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Q6P0K8

- PLAK_RAT

UniProt

Q6P0K8 - PLAK_RAT

Protein

Junction plakoglobin

Gene

Jup

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton By similarity.By similarity

    GO - Molecular functioni

    1. alpha-catenin binding Source: RefGenome
    2. cadherin binding Source: RefGenome
    3. protein binding Source: UniProt
    4. protein kinase binding Source: RGD
    5. structural molecule activity Source: RGD
    6. transcription coactivator activity Source: RefGenome

    GO - Biological processi

    1. atrioventricular valve morphogenesis Source: RefGenome
    2. bundle of His cell to Purkinje myocyte communication Source: Ensembl
    3. cell migration Source: Ensembl
    4. cell morphogenesis Source: RefGenome
    5. cellular response to indole-3-methanol Source: Ensembl
    6. cytoskeletal anchoring at plasma membrane Source: RefGenome
    7. desmosome assembly Source: Ensembl
    8. detection of mechanical stimulus Source: Ensembl
    9. ectoderm development Source: RefGenome
    10. gastrulation Source: RefGenome
    11. morphogenesis of embryonic epithelium Source: RefGenome
    12. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
    13. negative regulation of Wnt signaling pathway involved in heart development Source: RefGenome
    14. nervous system development Source: RefGenome
    15. oocyte development Source: RefGenome
    16. positive regulation of protein import into nucleus Source: Ensembl
    17. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    18. protein heterooligomerization Source: RGD
    19. regulation of cell proliferation Source: Ensembl
    20. regulation of heart rate by cardiac conduction Source: Ensembl
    21. single organismal cell-cell adhesion Source: RGD
    22. skin development Source: RefGenome
    23. ventricular cardiac muscle cell action potential Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Junction plakoglobin
    Gene namesi
    Name:Jup
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi620412. Jup.

    Subcellular locationi

    Cell junctionadherens junction By similarity. Cell junctiondesmosome By similarity. Cytoplasmcytoskeleton By similarity. Membrane By similarity; Peripheral membrane protein By similarity
    Note: Cytoplasmic in a soluble and membrane-associated form.By similarity

    GO - Cellular componenti

    1. apicolateral plasma membrane Source: RGD
    2. basolateral plasma membrane Source: RefGenome
    3. catenin complex Source: RefGenome
    4. cell-cell adherens junction Source: RGD
    5. cell-cell junction Source: RGD
    6. cytoplasm Source: RGD
    7. cytoplasmic side of plasma membrane Source: RGD
    8. cytosol Source: RefGenome
    9. desmosome Source: RGD
    10. fascia adherens Source: RGD
    11. gamma-catenin-TCF7L2 complex Source: Ensembl
    12. intermediate filament Source: Ensembl
    13. lateral plasma membrane Source: RGD
    14. protein-DNA complex Source: Ensembl
    15. Z disc Source: RefGenome
    16. zonula adherens Source: RefGenome

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 745745Junction plakoglobinPRO_0000064281Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Glycosylationi14 – 141O-linked (GlcNAc)By similarity
    Modified residuei182 – 1821PhosphoserineBy similarity
    Modified residuei665 – 6651PhosphoserineBy similarity

    Post-translational modificationi

    May be phosphorylated by FER.By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ6P0K8.
    PRIDEiQ6P0K8.

    PTM databases

    PhosphoSiteiQ6P0K8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P0K8.

    Interactioni

    Subunit structurei

    Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ6P0K8. 2 interactions.
    MINTiMINT-4566202.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P0K8.
    SMRiQ6P0K8. Positions 118-672.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati132 – 17140ARM 1Add
    BLAST
    Repeati172 – 21544ARM 2Add
    BLAST
    Repeati216 – 25540ARM 3Add
    BLAST
    Repeati258 – 29740ARM 4Add
    BLAST
    Repeati298 – 34144ARM 5Add
    BLAST
    Repeati342 – 38140ARM 6Add
    BLAST
    Repeati383 – 42038ARM 7Add
    BLAST
    Repeati423 – 46442ARM 8Add
    BLAST
    Repeati470 – 51041ARM 9Add
    BLAST
    Repeati512 – 55140ARM 10Add
    BLAST
    Repeati574 – 61340ARM 11Add
    BLAST
    Repeati615 – 66147ARM 12Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni132 – 297166Interaction with DSC1 and DSG1By similarityAdd
    BLAST
    Regioni574 – 66188Interaction with DSC1By similarityAdd
    BLAST

