Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor Sox-2

Gene

sox2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi38 – 10669HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: ZFIN
  • sequence-specific DNA binding Source: ZFIN

GO - Biological processi

  • cell proliferation Source: ZFIN
  • epithalamus development Source: ZFIN
  • eye morphogenesis Source: ZFIN
  • fin regeneration Source: ZFIN
  • inner ear receptor cell development Source: ZFIN
  • pineal gland development Source: ZFIN
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: ZFIN
  • regeneration Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sox-2
Gene namesi
Name:sox2Imported
ORF Names:zgc:65860, zgc:77389
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-030909-1. sox2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • transcription factor complex Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Transcription factor Sox-2PRO_0000238911Add
BLAST

Proteomic databases

PaxDbiQ6P0E1.
PRIDEiQ6P0E1.

Expressioni

Tissue specificityi

At the shield stage, expressed uniformly in the future ectoderm. At the 75-80% epiboly stage, becomes localized to the presumptive neuroectoderm; strong expression in the presumptive forebrain, weak expression in the presumptive spinal cord. At the tail bud to 3-somite stage, expressed in distinct regions of the future brain, the anterior margin of the neural plate and the future retina. At the 12-somite stage, strong expression in the central nervous system rostral to the hindbrain, including the optic vesicle. At the 21- to 25-somite stage, strong expression in the retina, otic placode and cerebellum. At 28-50 hours post-fertilization, restricted to the ventricular zone of the hindbrain. At 5 days, expressed in the esophageal endoderm.3 Publications

Developmental stagei

Expressed zygotically. First detected at the 30% epiboly stage.1 Publication

Gene expression databases

BgeeiENSDARG00000070913.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095266.

Structurei

3D structure databases

ProteinModelPortaliQ6P0E1.
SMRiQ6P0E1. Positions 36-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi243 – 2486Poly-SerSequence analysis

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPZI. Eukaryota.
ENOG411009V. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105663.
InParanoidiQ6P0E1.
KOiK16796.
OMAiMSALQYN.
OrthoDBiEOG091G0F15.
PhylomeDBiQ6P0E1.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR032643. SOX-2.
IPR022097. SOX_fam.
[Graphical view]
PANTHERiPTHR10270:SF231. PTHR10270:SF231. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P0E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNMMETELK PPAPQPNTGG TGNTNSSGNN QKNSPDRIKR PMNAFMVWSR
60 70 80 90 100
GQRRKMAQEN PKMHNSEISK RLGAEWKLLS ESEKRPFIDE AKRLRALHMK
110 120 130 140 150
EHPDYKYRPR RKTKTLMKKD KYTLPGGLLA PGGNGMGAGV GVGAGLGAGV
160 170 180 190 200
NQRMDSYAHM NGWTNGGYGM MQEQLGYPQH PSLNAHNTAQ MQPMHRYDMS
210 220 230 240 250
ALQYNSMTNS QTYMNGSPTY SMSYSQQSTP GMTLGSMGSV VKSESSSSPP
260 270 280 290 300
VVTSSSHSRA GQCQTGDLRD MISMYLPGAE VQDQSAQSRL HMSQHYQSAP
310
VPGTTINGTI PLSHM
Length:315
Mass (Da):34,698
Last modified:July 5, 2004 - v1
Checksum:iE398DB33C43330EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB242329 mRNA. Translation: BAE48583.1.
BC056743 mRNA. Translation: AAH56743.1.
BC065656 mRNA. Translation: AAH65656.1.
RefSeqiNP_998283.1. NM_213118.1.
UniGeneiDr.5379.

Genome annotation databases

EnsembliENSDART00000104493; ENSDARP00000095266; ENSDARG00000070913.
GeneIDi378723.
KEGGidre:378723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB242329 mRNA. Translation: BAE48583.1.
BC056743 mRNA. Translation: AAH56743.1.
BC065656 mRNA. Translation: AAH65656.1.
RefSeqiNP_998283.1. NM_213118.1.
UniGeneiDr.5379.

3D structure databases

ProteinModelPortaliQ6P0E1.
SMRiQ6P0E1. Positions 36-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095266.

Proteomic databases

PaxDbiQ6P0E1.
PRIDEiQ6P0E1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000104493; ENSDARP00000095266; ENSDARG00000070913.
GeneIDi378723.
KEGGidre:378723.

Organism-specific databases

CTDi6657.
ZFINiZDB-GENE-030909-1. sox2.

Phylogenomic databases

eggNOGiENOG410IPZI. Eukaryota.
ENOG411009V. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105663.
InParanoidiQ6P0E1.
KOiK16796.
OMAiMSALQYN.
OrthoDBiEOG091G0F15.
PhylomeDBiQ6P0E1.
TreeFamiTF351735.

Miscellaneous databases

PROiQ6P0E1.

Gene expression databases

BgeeiENSDARG00000070913.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR032643. SOX-2.
IPR022097. SOX_fam.
[Graphical view]
PANTHERiPTHR10270:SF231. PTHR10270:SF231. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOX2_DANRE
AccessioniPrimary (citable) accession number: Q6P0E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.