 UniProtKB Alternative sequence 1290 1386 . . . ID=VSP_051700;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q6P0Q8 UniProtKB Natural variant 69 69 . . . ID=VAR_040771;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs55914403,PMID:17344846 Q6P0Q8 UniProtKB Natural variant 275 275 . . . ID=VAR_040772;Note=In an ovarian mucinous carcinoma sample%3B somatic mutation. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Q6P0Q8 UniProtKB Natural variant 388 388 . . . ID=VAR_040773;Note=D->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12117771,ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs11211247,PMID:12117771,PMID:17344846 Q6P0Q8 UniProtKB Natural variant 655 655 . . . ID=VAR_040774;Note=In a breast mucinous carcinoma sample%3B somatic mutation. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Q6P0Q8 UniProtKB Natural variant 659 659 . . . ID=VAR_040775;Note=I->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12117771,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:9872452;Dbxref=dbSNP:rs1707336,PMID:12117771,PMID:15489334,PMID:17344846,PMID:9872452 Q6P0Q8 UniProtKB Natural variant 991 991 . . . ID=VAR_040776;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56114653,PMID:17344846 Q6P0Q8 UniProtKB Natural variant 1197 1197 . . . ID=VAR_040777;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs1052607,PMID:17344846 Q6P0Q8 UniProtKB Natural variant 1221 1221 . . . ID=VAR_040778;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56060730,PMID:17344846 Q6P0Q8 UniProtKB Natural variant 1246 1246 . . . ID=VAR_040779;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56309943,PMID:17344846 Q6P0Q8 UniProtKB Natural variant 1304 1304 . . . ID=VAR_040780;Note=V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs33931638,PMID:17344846 Q6P0Q8 UniProtKB Natural variant 1463 1463 . . . ID=VAR_040781;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs3737738,PMID:17344846 Q6P0Q8 UniProtKB Natural variant 1468 1468 . . . ID=VAR_040782;Note=G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs3737737,PMID:17344846 Q6P0Q8 UniProtKB Natural variant 1551 1551 . . . ID=VAR_040783;Note=D->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12117771,ECO:0000269|PubMed:17344846,ECO:0000269|PubMed:9872452;Dbxref=dbSNP:rs1052610,PMID:12117771,PMID:17344846,PMID:9872452 Q6P0Q8 UniProtKB Natural variant 1608 1608 . . . ID=VAR_051645;Note=T->I;Dbxref=dbSNP:rs35474583 Q6P0Q8 UniProtKB Natural variant 1673 1673 . . . ID=VAR_040784;Note=K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34070850,PMID:17344846 Q6P0Q8 UniProtKB Natural variant 1703 1703 . . . ID=VAR_040785;Note=G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 Q6P0Q8 UniProtKB Sequence conflict 1225 1225 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P0Q8 UniProtKB Beta strand 1104 1108 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KQF Q6P0Q8 UniProtKB Beta strand 1116 1124 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KQF Q6P0Q8 UniProtKB Beta strand 1126 1129 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KQF Q6P0Q8 UniProtKB Beta strand 1131 1140 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KQF Q6P0Q8 UniProtKB Beta strand 1142 1145 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KQF Q6P0Q8 UniProtKB Helix 1146 1149 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KQF Q6P0Q8 UniProtKB Beta strand 1156 1164 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KQF Q6P0Q8 UniProtKB Helix 1170 1180 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KQF Q6P0Q8 UniProtKB Beta strand 1182 1188 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2KQF