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Q6P0N0

- M18BP_HUMAN

UniProt

Q6P0N0 - M18BP_HUMAN

Protein

Mis18-binding protein 1

Gene

MIS18BP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.2 Publications

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. CENP-A containing nucleosome assembly Source: Reactome
    2. mitotic nuclear division Source: UniProtKB-KW
    3. nucleosome assembly Source: Reactome

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mis18-binding protein 1
    Alternative name(s):
    Kinetochore-associated protein KNL-2 homolog
    Short name:
    HsKNL-2
    P243
    Gene namesi
    Name:MIS18BP1
    Synonyms:C14orf106, KIAA1903, KNL2, M18BP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20190. MIS18BP1.

    Subcellular locationi

    Nucleus. Chromosome. Chromosomecentromere
    Note: Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB-SubCell
    2. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Centromere, Chromosome, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134927557.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11321132Mis18-binding protein 1PRO_0000197140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei110 – 1101Phosphoserine1 Publication
    Modified residuei135 – 1351Phosphoserine1 Publication
    Modified residuei172 – 1721Phosphoserine1 Publication
    Modified residuei299 – 2991Phosphoserine1 Publication
    Modified residuei653 – 6531Phosphothreonine3 Publications
    Modified residuei772 – 7721Phosphoserine1 Publication
    Modified residuei773 – 7731Phosphoserine1 Publication
    Modified residuei821 – 8211Phosphothreonine1 Publication
    Modified residuei824 – 8241Phosphoserine1 Publication
    Modified residuei860 – 8601Phosphoserine1 Publication
    Modified residuei1008 – 10081Phosphoserine4 Publications
    Modified residuei1086 – 10861Phosphoserine1 Publication
    Modified residuei1087 – 10871Phosphothreonine1 Publication
    Modified residuei1089 – 10891Phosphothreonine1 Publication
    Modified residuei1104 – 11041Phosphoserine4 Publications
    Modified residuei1116 – 11161Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6P0N0.
    PaxDbiQ6P0N0.
    PRIDEiQ6P0N0.

    PTM databases

    PhosphoSiteiQ6P0N0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P0N0.
    BgeeiQ6P0N0.
    CleanExiHS_C14orf106.
    GenevestigatoriQ6P0N0.

    Organism-specific databases

    HPAiHPA006504.

    Interactioni

    Subunit structurei

    Interacts (via N-terminus) with FLNA (via N-terminus) By similarity. Interacts with SP1 Probable. Interacts with MIS18A. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4.By similarity2 PublicationsCurated

    Protein-protein interaction databases

    BioGridi120601. 4 interactions.
    MINTiMINT-4992022.
    STRINGi9606.ENSP00000309790.

    Structurei

    Secondary structure

    1
    1132
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi882 – 89413
    Beta strandi897 – 9015
    Helixi902 – 9098
    Turni910 – 9123
    Helixi915 – 92410
    Beta strandi925 – 9295
    Beta strandi934 – 9363

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WGXNMR-A877-936[»]
    ProteinModelPortaliQ6P0N0.
    SMRiQ6P0N0. Positions 877-936.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6P0N0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini875 – 93056SANTPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1010 – 10134Poly-Asp

    Sequence similaritiesi

    Contains 1 SANT domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG73415.
    HOGENOMiHOG000113431.
    InParanoidiQ6P0N0.
    OMAiNDCDKYV.
    OrthoDBiEOG77M8R3.
    PhylomeDBiQ6P0N0.
    TreeFamiTF106401.

