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Q6P093

- ADCL2_HUMAN

UniProt

Q6P093 - ADCL2_HUMAN

Protein

Arylacetamide deacetylase-like 2

Gene

AADACL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 3 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei111 – 1111PROSITE-ProRule annotation
    Active sitei189 – 1891PROSITE-ProRule annotation

    GO - Molecular functioni

    1. carboxylic ester hydrolase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arylacetamide deacetylase-like 2 (EC:3.1.1.-)
    Gene namesi
    Name:AADACL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:24427. AADACL2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670463.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 401383Arylacetamide deacetylase-like 2PRO_0000314960Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi116 ↔ 338By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ6P093.
    PRIDEiQ6P093.

    PTM databases

    PhosphoSiteiQ6P093.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P093.
    BgeeiQ6P093.
    CleanExiHS_AADACL2.
    GenevestigatoriQ6P093.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000348911.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P093.
    SMRiQ6P093. Positions 88-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi111 – 1133Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

    Sequence similaritiesi

    Belongs to the 'GDXG' lipolytic enzyme family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0657.
    HOGENOMiHOG000033738.
    HOVERGENiHBG058974.
    InParanoidiQ6P093.
    KOiK14350.
    OMAiMRYEEFI.
    PhylomeDBiQ6P093.
    TreeFamiTF314978.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR013094. AB_hydrolase_3.
    IPR017157. Arylacetamide_deacetylase.
    IPR002168. Lipase_GDXG_AS.
    [Graphical view]
    PfamiPF07859. Abhydrolase_3. 2 hits.
    [Graphical view]
    PIRSFiPIRSF037251. Arylacetamide_deacetylase. 1 hit.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P093-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTAMCF    50
    ENMRIMRYEE FISMIFRLDY TQPLSDEYIT VTDTTFVDIP VRLYLPKRKS 100
    ETRRRAVIYF HGGGFCFGSS KQRAFDFLNR WTANTLDAVV VGVDYRLAPQ 150
    HHFPAQFEDG LAAVKFFLLE KILTKYGVDP TRICIAGDSS GGNLATAVTQ 200
    QVQNDAEIKH KIKMQVLLYP GLQITDSYLP SHRENEHGIV LTRDVAIKLV 250
    SLYFTKDEAL PWAMRRNQHM PLESRHLFKF VNWSILLPEK YRKDYVYTEP 300
    ILGGLSYSLP GLTDSRALPL LANDSQLQNL PLTYILTCQH DLLRDDGLMY 350
    VTRLRNVGVQ VVHEHIEDGI HGALSFMTSP FYLRLGLRIR DMYVSWLDKN 400
    L 401
    Length:401
    Mass (Da):46,099
    Last modified:November 24, 2009 - v3
    Checksum:i801AF004D9E6A3DA
    GO
    Isoform 2 (identifier: Q6P093-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         47-53: AMCFENM → NRGPLTS
         54-401: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:53
    Mass (Da):5,863
    Checksum:iC99D84CA5DBDA963
    GO

    Sequence cautioni

    The sequence CAI46075.1 differs from that shown. Reason: Wrong choice of CDS.
    The sequence AAH65724.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261N → S in CAI46075. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti186 – 1861A → S.1 Publication
    Corresponds to variant rs1972977 [ dbSNP | Ensembl ].
    VAR_038140
    Natural varianti343 – 3431L → I.
    Corresponds to variant rs1052562 [ dbSNP | Ensembl ].
    VAR_038141

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei47 – 537AMCFENM → NRGPLTS in isoform 2. 1 PublicationVSP_038389
    Alternative sequencei54 – 401348Missing in isoform 2. 1 PublicationVSP_038390Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX647585 mRNA. Translation: CAI46075.1. Sequence problems.
    AC069067 Genomic DNA. No translation available.
    BC065724 mRNA. Translation: AAH65724.1. Different initiation.
    CCDSiCCDS3161.2. [Q6P093-1]
    RefSeqiNP_997248.2. NM_207365.3. [Q6P093-1]
    UniGeneiHs.144710.

    Genome annotation databases

    EnsembliENST00000356517; ENSP00000348911; ENSG00000197953. [Q6P093-1]
    ENST00000570799; ENSP00000461239; ENSG00000261846. [Q6P093-1]
    GeneIDi344752.
    KEGGihsa:344752.
    UCSCiuc003ezc.3. human. [Q6P093-1]

    Polymorphism databases

    DMDMi269849709.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX647585 mRNA. Translation: CAI46075.1 . Sequence problems.
    AC069067 Genomic DNA. No translation available.
    BC065724 mRNA. Translation: AAH65724.1 . Different initiation.
    CCDSi CCDS3161.2. [Q6P093-1 ]
    RefSeqi NP_997248.2. NM_207365.3. [Q6P093-1 ]
    UniGenei Hs.144710.

    3D structure databases

    ProteinModelPortali Q6P093.
    SMRi Q6P093. Positions 88-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000348911.

    PTM databases

    PhosphoSitei Q6P093.

    Polymorphism databases

    DMDMi 269849709.

    Proteomic databases

    PaxDbi Q6P093.
    PRIDEi Q6P093.

    Protocols and materials databases

    DNASUi 344752.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356517 ; ENSP00000348911 ; ENSG00000197953 . [Q6P093-1 ]
    ENST00000570799 ; ENSP00000461239 ; ENSG00000261846 . [Q6P093-1 ]
    GeneIDi 344752.
    KEGGi hsa:344752.
    UCSCi uc003ezc.3. human. [Q6P093-1 ]

    Organism-specific databases

    CTDi 344752.
    GeneCardsi GC03P151451.
    H-InvDB HIX0024523.
    HGNCi HGNC:24427. AADACL2.
    neXtProti NX_Q6P093.
    PharmGKBi PA142670463.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0657.
    HOGENOMi HOG000033738.
    HOVERGENi HBG058974.
    InParanoidi Q6P093.
    KOi K14350.
    OMAi MRYEEFI.
    PhylomeDBi Q6P093.
    TreeFami TF314978.

    Miscellaneous databases

    GenomeRNAii 344752.
    NextBioi 98745.
    PROi Q6P093.

    Gene expression databases

    ArrayExpressi Q6P093.
    Bgeei Q6P093.
    CleanExi HS_AADACL2.
    Genevestigatori Q6P093.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR013094. AB_hydrolase_3.
    IPR017157. Arylacetamide_deacetylase.
    IPR002168. Lipase_GDXG_AS.
    [Graphical view ]
    Pfami PF07859. Abhydrolase_3. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF037251. Arylacetamide_deacetylase. 1 hit.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS01174. LIPASE_GDXG_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Adipose tissue.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-186.
      Tissue: Placenta.

    Entry informationi

    Entry nameiADCL2_HUMAN
    AccessioniPrimary (citable) accession number: Q6P093
    Secondary accession number(s): Q5HYJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 81 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3