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Q6NZJ6

- IF4G1_MOUSE

UniProt

Q6NZJ6 - IF4G1_MOUSE

Protein

Eukaryotic translation initiation factor 4 gamma 1

Gene

Eif4g1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. translation initiation factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of translational initiation Source: Ensembl

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis, Translation regulation

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_198533. ISG15 antiviral mechanism.
    REACT_198693. AUF1 (hnRNP D0) destabilizes mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 4 gamma 1
    Short name:
    eIF-4-gamma 1
    Short name:
    eIF-4G 1
    Short name:
    eIF-4G1
    Gene namesi
    Name:Eif4g1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2384784. Eif4g1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16001600Eukaryotic translation initiation factor 4 gamma 1PRO_0000213322Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei214 – 2141PhosphothreonineBy similarity
    Modified residuei606 – 6061N6-acetyllysine1 Publication
    Modified residuei651 – 6511PhosphothreonineBy similarity
    Modified residuei1032 – 10321PhosphoserineBy similarity
    Modified residuei1096 – 10961PhosphoserineBy similarity
    Modified residuei1099 – 10991N6-acetyllysineBy similarity
    Modified residuei1147 – 11471PhosphoserineBy similarity
    Modified residuei1149 – 11491PhosphoserineBy similarity
    Modified residuei1187 – 11871Phosphoserine; by PKC/PRKCABy similarity
    Modified residuei1189 – 11891Phosphoserine1 Publication
    Modified residuei1211 – 12111Phosphoserine1 Publication
    Modified residuei1213 – 12131PhosphothreonineBy similarity
    Modified residuei1231 – 12311Phosphoserine3 Publications
    Modified residuei1597 – 15971Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1187 by PRKCA induces binding to MKNK1 By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ6NZJ6.
    PaxDbiQ6NZJ6.
    PRIDEiQ6NZJ6.

    PTM databases

    PhosphoSiteiQ6NZJ6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6NZJ6.
    BgeeiQ6NZJ6.
    GenevestigatoriQ6NZJ6.

    Interactioni

    Subunit structurei

    eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts with CIRBP and MIF4GD. Interacts with RBM4. Interacts with EIF4E3. Interacts with HNRNPD/AUF1; the interaction requires RNA.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Eif3bQ8JZQ92EBI-8175606,EBI-4286513
    Eif3iQ9QZD93EBI-8175606,EBI-7466616
    Eif4a1P608432EBI-8175606,EBI-6665935
    Eif4eP630734EBI-8175606,EBI-2000006

    Protein-protein interaction databases

    BioGridi228998. 2 interactions.
    DIPiDIP-42771N.
    IntActiQ6NZJ6. 6 interactions.
    MINTiMINT-1856450.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NZJ6.
    SMRiQ6NZJ6. Positions 180-206, 755-995, 1234-1592.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini765 – 993229MIF4GPROSITE-ProRule annotationAdd
    BLAST
    Domaini1241 – 1363123MIPROSITE-ProRule annotationAdd
    BLAST
    Domaini1429 – 1599171W2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni179 – 20729PABPC1-bindingBy similarityAdd
    BLAST
    Regioni611 – 62212EIF4E-bindingBy similarityAdd
    BLAST
    Regioni686 – 1089404eIF3/EIF4A-bindingBy similarityAdd
    BLAST
    Regioni1450 – 1600151EIF4A-bindingBy similarityAdd
    BLAST
    Regioni1585 – 160016Necessary but not sufficient for MKNK1-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi464 – 48724Asp/Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MI domain.PROSITE-ProRule annotation
    Contains 1 MIF4G domain.Curated
    Contains 1 W2 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG301289.
    GeneTreeiENSGT00530000063038.
    HOGENOMiHOG000231658.
    HOVERGENiHBG052083.
    InParanoidiQ6NZJ6.
    KOiK03260.
    OMAiGSNWVPR.
    OrthoDBiEOG7D59N2.
    PhylomeDBiQ6NZJ6.
    TreeFamiTF101527.

