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Protein

Uncharacterized protein C8orf74

Gene

C8orf74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C8orf74
Gene namesi
Name:C8orf74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:32296. C8orf74.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672337.

Polymorphism and mutation databases

BioMutaiC8orf74.
DMDMi296439406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Uncharacterized protein C8orf74PRO_0000270931Add
BLAST

Proteomic databases

PaxDbiQ6P047.
PRIDEiQ6P047.

PTM databases

PhosphoSiteiQ6P047.

Expressioni

Gene expression databases

BgeeiQ6P047.
CleanExiHS_C8orf74.
ExpressionAtlasiQ6P047. baseline.
GenevisibleiQ6P047. HS.

Organism-specific databases

HPAiHPA027986.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603412EBI-8466055,EBI-710124
PRMT6Q96LA82EBI-8466055,EBI-912440
SUV39H1O434632EBI-8466055,EBI-349968

Protein-protein interaction databases

BioGridi128447. 7 interactions.
IntActiQ6P047. 4 interactions.
MINTiMINT-8417637.
STRINGi9606.ENSP00000307129.

Structurei

3D structure databases

ProteinModelPortaliQ6P047.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG25134.
GeneTreeiENSGT00390000010548.
HOGENOMiHOG000111621.
HOVERGENiHBG080723.
InParanoidiQ6P047.
OMAiVAHLEVC.
OrthoDBiEOG7SFJ02.
PhylomeDBiQ6P047.
TreeFamiTF343725.

Sequencei

Sequence statusi: Complete.

Q6P047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLTPQGVK EVFQLQRPQG RERLRRLLNW EEFDEQRDSR RSILLDTLYE
60 70 80 90 100
SIIFAVGKGF PWVEVAQVVK FTEELLRETK GCSITEAVTI LGNKLRDYRG
110 120 130 140 150
HFNTTHLLAL CDYFHHTFIR HYKLYQYVLG QDQQVDLTVA HLEVCMPPHP
160 170 180 190 200
LPLAEGMDRD LWIHEQQVAT LTEAEAQKRA DVLLLKEALR LERENSLQKA
210 220 230 240 250
FAAAAPAQPG QVLERQELES LICQAVHTQM ELLQELLQRQ IQNTFAILDL
260 270 280 290
KLQKKTLNLN APTPIPPPIT SHAGQEEALK PQRASKGKKA KARK
Length:294
Mass (Da):33,735
Last modified:May 18, 2010 - v3
Checksum:i555321ACEF4927C2
GO

Sequence cautioni

The sequence AAH65837.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151L → F.2 Publications
Corresponds to variant rs11250058 [ dbSNP | Ensembl ].
VAR_033684
Natural varianti222 – 2221I → V.
Corresponds to variant rs57041981 [ dbSNP | Ensembl ].
VAR_061596

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105001 Genomic DNA. No translation available.
CH471157 Genomic DNA. Translation: EAW65593.1.
BC065837 mRNA. Translation: AAH65837.1. Different initiation.
BC132852 mRNA. Translation: AAI32853.1.
BC132854 mRNA. Translation: AAI32855.1.
CCDSiCCDS47800.1.
RefSeqiNP_001035121.1. NM_001040032.1.
UniGeneiHs.371776.

Genome annotation databases

EnsembliENST00000304519; ENSP00000307129; ENSG00000171060.
GeneIDi203076.
KEGGihsa:203076.
UCSCiuc003wtd.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105001 Genomic DNA. No translation available.
CH471157 Genomic DNA. Translation: EAW65593.1.
BC065837 mRNA. Translation: AAH65837.1. Different initiation.
BC132852 mRNA. Translation: AAI32853.1.
BC132854 mRNA. Translation: AAI32855.1.
CCDSiCCDS47800.1.
RefSeqiNP_001035121.1. NM_001040032.1.
UniGeneiHs.371776.

3D structure databases

ProteinModelPortaliQ6P047.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128447. 7 interactions.
IntActiQ6P047. 4 interactions.
MINTiMINT-8417637.
STRINGi9606.ENSP00000307129.

PTM databases

PhosphoSiteiQ6P047.

Polymorphism and mutation databases

BioMutaiC8orf74.
DMDMi296439406.

Proteomic databases

PaxDbiQ6P047.
PRIDEiQ6P047.

Protocols and materials databases

DNASUi203076.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304519; ENSP00000307129; ENSG00000171060.
GeneIDi203076.
KEGGihsa:203076.
UCSCiuc003wtd.1. human.

Organism-specific databases

CTDi203076.
GeneCardsiGC08P010530.
HGNCiHGNC:32296. C8orf74.
HPAiHPA027986.
neXtProtiNX_Q6P047.
PharmGKBiPA142672337.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25134.
GeneTreeiENSGT00390000010548.
HOGENOMiHOG000111621.
HOVERGENiHBG080723.
InParanoidiQ6P047.
OMAiVAHLEVC.
OrthoDBiEOG7SFJ02.
PhylomeDBiQ6P047.
TreeFamiTF343725.

Miscellaneous databases

ChiTaRSiC8orf74. human.
GenomeRNAii203076.
NextBioi90337.
PROiQ6P047.

Gene expression databases

BgeeiQ6P047.
CleanExiHS_C8orf74.
ExpressionAtlasiQ6P047. baseline.
GenevisibleiQ6P047. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-15.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-15.
    Tissue: Testis.

Entry informationi

Entry nameiCH074_HUMAN
AccessioniPrimary (citable) accession number: Q6P047
Secondary accession number(s): A2RUD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.