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Protein

Exosome complex component MTR3

Gene

exosc6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-DRE-429958. mRNA decay by 3' to 5' exoribonuclease.
R-DRE-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-DRE-450604. KSRP (KHSRP) binds and destabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component MTR3
Alternative name(s):
Exosome component 6
mRNA transport regulator 3 homolog
Gene namesi
Name:exosc6
Synonyms:mtr3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-050522-362. exosc6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Exosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Exosome complex component MTR3PRO_0000287480Add
BLAST

Proteomic databases

PaxDbiQ6P0I8.

Expressioni

Gene expression databases

BgeeiQ6P0I8.
ExpressionAtlasiQ6P0I8. differential.

Interactioni

Subunit structurei

Component of the RNA exosome complex.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000052347.

Structurei

3D structure databases

ProteinModelPortaliQ6P0I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family.Curated

Phylogenomic databases

eggNOGiKOG1068. Eukaryota.
COG0689. LUCA.
GeneTreeiENSGT00550000074804.
HOGENOMiHOG000229515.
HOVERGENiHBG057826.
InParanoidiQ6P0I8.
KOiK12587.
OMAiCLHRYPR.
OrthoDBiEOG7BKCVP.
PhylomeDBiQ6P0I8.
TreeFamiTF323886.

Family and domain databases

Gene3Di3.30.230.70. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P0I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVDTKRIRG PEESQSPLLF LSPDKAPKAP SSRQGVRGNG DVRPVFARCG
60 70 80 90 100
LVSQAKGSAY IEAGNTKIIC SVYGPKETER RDETDMKTGR LVCDFRLAPF
110 120 130 140 150
SCVKRGAWIQ GSEERDLSAT LMESLRPGVC LHRYPRSQID VNVMVLENDG
160 170 180 190 200
SVLAHAVTCA SMALADAGIE MYDIVLGCTL RQSGNACLVD PSYAEECGSW
210 220 230 240 250
QEGYGDNQGC VTLALLPNLN QVSGLNADGE MREDTLTEAM RTCMDGCHKL
260 270
YPVVQQALTR AVKKKAPPPE K
Length:271
Mass (Da):29,457
Last modified:August 2, 2005 - v2
Checksum:iAEC1307B0E7FADBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065602 mRNA. Translation: AAH65602.2.
BC095173 mRNA. Translation: AAH95173.1.
RefSeqiNP_001018322.1. NM_001020486.1.
UniGeneiDr.80144.

Genome annotation databases

EnsembliENSDART00000052348; ENSDARP00000052347; ENSDARG00000036060.
GeneIDi326786.
KEGGidre:326786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065602 mRNA. Translation: AAH65602.2.
BC095173 mRNA. Translation: AAH95173.1.
RefSeqiNP_001018322.1. NM_001020486.1.
UniGeneiDr.80144.

3D structure databases

ProteinModelPortaliQ6P0I8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000052347.

Proteomic databases

PaxDbiQ6P0I8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000052348; ENSDARP00000052347; ENSDARG00000036060.
GeneIDi326786.
KEGGidre:326786.

Organism-specific databases

CTDi118460.
ZFINiZDB-GENE-050522-362. exosc6.

Phylogenomic databases

eggNOGiKOG1068. Eukaryota.
COG0689. LUCA.
GeneTreeiENSGT00550000074804.
HOGENOMiHOG000229515.
HOVERGENiHBG057826.
InParanoidiQ6P0I8.
KOiK12587.
OMAiCLHRYPR.
OrthoDBiEOG7BKCVP.
PhylomeDBiQ6P0I8.
TreeFamiTF323886.

Enzyme and pathway databases

ReactomeiR-DRE-429958. mRNA decay by 3' to 5' exoribonuclease.
R-DRE-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-DRE-450604. KSRP (KHSRP) binds and destabilizes mRNA.

Miscellaneous databases

NextBioi20809731.
PROiQ6P0I8.

Gene expression databases

BgeeiQ6P0I8.
ExpressionAtlasiQ6P0I8. differential.

Family and domain databases

Gene3Di3.30.230.70. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiEXOS6_DANRE
AccessioniPrimary (citable) accession number: Q6P0I8
Secondary accession number(s): Q503U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 2, 2005
Last modified: May 11, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.