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Protein

Arylacetamide deacetylase-like 2

Gene

AADACL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111PROSITE-ProRule annotation
Active sitei189 – 1891PROSITE-ProRule annotation

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Arylacetamide deacetylase-like 2 (EC:3.1.1.-)
Gene namesi
Name:AADACL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 3, Unplaced

Organism-specific databases

HGNCiHGNC:24427. AADACL2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670463.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 401383Arylacetamide deacetylase-like 2PRO_0000314960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi116 ↔ 338By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6P093.
PRIDEiQ6P093.

PTM databases

PhosphoSiteiQ6P093.

Expressioni

Gene expression databases

BgeeiQ6P093.
CleanExiHS_AADACL2.
ExpressionAtlasiQ6P093. baseline.
GenevestigatoriQ6P093.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348911.

Structurei

3D structure databases

ProteinModelPortaliQ6P093.
SMRiQ6P093. Positions 88-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi111 – 1133Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0657.
GeneTreeiENSGT00550000074556.
HOGENOMiHOG000033738.
HOVERGENiHBG058974.
InParanoidiQ6P093.
KOiK14350.
OMAiRRRAVIY.
PhylomeDBiQ6P093.
TreeFamiTF314978.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR017157. Arylacetamide_deacetylase.
IPR002168. Lipase_GDXG_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
PIRSFiPIRSF037251. Arylacetamide_deacetylase. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P093-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTAMCF
60 70 80 90 100
ENMRIMRYEE FISMIFRLDY TQPLSDEYIT VTDTTFVDIP VRLYLPKRKS
110 120 130 140 150
ETRRRAVIYF HGGGFCFGSS KQRAFDFLNR WTANTLDAVV VGVDYRLAPQ
160 170 180 190 200
HHFPAQFEDG LAAVKFFLLE KILTKYGVDP TRICIAGDSS GGNLATAVTQ
210 220 230 240 250
QVQNDAEIKH KIKMQVLLYP GLQITDSYLP SHRENEHGIV LTRDVAIKLV
260 270 280 290 300
SLYFTKDEAL PWAMRRNQHM PLESRHLFKF VNWSILLPEK YRKDYVYTEP
310 320 330 340 350
ILGGLSYSLP GLTDSRALPL LANDSQLQNL PLTYILTCQH DLLRDDGLMY
360 370 380 390 400
VTRLRNVGVQ VVHEHIEDGI HGALSFMTSP FYLRLGLRIR DMYVSWLDKN

L
Length:401
Mass (Da):46,099
Last modified:November 24, 2009 - v3
Checksum:i801AF004D9E6A3DA
GO
Isoform 2 (identifier: Q6P093-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-53: AMCFENM → NRGPLTS
     54-401: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:53
Mass (Da):5,863
Checksum:iC99D84CA5DBDA963
GO

Sequence cautioni

The sequence AAH65724.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI46075.1 differs from that shown.Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261N → S in CAI46075 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti186 – 1861A → S.1 Publication
Corresponds to variant rs1972977 [ dbSNP | Ensembl ].
VAR_038140
Natural varianti343 – 3431L → I.
Corresponds to variant rs1052562 [ dbSNP | Ensembl ].
VAR_038141

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 537AMCFENM → NRGPLTS in isoform 2. 1 PublicationVSP_038389
Alternative sequencei54 – 401348Missing in isoform 2. 1 PublicationVSP_038390Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647585 mRNA. Translation: CAI46075.1. Sequence problems.
AC069067 Genomic DNA. No translation available.
BC065724 mRNA. Translation: AAH65724.1. Different initiation.
CCDSiCCDS3161.2. [Q6P093-1]
RefSeqiNP_997248.2. NM_207365.3. [Q6P093-1]
UniGeneiHs.144710.

Genome annotation databases

EnsembliENST00000356517; ENSP00000348911; ENSG00000197953. [Q6P093-1]
ENST00000570799; ENSP00000461239; ENSG00000261846. [Q6P093-1]
GeneIDi344752.
KEGGihsa:344752.
UCSCiuc003ezc.3. human. [Q6P093-1]

Polymorphism databases

DMDMi269849709.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647585 mRNA. Translation: CAI46075.1. Sequence problems.
AC069067 Genomic DNA. No translation available.
BC065724 mRNA. Translation: AAH65724.1. Different initiation.
CCDSiCCDS3161.2. [Q6P093-1]
RefSeqiNP_997248.2. NM_207365.3. [Q6P093-1]
UniGeneiHs.144710.

3D structure databases

ProteinModelPortaliQ6P093.
SMRiQ6P093. Positions 88-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348911.

PTM databases

PhosphoSiteiQ6P093.

Polymorphism databases

DMDMi269849709.

Proteomic databases

PaxDbiQ6P093.
PRIDEiQ6P093.

Protocols and materials databases

DNASUi344752.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356517; ENSP00000348911; ENSG00000197953. [Q6P093-1]
ENST00000570799; ENSP00000461239; ENSG00000261846. [Q6P093-1]
GeneIDi344752.
KEGGihsa:344752.
UCSCiuc003ezc.3. human. [Q6P093-1]

Organism-specific databases

CTDi344752.
GeneCardsiGC03P151451.
H-InvDBHIX0024523.
HGNCiHGNC:24427. AADACL2.
neXtProtiNX_Q6P093.
PharmGKBiPA142670463.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0657.
GeneTreeiENSGT00550000074556.
HOGENOMiHOG000033738.
HOVERGENiHBG058974.
InParanoidiQ6P093.
KOiK14350.
OMAiRRRAVIY.
PhylomeDBiQ6P093.
TreeFamiTF314978.

Miscellaneous databases

GenomeRNAii344752.
NextBioi98745.
PROiQ6P093.

Gene expression databases

BgeeiQ6P093.
CleanExiHS_AADACL2.
ExpressionAtlasiQ6P093. baseline.
GenevestigatoriQ6P093.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR017157. Arylacetamide_deacetylase.
IPR002168. Lipase_GDXG_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
PIRSFiPIRSF037251. Arylacetamide_deacetylase. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Adipose tissue.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-186.
    Tissue: Placenta.

Entry informationi

Entry nameiADCL2_HUMAN
AccessioniPrimary (citable) accession number: Q6P093
Secondary accession number(s): Q5HYJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 24, 2009
Last modified: January 7, 2015
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.