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Protein

RNA-binding protein 26

Gene

Rbm26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri288 – 316C3H1-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 26
Alternative name(s):
Protein expressed in male leptotene and zygotene spermatocytes 393
Short name:
MLZ-393
RNA-binding motif protein 26
Gene namesi
Name:Rbm26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1921463. Rbm26.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002733771 – 1012RNA-binding protein 26Add BLAST1012

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei127PhosphoserineCombined sources1
Modified residuei501PhosphoserineBy similarity1
Modified residuei515N6-acetyllysineCombined sources1
Modified residuei523PhosphoserineBy similarity1
Modified residuei621PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6NZN0.
PeptideAtlasiQ6NZN0.
PRIDEiQ6NZN0.

PTM databases

iPTMnetiQ6NZN0.
PhosphoSitePlusiQ6NZN0.

Expressioni

Tissue specificityi

Expressed in testis and ovary.1 Publication

Developmental stagei

Expressed in testis and ovary at E15.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000022119.
CleanExiMM_RBM26.
ExpressionAtlasiQ6NZN0. baseline and differential.
GenevisibleiQ6NZN0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ6NZN0. 1 interactor.
MINTiMINT-4111851.
STRINGi10090.ENSMUSP00000097901.

Structurei

3D structure databases

ProteinModelPortaliQ6NZN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini537 – 611RRM 1PROSITE-ProRule annotationAdd BLAST75
Domaini896 – 965RRM 2PROSITE-ProRule annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili98 – 127Sequence analysisAdd BLAST30
Coiled coili724 – 800Sequence analysisAdd BLAST77
Coiled coili828 – 852Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 213Arg-richAdd BLAST80
Compositional biasi326 – 420Pro-richAdd BLAST95

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri288 – 316C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2135. Eukaryota.
ENOG41119BA. LUCA.
GeneTreeiENSGT00510000046929.
HOVERGENiHBG057372.
InParanoidiQ6NZN0.
KOiK13192.
PhylomeDBiQ6NZN0.

Family and domain databases

Gene3Di1.20.1390.10. 1 hit.
3.30.70.330. 2 hits.
4.10.1000.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR002483. PWI_dom.
IPR000504. RRM_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF01480. PWI. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NZN0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSKMIIENF EALKSWLSKT LEPICDADPS ALAKYVLALV KKDKSEKELK
60 70 80 90 100
ALCIDQLDVF LQKETQIFVE KLFDAVNTKS YLPPPEQPSS GSLKVDFLQH
110 120 130 140 150
QEKDIKKEEL TKEEEREKKF SRRLNHSPPQ SSSRYRDNRS RDERKKDDRS
160 170 180 190 200
RKRDYDRNPP RRDSYRDRYN RRRGRSRSYS RSRSRSWSKE RLRDRDRDRS
210 220 230 240 250
RTRSRSRTRS RERDLVKPKY DLDRTDPLEN NYTPVSSVSN ISSGHYPVPT
260 270 280 290 300
LSSTITVIAP THHGNNTTES WSEFHEDQVD HNSYVRPPMP KKRCRDYDEK
310 320 330 340 350
GFCMRGDMCP FDHGSDPVVV EDVNLPGMLP FPAQPPVVEG PPPPGLPPPP
360 370 380 390 400
PILTPPPVNL RPPVPPPGPL PPSLPPVTGP PPPLPPLQPS GMDAPPNSAT
410 420 430 440 450
SSVPTVVTTG IHHQPPPAPP SLFTAVFVLP DTYDTDGYNP EAPSITNTSR
460 470 480 490 500
PMYRHRVHAQ RPNLIGLTSG DMDLPPREKP PNKSSMRIVV DSESRKRTIG
510 520 530 540 550
SGEPGVSTKK TWFDKPNFNR TNSPGFQKKV QFGNENTKLE LRKVPPELNN
560 570 580 590 600
ISKLNEHFSR FGTLVNLQVA YNGDPEGALI QFATYEEAKK AISSTEAVLN
610 620 630 640 650
NRFIKVYWHR EGTTQQLQTT SPKVIQPLVQ QPILPVVKQS VKERLGPVPS
660 670 680 690 700
ATTEPAEAQS ATSELPQNVT KLSVKDRLGF VSKPSVSATE KVLSTSTGLT
710 720 730 740 750
KTVYNPAALK AAQKTLSVST PAVDNNEAQK KKQEALKLQQ DVRKRKQEIL
760 770 780 790 800
EKHIETQKML ISKLEKNKTM KSEDKAEIMK TLEILTKNIT KLKDEVKSTS
810 820 830 840 850
PGRCLPKSIK TKTQMQKELL DTELDLYKKM QAGEEVTELR RKYTELQLEA
860 870 880 890 900
AKRGILSSGR GRGIHTRGRG TAHGRGRGRG RGRGVPGHAV VDHRPRALEI
910 920 930 940 950
SAFTESDRED LLPHFAQYGE IEDCQIDDAS LHAIITFKTR AEAEAAAIHG
960 970 980 990 1000
ARFKGQDLKL AWNKPIANMS AVDTEEAEPD EEEFQEESLV DDSLLQDDDE
1010
EEEDNESRSW RR
Length:1,012
Mass (Da):114,143
Last modified:January 23, 2007 - v2
Checksum:iEBD1FD8C14BE106F
GO
Isoform 2 (identifier: Q6NZN0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     991-1012: DDSLLQDDDEEEEDNESRSWRR → VGFFFFSLVFPSLFIVLL

Note: No experimental confirmation available.
Show »
Length:1,008
Mass (Da):113,497
Checksum:i1696D8617EE9FFC6
GO
Isoform 3 (identifier: Q6NZN0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     426-430: Missing.
     991-1012: DDSLLQDDDEEEEDNESRSWRR → VGFFFFSLVFPSLFIVLL

Note: No experimental confirmation available.
Show »
Length:1,003
Mass (Da):112,941
Checksum:iF742835D77935983
GO
Isoform 4 (identifier: Q6NZN0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     426-430: Missing.

