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Protein

Cdc42 effector protein 5

Gene

CDC42EP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • GTP-Rho binding Source: UniProtKB

GO - Biological processi

  • JNK cascade Source: Ensembl
  • positive regulation of actin filament polymerization Source: UniProtKB
  • positive regulation of GTPase activity Source: GOC
  • positive regulation of pseudopodium assembly Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • Rho protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Cell shape

Enzyme and pathway databases

ReactomeiR-HSA-5687128. MAPK6/MAPK4 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 5
Alternative name(s):
Binder of Rho GTPases 3
Gene namesi
Name:CDC42EP5
Synonyms:BORG3, CEP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17408. CDC42EP5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • endomembrane system Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134989100.

Polymorphism and mutation databases

DMDMi71152342.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Cdc42 effector protein 5PRO_0000212653Add
BLAST

Proteomic databases

MaxQBiQ6NZY7.
PaxDbiQ6NZY7.
PeptideAtlasiQ6NZY7.
PRIDEiQ6NZY7.

PTM databases

PhosphoSiteiQ6NZY7.

Expressioni

Gene expression databases

BgeeiQ6NZY7.
CleanExiHS_CDC42EP5.
GenevisibleiQ6NZY7. HS.

Organism-specific databases

HPAiHPA043449.

Interactioni

Subunit structurei

Interacts with CDC42, in a GTP-dependent manner, and with SEPT7.By similarity

GO - Molecular functioni

  • GTP-Rho binding Source: UniProtKB

Protein-protein interaction databases

BioGridi127125. 5 interactions.
STRINGi9606.ENSP00000301200.

Structurei

3D structure databases

ProteinModelPortaliQ6NZY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 3715CRIBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 8732Pro-richAdd
BLAST
Compositional biasi114 – 1174Poly-Ala

Domaini

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated
Contains 1 CRIB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J2KV. Eukaryota.
ENOG410ZF7J. LUCA.
GeneTreeiENSGT00730000110869.
HOGENOMiHOG000043688.
HOVERGENiHBG080905.
InParanoidiQ6NZY7.
OMAiQHPRARC.
OrthoDBiEOG7T1RDC.
PhylomeDBiQ6NZY7.
TreeFamiTF331725.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NZY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVLKQLGPA QPKKRPDRGA LSISAPLGDF RHTLHVGRGG DAFGDTSFLS
60 70 80 90 100
RHGGGPPPEP RAPPAGAPRS PPPPAVPQSA APSPADPLLS FHLDLGPSML
110 120 130 140
DAVLGVMDAA RPEAAAAKPD AEPRPGTQPP QARCRPNADL ELNDVIGL
Length:148
Mass (Da):15,207
Last modified:July 5, 2004 - v1
Checksum:i48BC1A9B9307CEEC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591E → Q in AAH24327 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU467002 Genomic DNA. Translation: CAQ08958.1.
CU207370 Genomic DNA. Translation: CAQ52436.1.
CH471135 Genomic DNA. Translation: EAW72252.1.
BC024327 mRNA. Translation: AAH24327.1.
BC065910 mRNA. Translation: AAH65910.1.
CCDSiCCDS12896.1.
RefSeqiNP_659494.2. NM_145057.3.
UniGeneiHs.415791.

Genome annotation databases

EnsembliENST00000301200; ENSP00000301200; ENSG00000167617.
ENST00000611094; ENSP00000484985; ENSG00000273622.
ENST00000617756; ENSP00000484158; ENSG00000273633.
ENST00000619217; ENSP00000479726; ENSG00000278444.
GeneIDi148170.
KEGGihsa:148170.
UCSCiuc002qfz.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU467002 Genomic DNA. Translation: CAQ08958.1.
CU207370 Genomic DNA. Translation: CAQ52436.1.
CH471135 Genomic DNA. Translation: EAW72252.1.
BC024327 mRNA. Translation: AAH24327.1.
BC065910 mRNA. Translation: AAH65910.1.
CCDSiCCDS12896.1.
RefSeqiNP_659494.2. NM_145057.3.
UniGeneiHs.415791.

3D structure databases

ProteinModelPortaliQ6NZY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127125. 5 interactions.
STRINGi9606.ENSP00000301200.

PTM databases

PhosphoSiteiQ6NZY7.

Polymorphism and mutation databases

DMDMi71152342.

Proteomic databases

MaxQBiQ6NZY7.
PaxDbiQ6NZY7.
PeptideAtlasiQ6NZY7.
PRIDEiQ6NZY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301200; ENSP00000301200; ENSG00000167617.
ENST00000611094; ENSP00000484985; ENSG00000273622.
ENST00000617756; ENSP00000484158; ENSG00000273633.
ENST00000619217; ENSP00000479726; ENSG00000278444.
GeneIDi148170.
KEGGihsa:148170.
UCSCiuc002qfz.3. human.

Organism-specific databases

CTDi148170.
GeneCardsiCDC42EP5.
HGNCiHGNC:17408. CDC42EP5.
HPAiHPA043449.
MIMi609171. gene.
neXtProtiNX_Q6NZY7.
PharmGKBiPA134989100.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2KV. Eukaryota.
ENOG410ZF7J. LUCA.
GeneTreeiENSGT00730000110869.
HOGENOMiHOG000043688.
HOVERGENiHBG080905.
InParanoidiQ6NZY7.
OMAiQHPRARC.
OrthoDBiEOG7T1RDC.
PhylomeDBiQ6NZY7.
TreeFamiTF331725.

Enzyme and pathway databases

ReactomeiR-HSA-5687128. MAPK6/MAPK4 signaling.

Miscellaneous databases

ChiTaRSiCDC42EP5. human.
GenomeRNAii148170.
NextBioi85849.
PROiQ6NZY7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NZY7.
CleanExiHS_CDC42EP5.
GenevisibleiQ6NZY7. HS.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone and Pancreas.

Entry informationi

Entry nameiBORG3_HUMAN
AccessioniPrimary (citable) accession number: Q6NZY7
Secondary accession number(s): B0VJZ2, Q8TB51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.