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Q6NZA9

- TAF9B_MOUSE

UniProt

Q6NZA9 - TAF9B_MOUSE

Protein

Transcription initiation factor TFIID subunit 9B

Gene

Taf9b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription By similarity.By similarity

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor TFIID subunit 9B
    Alternative name(s):
    Transcription initiation factor TFIID subunit 9-like
    Transcription-associated factor TAFII31L
    Gene namesi
    Name:Taf9b
    Synonyms:Taf9l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:3039562. Taf9b.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249Transcription initiation factor TFIID subunit 9BPRO_0000118892Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei172 – 1721PhosphothreonineBy similarity
    Modified residuei175 – 1751PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ6NZA9.
    PRIDEiQ6NZA9.

    PTM databases

    PhosphoSiteiQ6NZA9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6NZA9.
    BgeeiQ6NZA9.
    GenevestigatoriQ6NZA9.

    Interactioni

    Subunit structurei

    Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6NZA9.
    SMRiQ6NZA9. Positions 13-76.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi241 – 2477Poly-AspSequence Analysis

    Sequence similaritiesi

    Belongs to the TAF9 family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG5094.
    GeneTreeiENSGT00390000001626.
    HOGENOMiHOG000231730.
    HOVERGENiHBG002304.
    InParanoidiA2AP80.
    KOiK03133.
    OrthoDBiEOG7HF1KM.
    PhylomeDBiQ6NZA9.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR003162. TFIID-31.
    [Graphical view]
    PANTHERiPTHR12075. PTHR12075. 1 hit.
    PfamiPF02291. TFIID-31kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6NZA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPAKMAPIK NAPRDALVMA QILKDMGITE YEPRVINQML EFAFRYVTTI    50
    LDDAKIYSSH AKKPTVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQKN 100
    QTPLPLIKPY AGPRLPPDRY CLTAPNYRLK SLVKKGPNQG RLVPRLSAVS 150
    SRPTTPPVAP PQAVSGPNKA ATPVSVTSQR FAVQIPPSQS TPAKPAPAAT 200
    AVQNVLINPS MIGPKNILIT TSMVSSQNTA TDSNPLKRKH DDDDDNDTM 249
    Length:249
    Mass (Da):27,172
    Last modified:January 24, 2006 - v2
    Checksum:i5615C356885322FD
    GO

    Sequence cautioni

    The sequence AAH51635.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAE20773.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281I → T in AAH66223. (PubMed:15489334)Curated
    Sequence conflicti193 – 1931A → T in BAE22420. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131710 mRNA. Translation: BAE20773.1. Different initiation.
    AK135097 mRNA. Translation: BAE22420.1.
    AL833778 Genomic DNA. Translation: CAM23480.1.
    BC051635 mRNA. Translation: AAH51635.1. Different initiation.
    BC066223 mRNA. Translation: AAH66223.1.
    CCDSiCCDS30340.1.
    RefSeqiNP_001001176.2. NM_001001176.2.
    NP_001161460.1. NM_001167988.1.
    UniGeneiMm.19440.

    Genome annotation databases

    EnsembliENSMUST00000055497; ENSMUSP00000059751; ENSMUSG00000047242.
    GeneIDi407786.
    KEGGimmu:407786.
    UCSCiuc009ubq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK131710 mRNA. Translation: BAE20773.1 . Different initiation.
    AK135097 mRNA. Translation: BAE22420.1 .
    AL833778 Genomic DNA. Translation: CAM23480.1 .
    BC051635 mRNA. Translation: AAH51635.1 . Different initiation.
    BC066223 mRNA. Translation: AAH66223.1 .
    CCDSi CCDS30340.1.
    RefSeqi NP_001001176.2. NM_001001176.2.
    NP_001161460.1. NM_001167988.1.
    UniGenei Mm.19440.

    3D structure databases

    ProteinModelPortali Q6NZA9.
    SMRi Q6NZA9. Positions 13-76.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6NZA9.

    Proteomic databases

    PaxDbi Q6NZA9.
    PRIDEi Q6NZA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055497 ; ENSMUSP00000059751 ; ENSMUSG00000047242 .
    GeneIDi 407786.
    KEGGi mmu:407786.
    UCSCi uc009ubq.2. mouse.

    Organism-specific databases

    CTDi 51616.
    MGIi MGI:3039562. Taf9b.

    Phylogenomic databases

    eggNOGi COG5094.
    GeneTreei ENSGT00390000001626.
    HOGENOMi HOG000231730.
    HOVERGENi HBG002304.
    InParanoidi A2AP80.
    KOi K03133.
    OrthoDBi EOG7HF1KM.
    PhylomeDBi Q6NZA9.

    Miscellaneous databases

    NextBioi 407183.
    PROi Q6NZA9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6NZA9.
    Bgeei Q6NZA9.
    Genevestigatori Q6NZA9.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR003162. TFIID-31.
    [Graphical view ]
    PANTHERi PTHR12075. PTHR12075. 1 hit.
    Pfami PF02291. TFIID-31kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: Olfactory bulbImported and TestisImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported and C57BL/6JImported.
      Tissue: EmbryoImported and KidneyImported.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiTAF9B_MOUSE
    AccessioniPrimary (citable) accession number: Q6NZA9
    Secondary accession number(s): A2AP80
    , Q3UXZ3, Q3V2M4, Q80WW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3