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Q6NZJ6

- IF4G1_MOUSE

UniProt

Q6NZJ6 - IF4G1_MOUSE

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Protein

Eukaryotic translation initiation factor 4 gamma 1

Gene

Eif4g1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. lung development Source: Ensembl
  2. regulation of translational initiation Source: Ensembl
  3. response to ethanol Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_198533. ISG15 antiviral mechanism.
REACT_198693. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_229737. S6K1 signalling.
REACT_236458. Ribosomal scanning and start codon recognition.
REACT_244119. Deadenylation of mRNA.
REACT_255163. Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.
REACT_256488. Translation initiation complex formation.
REACT_259469. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_262078. GTP hydrolysis and joining of the 60S ribosomal subunit.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma 1
Short name:
eIF-4-gamma 1
Short name:
eIF-4G 1
Short name:
eIF-4G1
Gene namesi
Name:Eif4g1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2384784. Eif4g1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. eukaryotic translation initiation factor 4F complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16001600Eukaryotic translation initiation factor 4 gamma 1PRO_0000213322Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141PhosphothreonineBy similarity
Modified residuei606 – 6061N6-acetyllysine1 Publication
Modified residuei651 – 6511PhosphothreonineBy similarity
Modified residuei1032 – 10321PhosphoserineBy similarity
Modified residuei1096 – 10961PhosphoserineBy similarity
Modified residuei1099 – 10991N6-acetyllysineBy similarity
Modified residuei1147 – 11471PhosphoserineBy similarity
Modified residuei1149 – 11491PhosphoserineBy similarity
Modified residuei1187 – 11871Phosphoserine; by PKC/PRKCABy similarity
Modified residuei1189 – 11891Phosphoserine1 Publication
Modified residuei1211 – 12111Phosphoserine1 Publication
Modified residuei1213 – 12131PhosphothreonineBy similarity
Modified residuei1231 – 12311Phosphoserine3 Publications
Modified residuei1597 – 15971Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1187 by PRKCA induces binding to MKNK1 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6NZJ6.
PaxDbiQ6NZJ6.
PRIDEiQ6NZJ6.

PTM databases

PhosphoSiteiQ6NZJ6.

Expressioni

Gene expression databases

BgeeiQ6NZJ6.
ExpressionAtlasiQ6NZJ6. baseline and differential.
GenevestigatoriQ6NZJ6.

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts with CIRBP and MIF4GD. Interacts with RBM4. Interacts with EIF4E3. Interacts with HNRNPD/AUF1; the interaction requires RNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Eif3bQ8JZQ92EBI-8175606,EBI-4286513
Eif3iQ9QZD93EBI-8175606,EBI-7466616
Eif4a1P608432EBI-8175606,EBI-6665935
Eif4eP630734EBI-8175606,EBI-2000006

Protein-protein interaction databases

BioGridi228998. 2 interactions.
DIPiDIP-42771N.
IntActiQ6NZJ6. 6 interactions.
MINTiMINT-1856450.

