##gff-version 3 Q6NZY4 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Q6NZY4 UniProtKB Chain 2 707 . . . ID=PRO_0000150960;Note=Zinc finger CCHC domain-containing protein 8 Q6NZY4 UniProtKB Zinc finger 227 244 . . . Note=CCHC-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00047 Q6NZY4 UniProtKB Region 16 44 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NZY4 UniProtKB Region 286 299 . . . Note=RBM7 binding;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27905398,ECO:0007744|PDB:5LXR,ECO:0007744|PDB:5LXY;Dbxref=PMID:27905398 Q6NZY4 UniProtKB Region 309 324 . . . Note=RBM7 binding;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:27905398,ECO:0007744|PDB:5LXR,ECO:0007744|PDB:5LXY;Dbxref=PMID:27905398 Q6NZY4 UniProtKB Region 409 518 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NZY4 UniProtKB Region 531 607 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NZY4 UniProtKB Region 641 660 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NZY4 UniProtKB Region 659 707 . . . Note=MTREX binding;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:29844170,ECO:0007744|PDB:6C90;Dbxref=PMID:29844170 Q6NZY4 UniProtKB Coiled coil 45 80 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6NZY4 UniProtKB Coiled coil 516 539 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6NZY4 UniProtKB Compositional bias 16 35 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NZY4 UniProtKB Compositional bias 409 442 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NZY4 UniProtKB Compositional bias 466 496 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NZY4 UniProtKB Compositional bias 534 559 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NZY4 UniProtKB Compositional bias 573 589 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NZY4 UniProtKB Compositional bias 641 658 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6NZY4 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19413330;Dbxref=PMID:19413330 Q6NZY4 UniProtKB Modified residue 342 342 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6NZY4 UniProtKB Modified residue 472 472 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q6NZY4 UniProtKB Modified residue 479 479 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569 Q6NZY4 UniProtKB Modified residue 485 485 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 Q6NZY4 UniProtKB Modified residue 492 492 . . . Note=Phosphothreonine%3B by GSK3;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:16263084,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:16263084,PMID:23186163,PMID:24275569 Q6NZY4 UniProtKB Modified residue 577 577 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6NZY4 UniProtKB Modified residue 598 598 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q6NZY4 UniProtKB Modified residue 648 648 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6NZY4 UniProtKB Modified residue 649 649 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6NZY4 UniProtKB Modified residue 658 658 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163,PMID:24275569 Q6NZY4 UniProtKB Modified residue 695 695 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q6NZY4 UniProtKB Cross-link 413 413 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q6NZY4 UniProtKB Alternative sequence 1 238 . . . ID=VSP_013717;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q6NZY4 UniProtKB Natural variant 186 186 . . . ID=VAR_083448;Note=In PFBMFT5%3B decreased levels of mature TERC in patient cells consistent with impaired function in RNA processing%3B decreased levels of mutant protein in patient cells. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:31488579;Dbxref=PMID:31488579 Q6NZY4 UniProtKB Natural variant 672 672 . . . ID=VAR_034585;Note=P->A;Dbxref=dbSNP:rs1063155 Q6NZY4 UniProtKB Mutagenesis 295 295 . . . Note=Impaired interaction with ZCCHC8%3B when associated with E-299. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27905398;Dbxref=PMID:27905398 Q6NZY4 UniProtKB Mutagenesis 299 299 . . . Note=Impaired interaction with ZCCHC8%3B when associated with E-295. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27905398;Dbxref=PMID:27905398 Q6NZY4 UniProtKB Mutagenesis 309 309 . . . Note=Reduced interaction with ZCCHC8%3B when associated with E-313. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27905398;Dbxref=PMID:27905398 Q6NZY4 UniProtKB Mutagenesis 313 313 . . . Note=Reduced interaction with ZCCHC8%3B when associated with A-309. M->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27905398;Dbxref=PMID:27905398 Q6NZY4 UniProtKB Mutagenesis 492 492 . . . Note=Impaired phosphorylation by GSK3. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16263084;Dbxref=PMID:16263084 Q6NZY4 UniProtKB Mutagenesis 662 662 . . . Note=Does not alter RNA helicase activity of NEXT complex%3B when associated with K-666. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29844170;Dbxref=PMID:29844170 Q6NZY4 UniProtKB Mutagenesis 666 666 . . . Note=Does not alter RNA helicase activity of NEXT complex%3B when associated with A-662. F->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29844170;Dbxref=PMID:29844170 Q6NZY4 UniProtKB Mutagenesis 673 673 . . . Note=Does not affect RNA helicase activity of NEXT complex%3B when associated with A-675. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29844170;Dbxref=PMID:29844170 Q6NZY4 UniProtKB Mutagenesis 674 674 . . . Note=Does not affect RNA helicase activity of NEXT complex%3B when associated with A-676. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29844170;Dbxref=PMID:29844170 Q6NZY4 UniProtKB Mutagenesis 675 675 . . . Note=Does not affect RNA helicase activity of NEXT complex%3B when associated with A-673. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29844170;Dbxref=PMID:29844170 Q6NZY4 UniProtKB Mutagenesis 676 676 . . . Note=Does not affect RNA helicase activity of NEXT complex%3B when associated with A-674. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29844170;Dbxref=PMID:29844170 Q6NZY4 UniProtKB Mutagenesis 688 688 . . . Note=Loss of RNA helicase activity of NEXT complex%3B when associated with E-692. I->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29844170;Dbxref=PMID:29844170 Q6NZY4 UniProtKB Mutagenesis 692 692 . . . Note=Loss of RNA helicase activity of NEXT complex%3B when associated with E-688. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29844170;Dbxref=PMID:29844170 Q6NZY4 UniProtKB Sequence conflict 20 20 . . . Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6NZY4 UniProtKB Sequence conflict 216 219 . . . Note=QEIQ->DAWV;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6NZY4 UniProtKB Sequence conflict 326 326 . . . Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6NZY4 UniProtKB Sequence conflict 461 461 . . . Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6NZY4 UniProtKB Sequence conflict 582 582 . . . Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6NZY4 UniProtKB Sequence conflict 663 663 . . . Note=M->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6NZY4 UniProtKB Helix 293 299 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5LXR Q6NZY4 UniProtKB Helix 308 316 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5LXR Q6NZY4 UniProtKB Helix 320 322 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5LXR Q6NZY4 UniProtKB Helix 663 667 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6C90 Q6NZY4 UniProtKB Helix 684 690 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6C90 Q6NZY4 UniProtKB Helix 696 699 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6C90