    Family and domain databases

    Gene3Di1.25.40.180. 3 hits.
    InterProiIPR016024. ARM-type_fold.
    IPR003891. Initiation_fac_eIF4g_MI.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR003890. MIF4G-like_typ-3.
    IPR003307. W2_domain.
    [Graphical view]
    PfamiPF02847. MA3. 1 hit.
    PF02854. MIF4G. 1 hit.
    PF02020. W2. 1 hit.
    [Graphical view]
    SMARTiSM00515. eIF5C. 1 hit.
    SM00544. MA3. 1 hit.
    SM00543. MIF4G. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.
    PROSITEiPS51366. MI. 1 hit.
    PS51363. W2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6NZJ6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNKAPQPTGP PPARSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG     50
    GFRSLQHFYP SRAQPPSSAA SRVQSAAPAR PGPAPHVYPA GSQVMMIPSQ 100
    ISYSASQGAY YIPGQGRSTY VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG 150
    AYYPAQGVQQ FPASVAPAPV LMNQPPQIAP KRERKTIRIR DPNQGGKDIT 200
    EEIMSGARTA STPTPPQTGG SLEPQPNGES PQVAVIIRPD DRSQGAAIGG 250
    RPGLPGPEHS PGTESQPSSP SPTPSPPPIL EPGSESNLGV LSIPGDTMTT 300
    GMIPMSVEES TPISCETGEP YCLSPEPTLA EPILEVEVTL SKPIPESEFS 350
    SSPLQVSTAL VPHKVETHEP NGVIPSEDLE PEVESSTEPA PPPLSPCASE 400
    SLVPIAPTAQ PEELLNGAPS PPAVDLSPVS EPEEQAKKVS SAALASILSP 450
    APPVAPSDTS PAQEEEMEED DDDEEGGEAE SEKGGEDVPL DSTPVPAQLS 500
    QNLEVAAATQ VAVSVPKRRR KIKELNKKEA VGDLLDAFKE VDPAVPEVEN 550
    QPPTGSNPSP ESEGSMVPTQ PEETEETWDS KEDKIHNAEN IQPGEQKYEY 600
    KSDQWKPLNL EEKKRYDREF LLGFQFIFAS MQKPEGLPHI TDVVLDKANK 650
    TPLRQLDPSR LPGINCGPDF TPSFANLGRP ALSNRGPPRG GPGGELPRGP 700
    AGLGPRRSQQ GPRKETRKII SSVIMTEDIK LNKAEKAWKP SSKRTAADKD 750
    RGEEDADGSK TQDLFRRVRS ILNKLTPQMF QQLMKQVTQL AIDTEERLKG 800
    VIDLIFEKAI SEPNFSVAYA NMCRCLMALK VPTTEKPTVT VNFRKLLLNR 850
    CQKEFEKDKD DDEVFEKKQK EMDEAATAEE RGRLKEELEE ARDIARRRSL 900
    GNIKFIGELF KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL 950
    DFAKAKPRMD QYFNQMEKII KEKKTSSRIR FMLQDVLDLR QSNWVPRRGD 1000
    QGPKTIDQIH KEAEMEEHRE HIKVQQLMAK GSDKRRGGPP GPPINRGLPL 1050
    VDDGGWNTVP ISKGSRPIDT SRLTKITKPG SIDSNNQLFA PGGRLSWGKG 1100
    SSGGSGAKPS DTASEATRPA TLNRFSALQQ TLPAENTDNR RVVQRSSLSR 1150
    ERGEKAGDRG DRLERSERGG DRGDRLDRAR TPATKRSFSK EVEERSRERP 1200
    SQPEGLRKAA SLTEDRGRDP VKREATLPPV SPPKAALSVD EVEKKSKAII 1250
    EEYLHLNDMK EAVQCVQELA SPSLLFIFVR LGIESTLERS TIAREHMGRL 1300
    LHQLLCAGHL STAQYYQGLY ETLELAEDME IDIPHVWLYL AELITPILQE 1350
    DGVPMGELFR EITKPLRPMG KATSLLLEIL GLLCKSMGPK KVGMLWREAG 1400
    LSWREFLAEG QDVGSFVAEK KVEYTLGEES EAPGQRTLAF EELRRQLEKL 1450
    LKDGGSNQRV FDWIDANLNE QQIASNTLVR ALMTTVCYSA IIFETPLRVD 1500
    VQVLKVRARL LQKYLCDEQK ELQALYALQA LVVTLEQPAN LLRMFFDALY 1550
    DEDVVKEDAF YSWESSKDPA EQQGKGVALK SVTAFFNWLR EAEDEESDHN 1600
    Length:1,600
    Mass (Da):176,077
    Last modified:July 5, 2004 - v1
    Checksum:i8664A8B449C7A128
    GO
    Isoform 2 (identifier: Q6NZJ6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         49-55: Missing.
         1046-1052: Missing.

    Show »
    Length:1,586
    Mass (Da):174,580
    Checksum:i78C8FF512118F134
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei49 – 557Missing in isoform 2. 2 PublicationsVSP_013974
    Alternative sequencei1046 – 10527Missing in isoform 2. 2 PublicationsVSP_013975

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC066038 mRNA. Translation: AAH66038.1.
    BC066103 mRNA. Translation: AAH66103.1.
    BC079675 mRNA. Translation: AAH79675.1.
    AK053144 mRNA. Translation: BAC35282.1.
    CCDSiCCDS28055.1. [Q6NZJ6-1]
    RefSeqiNP_001005331.1. NM_001005331.1.
    NP_666053.2. NM_145941.2. [Q6NZJ6-1]
    XP_006522000.1. XM_006521937.1. [Q6NZJ6-1]
    UniGeneiMm.260256.