Structurei

3D structure databases

ProteinModelPortaliQ6NZJ6.
SMRiQ6NZJ6. Positions 180-206, 755-995, 1234-1592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini765 – 993229MIF4GPROSITE-ProRule annotationAdd
BLAST
Domaini1241 – 1363123MIPROSITE-ProRule annotationAdd
BLAST
Domaini1429 – 1599171W2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni179 – 20729PABPC1-bindingBy similarityAdd
BLAST
Regioni611 – 62212EIF4E-bindingBy similarityAdd
BLAST
Regioni686 – 1089404eIF3/EIF4A-bindingBy similarityAdd
BLAST
Regioni1450 – 1600151EIF4A-bindingBy similarityAdd
BLAST
Regioni1585 – 160016Necessary but not sufficient for MKNK1-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi464 – 48724Asp/Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 MI domain.PROSITE-ProRule annotation
Contains 1 MIF4G domain.Curated
Contains 1 W2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG301289.
GeneTreeiENSGT00530000063038.
HOGENOMiHOG000231658.
HOVERGENiHBG052083.
InParanoidiQ6NZJ6.
KOiK03260.
OMAiGSNWVPR.
OrthoDBiEOG7D59N2.
PhylomeDBiQ6NZJ6.
TreeFamiTF101527.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6NZJ6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKAPQPTGP PPARSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG
60 70 80 90 100
GFRSLQHFYP SRAQPPSSAA SRVQSAAPAR PGPAPHVYPA GSQVMMIPSQ
110 120 130 140 150
ISYSASQGAY YIPGQGRSTY VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG
160 170 180 190 200
AYYPAQGVQQ FPASVAPAPV LMNQPPQIAP KRERKTIRIR DPNQGGKDIT
210 220 230 240 250
EEIMSGARTA STPTPPQTGG SLEPQPNGES PQVAVIIRPD DRSQGAAIGG
260 270 280 290 300
RPGLPGPEHS PGTESQPSSP SPTPSPPPIL EPGSESNLGV LSIPGDTMTT
310 320 330 340 350
GMIPMSVEES TPISCETGEP YCLSPEPTLA EPILEVEVTL SKPIPESEFS
360 370 380 390 400
SSPLQVSTAL VPHKVETHEP NGVIPSEDLE PEVESSTEPA PPPLSPCASE
410 420 430 440 450
SLVPIAPTAQ PEELLNGAPS PPAVDLSPVS EPEEQAKKVS SAALASILSP
460 470 480 490 500
APPVAPSDTS PAQEEEMEED DDDEEGGEAE SEKGGEDVPL DSTPVPAQLS
510 520 530 540 550
QNLEVAAATQ VAVSVPKRRR KIKELNKKEA VGDLLDAFKE VDPAVPEVEN
560 570 580 590 600
QPPTGSNPSP ESEGSMVPTQ PEETEETWDS KEDKIHNAEN IQPGEQKYEY
610 620 630 640 650
KSDQWKPLNL EEKKRYDREF LLGFQFIFAS MQKPEGLPHI TDVVLDKANK
660 670 680 690 700
TPLRQLDPSR LPGINCGPDF TPSFANLGRP ALSNRGPPRG GPGGELPRGP
710 720 730 740 750
AGLGPRRSQQ GPRKETRKII SSVIMTEDIK LNKAEKAWKP SSKRTAADKD
760 770 780 790 800
RGEEDADGSK TQDLFRRVRS ILNKLTPQMF QQLMKQVTQL AIDTEERLKG
810 820 830 840 850
VIDLIFEKAI SEPNFSVAYA NMCRCLMALK VPTTEKPTVT VNFRKLLLNR
860 870 880 890 900
CQKEFEKDKD DDEVFEKKQK EMDEAATAEE RGRLKEELEE ARDIARRRSL
910 920 930 940 950
GNIKFIGELF KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL
960 970 980 990 1000
DFAKAKPRMD QYFNQMEKII KEKKTSSRIR FMLQDVLDLR QSNWVPRRGD
1010 1020 1030 1040 1050
QGPKTIDQIH KEAEMEEHRE HIKVQQLMAK GSDKRRGGPP GPPINRGLPL
1060 1070 1080 1090 1100
VDDGGWNTVP ISKGSRPIDT SRLTKITKPG SIDSNNQLFA PGGRLSWGKG
1110 1120 1130 1140 1150
SSGGSGAKPS DTASEATRPA TLNRFSALQQ TLPAENTDNR RVVQRSSLSR
1160 1170 1180 1190 1200
ERGEKAGDRG DRLERSERGG DRGDRLDRAR TPATKRSFSK EVEERSRERP
1210 1220 1230 1240 1250
SQPEGLRKAA SLTEDRGRDP VKREATLPPV SPPKAALSVD EVEKKSKAII
1260 1270 1280 1290 1300
EEYLHLNDMK EAVQCVQELA SPSLLFIFVR LGIESTLERS TIAREHMGRL
1310 1320 1330 1340 1350
LHQLLCAGHL STAQYYQGLY ETLELAEDME IDIPHVWLYL AELITPILQE
1360 1370 1380 1390 1400
DGVPMGELFR EITKPLRPMG KATSLLLEIL GLLCKSMGPK KVGMLWREAG
1410 1420 1430 1440 1450
LSWREFLAEG QDVGSFVAEK KVEYTLGEES EAPGQRTLAF EELRRQLEKL
1460 1470 1480 1490 1500
LKDGGSNQRV FDWIDANLNE QQIASNTLVR ALMTTVCYSA IIFETPLRVD
1510 1520 1530 1540 1550
VQVLKVRARL LQKYLCDEQK ELQALYALQA LVVTLEQPAN LLRMFFDALY
1560 1570 1580 1590 1600
DEDVVKEDAF YSWESSKDPA EQQGKGVALK SVTAFFNWLR EAEDEESDHN
Length:1,600
Mass (Da):176,077
Last modified:July 5, 2004 - v1
Checksum:i8664A8B449C7A128
GO
Isoform 2 (identifier: Q6NZJ6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-55: Missing.
     1046-1052: Missing.

