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Protein
Submitted name:

5'-nucleotidase, ecto (CD73)

Gene

NT5E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandNucleotide-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
5'-nucleotidase, ecto (CD73)Imported
Gene namesi
Name:NT5EImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei555 – 573HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31804

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26UniRule annotationAdd BLAST26
ChainiPRO_500427766927 – 574UniRule annotationAdd BLAST548

Proteomic databases

PeptideAtlasiQ6NZX3
PRIDEiQ6NZX3

Expressioni

Gene expression databases

GenevisibleiQ6NZX3 HS

Structurei

3D structure databases

ProteinModelPortaliQ6NZX3
SMRiQ6NZX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 244MetallophosInterPro annotationAdd BLAST216
Domaini339 – 5125_nucleotid_CInterPro annotationAdd BLAST174

Sequence similaritiesi

Belongs to the 5'-nucleotidase family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4419 Eukaryota
COG0737 LUCA
HOVERGENiHBG000026
KOiK19970

Family and domain databases

Gene3Di3.60.21.10, 1 hit
3.90.780.10, 1 hit
InterProiView protein in InterPro
IPR008334 5'-Nucleotdase_C
IPR036907 5'-Nucleotdase_C_sf
IPR006146 5'-Nucleotdase_CS
IPR006179 5_nucleotidase/apyrase
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PANTHERiPTHR11575 PTHR11575, 1 hit
PfamiView protein in Pfam
PF02872 5_nucleotid_C, 1 hit
PF00149 Metallophos, 1 hit
PRINTSiPR01607 APYRASEFAMLY
SUPFAMiSSF55816 SSF55816, 1 hit
PROSITEiView protein in PROSITE
PS00785 5_NUCLEOTIDASE_1, 1 hit
PS00786 5_NUCLEOTIDASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NZX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK
60 70 80 90 100
CVNASRCMGG VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE
110 120 130 140 150
VAHFMNALRY DAMALGNHEF DNGVEGLIEP LLKEAKFPIL SANIKAKGPL
160 170 180 190 200
ASQISGLYLP YKVLPVGDEV VGIVGYTSKE TPFLSNPGTN LVFEDEITAL
210 220 230 240 250
QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV GGHSNTFLYT
260 270 280 290 300
GNPPSKEVPA GKYPFIVTSD DGRKVPVVQA YAFGKYLGYL KIEFDERGNV
310 320 330 340 350
ISSHGNPILL NSSIPEDPSI KADINKWRIK LDNYSTQELG KTIVYLDGSS
360 370 380 390 400
QSCRFRECNM GNLICDAMIN NNLRHADETF WNHVSMCILN GGGIRSPIDE
410 420 430 440 450
RNNGTITWEN LAAVLPFGGT FDLVQLKGST LKKAFEHSVH RYGQSTGEFL
460 470 480 490 500
QVGGIHVVYD LSRKPGDRVV KLDVLCTKCR VPSYDPLKMD EVYKVILPNF
510 520 530 540 550
LANGGDGFQM IKDELLRHDS GDQDINVVST YISKMKVIYP AVEGRIKFST
560 570
GSHCHGSFSL IFLSLWAVIF VLYQ
Length:574
Mass (Da):63,308
Last modified:July 5, 2004 - v1
Checksum:iF64C54E50056B196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065937 mRNA Translation: AAH65937.1
RefSeqiNP_001191742.1, NM_001204813.1
NP_002517.1, NM_002526.3
UniGeneiHs.153952

Genome annotation databases

GeneIDi4907
KEGGihsa:4907

Similar proteinsi

Entry informationi

Entry nameiQ6NZX3_HUMAN
AccessioniPrimary (citable) accession number: Q6NZX3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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