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Protein

Sorcin

Gene

Sri

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi83 – 94121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi113 – 124122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.
R-MMU-418359. Reduction of cytosolic Ca++ levels.
R-MMU-425561. Sodium/Calcium exchangers.
R-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorcin
Gene namesi
Name:Sri
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:98419. Sri.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: Ensembl
  • chromaffin granule membrane Source: Ensembl
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • dendritic spine neck Source: Ensembl
  • endoplasmic reticulum membrane Source: MGI
  • extracellular exosome Source: MGI
  • intracellular Source: MGI
  • membrane Source: MGI
  • mitochondrion Source: Ensembl
  • nucleoplasm Source: MGI
  • plasma membrane Source: MGI
  • sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
  • smooth endoplasmic reticulum Source: Ensembl
  • T-tubule Source: Ensembl
  • vesicle Source: MGI
  • Z disc Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198SorcinPRO_0000073726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6P069.
PaxDbiQ6P069.
PeptideAtlasiQ6P069.
PRIDEiQ6P069.

2D gel databases

REPRODUCTION-2DPAGEIPI00556765.

PTM databases

iPTMnetiQ6P069.
PhosphoSiteiQ6P069.

Expressioni

Tissue specificityi

Detected in cardiac myocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000003161.
CleanExiMM_SRI.
GenevisibleiQ6P069. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with GCA, RYR2 and ANXA7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi224853. 3 interactions.
IntActiQ6P069. 1 interaction.
MINTiMINT-4125025.
STRINGi10090.ENSMUSP00000118221.

Structurei

3D structure databases

ProteinModelPortaliQ6P069.
SMRiQ6P069. Positions 33-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 6436EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini70 – 10334EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini100 – 13536EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 16936EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOGENOMiHOG000231982.
HOVERGENiHBG004492.
InParanoidiQ6P069.
OMAiGQQGVVN.
OrthoDBiEOG091G0ISY.
PhylomeDBiQ6P069.
TreeFamiTF314682.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P069-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYPGHPGAG GGYYPGGYGG APGGPAFPGQ TQDPLYGYFA AVAGQDGQID
60 70 80 90 100
ADELQRCLTQ SGIAGGYKPF NLETCRLMVS MLDRDMSGTM GFNEFKELWA
110 120 130 140 150
VLNGWRQHFI SFDSDRSGTV DPQELQKALT TMGFRLSPQT VNSVAKRYST
160 170 180 190
SGKITFDDYI ACCVKLRALT DSFRRRDSGQ QGVVNFSYDD FIQCVMTV
Length:198
Mass (Da):21,627
Last modified:July 5, 2004 - v1
Checksum:i254588544495E1BF
GO
Isoform 2 (identifier: Q6P069-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAYPGHPGAGGGYYPGG → MQ

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):20,296
Checksum:i27752F6BEBBB953D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251P → A in BAB25891 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717MAYPG…YYPGG → MQ in isoform 2. 1 PublicationVSP_013448Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008404 mRNA. Translation: BAB25652.1.
AK008783 mRNA. Translation: BAB25891.1.
AK008970 mRNA. Translation: BAB25997.1.
AK134747 mRNA. Translation: BAE22266.1.
AK146071 mRNA. Translation: BAE26876.1.
AK146911 mRNA. Translation: BAE27523.1.
AK168572 mRNA. Translation: BAE40442.1.
AK168792 mRNA. Translation: BAE40625.1.
AK168900 mRNA. Translation: BAE40716.1.
BC065790 mRNA. Translation: AAH65790.1.
CCDSiCCDS19079.1. [Q6P069-2]
CCDS39009.1. [Q6P069-1]
RefSeqiNP_001074443.1. NM_001080974.2. [Q6P069-1]
NP_079894.2. NM_025618.3. [Q6P069-2]
UniGeneiMm.96211.

Genome annotation databases

EnsembliENSMUST00000088786; ENSMUSP00000086165; ENSMUSG00000003161. [Q6P069-2]
ENSMUST00000148633; ENSMUSP00000118221; ENSMUSG00000003161. [Q6P069-1]
GeneIDi109552.
KEGGimmu:109552.
UCSCiuc008wjh.2. mouse. [Q6P069-2]
uc008wji.2. mouse. [Q6P069-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008404 mRNA. Translation: BAB25652.1.
AK008783 mRNA. Translation: BAB25891.1.
AK008970 mRNA. Translation: BAB25997.1.
AK134747 mRNA. Translation: BAE22266.1.
AK146071 mRNA. Translation: BAE26876.1.
AK146911 mRNA. Translation: BAE27523.1.
AK168572 mRNA. Translation: BAE40442.1.
AK168792 mRNA. Translation: BAE40625.1.
AK168900 mRNA. Translation: BAE40716.1.
BC065790 mRNA. Translation: AAH65790.1.
CCDSiCCDS19079.1. [Q6P069-2]
CCDS39009.1. [Q6P069-1]
RefSeqiNP_001074443.1. NM_001080974.2. [Q6P069-1]
NP_079894.2. NM_025618.3. [Q6P069-2]
UniGeneiMm.96211.

3D structure databases

ProteinModelPortaliQ6P069.
SMRiQ6P069. Positions 33-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224853. 3 interactions.
IntActiQ6P069. 1 interaction.
MINTiMINT-4125025.
STRINGi10090.ENSMUSP00000118221.

PTM databases

iPTMnetiQ6P069.
PhosphoSiteiQ6P069.

2D gel databases

REPRODUCTION-2DPAGEIPI00556765.

Proteomic databases

MaxQBiQ6P069.
PaxDbiQ6P069.
PeptideAtlasiQ6P069.
PRIDEiQ6P069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088786; ENSMUSP00000086165; ENSMUSG00000003161. [Q6P069-2]
ENSMUST00000148633; ENSMUSP00000118221; ENSMUSG00000003161. [Q6P069-1]
GeneIDi109552.
KEGGimmu:109552.
UCSCiuc008wjh.2. mouse. [Q6P069-2]
uc008wji.2. mouse. [Q6P069-1]

Organism-specific databases

CTDi6717.
MGIiMGI:98419. Sri.

Phylogenomic databases

eggNOGiKOG0037. Eukaryota.
ENOG410YKQK. LUCA.
GeneTreeiENSGT00620000087734.
HOGENOMiHOG000231982.
HOVERGENiHBG004492.
InParanoidiQ6P069.
OMAiGQQGVVN.
OrthoDBiEOG091G0ISY.
PhylomeDBiQ6P069.
TreeFamiTF314682.

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.
R-MMU-418359. Reduction of cytosolic Ca++ levels.
R-MMU-425561. Sodium/Calcium exchangers.
R-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiSri. mouse.
PROiQ6P069.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003161.
CleanExiMM_SRI.
GenevisibleiQ6P069. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSORCN_MOUSE
AccessioniPrimary (citable) accession number: Q6P069
Secondary accession number(s): Q3UKC5, Q9CR38, Q9D7V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has been shown to bind calcium with high affinity.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.