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Protein

Sorcin

Gene

Sri

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.1 Publication

Miscellaneous

This protein has been shown to bind calcium with high affinity.By similarity

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi83 – 941PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi113 – 1242PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-2672351 Stimuli-sensing channels
R-MMU-418359 Reduction of cytosolic Ca++ levels
R-MMU-425561 Sodium/Calcium exchangers
R-MMU-5578775 Ion homeostasis
R-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Sorcin
Gene namesi
Name:Sri
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:98419 Sri

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737261 – 198SorcinAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P069
PeptideAtlasiQ6P069
PRIDEiQ6P069

2D gel databases

REPRODUCTION-2DPAGEiIPI00556765

PTM databases

iPTMnetiQ6P069
PhosphoSitePlusiQ6P069

Expressioni

Tissue specificityi

Detected in cardiac myocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000003161
CleanExiMM_SRI
GenevisibleiQ6P069 MM

Interactioni

Subunit structurei

Homodimer. Interacts with GCA, RYR2 and ANXA7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2248533 interactors.
IntActiQ6P069 1 interactor.
MINTiQ6P069
STRINGi10090.ENSMUSP00000118221

Structurei

3D structure databases

ProteinModelPortaliQ6P069
SMRiQ6P069
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 64EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini70 – 103EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini100 – 135EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini134 – 169EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
ENOG410YKQK LUCA
GeneTreeiENSGT00620000087734
HOGENOMiHOG000231982
HOVERGENiHBG004492
InParanoidiQ6P069
OMAiIQCVMSI
OrthoDBiEOG091G0ISY
PhylomeDBiQ6P069
TreeFamiTF314682

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P069-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYPGHPGAG GGYYPGGYGG APGGPAFPGQ TQDPLYGYFA AVAGQDGQID
60 70 80 90 100
ADELQRCLTQ SGIAGGYKPF NLETCRLMVS MLDRDMSGTM GFNEFKELWA
110 120 130 140 150
VLNGWRQHFI SFDSDRSGTV DPQELQKALT TMGFRLSPQT VNSVAKRYST
160 170 180 190
SGKITFDDYI ACCVKLRALT DSFRRRDSGQ QGVVNFSYDD FIQCVMTV
Length:198
Mass (Da):21,627
Last modified:July 5, 2004 - v1
Checksum:i254588544495E1BF
GO
Isoform 2 (identifier: Q6P069-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAYPGHPGAGGGYYPGG → MQ

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):20,296
Checksum:i27752F6BEBBB953D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25P → A in BAB25891 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0134481 – 17MAYPG…YYPGG → MQ in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008404 mRNA Translation: BAB25652.1
AK008783 mRNA Translation: BAB25891.1
AK008970 mRNA Translation: BAB25997.1
AK134747 mRNA Translation: BAE22266.1
AK146071 mRNA Translation: BAE26876.1
AK146911 mRNA Translation: BAE27523.1
AK168572 mRNA Translation: BAE40442.1
AK168792 mRNA Translation: BAE40625.1
AK168900 mRNA Translation: BAE40716.1
BC065790 mRNA Translation: AAH65790.1
CCDSiCCDS19079.1 [Q6P069-2]
CCDS39009.1 [Q6P069-1]
RefSeqiNP_001074443.1, NM_001080974.2 [Q6P069-1]
NP_079894.2, NM_025618.3 [Q6P069-2]
UniGeneiMm.96211

Genome annotation databases

EnsembliENSMUST00000088786; ENSMUSP00000086165; ENSMUSG00000003161 [Q6P069-2]
ENSMUST00000148633; ENSMUSP00000118221; ENSMUSG00000003161 [Q6P069-1]
GeneIDi109552
KEGGimmu:109552
UCSCiuc008wjh.2 mouse [Q6P069-2]
uc008wji.2 mouse [Q6P069-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSORCN_MOUSE
AccessioniPrimary (citable) accession number: Q6P069
Secondary accession number(s): Q3UKC5, Q9CR38, Q9D7V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome