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Q6P093 (ADCL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arylacetamide deacetylase-like 2

EC=3.1.1.-
Gene names
Name:AADACL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted.

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Sequence caution

The sequence AAH65724.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI46075.1 differs from that shown. Reason: Wrong choice of CDS.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionHydrolase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncarboxylic ester hydrolase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6P093-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6P093-3)

The sequence of this isoform differs from the canonical sequence as follows:
     47-53: AMCFENM → NRGPLTS
     54-401: Missing.
Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 401383Arylacetamide deacetylase-like 2
PRO_0000314960

Regions

Motif111 – 1133Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole By similarity

Sites

Active site1111 Potential
Active site1891 Potential

Amino acid modifications

Disulfide bond116 ↔ 338 By similarity

Natural variations

Alternative sequence47 – 537AMCFENM → NRGPLTS in isoform 2.
VSP_038389
Alternative sequence54 – 401348Missing in isoform 2.
VSP_038390
Natural variant1861A → S. Ref.3
Corresponds to variant rs1972977 [ dbSNP | Ensembl ].
VAR_038140
Natural variant3431L → I.
Corresponds to variant rs1052562 [ dbSNP | Ensembl ].
VAR_038141

Experimental info

Sequence conflict261N → S in CAI46075. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 24, 2009. Version 3.
Checksum: 801AF004D9E6A3DA

FASTA40146,099
        10         20         30         40         50         60 
MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTAMCF ENMRIMRYEE 

        70         80         90        100        110        120 
FISMIFRLDY TQPLSDEYIT VTDTTFVDIP VRLYLPKRKS ETRRRAVIYF HGGGFCFGSS 

       130        140        150        160        170        180 
KQRAFDFLNR WTANTLDAVV VGVDYRLAPQ HHFPAQFEDG LAAVKFFLLE KILTKYGVDP 

       190        200        210        220        230        240 
TRICIAGDSS GGNLATAVTQ QVQNDAEIKH KIKMQVLLYP GLQITDSYLP SHRENEHGIV 

       250        260        270        280        290        300 
LTRDVAIKLV SLYFTKDEAL PWAMRRNQHM PLESRHLFKF VNWSILLPEK YRKDYVYTEP 

       310        320        330        340        350        360 
ILGGLSYSLP GLTDSRALPL LANDSQLQNL PLTYILTCQH DLLRDDGLMY VTRLRNVGVQ 

       370        380        390        400 
VVHEHIEDGI HGALSFMTSP FYLRLGLRIR DMYVSWLDKN L 

« Hide

Isoform 2 [UniParc].

Checksum: C99D84CA5DBDA963
Show »

FASTA535,863

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Adipose tissue.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-186.
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX647585 mRNA. Translation: CAI46075.1. Sequence problems.
AC069067 Genomic DNA. No translation available.
BC065724 mRNA. Translation: AAH65724.1. Different initiation.
RefSeqNP_997248.2. NM_207365.3.
UniGeneHs.144710.

3D structure databases

ProteinModelPortalQ6P093.
SMRQ6P093. Positions 88-376.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000348911.

PTM databases

PhosphoSiteQ6P093.

Polymorphism databases

DMDM269849709.

Proteomic databases

PaxDbQ6P093.
PRIDEQ6P093.

Protocols and materials databases

DNASU344752.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356517; ENSP00000348911; ENSG00000197953. [Q6P093-1]
ENST00000570799; ENSP00000461239; ENSG00000261846. [Q6P093-1]
GeneID344752.
KEGGhsa:344752.
UCSCuc003ezc.3. human. [Q6P093-1]

Organism-specific databases

CTD344752.
GeneCardsGC03P151451.
H-InvDBHIX0024523.
HGNCHGNC:24427. AADACL2.
neXtProtNX_Q6P093.
PharmGKBPA142670463.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0657.
HOGENOMHOG000033738.
HOVERGENHBG058974.
InParanoidQ6P093.
KOK14350.
OMAMRYEEFI.
PhylomeDBQ6P093.
TreeFamTF314978.

Gene expression databases

ArrayExpressQ6P093.
BgeeQ6P093.
CleanExHS_AADACL2.
GenevestigatorQ6P093.

Family and domain databases

InterProIPR013094. AB_hydrolase_3.
IPR017157. Arylacetamide_deacetylase.
IPR002168. Lipase_GDXG_AS.
[Graphical view]
PfamPF07859. Abhydrolase_3. 2 hits.
[Graphical view]
PIRSFPIRSF037251. Arylacetamide_deacetylase. 1 hit.
PROSITEPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi344752.
NextBio98745.
PROQ6P093.

Entry information

Entry nameADCL2_HUMAN
AccessionPrimary (citable) accession number: Q6P093
Secondary accession number(s): Q5HYJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 24, 2009
Last modified: April 16, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM