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Protein

F-box and leucine-rich protein 22

Gene

FBXL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).1 Publication

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box and leucine-rich protein 22
Gene namesi
Name:FBXL22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000197361.6
HGNCiHGNC:27537 FBXL22
MIMi609088 gene
neXtProtiNX_Q6P050

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi283807
OpenTargetsiENSG00000197361
PharmGKBiPA134959373

Polymorphism and mutation databases

BioMutaiFBXL22
DMDMi519668655

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471491 – 247F-box and leucine-rich protein 22Add BLAST247

Proteomic databases

PaxDbiQ6P050
PeptideAtlasiQ6P050
PRIDEiQ6P050

Expressioni

Tissue specificityi

Enriched in cardiac muscle.1 Publication

Gene expression databases

BgeeiENSG00000197361
CleanExiHS_FBXL22
ExpressionAtlasiQ6P050 baseline and differential

Organism-specific databases

HPAiHPA047624
HPA054627

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.1 Publication

Protein-protein interaction databases

BioGridi1296754 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6P050
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 52F-boxAdd BLAST47

Phylogenomic databases

eggNOGiENOG410JR3A Eukaryota
ENOG410ZQWR LUCA
GeneTreeiENSGT00390000003748
HOGENOMiHOG000112678
InParanoidiQ6P050
KOiK10288
OMAiPDHSEFA
OrthoDBiEOG091G0H2Y
PhylomeDBiQ6P050
TreeFamiTF332457

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPLLTMHIT QLNRECLLHL FSFLDKDSRK SLARTCSQLH DVFEDPALWS
60 70 80 90 100
LLHFRSLTEL QKDNFLLGPA LRSLSICWHS SRVQVCSIED WLKSAFQRSI
110 120 130 140 150
CSRHESLVND FLLRVCDRLS AVRSPRRREA PAPSSGTPIA VGPKSPRWGG
160 170 180 190 200
PDHSEFADLR SGVTGARAAA RRGLGSLRAE RPSETPPAPG VSWGPPPPGA
210 220 230 240
PVVISVKQEE GKQGRTGRRS HRAAPPCGFA RTRVCPPTFP GADAFPQ
Length:247
Mass (Da):27,269
Last modified:June 26, 2013 - v2
Checksum:i9966D98688B8FF26
GO

Sequence cautioni

The sequence AAH65833 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033940115V → L. Corresponds to variant dbSNP:rs8035931Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118274 Genomic DNA No translation available.
BC065833 mRNA Translation: AAH65833.1 Different initiation.
CCDSiCCDS10187.2
RefSeqiNP_976307.2, NM_203373.2
UniGeneiHs.631163
Hs.656997

Genome annotation databases

EnsembliENST00000360587; ENSP00000353794; ENSG00000197361
GeneIDi283807
KEGGihsa:283807
UCSCiuc002amn.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFXL22_HUMAN
AccessioniPrimary (citable) accession number: Q6P050
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 26, 2013
Last modified: January 31, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome