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Protein

Zinc finger protein 740

Gene

Znf740

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 110C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri116 – 138C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri144 – 166C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 740
Gene namesi
Name:Znf740
Synonyms:Zfp740
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915994. Zfp740.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514021 – 180Zinc finger protein 740Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6NZQ6.
PeptideAtlasiQ6NZQ6.
PRIDEiQ6NZQ6.

PTM databases

iPTMnetiQ6NZQ6.
PhosphoSitePlusiQ6NZQ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046897.
CleanExiMM_ZFP740.
ExpressionAtlasiQ6NZQ6. baseline and differential.
GenevisibleiQ6NZQ6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ6NZQ6. 1 interactor.
MINTiMINT-4116638.
STRINGi10090.ENSMUSP00000113281.

Structurei

3D structure databases

ProteinModelPortaliQ6NZQ6.
SMRiQ6NZQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 110C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri116 – 138C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri144 – 166C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063238.
HOGENOMiHOG000013198.
HOVERGENiHBG061583.
InParanoidiQ6NZQ6.
OMAiHRKESDK.
OrthoDBiEOG091G0L6G.
PhylomeDBiQ6NZQ6.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NZQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLSQIASKQ AENGERAGSP DVLRCSSQMD CKPRFDLSSK GHRKDSDKSR
60 70 80 90 100
NRKEDDSLAE ASHSKKTVKK VVVVEQNGSF QVKIPKNFIC EHCFGAFRSS
110 120 130 140 150
YHLKRHVLIH TGEKPFECDV CDMRFIQKYH LERHKRVHSG EKPYQCERCH
160 170 180
QCFSRTDRLL RHKRMCQGCQ SKTSEGQFSL
Length:180
Mass (Da):20,892
Last modified:July 5, 2004 - v1
Checksum:iDE801DFFC2C98BCE
GO
Isoform 2 (identifier: Q6NZQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-40: Missing.

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):19,483
Checksum:i44736030DC093ACE
GO
Isoform 3 (identifier: Q6NZQ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.
     64-70: SKKTVKK → MPDCCPQ

Note: No experimental confirmation available.
Show »
Length:117
Mass (Da):13,861
Checksum:iB53A582BA3518277
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8S → T in BAE26025 (PubMed:16141072).Curated1
Sequence conflicti154S → P in BAE26025 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0207561 – 63Missing in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_02075729 – 40Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02075864 – 70SKKTVKK → MPDCCPQ in isoform 3. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144707 mRNA. Translation: BAE26025.1.
BC030410 mRNA. Translation: AAH30410.1.
BC066011 mRNA. Translation: AAH66011.1.
CCDSiCCDS70672.1. [Q6NZQ6-1]
CCDS79416.1. [Q6NZQ6-2]
RefSeqiNP_001276620.1. NM_001289691.1. [Q6NZQ6-2]
NP_001276624.1. NM_001289695.1. [Q6NZQ6-1]
XP_006521399.1. XM_006521336.2. [Q6NZQ6-2]
XP_011244021.1. XM_011245719.1. [Q6NZQ6-1]
XP_017172230.1. XM_017316741.1. [Q6NZQ6-1]
UniGeneiMm.352945.

Genome annotation databases

EnsembliENSMUST00000118729; ENSMUSP00000112985; ENSMUSG00000046897. [Q6NZQ6-2]
ENSMUST00000119800; ENSMUSP00000113770; ENSMUSG00000046897. [Q6NZQ6-1]
GeneIDi68744.
KEGGimmu:68744.
UCSCiuc007xuw.2. mouse. [Q6NZQ6-2]
uc007xuz.2. mouse. [Q6NZQ6-1]
uc007xva.2. mouse. [Q6NZQ6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144707 mRNA. Translation: BAE26025.1.
BC030410 mRNA. Translation: AAH30410.1.
BC066011 mRNA. Translation: AAH66011.1.
CCDSiCCDS70672.1. [Q6NZQ6-1]
CCDS79416.1. [Q6NZQ6-2]
RefSeqiNP_001276620.1. NM_001289691.1. [Q6NZQ6-2]
NP_001276624.1. NM_001289695.1. [Q6NZQ6-1]
XP_006521399.1. XM_006521336.2. [Q6NZQ6-2]
XP_011244021.1. XM_011245719.1. [Q6NZQ6-1]
XP_017172230.1. XM_017316741.1. [Q6NZQ6-1]
UniGeneiMm.352945.

3D structure databases

ProteinModelPortaliQ6NZQ6.
SMRiQ6NZQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NZQ6. 1 interactor.
MINTiMINT-4116638.
STRINGi10090.ENSMUSP00000113281.

PTM databases

iPTMnetiQ6NZQ6.
PhosphoSitePlusiQ6NZQ6.

Proteomic databases

PaxDbiQ6NZQ6.
PeptideAtlasiQ6NZQ6.
PRIDEiQ6NZQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118729; ENSMUSP00000112985; ENSMUSG00000046897. [Q6NZQ6-2]
ENSMUST00000119800; ENSMUSP00000113770; ENSMUSG00000046897. [Q6NZQ6-1]
GeneIDi68744.
KEGGimmu:68744.
UCSCiuc007xuw.2. mouse. [Q6NZQ6-2]
uc007xuz.2. mouse. [Q6NZQ6-1]
uc007xva.2. mouse. [Q6NZQ6-3]

Organism-specific databases

CTDi68744.
MGIiMGI:1915994. Zfp740.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063238.
HOGENOMiHOG000013198.
HOVERGENiHBG061583.
InParanoidiQ6NZQ6.
OMAiHRKESDK.
OrthoDBiEOG091G0L6G.
PhylomeDBiQ6NZQ6.

Miscellaneous databases

PROiQ6NZQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046897.
CleanExiMM_ZFP740.
ExpressionAtlasiQ6NZQ6. baseline and differential.
GenevisibleiQ6NZQ6. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN740_MOUSE
AccessioniPrimary (citable) accession number: Q6NZQ6
Secondary accession number(s): Q3UMS3, Q8JZR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.