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Q6P047

- CH074_HUMAN

UniProt

Q6P047 - CH074_HUMAN

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Protein

Uncharacterized protein C8orf74

Gene

C8orf74

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C8orf74
Gene namesi
Name:C8orf74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:32296. C8orf74.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Uncharacterized protein C8orf74PRO_0000270931Add
BLAST

Proteomic databases

PaxDbiQ6P047.
PRIDEiQ6P047.

PTM databases

PhosphoSiteiQ6P047.

Expressioni

Gene expression databases

BgeeiQ6P047.
CleanExiHS_C8orf74.
ExpressionAtlasiQ6P047. baseline.
GenevestigatoriQ6P047.

Organism-specific databases

HPAiHPA027986.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KDM1AO603412EBI-8466055,EBI-710124
PRMT6Q96LA82EBI-8466055,EBI-912440
SUV39H1O434632EBI-8466055,EBI-349968

Protein-protein interaction databases

BioGridi128447. 7 interactions.
IntActiQ6P047. 4 interactions.
MINTiMINT-8417637.
STRINGi9606.ENSP00000307129.

Structurei

3D structure databases

ProteinModelPortaliQ6P047.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG25134.
GeneTreeiENSGT00390000010548.
HOGENOMiHOG000111621.
HOVERGENiHBG080723.
InParanoidiQ6P047.
OMAiVAHLEVC.
OrthoDBiEOG7SFJ02.
PhylomeDBiQ6P047.
TreeFamiTF343725.

Sequencei

Sequence statusi: Complete.

Q6P047-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MALLTPQGVK EVFQLQRPQG RERLRRLLNW EEFDEQRDSR RSILLDTLYE
60 70 80 90 100
SIIFAVGKGF PWVEVAQVVK FTEELLRETK GCSITEAVTI LGNKLRDYRG
110 120 130 140 150
HFNTTHLLAL CDYFHHTFIR HYKLYQYVLG QDQQVDLTVA HLEVCMPPHP
160 170 180 190 200
LPLAEGMDRD LWIHEQQVAT LTEAEAQKRA DVLLLKEALR LERENSLQKA
210 220 230 240 250
FAAAAPAQPG QVLERQELES LICQAVHTQM ELLQELLQRQ IQNTFAILDL
260 270 280 290
KLQKKTLNLN APTPIPPPIT SHAGQEEALK PQRASKGKKA KARK
Length:294
Mass (Da):33,735
Last modified:May 18, 2010 - v3
Checksum:i555321ACEF4927C2
GO

Sequence cautioni

The sequence AAH65837.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151L → F.2 Publications
Corresponds to variant rs11250058 [ dbSNP | Ensembl ].
VAR_033684
Natural varianti222 – 2221I → V.
Corresponds to variant rs57041981 [ dbSNP | Ensembl ].
VAR_061596

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105001 Genomic DNA. No translation available.
CH471157 Genomic DNA. Translation: EAW65593.1.
BC065837 mRNA. Translation: AAH65837.1. Different initiation.
BC132852 mRNA. Translation: AAI32853.1.
BC132854 mRNA. Translation: AAI32855.1.
CCDSiCCDS47800.1.
RefSeqiNP_001035121.1. NM_001040032.1.
UniGeneiHs.371776.

Genome annotation databases

EnsembliENST00000304519; ENSP00000307129; ENSG00000171060.
GeneIDi203076.
KEGGihsa:203076.
UCSCiuc003wtd.1. human.

Polymorphism databases

DMDMi296439406.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105001 Genomic DNA. No translation available.
CH471157 Genomic DNA. Translation: EAW65593.1 .
BC065837 mRNA. Translation: AAH65837.1 . Different initiation.
BC132852 mRNA. Translation: AAI32853.1 .
BC132854 mRNA. Translation: AAI32855.1 .
CCDSi CCDS47800.1.
RefSeqi NP_001035121.1. NM_001040032.1.
UniGenei Hs.371776.

3D structure databases

ProteinModelPortali Q6P047.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128447. 7 interactions.
IntActi Q6P047. 4 interactions.
MINTi MINT-8417637.
STRINGi 9606.ENSP00000307129.

PTM databases

PhosphoSitei Q6P047.

Polymorphism databases

DMDMi 296439406.

Proteomic databases

PaxDbi Q6P047.
PRIDEi Q6P047.

Protocols and materials databases

DNASUi 203076.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304519 ; ENSP00000307129 ; ENSG00000171060 .
GeneIDi 203076.
KEGGi hsa:203076.
UCSCi uc003wtd.1. human.

Organism-specific databases

CTDi 203076.
GeneCardsi GC08P010530.
HGNCi HGNC:32296. C8orf74.
HPAi HPA027986.
neXtProti NX_Q6P047.
PharmGKBi PA142672337.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25134.
GeneTreei ENSGT00390000010548.
HOGENOMi HOG000111621.
HOVERGENi HBG080723.
InParanoidi Q6P047.
OMAi VAHLEVC.
OrthoDBi EOG7SFJ02.
PhylomeDBi Q6P047.
TreeFami TF343725.

Miscellaneous databases

ChiTaRSi C8orf74. human.
GenomeRNAii 203076.
NextBioi 90337.

Gene expression databases

Bgeei Q6P047.
CleanExi HS_C8orf74.
ExpressionAtlasi Q6P047. baseline.
Genevestigatori Q6P047.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-15.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-15.
    Tissue: Testis.

Entry informationi

Entry nameiCH074_HUMAN
AccessioniPrimary (citable) accession number: Q6P047
Secondary accession number(s): A2RUD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3