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Protein

Transcription initiation factor TFIID subunit 9B

Gene

Taf9b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 9B
Alternative name(s):
Transcription initiation factor TFIID subunit 9-like
Transcription-associated factor TAFII31L
Gene namesi
Name:Taf9b
Synonyms:Taf9l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3039562 Taf9b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188921 – 249Transcription initiation factor TFIID subunit 9BAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei147PhosphoserineBy similarity1
Modified residuei172PhosphothreonineBy similarity1
Modified residuei175PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6NZA9
PaxDbiQ6NZA9
PRIDEiQ6NZA9

PTM databases

iPTMnetiQ6NZA9
PhosphoSitePlusiQ6NZA9

Expressioni

Gene expression databases

BgeeiENSMUSG00000047242
ExpressionAtlasiQ6NZA9 baseline and differential
GenevisibleiQ6NZA9 MM

Interactioni

Subunit structurei

Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109123

Structurei

3D structure databases

ProteinModelPortaliQ6NZA9
SMRiQ6NZA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi241 – 247Poly-AspSequence analysis7

Sequence similaritiesi

Belongs to the TAF9 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3334 Eukaryota
COG5094 LUCA
GeneTreeiENSGT00390000001626
HOGENOMiHOG000231730
HOVERGENiHBG002304
InParanoidiQ6NZA9
KOiK03133
PhylomeDBiQ6NZA9

Family and domain databases

CDDicd07979 TAF9, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR003162 TFIID-31
PfamiView protein in Pfam
PF02291 TFIID-31kDa, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NZA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAKMAPIK NAPRDALVMA QILKDMGITE YEPRVINQML EFAFRYVTTI
60 70 80 90 100
LDDAKIYSSH AKKPTVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN
110 120 130 140 150
QTPLPLIKPY AGPRLPPDRY CLTAPNYRLK SLVKKGPNQG RLVPRLSAVS
160 170 180 190 200
SRPTTPPVAP PQAVSGPNKA ATPVSVTSQR FAVQIPPSQS TPAKPAPAAT
210 220 230 240
AVQNVLINPS MIGPKNILIT TSMVSSQNTA TDSNPLKRKH DDDDDNDTM
Length:249
Mass (Da):27,172
Last modified:January 24, 2006 - v2
Checksum:i5615C356885322FD
GO

Sequence cautioni

The sequence AAH51635 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE20773 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28I → T in AAH66223 (PubMed:15489334).Curated1
Sequence conflicti193A → T in BAE22420 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131710 mRNA Translation: BAE20773.1 Different initiation.
AK135097 mRNA Translation: BAE22420.1
AL833778 Genomic DNA No translation available.
BC051635 mRNA Translation: AAH51635.1 Different initiation.
BC066223 mRNA Translation: AAH66223.1
CCDSiCCDS30340.1
RefSeqiNP_001001176.2, NM_001001176.2
NP_001161460.1, NM_001167988.1
UniGeneiMm.19440

Genome annotation databases

EnsembliENSMUST00000055497; ENSMUSP00000059751; ENSMUSG00000047242
GeneIDi407786
KEGGimmu:407786
UCSCiuc009ubq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTAF9B_MOUSE
AccessioniPrimary (citable) accession number: Q6NZA9
Secondary accession number(s): A2AP80
, Q3UXZ3, Q3V2M4, Q80WW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health