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Q6P0K8

- PLAK_RAT

UniProt

Q6P0K8 - PLAK_RAT

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Protein

Junction plakoglobin

Gene

Jup

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).By similarity

GO - Molecular functioni

  1. alpha-catenin binding Source: RefGenome
  2. cadherin binding Source: RefGenome
  3. protein kinase binding Source: RGD
  4. structural molecule activity Source: RGD
  5. transcription coactivator activity Source: RefGenome

GO - Biological processi

  1. atrioventricular valve morphogenesis Source: RefGenome
  2. bundle of His cell to Purkinje myocyte communication Source: Ensembl
  3. cell migration Source: Ensembl
  4. cell morphogenesis Source: RefGenome
  5. cellular response to indole-3-methanol Source: Ensembl
  6. cytoskeletal anchoring at plasma membrane Source: RefGenome
  7. desmosome assembly Source: Ensembl
  8. detection of mechanical stimulus Source: Ensembl
  9. ectoderm development Source: RefGenome
  10. establishment of protein localization to plasma membrane Source: Ensembl
  11. gastrulation Source: RefGenome
  12. morphogenesis of embryonic epithelium Source: RefGenome
  13. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
  14. negative regulation of Wnt signaling pathway involved in heart development Source: RefGenome
  15. nervous system development Source: RefGenome
  16. oocyte development Source: RefGenome
  17. positive regulation of protein import into nucleus Source: Ensembl
  18. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  19. protein heterooligomerization Source: RGD
  20. regulation of cell proliferation Source: Ensembl
  21. regulation of heart rate by cardiac conduction Source: Ensembl
  22. single organismal cell-cell adhesion Source: RGD
  23. skin development Source: RefGenome
  24. ventricular cardiac muscle cell action potential Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Junction plakoglobin
Gene namesi
Name:Jup
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi620412. Jup.

Subcellular locationi

Cell junctionadherens junction By similarity. Cell junctiondesmosome By similarity. Cytoplasmcytoskeleton By similarity. Membrane By similarity; Peripheral membrane protein By similarity
Note: Cytoplasmic in a soluble and membrane-associated form.By similarity

GO - Cellular componenti

  1. apicolateral plasma membrane Source: RGD
  2. basolateral plasma membrane Source: RefGenome
  3. catenin complex Source: RefGenome
  4. cell-cell adherens junction Source: RGD
  5. cell-cell junction Source: RGD
  6. cytoplasm Source: RGD
  7. cytoplasmic side of plasma membrane Source: RGD
  8. cytosol Source: RefGenome
  9. desmosome Source: RGD
  10. extracellular vesicular exosome Source: Ensembl
  11. fascia adherens Source: RGD
  12. gamma-catenin-TCF7L2 complex Source: Ensembl
  13. intermediate filament Source: Ensembl
  14. lateral plasma membrane Source: RGD
  15. protein-DNA complex Source: Ensembl
  16. Z disc Source: RefGenome
  17. zonula adherens Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745Junction plakoglobinPRO_0000064281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Glycosylationi14 – 141O-linked (GlcNAc)By similarity
Modified residuei182 – 1821PhosphoserineBy similarity
Modified residuei665 – 6651PhosphoserineBy similarity

Post-translational modificationi

May be phosphorylated by FER.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6P0K8.
PRIDEiQ6P0K8.

PTM databases

PhosphoSiteiQ6P0K8.

Expressioni

Gene expression databases

GenevestigatoriQ6P0K8.

Interactioni

Subunit structurei

Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6P0K8. 2 interactions.
MINTiMINT-4566202.

