Q6P093 (ADCL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylacetamide deacetylase-like 2
EC=3.1.1.-

Gene names

Name:

AADACL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted.
Sequence similarities	Belongs to the 'GDXG' lipolytic enzyme family.
Sequence caution	The sequence AAH65724.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI46075.1 differs from that shown. Reason: Wrong choice of CDS.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Hydrolase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	carboxylesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P093-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P093-3)

The sequence of this isoform differs from the canonical sequence as follows:
     47-53: AMCFENM → NRGPLTS
     54-401: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 401	383	Arylacetamide deacetylase-like 2		PRO_0000314960
Sites
	Active site	111	1	Potential
	Active site	189	1	Potential
Amino acid modifications
	Disulfide bond	116 ↔ 338		By similarity
Natural variations
	Alternative sequence	47 – 53	7	AMCFENM → NRGPLTS in isoform 2.		VSP_038389
	Alternative sequence	54 – 401	348	Missing in isoform 2.		VSP_038390
	Natural variant	186	1	A → S. Ref.3 Corresponds to variant rs1972977 [ dbSNP | Ensembl ].		VAR_038140
	Natural variant	343	1	L → I. Corresponds to variant rs1052562 [ dbSNP | Ensembl ].		VAR_038141
Experimental info
	Sequence conflict	26	1	N → S in CAI46075. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 24, 2009. Version 3. Checksum: 801AF004D9E6A3DA	FASTA	401	46,099
	10 20 30 40 50 60 MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTAMCF ENMRIMRYEE 70 80 90 100 110 120 FISMIFRLDY TQPLSDEYIT VTDTTFVDIP VRLYLPKRKS ETRRRAVIYF HGGGFCFGSS 130 140 150 160 170 180 KQRAFDFLNR WTANTLDAVV VGVDYRLAPQ HHFPAQFEDG LAAVKFFLLE KILTKYGVDP 190 200 210 220 230 240 TRICIAGDSS GGNLATAVTQ QVQNDAEIKH KIKMQVLLYP GLQITDSYLP SHRENEHGIV 250 260 270 280 290 300 LTRDVAIKLV SLYFTKDEAL PWAMRRNQHM PLESRHLFKF VNWSILLPEK YRKDYVYTEP 310 320 330 340 350 360 ILGGLSYSLP GLTDSRALPL LANDSQLQNL PLTYILTCQH DLLRDDGLMY VTRLRNVGVQ 370 380 390 400 VVHEHIEDGI HGALSFMTSP FYLRLGLRIR DMYVSWLDKN L
	Isoform 2 [UniParc]. Checksum: C99D84CA5DBDA963	FASTA	53	5,863
	10 20 30 40 50 MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTNRGP LTS

References

[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Adipose tissue.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-186. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX647585 mRNA. Translation: CAI46075.1. Sequence problems. AC069067 Genomic DNA. No translation available. BC065724 mRNA. Translation: AAH65724.1. Different initiation.
IPI	IPI00410438. IPI00954047.
RefSeq	NP_997248.2. NM_207365.3.
UniGene	Hs.144710.
3D structure databases
ProteinModelPortal	Q6P093.
SMR	Q6P093. Positions 88-376.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000348911.
PTM databases
PhosphoSite	Q6P093.
Polymorphism databases
DMDM	269849709.
Proteomic databases
PaxDb	Q6P093.
PRIDE	Q6P093.
Protocols and materials databases
DNASU	344752.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356517; ENSP00000348911; ENSG00000197953. ENST00000570799; ENSP00000461239; ENSG00000261846.
GeneID	344752.
KEGG	hsa:344752.
UCSC	uc003ezc.3. human.
Organism-specific databases
CTD	344752.
GeneCards	GC03P151451.
H-InvDB	HIX0024523.
HGNC	HGNC:24427. AADACL2.
neXtProt	NX_Q6P093.
PharmGKB	PA142670463.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0657.
HOGENOM	HOG000033738.
HOVERGEN	HBG058974.
InParanoid	Q6P093.
KO	K14350.
OMA	TKDEALP.
Gene expression databases
ArrayExpress	Q6P093.
Bgee	Q6P093.
CleanEx	HS_AADACL2.
Genevestigator	Q6P093.
Family and domain databases
InterPro	IPR013094. AB_hydrolase_3. IPR017157. Arylacetamide_deacetylase. IPR002168. Lipase_GDXG_AS. [Graphical view]
Pfam	PF07859. Abhydrolase_3. 2 hits. [Graphical view]
PIRSF	PIRSF037251. Arylacetamide_deacetylase. 1 hit.
PROSITE	PS01173. LIPASE_GDXG_HIS. False negative. PS01174. LIPASE_GDXG_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	344752.
NextBio	98745.

Entry information

Entry name

ADCL2_HUMAN

Accession

Primary (citable) accession number: Q6P093
Secondary accession number(s): Q5HYJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 24, 2009
Last modified:	May 29, 2013
This is version 72 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.