    Family and domain databases

    InterProiIPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR015216. SANTA.
    [Graphical view]
    PfamiPF09133. SANTA. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51293. SANT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P0N0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIATPLKHSR IYLPPEASSQ RRNLPMDAIF FDSIPSGTLT PVKDLVKYQN     50
    SSLKLNDHKK NQFLKMTTFN NKNIFQSTML TEATTSNSSL DISAIKPNKD 100
    GLKNKANYES PGKIFLRMKE KVLRDKQEQP SRNSSLLEPQ KSGNNETFTP 150
    NRVEKKKLQH TYLCEEKENN KSFQSDDSSL RASVQGVPLE SSNNDIFLPV 200
    KQKIQCQQEK KAPLHNLTYE LPTLNQEQEN FLAVEARNKT LTRAQLAKQI 250
    FHSKESIVAT TKSKKDTFVL ESVDSADEQF QNTNAETLST NCIPIKNGSL 300
    LMVSDSERTT EGTSQQKVKE GNGKTVPGET GLPGSMKDTC KIVLATPRLH 350
    ITIPRRSKRN ISKLSPPRIF QTVTNGLKKN QVVQLQEWMI KSINNNTAIC 400
    VEGKLIDVTN IYWHSNVIIE RIEHNKLRTI SGNVYILKGM IDQISMKEAG 450
    YPNYLIRKFM FGFPENWKEH IDNFLEQLRA GEKNREKTKQ KQKTGRSVRD 500
    IRKSMKNDAR ENQTDTAQRA TTTYDFDCDN LELKSNKHSE SPGATELNMC 550
    HSNCQNKPTL RFPDDQVNNT IQNGGGDDLS NQELIGKKEY KMSSKKLKIG 600
    ERTNERIIKS QKQETTEELD VSIDILTSRE QFFSDEERKY MAINQKKAYI 650
    LVTPLKSRKV IEQRCMRYNL SAGTIKAVTD FVIPECQKKS PISKSMGTLE 700
    NTFEGHKSKN KEDCDERDLL TVNRKIKISN LEKEQMLTSD FKKNTRLLPK 750
    LKKIENQVAM SFYKHQSSPD LSSEESETEK EIKRKAEVKK TKAGNTKEAV 800
    VHLRKSTRNT SNIPVILEPE TEESENEFYI KQKKARPSVK ETLQKSGVRK 850
    EFPITEAVGS DKTNRHPLEC LPGLIQDKEW NEKELQKLHC AFASLPKHKP 900
    GFWSEVAAAV GSRSPEECQR KYMENPRGKG SQKHVTKKKP ANSKGQNGKR 950
    GDADQKQTIK ITAKVGTLKR KQQMREFLEQ LPKDDHDDFF STTPLQHQRI 1000
    LLPSFQDSED DDDILPNMDK NPTTPSSVIF PLVKTPQCQH VSPGMLGSIN 1050
    RNDCDKYVFR MQKYHKSNGG IVWGNIKKKL VETDFSTPTP RRKTPFNTDL 1100
    GENSGIGKLF TNAVESLDEE EKDYYFSNSD SA 1132
    Length:1,132
    Mass (Da):129,085
    Last modified:July 5, 2004 - v1
    Checksum:i92F2787CD4687059
    GO
    Isoform 2 (identifier: Q6P0N0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         391-1132: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:390
    Mass (Da):43,994
    Checksum:iB4B1B945CE91C8A8
    GO

    Sequence cautioni

    The sequence AK002048 differs from that shown. Reason: Frameshift at position 157.
    The sequence BAB67796.1 differs from that shown. Reason: Frameshift at position 154.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti510 – 5101R → Q in BAB67796. (PubMed:11572484)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti164 – 1641C → R.
    Corresponds to variant rs1269008 [ dbSNP | Ensembl ].
    VAR_050184
    Natural varianti347 – 3471P → R.
    Corresponds to variant rs34168608 [ dbSNP | Ensembl ].
    VAR_050185
    Natural varianti583 – 5831E → D.
    Corresponds to variant rs34101857 [ dbSNP | Ensembl ].
    VAR_050186
    Natural varianti851 – 8511E → Q.
    Corresponds to variant rs34402741 [ dbSNP | Ensembl ].
    VAR_050187

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei391 – 1132742Missing in isoform 2. 1 PublicationVSP_014105Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB067490 mRNA. Translation: BAB67796.1. Frameshift.
    AK002048 mRNA. No translation available.
    AL121809 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65778.1.
    CH471078 Genomic DNA. Translation: EAW65779.1.
    CH471078 Genomic DNA. Translation: EAW65780.1.
    BC051885 mRNA. Translation: AAH51885.1.
    BC065544 mRNA. Translation: AAH65544.1.
    AJ242977 mRNA. Translation: CAB45134.1.
    CCDSiCCDS9684.1. [Q6P0N0-1]
    RefSeqiNP_060823.3. NM_018353.4. [Q6P0N0-1]
    XP_005267890.1. XM_005267833.2. [Q6P0N0-1]
    UniGeneiHs.732769.