Structurei

3D structure databases

ProteinModelPortaliQ6P0K8.
SMRiQ6P0K8. Positions 118-672.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati132 – 17140ARM 1Add
BLAST
Repeati172 – 21544ARM 2Add
BLAST
Repeati216 – 25540ARM 3Add
BLAST
Repeati258 – 29740ARM 4Add
BLAST
Repeati298 – 34144ARM 5Add
BLAST
Repeati342 – 38140ARM 6Add
BLAST
Repeati383 – 42038ARM 7Add
BLAST
Repeati423 – 46442ARM 8Add
BLAST
Repeati470 – 51041ARM 9Add
BLAST
Repeati512 – 55140ARM 10Add
BLAST
Repeati574 – 61340ARM 11Add
BLAST
Repeati615 – 66147ARM 12Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 297166Interaction with DSC1 and DSG1By similarityAdd
BLAST
Regioni574 – 66188Interaction with DSC1By similarityAdd
BLAST

Domaini

The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region (By similarity).By similarity

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 12 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
GeneTreeiENSGT00730000110821.
HOGENOMiHOG000230958.
HOVERGENiHBG000919.
InParanoidiQ6P0K8.
KOiK10056.
OMAiMNLIEQP.
OrthoDBiEOG7X9G6B.
PhylomeDBiQ6P0K8.
TreeFamiTF317997.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 4 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P0K8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GLLDEDDTCG
60 70 80 90 100
RQYTLKKTTT YTQGVPQSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL
110 120 130 140 150
LLATQVEGQT TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL
160 170 180 190 200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD
210 220 230 240 250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL
260 270 280 290 300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ
310 320 330 340 350
ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE
360 370 380 390 400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE NVLKILVNQL
410 420 430 440 450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD
460 470 480 490 500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA
510 520 530 540 550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY
560 570 580 590 600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI
610 620 630 640 650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF
660 670 680 690 700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT
710 720 730 740
YRPMYSSDVP LDPLDMHMDM DGDYPMDTYS DGLRPPYPAA DHMLA
Length:745
Mass (Da):81,801
Last modified:July 5, 2004 - v1
Checksum:iBF8673E1B797954D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC065580 mRNA. Translation: AAH65580.1.
RefSeqiNP_112309.2. NM_031047.2.
XP_006247491.1. XM_006247429.1.
XP_006247492.1. XM_006247430.2.
UniGeneiRn.11255.

Genome annotation databases

EnsembliENSRNOT00000040845; ENSRNOP00000043950; ENSRNOG00000015380.
GeneIDi81679.
KEGGirno:81679.
UCSCiRGD:620412. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC065580 mRNA. Translation: AAH65580.1 .
RefSeqi NP_112309.2. NM_031047.2.
XP_006247491.1. XM_006247429.1.
XP_006247492.1. XM_006247430.2.
UniGenei Rn.11255.

3D structure databases

ProteinModelPortali Q6P0K8.
SMRi Q6P0K8. Positions 118-672.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6P0K8. 2 interactions.
MINTi MINT-4566202.

PTM databases

PhosphoSitei Q6P0K8.

Proteomic databases

PaxDbi Q6P0K8.
PRIDEi Q6P0K8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000040845 ; ENSRNOP00000043950 ; ENSRNOG00000015380 .
GeneIDi 81679.
KEGGi rno:81679.
UCSCi RGD:620412. rat.

Organism-specific databases

CTDi 3728.
RGDi 620412. Jup.

Phylogenomic databases

eggNOGi NOG297695.
GeneTreei ENSGT00730000110821.
HOGENOMi HOG000230958.
HOVERGENi HBG000919.
InParanoidi Q6P0K8.
KOi K10056.
OMAi MNLIEQP.
OrthoDBi EOG7X9G6B.
PhylomeDBi Q6P0K8.
TreeFami TF317997.

Miscellaneous databases

NextBioi 615292.
PROi Q6P0K8.

Gene expression databases

Genevestigatori Q6P0K8.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view ]
Pfami PF00514. Arm. 4 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 12 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-12; 58-81; 192-203 AND 262-279, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiPLAK_RAT
AccessioniPrimary (citable) accession number: Q6P0K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3