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Q6P047

- CH074_HUMAN

UniProt

Q6P047 - CH074_HUMAN

Protein

Uncharacterized protein C8orf74

Gene

C8orf74

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C8orf74
    Gene namesi
    Name:C8orf74
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:32296. C8orf74.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672337.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Uncharacterized protein C8orf74PRO_0000270931Add
    BLAST

    Proteomic databases

    PaxDbiQ6P047.
    PRIDEiQ6P047.

    PTM databases

    PhosphoSiteiQ6P047.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P047.
    BgeeiQ6P047.
    CleanExiHS_C8orf74.
    GenevestigatoriQ6P047.

    Organism-specific databases

    HPAiHPA027986.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KDM1AO603412EBI-8466055,EBI-710124
    PRMT6Q96LA82EBI-8466055,EBI-912440
    SUV39H1O434632EBI-8466055,EBI-349968

    Protein-protein interaction databases

    BioGridi128447. 4 interactions.
    IntActiQ6P047. 4 interactions.
    MINTiMINT-8417637.
    STRINGi9606.ENSP00000307129.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P047.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG25134.
    HOGENOMiHOG000111621.
    HOVERGENiHBG080723.
    InParanoidiQ6P047.
    OMAiVAHLEVC.
    OrthoDBiEOG7SFJ02.
    PhylomeDBiQ6P047.
    TreeFamiTF343725.

    Sequencei

    Sequence statusi: Complete.

    Q6P047-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLTPQGVK EVFQLQRPQG RERLRRLLNW EEFDEQRDSR RSILLDTLYE    50
    SIIFAVGKGF PWVEVAQVVK FTEELLRETK GCSITEAVTI LGNKLRDYRG 100
    HFNTTHLLAL CDYFHHTFIR HYKLYQYVLG QDQQVDLTVA HLEVCMPPHP 150
    LPLAEGMDRD LWIHEQQVAT LTEAEAQKRA DVLLLKEALR LERENSLQKA 200
    FAAAAPAQPG QVLERQELES LICQAVHTQM ELLQELLQRQ IQNTFAILDL 250
    KLQKKTLNLN APTPIPPPIT SHAGQEEALK PQRASKGKKA KARK 294
    Length:294
    Mass (Da):33,735
    Last modified:May 18, 2010 - v3
    Checksum:i555321ACEF4927C2
    GO

    Sequence cautioni

    The sequence AAH65837.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151L → F.2 Publications
    Corresponds to variant rs11250058 [ dbSNP | Ensembl ].
    VAR_033684
    Natural varianti222 – 2221I → V.
    Corresponds to variant rs57041981 [ dbSNP | Ensembl ].
    VAR_061596

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC105001 Genomic DNA. No translation available.
    CH471157 Genomic DNA. Translation: EAW65593.1.
    BC065837 mRNA. Translation: AAH65837.1. Different initiation.
    BC132852 mRNA. Translation: AAI32853.1.
    BC132854 mRNA. Translation: AAI32855.1.
    CCDSiCCDS47800.1.
    RefSeqiNP_001035121.1. NM_001040032.1.
    UniGeneiHs.371776.

    Genome annotation databases

    EnsembliENST00000304519; ENSP00000307129; ENSG00000171060.
    GeneIDi203076.
    KEGGihsa:203076.
    UCSCiuc003wtd.1. human.

    Polymorphism databases

    DMDMi296439406.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC105001 Genomic DNA. No translation available.
    CH471157 Genomic DNA. Translation: EAW65593.1 .
    BC065837 mRNA. Translation: AAH65837.1 . Different initiation.
    BC132852 mRNA. Translation: AAI32853.1 .
    BC132854 mRNA. Translation: AAI32855.1 .
    CCDSi CCDS47800.1.
    RefSeqi NP_001035121.1. NM_001040032.1.
    UniGenei Hs.371776.

    3D structure databases

    ProteinModelPortali Q6P047.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128447. 4 interactions.
    IntActi Q6P047. 4 interactions.
    MINTi MINT-8417637.
    STRINGi 9606.ENSP00000307129.

    PTM databases

    PhosphoSitei Q6P047.

    Polymorphism databases

    DMDMi 296439406.

    Proteomic databases

    PaxDbi Q6P047.
    PRIDEi Q6P047.

    Protocols and materials databases

    DNASUi 203076.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304519 ; ENSP00000307129 ; ENSG00000171060 .
    GeneIDi 203076.
    KEGGi hsa:203076.
    UCSCi uc003wtd.1. human.

    Organism-specific databases

    CTDi 203076.
    GeneCardsi GC08P010530.
    HGNCi HGNC:32296. C8orf74.
    HPAi HPA027986.
    neXtProti NX_Q6P047.
    PharmGKBi PA142672337.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25134.
    HOGENOMi HOG000111621.
    HOVERGENi HBG080723.
    InParanoidi Q6P047.
    OMAi VAHLEVC.
    OrthoDBi EOG7SFJ02.
    PhylomeDBi Q6P047.
    TreeFami TF343725.

    Miscellaneous databases

    GenomeRNAii 203076.
    NextBioi 90337.

    Gene expression databases

    ArrayExpressi Q6P047.
    Bgeei Q6P047.
    CleanExi HS_C8orf74.
    Genevestigatori Q6P047.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-15.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-15.
      Tissue: Testis.

    Entry informationi

    Entry nameiCH074_HUMAN
    AccessioniPrimary (citable) accession number: Q6P047
    Secondary accession number(s): A2RUD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 65 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3