Note: No experimental confirmation available.
Show »
Length:1,007
Mass (Da):113,587
Checksum:iE7AEF647856A4B53
GO
Isoform 5 (identifier: Q6NZN0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     984-1012: FQEESLVDDSLLQDDDEEEEDNESRSWRR → RENITA

Note: No experimental confirmation available.
Show »
Length:989
Mass (Da):111,274
Checksum:i1FF8AE32674D6408
GO

Sequence cautioni

The sequence AAH29079 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC33537 differs from that shown. Reason: Frameshift at position 442.Curated
The sequence BAC34721 differs from that shown. Reason: Frameshift at position 40.Curated
The sequence BAE23881 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE42792 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BC066051 differs from that shown. Reason: Frameshift at position 990.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti324N → K in BAC33537 (PubMed:16141072).Curated1
Sequence conflicti494S → Y in BAC33537 (PubMed:16141072).Curated1
Sequence conflicti550N → S in BAE42792 (PubMed:16141072).Curated1
Sequence conflicti777E → G in BAC33537 (PubMed:16141072).Curated1
Sequence conflicti786T → S in BAC33537 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022533426 – 430Missing in isoform 3 and isoform 4. 1 Publication5
Alternative sequenceiVSP_022534984 – 1012FQEES…RSWRR → RENITA in isoform 5. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_022535991 – 1012DDSLL…RSWRR → VGFFFFSLVFPSLFIVLL in isoform 2 and isoform 3. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011531 mRNA. Translation: AAH11531.1.
BC029079 mRNA. Translation: AAH29079.1. Different initiation.
BC066051 mRNA. No translation available.
AK049083 mRNA. Translation: BAC33537.1. Frameshift.
AK051686 mRNA. Translation: BAC34721.1. Frameshift.
AK139077 mRNA. Translation: BAE23881.1. Different initiation.
AK172039 mRNA. Translation: BAE42792.1. Different initiation.
RefSeqiNP_598838.3. NM_134077.4.
UniGeneiMm.474531.

Genome annotation databases

EnsembliENSMUST00000022715; ENSMUSP00000022715; ENSMUSG00000022119. [Q6NZN0-4]
GeneIDi74213.
KEGGimmu:74213.
UCSCiuc007uxl.2. mouse. [Q6NZN0-4]
uc007uxn.1. mouse. [Q6NZN0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011531 mRNA. Translation: AAH11531.1.
BC029079 mRNA. Translation: AAH29079.1. Different initiation.
BC066051 mRNA. No translation available.
AK049083 mRNA. Translation: BAC33537.1. Frameshift.
AK051686 mRNA. Translation: BAC34721.1. Frameshift.
AK139077 mRNA. Translation: BAE23881.1. Different initiation.
AK172039 mRNA. Translation: BAE42792.1. Different initiation.
RefSeqiNP_598838.3. NM_134077.4.
UniGeneiMm.474531.

3D structure databases

ProteinModelPortaliQ6NZN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NZN0. 1 interactor.
MINTiMINT-4111851.
STRINGi10090.ENSMUSP00000097901.

PTM databases

iPTMnetiQ6NZN0.
PhosphoSitePlusiQ6NZN0.

Proteomic databases

PaxDbiQ6NZN0.
PeptideAtlasiQ6NZN0.
PRIDEiQ6NZN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022715; ENSMUSP00000022715; ENSMUSG00000022119. [Q6NZN0-4]
GeneIDi74213.
KEGGimmu:74213.
UCSCiuc007uxl.2. mouse. [Q6NZN0-4]
uc007uxn.1. mouse. [Q6NZN0-3]

Organism-specific databases

CTDi64062.
MGIiMGI:1921463. Rbm26.

Phylogenomic databases

eggNOGiKOG2135. Eukaryota.
ENOG41119BA. LUCA.
GeneTreeiENSGT00510000046929.
HOVERGENiHBG057372.
InParanoidiQ6NZN0.
KOiK13192.
PhylomeDBiQ6NZN0.

Miscellaneous databases

ChiTaRSiRbm26. mouse.
PROiQ6NZN0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022119.
CleanExiMM_RBM26.
ExpressionAtlasiQ6NZN0. baseline and differential.
GenevisibleiQ6NZN0. MM.

Family and domain databases

Gene3Di1.20.1390.10. 1 hit.
3.30.70.330. 2 hits.
4.10.1000.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR002483. PWI_dom.
IPR000504. RRM_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF01480. PWI. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM26_MOUSE
AccessioniPrimary (citable) accession number: Q6NZN0
Secondary accession number(s): Q3TA77
, Q3UTU9, Q8BQ22, Q8C7W9, Q8K101, Q921K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.