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Q6P0K8

- PLAK_RAT

UniProt

Q6P0K8 - PLAK_RAT

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Protein
Junction plakoglobin
Gene
Jup
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton By similarity.

GO - Molecular functioni

  1. alpha-catenin binding Source: RefGenome
  2. cadherin binding Source: RefGenome
  3. protein binding Source: UniProt
  4. protein kinase binding Source: RGD
  5. structural molecule activity Source: RGD
  6. transcription coactivator activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. atrioventricular valve morphogenesis Source: RefGenome
  2. bundle of His cell to Purkinje myocyte communication Source: Ensembl
  3. cell migration Source: Ensembl
  4. cell morphogenesis Source: RefGenome
  5. cellular response to indole-3-methanol Source: Ensembl
  6. cytoskeletal anchoring at plasma membrane Source: RefGenome
  7. desmosome assembly Source: Ensembl
  8. detection of mechanical stimulus Source: Ensembl
  9. ectoderm development Source: RefGenome
  10. gastrulation Source: RefGenome
  11. morphogenesis of embryonic epithelium Source: RefGenome
  12. negative regulation of Wnt signaling pathway involved in heart development Source: RefGenome
  13. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
  14. nervous system development Source: RefGenome
  15. oocyte development Source: RefGenome
  16. positive regulation of protein import into nucleus Source: Ensembl
  17. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  18. protein heterooligomerization Source: RGD
  19. regulation of cell proliferation Source: Ensembl
  20. regulation of heart rate by cardiac conduction Source: Ensembl
  21. single organismal cell-cell adhesion Source: RGD
  22. skin development Source: RefGenome
  23. ventricular cardiac muscle cell action potential Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Junction plakoglobin
Gene namesi
Name:Jup
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi620412. Jup.

Subcellular locationi

Cell junctionadherens junction By similarity. Cell junctiondesmosome By similarity. Cytoplasmcytoskeleton By similarity. Membrane; Peripheral membrane protein By similarity
Note: Cytoplasmic in a soluble and membrane-associated form By similarity.

GO - Cellular componenti

  1. Z disc Source: RefGenome
  2. apicolateral plasma membrane Source: RGD
  3. basolateral plasma membrane Source: RefGenome
  4. catenin complex Source: RefGenome
  5. cell-cell adherens junction Source: RGD
  6. cell-cell junction Source: RGD
  7. cytoplasm Source: RGD
  8. cytoplasmic side of plasma membrane Source: RGD
  9. cytosol Source: RefGenome
  10. desmosome Source: RGD
  11. fascia adherens Source: RGD
  12. gamma-catenin-TCF7L2 complex Source: Ensembl
  13. intermediate filament Source: Ensembl
  14. lateral plasma membrane Source: RGD
  15. protein-DNA complex Source: Ensembl
  16. zonula adherens Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745Junction plakoglobin
PRO_0000064281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Glycosylationi14 – 141O-linked (GlcNAc) By similarity
Modified residuei182 – 1821Phosphoserine By similarity
Modified residuei665 – 6651Phosphoserine By similarity

Post-translational modificationi

May be phosphorylated by FER By similarity.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6P0K8.
PRIDEiQ6P0K8.

PTM databases

PhosphoSiteiQ6P0K8.

Expressioni

Gene expression databases

GenevestigatoriQ6P0K8.

Interactioni

Subunit structurei

Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2 By similarity.

Protein-protein interaction databases

IntActiQ6P0K8. 2 interactions.
MINTiMINT-4566202.

Structurei

3D structure databases

ProteinModelPortaliQ6P0K8.
SMRiQ6P0K8. Positions 118-672.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati132 – 17140ARM 1
Add
BLAST
Repeati172 – 21544ARM 2
Add
BLAST
Repeati216 – 25540ARM 3
Add
BLAST
Repeati258 – 29740ARM 4
Add
BLAST
Repeati298 – 34144ARM 5
Add
BLAST
Repeati342 – 38140ARM 6
Add
BLAST
Repeati383 – 42038ARM 7
Add
BLAST
Repeati423 – 46442ARM 8
Add
BLAST
Repeati470 – 51041ARM 9
Add
BLAST
Repeati512 – 55140ARM 10
Add
BLAST
Repeati574 – 61340ARM 11
Add
BLAST
Repeati615 – 66147ARM 12
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 297166Interaction with DSC1 and DSG1 By similarity
Add
BLAST
Regioni574 – 66188Interaction with DSC1 By similarity
Add
BLAST

Domaini

The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region By similarity.

Sequence similaritiesi

Belongs to the beta-catenin family.
Contains 12 ARM repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000230958.
HOVERGENiHBG000919.
InParanoidiQ6P0K8.
KOiK10056.
OMAiMNLIEQP.
OrthoDBiEOG7X9G6B.
PhylomeDBiQ6P0K8.
TreeFamiTF317997.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P0K8-1 [UniParc]FASTAAdd to Basket

« Hide

MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GLLDEDDTCG    50
RQYTLKKTTT YTQGVPQSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL 100
LLATQVEGQT TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL 150
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD 200
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL 250
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 300
ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE 350
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE NVLKILVNQL 400
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD 450
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA 500
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY 550
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 600
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF 650
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT 700
YRPMYSSDVP LDPLDMHMDM DGDYPMDTYS DGLRPPYPAA DHMLA 745
Length:745
Mass (Da):81,801
Last modified:July 5, 2004 - v1
Checksum:iBF8673E1B797954D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC065580 mRNA. Translation: AAH65580.1.
RefSeqiNP_112309.2. NM_031047.2.
XP_006247491.1. XM_006247429.1.
XP_006247492.1. XM_006247430.1.
UniGeneiRn.11255.

Genome annotation databases

EnsembliENSRNOT00000040845; ENSRNOP00000043950; ENSRNOG00000015380.
GeneIDi81679.
KEGGirno:81679.
UCSCiRGD:620412. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC065580 mRNA. Translation: AAH65580.1 .
RefSeqi NP_112309.2. NM_031047.2.
XP_006247491.1. XM_006247429.1.
XP_006247492.1. XM_006247430.1.
UniGenei Rn.11255.

3D structure databases

ProteinModelPortali Q6P0K8.
SMRi Q6P0K8. Positions 118-672.
ModBasei Search...

Protein-protein interaction databases

IntActi Q6P0K8. 2 interactions.
MINTi MINT-4566202.

PTM databases

PhosphoSitei Q6P0K8.

Proteomic databases

PaxDbi Q6P0K8.
PRIDEi Q6P0K8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000040845 ; ENSRNOP00000043950 ; ENSRNOG00000015380 .
GeneIDi 81679.
KEGGi rno:81679.
UCSCi RGD:620412. rat.

Organism-specific databases

CTDi 3728.
RGDi 620412. Jup.

Phylogenomic databases

eggNOGi NOG297695.
GeneTreei ENSGT00730000110821.
HOGENOMi HOG000230958.
HOVERGENi HBG000919.
InParanoidi Q6P0K8.
KOi K10056.
OMAi MNLIEQP.
OrthoDBi EOG7X9G6B.
PhylomeDBi Q6P0K8.
TreeFami TF317997.

Miscellaneous databases

NextBioi 615292.
PROi Q6P0K8.

Gene expression databases

Genevestigatori Q6P0K8.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view ]
Pfami PF00514. Arm. 4 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 12 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-12; 58-81; 192-203 AND 262-279, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiPLAK_RAT
AccessioniPrimary (citable) accession number: Q6P0K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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