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Protein

COP9 signalosome complex subunit 4

Gene

cops4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).By similarity

Enzyme and pathway databases

ReactomeiR-DRE-5696394. DNA Damage Recognition in GG-NER.
R-DRE-6781823. Formation of TC-NER Pre-Incision Complex.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 4
Short name:
Signalosome subunit 4
Gene namesi
Name:cops4
Synonyms:csn4
ORF Names:zgc:77137
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-030131-4317. cops4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Nucleus, Signalosome, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406COP9 signalosome complex subunit 4PRO_0000120990Add
BLAST

Proteomic databases

PaxDbiQ6P0H6.
PRIDEiQ6P0H6.

Expressioni

Gene expression databases

BgeeiQ6P0H6.

Interactioni

Subunit structurei

Component of the CSN complex.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000064214.

Structurei

3D structure databases

ProteinModelPortaliQ6P0H6.
SMRiQ6P0H6. Positions 299-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini201 – 363163PCIAdd
BLAST

Sequence similaritiesi

Belongs to the CSN4 family.Curated
Contains 1 PCI domain.Curated

Phylogenomic databases

eggNOGiKOG1497. Eukaryota.
ENOG410XPDE. LUCA.
GeneTreeiENSGT00730000111161.
HOGENOMiHOG000158382.
HOVERGENiHBG051136.
InParanoidiQ6P0H6.
KOiK12178.
OMAiINLESTQ.
OrthoDBiEOG7P02HX.
PhylomeDBiQ6P0H6.
TreeFamiTF101147.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR000717. PCI_dom.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P0H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVRQELA QLMNSSGSHK DLAGKYRQIL EKALQFTDAE QLEALKAFVE
60 70 80 90 100
AMVNENVSLV ISRQLLTDFC AHLPNLPDDI AKVVCHFTLE KIQPRVISFE
110 120 130 140 150
EQVASIRQHL ATIYEKQEDW RNAAQVLVGI PLETGQKQYN VDYKLDTYLK
160 170 180 190 200
IARLYLEDDD PVQAEAYINR ASLLQNESTN EQLQIHYKVC YARVLDYRRK
210 220 230 240 250
FIEAAQRYNE LSYKSIVHET ERLEALKHAL HCTILASAGQ QRSRMLATLF
260 270 280 290 300
KDERCQQLAA YGILEKMYLD RIIRGNQLQE FAAMLMPHQK ATTADGSSIL
310 320 330 340 350
DRAVIEHNLL SASKLYNNIT FEELGALLEI PPAKAEKIAS QMITEGRMNG
360 370 380 390 400
FIDQIDGIVH FETREPLPTW DKQIQSLCFQ VNNLLEKISQ TAPEWTAQAI

EAQMSQ
Length:406
Mass (Da):46,346
Last modified:July 5, 2004 - v1
Checksum:i2074D77CE2CF0A2A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 2981S → SS in AAH56527 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056527 mRNA. Translation: AAH56527.1.
BC065617 mRNA. Translation: AAH65617.1.
RefSeqiNP_991119.1. NM_205556.1.
UniGeneiDr.77245.

Genome annotation databases

EnsembliENSDART00000064215; ENSDARP00000064214; ENSDARG00000043732.
GeneIDi325592.
KEGGidre:325592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056527 mRNA. Translation: AAH56527.1.
BC065617 mRNA. Translation: AAH65617.1.
RefSeqiNP_991119.1. NM_205556.1.
UniGeneiDr.77245.

3D structure databases

ProteinModelPortaliQ6P0H6.
SMRiQ6P0H6. Positions 299-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000064214.

Proteomic databases

PaxDbiQ6P0H6.
PRIDEiQ6P0H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000064215; ENSDARP00000064214; ENSDARG00000043732.
GeneIDi325592.
KEGGidre:325592.

Organism-specific databases

CTDi51138.
ZFINiZDB-GENE-030131-4317. cops4.

Phylogenomic databases

eggNOGiKOG1497. Eukaryota.
ENOG410XPDE. LUCA.
GeneTreeiENSGT00730000111161.
HOGENOMiHOG000158382.
HOVERGENiHBG051136.
InParanoidiQ6P0H6.
KOiK12178.
OMAiINLESTQ.
OrthoDBiEOG7P02HX.
PhylomeDBiQ6P0H6.
TreeFamiTF101147.

Enzyme and pathway databases

ReactomeiR-DRE-5696394. DNA Damage Recognition in GG-NER.
R-DRE-6781823. Formation of TC-NER Pre-Incision Complex.

Miscellaneous databases

NextBioi20809371.
PROiQ6P0H6.

Gene expression databases

BgeeiQ6P0H6.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR000717. PCI_dom.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCSN4_DANRE
AccessioniPrimary (citable) accession number: Q6P0H6
Secondary accession number(s): Q6PHJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.