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Q6NZA9

- TAF9B_MOUSE

UniProt

Q6NZA9 - TAF9B_MOUSE

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Protein

Transcription initiation factor TFIID subunit 9B

Gene

Taf9b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity).By similarity

GO - Biological processi

  1. DNA-templated transcription, initiation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 9B
Alternative name(s):
Transcription initiation factor TFIID subunit 9-like
Transcription-associated factor TAFII31L
Gene namesi
Name:Taf9b
Synonyms:Taf9l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:3039562. Taf9b.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Transcription initiation factor TFIID subunit 9BPRO_0000118892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei172 – 1721PhosphothreonineBy similarity
Modified residuei175 – 1751PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6NZA9.
PaxDbiQ6NZA9.
PRIDEiQ6NZA9.

PTM databases

PhosphoSiteiQ6NZA9.

Expressioni

Gene expression databases

BgeeiQ6NZA9.
ExpressionAtlasiQ6NZA9. baseline and differential.
GenevestigatoriQ6NZA9.

Interactioni

Subunit structurei

Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6NZA9.
SMRiQ6NZA9. Positions 13-76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi241 – 2477Poly-AspSequence Analysis

Sequence similaritiesi

Belongs to the TAF9 family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG5094.
GeneTreeiENSGT00390000001626.
HOGENOMiHOG000231730.
HOVERGENiHBG002304.
InParanoidiQ6NZA9.
KOiK03133.
OrthoDBiEOG7HF1KM.
PhylomeDBiQ6NZA9.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003162. TFIID-31.
[Graphical view]
PANTHERiPTHR12075. PTHR12075. 1 hit.
PfamiPF02291. TFIID-31kDa. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NZA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPAKMAPIK NAPRDALVMA QILKDMGITE YEPRVINQML EFAFRYVTTI
60 70 80 90 100
LDDAKIYSSH AKKPTVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN
110 120 130 140 150
QTPLPLIKPY AGPRLPPDRY CLTAPNYRLK SLVKKGPNQG RLVPRLSAVS
160 170 180 190 200
SRPTTPPVAP PQAVSGPNKA ATPVSVTSQR FAVQIPPSQS TPAKPAPAAT
210 220 230 240
AVQNVLINPS MIGPKNILIT TSMVSSQNTA TDSNPLKRKH DDDDDNDTM
Length:249
Mass (Da):27,172
Last modified:January 24, 2006 - v2
Checksum:i5615C356885322FD
GO

Sequence cautioni

The sequence AAH51635.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE20773.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281I → T in AAH66223. (PubMed:15489334)Curated
Sequence conflicti193 – 1931A → T in BAE22420. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131710 mRNA. Translation: BAE20773.1. Different initiation.
AK135097 mRNA. Translation: BAE22420.1.
AL833778 Genomic DNA. Translation: CAM23480.1.
BC051635 mRNA. Translation: AAH51635.1. Different initiation.
BC066223 mRNA. Translation: AAH66223.1.
CCDSiCCDS30340.1.
RefSeqiNP_001001176.2. NM_001001176.2.
NP_001161460.1. NM_001167988.1.
UniGeneiMm.19440.

Genome annotation databases

EnsembliENSMUST00000055497; ENSMUSP00000059751; ENSMUSG00000047242.
GeneIDi407786.
KEGGimmu:407786.
UCSCiuc009ubq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK131710 mRNA. Translation: BAE20773.1 . Different initiation.
AK135097 mRNA. Translation: BAE22420.1 .
AL833778 Genomic DNA. Translation: CAM23480.1 .
BC051635 mRNA. Translation: AAH51635.1 . Different initiation.
BC066223 mRNA. Translation: AAH66223.1 .
CCDSi CCDS30340.1.
RefSeqi NP_001001176.2. NM_001001176.2.
NP_001161460.1. NM_001167988.1.
UniGenei Mm.19440.

3D structure databases

ProteinModelPortali Q6NZA9.
SMRi Q6NZA9. Positions 13-76.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6NZA9.

Proteomic databases

MaxQBi Q6NZA9.
PaxDbi Q6NZA9.
PRIDEi Q6NZA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055497 ; ENSMUSP00000059751 ; ENSMUSG00000047242 .
GeneIDi 407786.
KEGGi mmu:407786.
UCSCi uc009ubq.2. mouse.

Organism-specific databases

CTDi 51616.
MGIi MGI:3039562. Taf9b.

Phylogenomic databases

eggNOGi COG5094.
GeneTreei ENSGT00390000001626.
HOGENOMi HOG000231730.
HOVERGENi HBG002304.
InParanoidi Q6NZA9.
KOi K03133.
OrthoDBi EOG7HF1KM.
PhylomeDBi Q6NZA9.

Miscellaneous databases

NextBioi 407183.
PROi Q6NZA9.
SOURCEi Search...

Gene expression databases

Bgeei Q6NZA9.
ExpressionAtlasi Q6NZA9. baseline and differential.
Genevestigatori Q6NZA9.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
InterProi IPR009072. Histone-fold.
IPR003162. TFIID-31.
[Graphical view ]
PANTHERi PTHR12075. PTHR12075. 1 hit.
Pfami PF02291. TFIID-31kDa. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: Olfactory bulbImported and TestisImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported and C57BL/6JImported.
    Tissue: EmbryoImported and KidneyImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTAF9B_MOUSE
AccessioniPrimary (citable) accession number: Q6NZA9
Secondary accession number(s): A2AP80
, Q3UXZ3, Q3V2M4, Q80WW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3