    Domaini

    The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region By similarity.By similarity

    Sequence similaritiesi

    Belongs to the beta-catenin family.Curated
    Contains 12 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG297695.
    GeneTreeiENSGT00730000110821.
    HOGENOMiHOG000230958.
    HOVERGENiHBG000919.
    InParanoidiQ6P0K8.
    KOiK10056.
    OMAiMNLIEQP.
    OrthoDBiEOG7X9G6B.
    PhylomeDBiQ6P0K8.
    TreeFamiTF317997.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view]
    PfamiPF00514. Arm. 4 hits.
    [Graphical view]
    PRINTSiPR01869. BCATNINFAMLY.
    SMARTiSM00185. ARM. 12 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P0K8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GLLDEDDTCG    50
    RQYTLKKTTT YTQGVPQSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL 100
    LLATQVEGQT TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL 150
    LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD 200
    TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL 250
    HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 300
    ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE 350
    AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE NVLKILVNQL 400
    SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD 450
    ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA 500
    TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY 550
    TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 600
    QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF 650
    RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT 700
    YRPMYSSDVP LDPLDMHMDM DGDYPMDTYS DGLRPPYPAA DHMLA 745
    Length:745
    Mass (Da):81,801
    Last modified:July 5, 2004 - v1
    Checksum:iBF8673E1B797954D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC065580 mRNA. Translation: AAH65580.1.
    RefSeqiNP_112309.2. NM_031047.2.
    XP_006247491.1. XM_006247429.1.
    XP_006247492.1. XM_006247430.1.
    UniGeneiRn.11255.

    Genome annotation databases

    EnsembliENSRNOT00000040845; ENSRNOP00000043950; ENSRNOG00000015380.
    GeneIDi81679.
    KEGGirno:81679.
    UCSCiRGD:620412. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC065580 mRNA. Translation: AAH65580.1 .
    RefSeqi NP_112309.2. NM_031047.2.
    XP_006247491.1. XM_006247429.1.
    XP_006247492.1. XM_006247430.1.
    UniGenei Rn.11255.

    3D structure databases

    ProteinModelPortali Q6P0K8.
    SMRi Q6P0K8. Positions 118-672.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6P0K8. 2 interactions.
    MINTi MINT-4566202.

    PTM databases

    PhosphoSitei Q6P0K8.

    Proteomic databases

    PaxDbi Q6P0K8.
    PRIDEi Q6P0K8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000040845 ; ENSRNOP00000043950 ; ENSRNOG00000015380 .
    GeneIDi 81679.
    KEGGi rno:81679.
    UCSCi RGD:620412. rat.

    Organism-specific databases

    CTDi 3728.
    RGDi 620412. Jup.

    Phylogenomic databases

    eggNOGi NOG297695.
    GeneTreei ENSGT00730000110821.
    HOGENOMi HOG000230958.
    HOVERGENi HBG000919.
    InParanoidi Q6P0K8.
    KOi K10056.
    OMAi MNLIEQP.
    OrthoDBi EOG7X9G6B.
    PhylomeDBi Q6P0K8.
    TreeFami TF317997.

    Miscellaneous databases

    NextBioi 615292.
    PROi Q6P0K8.

    Gene expression databases

    Genevestigatori Q6P0K8.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR013284. Beta-catenin.
    [Graphical view ]
    Pfami PF00514. Arm. 4 hits.
    [Graphical view ]
    PRINTSi PR01869. BCATNINFAMLY.
    SMARTi SM00185. ARM. 12 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    2. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-12; 58-81; 192-203 AND 262-279, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiPLAK_RAT
    AccessioniPrimary (citable) accession number: Q6P0K8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3