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Protein
Submitted name:

IARS protein

Gene

IARS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
IARS proteinImported
Gene namesi
Name:IARSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiQ6P0M4.
PaxDbiQ6P0M4.
PRIDEiQ6P0M4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364794.

Structurei

3D structure databases

ProteinModelPortaliQ6P0M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 483483tRNA-synt_1InterPro annotationAdd
BLAST
Domaini538 – 693156Anticodon_1InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0434. Eukaryota.
COG0060. LUCA.
HOGENOMiHOG000246403.
HOVERGENiHBG013511.
KOiK01870.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P0M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESVWWVFKQ LYDKGLVYRG VKVMPFSTAC NTPLSNFESH QNYKDVQDPS
60 70 80 90 100
VFVTFPLEED ETVSLVAWTT TPWTLPSNLA VCVNPEMQYV KIKDVARGRL
110 120 130 140 150
LILMEARLSA LYKLESDYEI LERFPGAYLK GKKYRPLFDY FLKCKENGAF
160 170 180 190 200
TVLVDNYVKE EEGTGVVHQA PYFGAEDYRV CMDFNIIRKD SLPVCPVDAS
210 220 230 240 250
GCFTTEVTDF AGQYVKDADK SIIRTLKEQG RLLVATTFTH SYPFCWRSDT
260 270 280 290 300
PLIYKAVPSW FVRVENMVDQ LLRNNDLCYW VPELVREKRF GNWLKDARDW
310 320 330 340 350
TISRNRYWGT PIPLWVSDDF EEVVCIGSVA ELEELSGAKI SDLHRESVDH
360 370 380 390 400
LTIPSRCGKG SLHRISEVFD CWFESGSMPY AQVHYPFENK REFEDAFPAD
410 420 430 440 450
FIAEGIDQTR GWFYTLLVLA TALFGQPPFK NVIVNGLVLA SDGQKMSKRK
460 470 480 490 500
KNYPDPVSII QKYGADALRL YLINSPVVRA ENLRFKEEGV RDVLKDVLLP
510 520 530 540 550
WYNAYRFLIQ NVLRLQKEEE IEFLYNENTV RESPNITDRW ILSFMQSLIG
560 570 580 590 600
FFETEMAAYR LYTVVPRLVK FVDILTNWYV RMNRRRLKGE NGMEDCVMAL
610 620 630 640 650
ETLFSVLLSL CRLMAPYTPF LTELMYQNLK VLIDPVSVQD KDTLSIHYLM
660 670 680 690 700
LPRVREELID KKTESAVSQM QSVIELGRVI RDRKTIPIKY PLKEIVVIHQ
710 720 730 740 750
DPEALKDIKS LEKYIIEELN VRKVTLSTDK NKYGIRLRAE PDHMVLGKRL
760 770 780 790 800
KGAFKAVMTS IKQLSSEELE QFQKTGTIVA EGHELHDEDI RLMYTFDQAT
810 820 830 840 850
GGTAQFEAHS DAQALVLLDV TPDQSMVDEG MAREVINRIQ KLRKKCNLVP
860 870 880 890 900
TDEITVYYKA KSEGTYLNSV IESHTEFIFT TIKAPLKPYP VSPSDKVLIQ
910 920 930 940 950
EKTQLKGSEL EITLTRGSSL PGPACAYVNL NICANGSEQG GVLLLENPKG
960 970 980 990 1000
SAPSLINSSS TLLCQYINLQ LLNAKPQECL MGTVGTLLLE NPLGQNGLTH
1010 1020 1030 1040 1050
QGLLYEAAKV FGLRSRKLKL FLNETQTQEI TEDIPVKTLN MKTVYVSVLP

TTADF
Length:1,055
Mass (Da):120,627
Last modified:July 5, 2004 - v1
Checksum:i14E54F1D7332CBE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065552 mRNA. Translation: AAH65552.1.
RefSeqiNP_002152.2. NM_002161.5.
UniGeneiHs.445403.

Genome annotation databases

GeneIDi3376.
KEGGihsa:3376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065552 mRNA. Translation: AAH65552.1.
RefSeqiNP_002152.2. NM_002161.5.
UniGeneiHs.445403.

3D structure databases

ProteinModelPortaliQ6P0M4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364794.

Proteomic databases

MaxQBiQ6P0M4.
PaxDbiQ6P0M4.
PRIDEiQ6P0M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3376.
KEGGihsa:3376.

Organism-specific databases

CTDi3376.

Phylogenomic databases

eggNOGiKOG0434. Eukaryota.
COG0060. LUCA.
HOGENOMiHOG000246403.
HOVERGENiHBG013511.
KOiK01870.

Miscellaneous databases

ChiTaRSiIARS. human.
GenomeRNAii3376.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.

Entry informationi

Entry nameiQ6P0M4_HUMAN
AccessioniPrimary (citable) accession number: Q6P0M4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 13, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.