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Protein

Exosome complex component MTR3

Gene

exosc6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processrRNA processing

Enzyme and pathway databases

ReactomeiR-DRE-429958 mRNA decay by 3' to 5' exoribonuclease
R-DRE-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-DRE-450604 KSRP (KHSRP) binds and destabilizes mRNA
R-DRE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component MTR3
Alternative name(s):
Exosome component 6
mRNA transport regulator 3 homolog
Gene namesi
Name:exosc6
Synonyms:mtr3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-050522-362 exosc6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Exosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874801 – 271Exosome complex component MTR3Add BLAST271

Proteomic databases

PaxDbiQ6P0I8

Expressioni

Gene expression databases

BgeeiENSDARG00000036060
ExpressionAtlasiQ6P0I8 baseline

Interactioni

Subunit structurei

Component of the RNA exosome complex.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000052347

Structurei

3D structure databases

ProteinModelPortaliQ6P0I8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family.Curated

Phylogenomic databases

eggNOGiKOG1068 Eukaryota
COG0689 LUCA
GeneTreeiENSGT00550000074804
HOGENOMiHOG000229515
HOVERGENiHBG057826
InParanoidiQ6P0I8
KOiK12587
OMAiCDFRRAP
OrthoDBiEOG091G0HTJ
PhylomeDBiQ6P0I8
TreeFamiTF323886

Family and domain databases

Gene3Di3.30.230.70, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR036345 ExoRNase_PH_dom2_sf
IPR027408 PNPase/RNase_PH_dom_sf
IPR020568 Ribosomal_S5_D2-typ_fold
PfamiView protein in Pfam
PF01138 RNase_PH, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55666 SSF55666, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P0I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVDTKRIRG PEESQSPLLF LSPDKAPKAP SSRQGVRGNG DVRPVFARCG
60 70 80 90 100
LVSQAKGSAY IEAGNTKIIC SVYGPKETER RDETDMKTGR LVCDFRLAPF
110 120 130 140 150
SCVKRGAWIQ GSEERDLSAT LMESLRPGVC LHRYPRSQID VNVMVLENDG
160 170 180 190 200
SVLAHAVTCA SMALADAGIE MYDIVLGCTL RQSGNACLVD PSYAEECGSW
210 220 230 240 250
QEGYGDNQGC VTLALLPNLN QVSGLNADGE MREDTLTEAM RTCMDGCHKL
260 270
YPVVQQALTR AVKKKAPPPE K
Length:271
Mass (Da):29,457
Last modified:August 2, 2005 - v2
Checksum:iAEC1307B0E7FADBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065602 mRNA Translation: AAH65602.2
BC095173 mRNA Translation: AAH95173.1
RefSeqiNP_001018322.1, NM_001020486.1
UniGeneiDr.80144

Genome annotation databases

EnsembliENSDART00000052348; ENSDARP00000052347; ENSDARG00000036060
GeneIDi326786
KEGGidre:326786

Similar proteinsi

Entry informationi

Entry nameiEXOS6_DANRE
AccessioniPrimary (citable) accession number: Q6P0I8
Secondary accession number(s): Q503U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health