Show »
Length:1,586
Mass (Da):174,580
Checksum:i78C8FF512118F134
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei49 – 557Missing in isoform 2. 2 PublicationsVSP_013974
Alternative sequencei1046 – 10527Missing in isoform 2. 2 PublicationsVSP_013975

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066038 mRNA. Translation: AAH66038.1.
BC066103 mRNA. Translation: AAH66103.1.
BC079675 mRNA. Translation: AAH79675.1.
AK053144 mRNA. Translation: BAC35282.1.
CCDSiCCDS28055.1. [Q6NZJ6-1]
RefSeqiNP_001005331.1. NM_001005331.1.
NP_666053.2. NM_145941.2. [Q6NZJ6-1]
XP_006522000.1. XM_006521937.1. [Q6NZJ6-1]
UniGeneiMm.260256.

Genome annotation databases

EnsembliENSMUST00000044783; ENSMUSP00000047678; ENSMUSG00000045983. [Q6NZJ6-1]
ENSMUST00000115460; ENSMUSP00000111120; ENSMUSG00000045983. [Q6NZJ6-1]
ENSMUST00000115463; ENSMUSP00000111123; ENSMUSG00000045983. [Q6NZJ6-2]
GeneIDi208643.
KEGGimmu:208643.
UCSCiuc007yqs.1. mouse. [Q6NZJ6-1]
uc012acy.1. mouse. [Q6NZJ6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066038 mRNA. Translation: AAH66038.1 .
BC066103 mRNA. Translation: AAH66103.1 .
BC079675 mRNA. Translation: AAH79675.1 .
AK053144 mRNA. Translation: BAC35282.1 .
CCDSi CCDS28055.1. [Q6NZJ6-1 ]
RefSeqi NP_001005331.1. NM_001005331.1.
NP_666053.2. NM_145941.2. [Q6NZJ6-1 ]
XP_006522000.1. XM_006521937.1. [Q6NZJ6-1 ]
UniGenei Mm.260256.

3D structure databases

ProteinModelPortali Q6NZJ6.
SMRi Q6NZJ6. Positions 180-206, 755-995, 1234-1592.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 228998. 2 interactions.
DIPi DIP-42771N.
IntActi Q6NZJ6. 6 interactions.
MINTi MINT-1856450.

PTM databases

PhosphoSitei Q6NZJ6.

Proteomic databases

MaxQBi Q6NZJ6.
PaxDbi Q6NZJ6.
PRIDEi Q6NZJ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044783 ; ENSMUSP00000047678 ; ENSMUSG00000045983 . [Q6NZJ6-1 ]
ENSMUST00000115460 ; ENSMUSP00000111120 ; ENSMUSG00000045983 . [Q6NZJ6-1 ]
ENSMUST00000115463 ; ENSMUSP00000111123 ; ENSMUSG00000045983 . [Q6NZJ6-2 ]
GeneIDi 208643.
KEGGi mmu:208643.
UCSCi uc007yqs.1. mouse. [Q6NZJ6-1 ]
uc012acy.1. mouse. [Q6NZJ6-2 ]

Organism-specific databases

CTDi 1981.
MGIi MGI:2384784. Eif4g1.

Phylogenomic databases

eggNOGi NOG301289.
GeneTreei ENSGT00530000063038.
HOGENOMi HOG000231658.
HOVERGENi HBG052083.
InParanoidi Q6NZJ6.
KOi K03260.
OMAi GSNWVPR.
OrthoDBi EOG7D59N2.
PhylomeDBi Q6NZJ6.
TreeFami TF101527.

Enzyme and pathway databases

Reactomei REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_198533. ISG15 antiviral mechanism.
REACT_198693. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_229737. S6K1 signalling.
REACT_236458. Ribosomal scanning and start codon recognition.
REACT_244119. Deadenylation of mRNA.
REACT_255163. Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.
REACT_256488. Translation initiation complex formation.
REACT_259469. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_262078. GTP hydrolysis and joining of the 60S ribosomal subunit.

Miscellaneous databases

ChiTaRSi Eif4g1. mouse.
NextBioi 372353.
PROi Q6NZJ6.
SOURCEi Search...

Gene expression databases

Bgeei Q6NZJ6.
ExpressionAtlasi Q6NZJ6. baseline and differential.
Genevestigatori Q6NZJ6.

Family and domain databases

Gene3Di 1.25.40.180. 3 hits.
InterProi IPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view ]
Pfami PF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view ]
SMARTi SM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
PROSITEi PS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Brain and Fetal brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-520 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Lung.
  3. "Characterization of mammalian eIF4E-family members."
    Joshi B., Cameron A., Jagus R.
    Eur. J. Biochem. 271:2189-2203(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EIF4E3.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1189 AND SER-1231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1231 AND SER-1597, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-606, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiIF4G1_MOUSE
AccessioniPrimary (citable) accession number: Q6NZJ6
Secondary accession number(s): Q6NZN8, Q8BW99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3