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Protein

Transcription factor Sox-2

Gene

sox2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 106HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • chromatin binding Source: ZFIN
  • sequence-specific DNA binding Source: ZFIN

GO - Biological processi

  • cell proliferation Source: ZFIN
  • epithalamus development Source: ZFIN
  • eye morphogenesis Source: ZFIN
  • fin regeneration Source: ZFIN
  • inner ear receptor cell development Source: ZFIN
  • pineal gland development Source: ZFIN
  • positive regulation of DNA binding transcription factor activity Source: ZFIN
  • regeneration Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DRE-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sox-2
Gene namesi
Name:sox2Imported
ORF Names:zgc:65860, zgc:77389
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-030909-1 sox2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002389111 – 315Transcription factor Sox-2Add BLAST315

Proteomic databases

PaxDbiQ6P0E1

Expressioni

Tissue specificityi

At the shield stage, expressed uniformly in the future ectoderm. At the 75-80% epiboly stage, becomes localized to the presumptive neuroectoderm; strong expression in the presumptive forebrain, weak expression in the presumptive spinal cord. At the tail bud to 3-somite stage, expressed in distinct regions of the future brain, the anterior margin of the neural plate and the future retina. At the 12-somite stage, strong expression in the central nervous system rostral to the hindbrain, including the optic vesicle. At the 21- to 25-somite stage, strong expression in the retina, otic placode and cerebellum. At 28-50 hours post-fertilization, restricted to the ventricular zone of the hindbrain. At 5 days, expressed in the esophageal endoderm.3 Publications

Developmental stagei

Expressed zygotically. First detected at the 30% epiboly stage.1 Publication

Gene expression databases

BgeeiENSDARG00000070913

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095266

Structurei

3D structure databases

ProteinModelPortaliQ6P0E1
SMRiQ6P0E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi243 – 248Poly-SerSequence analysis6

Phylogenomic databases

eggNOGiENOG410IPZI Eukaryota
ENOG411009V LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231647
HOVERGENiHBG105663
InParanoidiQ6P0E1
KOiK16796
OMAiQSYMNGS
OrthoDBiEOG091G0F15
PhylomeDBiQ6P0E1
TreeFamiTF351735

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR032643 SOX-2
IPR022097 SOX_fam
PANTHERiPTHR10270:SF231 PTHR10270:SF231, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12336 SOXp, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P0E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNMMETELK PPAPQPNTGG TGNTNSSGNN QKNSPDRIKR PMNAFMVWSR
60 70 80 90 100
GQRRKMAQEN PKMHNSEISK RLGAEWKLLS ESEKRPFIDE AKRLRALHMK
110 120 130 140 150
EHPDYKYRPR RKTKTLMKKD KYTLPGGLLA PGGNGMGAGV GVGAGLGAGV
160 170 180 190 200
NQRMDSYAHM NGWTNGGYGM MQEQLGYPQH PSLNAHNTAQ MQPMHRYDMS
210 220 230 240 250
ALQYNSMTNS QTYMNGSPTY SMSYSQQSTP GMTLGSMGSV VKSESSSSPP
260 270 280 290 300
VVTSSSHSRA GQCQTGDLRD MISMYLPGAE VQDQSAQSRL HMSQHYQSAP
310
VPGTTINGTI PLSHM
Length:315
Mass (Da):34,698
Last modified:July 5, 2004 - v1
Checksum:iE398DB33C43330EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB242329 mRNA Translation: BAE48583.1
BC056743 mRNA Translation: AAH56743.1
BC065656 mRNA Translation: AAH65656.1
RefSeqiNP_998283.1, NM_213118.1
UniGeneiDr.5379

Genome annotation databases

EnsembliENSDART00000104493; ENSDARP00000095266; ENSDARG00000070913
GeneIDi378723
KEGGidre:378723

Similar proteinsi

Entry informationi

Entry nameiSOX2_DANRE
AccessioniPrimary (citable) accession number: Q6P0E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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