##gff-version 3 Q6P073 UniProtKB Chain 1 259 . . . ID=PRO_0000082597;Note=Ubiquitin-conjugating enzyme E2 J2 Q6P073 UniProtKB Topological domain 1 226 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6P073 UniProtKB Transmembrane 227 247 . . . Note=Helical%3B Anchor for type IV membrane protein;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6P073 UniProtKB Topological domain 248 259 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6P073 UniProtKB Domain 12 162 . . . Note=UBC core;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00388 Q6P073 UniProtKB Active site 94 94 . . . Note=Glycyl thioester intermediate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00388 Q6P073 UniProtKB Mutagenesis 94 94 . . . Note=Loss of catalytic activity. Slows down degradation of misfolded proteins from the ER. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11278356,ECO:0000269|PubMed:12082160;Dbxref=PMID:11278356,PMID:12082160 Q6P073 UniProtKB Sequence conflict 25 25 . . . Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 32 32 . . . Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 49 49 . . . Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 80 80 . . . Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 84 84 . . . Note=N->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 87 87 . . . Note=F->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 133 133 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 150 150 . . . Note=N->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 157 157 . . . Note=C->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 162 162 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 186 186 . . . Note=L->W;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 217 218 . . . Note=AG->GW;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 237 237 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6P073 UniProtKB Sequence conflict 246 246 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305