    Genome annotation databases

    EnsembliENSMUST00000044783; ENSMUSP00000047678; ENSMUSG00000045983. [Q6NZJ6-1]
    ENSMUST00000115460; ENSMUSP00000111120; ENSMUSG00000045983. [Q6NZJ6-1]
    ENSMUST00000115463; ENSMUSP00000111123; ENSMUSG00000045983. [Q6NZJ6-2]
    GeneIDi208643.
    KEGGimmu:208643.
    UCSCiuc007yqs.1. mouse. [Q6NZJ6-1]
    uc012acy.1. mouse. [Q6NZJ6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC066038 mRNA. Translation: AAH66038.1 .
    BC066103 mRNA. Translation: AAH66103.1 .
    BC079675 mRNA. Translation: AAH79675.1 .
    AK053144 mRNA. Translation: BAC35282.1 .
    CCDSi CCDS28055.1. [Q6NZJ6-1 ]
    RefSeqi NP_001005331.1. NM_001005331.1.
    NP_666053.2. NM_145941.2. [Q6NZJ6-1 ]
    XP_006522000.1. XM_006521937.1. [Q6NZJ6-1 ]
    UniGenei Mm.260256.

    3D structure databases

    ProteinModelPortali Q6NZJ6.
    SMRi Q6NZJ6. Positions 180-206, 755-995, 1234-1592.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 228998. 2 interactions.
    DIPi DIP-42771N.
    IntActi Q6NZJ6. 6 interactions.
    MINTi MINT-1856450.

    PTM databases

    PhosphoSitei Q6NZJ6.

    Proteomic databases

    MaxQBi Q6NZJ6.
    PaxDbi Q6NZJ6.
    PRIDEi Q6NZJ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044783 ; ENSMUSP00000047678 ; ENSMUSG00000045983 . [Q6NZJ6-1 ]
    ENSMUST00000115460 ; ENSMUSP00000111120 ; ENSMUSG00000045983 . [Q6NZJ6-1 ]
    ENSMUST00000115463 ; ENSMUSP00000111123 ; ENSMUSG00000045983 . [Q6NZJ6-2 ]
    GeneIDi 208643.
    KEGGi mmu:208643.
    UCSCi uc007yqs.1. mouse. [Q6NZJ6-1 ]
    uc012acy.1. mouse. [Q6NZJ6-2 ]

    Organism-specific databases

    CTDi 1981.
    MGIi MGI:2384784. Eif4g1.

    Phylogenomic databases

    eggNOGi NOG301289.
    GeneTreei ENSGT00530000063038.
    HOGENOMi HOG000231658.
    HOVERGENi HBG052083.
    InParanoidi Q6NZJ6.
    KOi K03260.
    OMAi GSNWVPR.
    OrthoDBi EOG7D59N2.
    PhylomeDBi Q6NZJ6.
    TreeFami TF101527.

    Enzyme and pathway databases

    Reactomei REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_198533. ISG15 antiviral mechanism.
    REACT_198693. AUF1 (hnRNP D0) destabilizes mRNA.

    Miscellaneous databases

    NextBioi 372353.
    PROi Q6NZJ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6NZJ6.
    Bgeei Q6NZJ6.
    Genevestigatori Q6NZJ6.

    Family and domain databases

    Gene3Di 1.25.40.180. 3 hits.
    InterProi IPR016024. ARM-type_fold.
    IPR003891. Initiation_fac_eIF4g_MI.
    IPR016021. MIF4-like_typ_1/2/3.
    IPR003890. MIF4G-like_typ-3.
    IPR003307. W2_domain.
    [Graphical view ]
    Pfami PF02847. MA3. 1 hit.
    PF02854. MIF4G. 1 hit.
    PF02020. W2. 1 hit.
    [Graphical view ]
    SMARTi SM00515. eIF5C. 1 hit.
    SM00544. MA3. 1 hit.
    SM00543. MIF4G. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    PROSITEi PS51366. MI. 1 hit.
    PS51363. W2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Brain and Fetal brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-520 (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Lung.
    3. "Characterization of mammalian eIF4E-family members."
      Joshi B., Cameron A., Jagus R.
      Eur. J. Biochem. 271:2189-2203(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EIF4E3.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1189 AND SER-1231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1231 AND SER-1597, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-606, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiIF4G1_MOUSE
    AccessioniPrimary (citable) accession number: Q6NZJ6
    Secondary accession number(s): Q6NZN8, Q8BW99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3