Q6P047 (CH074_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C8orf74

Gene names

Name:

C8orf74

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence AAH65837.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Uncharacterized protein C8orf74		PRO_0000270931
Natural variations
	Natural variant	15	1	L → F. Ref.2 Ref.3 Corresponds to variant rs11250058 [ dbSNP | Ensembl ].		VAR_033684
	Natural variant	222	1	I → V. Corresponds to variant rs57041981 [ dbSNP | Ensembl ].		VAR_061596

Sequences

	Sequence		Length	Mass (Da)
	Q6P047 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 555321ACEF4927C2	FASTA	294	33,735
	10 20 30 40 50 60 MALLTPQGVK EVFQLQRPQG RERLRRLLNW EEFDEQRDSR RSILLDTLYE SIIFAVGKGF 70 80 90 100 110 120 PWVEVAQVVK FTEELLRETK GCSITEAVTI LGNKLRDYRG HFNTTHLLAL CDYFHHTFIR 130 140 150 160 170 180 HYKLYQYVLG QDQQVDLTVA HLEVCMPPHP LPLAEGMDRD LWIHEQQVAT LTEAEAQKRA 190 200 210 220 230 240 DVLLLKEALR LERENSLQKA FAAAAPAQPG QVLERQELES LICQAVHTQM ELLQELLQRQ 250 260 270 280 290 IQNTFAILDL KLQKKTLNLN APTPIPPPIT SHAGQEEALK PQRASKGKKA KARK

References

[1]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT PHE-15.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-15. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC105001 Genomic DNA. No translation available. CH471157 Genomic DNA. Translation: EAW65593.1. BC065837 mRNA. Translation: AAH65837.1. Different initiation. BC132852 mRNA. Translation: AAI32853.1. BC132854 mRNA. Translation: AAI32855.1.
IPI	IPI00741453.
RefSeq	NP_001035121.1. NM_001040032.1.
UniGene	Hs.371776.
3D structure databases
ProteinModelPortal	Q6P047.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-8417637.
STRING	9606.ENSP00000307129.
PTM databases
PhosphoSite	Q6P047.
Polymorphism databases
DMDM	296439406.
Proteomic databases
PaxDb	Q6P047.
PRIDE	Q6P047.
Protocols and materials databases
DNASU	203076.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304519; ENSP00000307129; ENSG00000171060.
GeneID	203076.
KEGG	hsa:203076.
UCSC	uc003wtd.1. human.
Organism-specific databases
CTD	203076.
GeneCards	GC08P010530.
HGNC	HGNC:32296. C8orf74.
HPA	HPA027986.
neXtProt	NX_Q6P047.
PharmGKB	PA142672337.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25134.
HOGENOM	HOG000111621.
HOVERGEN	HBG080723.
InParanoid	Q6P047.
OMA	YQYVLGQ.
OrthoDB	EOG4NGGNJ.
Gene expression databases
ArrayExpress	Q6P047.
Bgee	Q6P047.
CleanEx	HS_C8orf74.
Genevestigator	Q6P047.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	203076.
NextBio	90337.

Entry information

Entry name

CH074_HUMAN

Accession

Primary (citable) accession number: Q6P047
Secondary accession number(s): A2RUD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	May 18, 2010
Last modified:	May 29, 2013
This is version 57 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.