    Genome annotation databases

    EnsembliENST00000310806; ENSP00000309790; ENSG00000129534. [Q6P0N0-1]
    GeneIDi55320.
    KEGGihsa:55320.
    UCSCiuc001wwf.3. human. [Q6P0N0-1]

    Polymorphism databases

    DMDMi68052324.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB067490 mRNA. Translation: BAB67796.1 . Frameshift.
    AK002048 mRNA. No translation available.
    AL121809 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65778.1 .
    CH471078 Genomic DNA. Translation: EAW65779.1 .
    CH471078 Genomic DNA. Translation: EAW65780.1 .
    BC051885 mRNA. Translation: AAH51885.1 .
    BC065544 mRNA. Translation: AAH65544.1 .
    AJ242977 mRNA. Translation: CAB45134.1 .
    CCDSi CCDS9684.1. [Q6P0N0-1 ]
    RefSeqi NP_060823.3. NM_018353.4. [Q6P0N0-1 ]
    XP_005267890.1. XM_005267833.2. [Q6P0N0-1 ]
    UniGenei Hs.732769.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WGX NMR - A 877-936 [» ]
    ProteinModelPortali Q6P0N0.
    SMRi Q6P0N0. Positions 877-936.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120601. 4 interactions.
    MINTi MINT-4992022.
    STRINGi 9606.ENSP00000309790.

    PTM databases

    PhosphoSitei Q6P0N0.

    Polymorphism databases

    DMDMi 68052324.

    Proteomic databases

    MaxQBi Q6P0N0.
    PaxDbi Q6P0N0.
    PRIDEi Q6P0N0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310806 ; ENSP00000309790 ; ENSG00000129534 . [Q6P0N0-1 ]
    GeneIDi 55320.
    KEGGi hsa:55320.
    UCSCi uc001wwf.3. human. [Q6P0N0-1 ]

    Organism-specific databases

    CTDi 55320.
    GeneCardsi GC14M045673.
    HGNCi HGNC:20190. MIS18BP1.
    HPAi HPA006504.
    neXtProti NX_Q6P0N0.
    PharmGKBi PA134927557.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73415.
    HOGENOMi HOG000113431.
    InParanoidi Q6P0N0.
    OMAi NDCDKYV.
    OrthoDBi EOG77M8R3.
    PhylomeDBi Q6P0N0.
    TreeFami TF106401.

    Enzyme and pathway databases

    Reactomei REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.

    Miscellaneous databases

    EvolutionaryTracei Q6P0N0.
    GeneWikii C14orf106.
    GenomeRNAii 55320.
    NextBioi 59574.
    PROi Q6P0N0.

    Gene expression databases

    ArrayExpressi Q6P0N0.
    Bgeei Q6P0N0.
    CleanExi HS_C14orf106.
    Genevestigatori Q6P0N0.

    Family and domain databases

    InterProi IPR009057. Homeodomain-like.
    IPR001005. SANT/Myb.
    IPR017884. SANT_dom.
    IPR015216. SANTA.
    [Graphical view ]
    Pfami PF09133. SANTA. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51293. SANT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis and Uterus.
    6. "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening."
      Gunther M., Laithier M., Brison O.
      Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 523-760, INTERACTION WITH SP1.
      Tissue: Colon carcinoma.
    7. "Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1."
      Fujita Y., Hayashi T., Kiyomitsu T., Toyoda Y., Kokubu A., Obuse C., Yanagida M.
      Dev. Cell 12:17-30(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH MIS18A, IDENTIFICATION IN A COMPLEX CONTAINING MIS18A; MIS18B; MIS18BP1; RBBP7 AND RBBP4.
    8. "Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin."
      Maddox P.S., Hyndman F., Monen J., Oegema K., Desai A.
      J. Cell Biol. 176:757-763(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-110; THR-653; THR-821; SER-824; SER-1008; SER-1086; THR-1087; THR-1089 AND SER-1104, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1008 AND SER-1104, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-653; SER-860; SER-1008; SER-1104 AND SER-1116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135; SER-172; SER-299; THR-653; SER-772; SER-773; SER-1008; SER-1104 AND SER-1116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Solution structure of RSGI RUH-022, a Myb DNA-binding domain in human cDNA."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 877-936.

    Entry informationi

    Entry nameiM18BP_HUMAN
    AccessioniPrimary (citable) accession number: Q6P0N0
    Secondary accession number(s): D3DSA7
    , Q86V14, Q96PY4, Q9NUR5, Q9Y4X9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3