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Q6P047 (CH074_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C8orf74
Gene names
Name:C8orf74
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence caution

The sequence AAH65837.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Uncharacterized protein C8orf74
PRO_0000270931

Natural variations

Natural variant151L → F. Ref.2 Ref.3
Corresponds to variant rs11250058 [ dbSNP | Ensembl ].
VAR_033684
Natural variant2221I → V.
Corresponds to variant rs57041981 [ dbSNP | Ensembl ].
VAR_061596

Sequences

Sequence LengthMass (Da)Tools
Q6P047 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 555321ACEF4927C2

FASTA29433,735
        10         20         30         40         50         60 
MALLTPQGVK EVFQLQRPQG RERLRRLLNW EEFDEQRDSR RSILLDTLYE SIIFAVGKGF 

        70         80         90        100        110        120 
PWVEVAQVVK FTEELLRETK GCSITEAVTI LGNKLRDYRG HFNTTHLLAL CDYFHHTFIR 

       130        140        150        160        170        180 
HYKLYQYVLG QDQQVDLTVA HLEVCMPPHP LPLAEGMDRD LWIHEQQVAT LTEAEAQKRA 

       190        200        210        220        230        240 
DVLLLKEALR LERENSLQKA FAAAAPAQPG QVLERQELES LICQAVHTQM ELLQELLQRQ 

       250        260        270        280        290 
IQNTFAILDL KLQKKTLNLN APTPIPPPIT SHAGQEEALK PQRASKGKKA KARK 

« Hide

References

[1]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-15.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-15.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC105001 Genomic DNA. No translation available.
CH471157 Genomic DNA. Translation: EAW65593.1.
BC065837 mRNA. Translation: AAH65837.1. Different initiation.
BC132852 mRNA. Translation: AAI32853.1.
BC132854 mRNA. Translation: AAI32855.1.
RefSeqNP_001035121.1. NM_001040032.1.
UniGeneHs.371776.

3D structure databases

ProteinModelPortalQ6P047.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128447. 4 interactions.
IntActQ6P047. 4 interactions.
MINTMINT-8417637.
STRING9606.ENSP00000307129.

PTM databases

PhosphoSiteQ6P047.

Polymorphism databases

DMDM296439406.

Proteomic databases

PaxDbQ6P047.
PRIDEQ6P047.

Protocols and materials databases

DNASU203076.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304519; ENSP00000307129; ENSG00000171060.
GeneID203076.
KEGGhsa:203076.
UCSCuc003wtd.1. human.

Organism-specific databases

CTD203076.
GeneCardsGC08P010530.
HGNCHGNC:32296. C8orf74.
HPAHPA027986.
neXtProtNX_Q6P047.
PharmGKBPA142672337.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25134.
HOGENOMHOG000111621.
HOVERGENHBG080723.
InParanoidQ6P047.
OMAVAHLEVC.
OrthoDBEOG7SFJ02.
PhylomeDBQ6P047.
TreeFamTF343725.

Gene expression databases

ArrayExpressQ6P047.
BgeeQ6P047.
CleanExHS_C8orf74.
GenevestigatorQ6P047.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi203076.
NextBio90337.

Entry information

Entry nameCH074_HUMAN
AccessionPrimary (citable) accession number: Q6P047
Secondary accession number(s): A2RUD6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM