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Protein

Proteasome subunit beta type

Gene

psmb8a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Protein family/group databases

MEROPSiT01.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:psmb8aImported
Synonyms:psmb8Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990415-141. psmb8a.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation
  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomeUniRule annotationImported

PTM / Processingi

Proteomic databases

PaxDbiQ6NZ73.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.UniRule annotation

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095608.

Structurei

3D structure databases

ProteinModelPortaliQ6NZ73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0175. Eukaryota.
ENOG410XQRP. LUCA.
HOVERGENiHBG108297.
PhylomeDBiQ6NZ73.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NZ73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLDVSGYK YNSASQFGFK QTLLDRSNHY SFGTKCQEFA VPVGVDPSKF
60 70 80 90 100
LKSCSCEDGV CIDLNHGTTT LAFKFRHGVI VAVDSRASAG KYIDSKEANK
110 120 130 140 150
VIEINPYLLG TMSGSAADCQ YWERLLAKEC RLYKLRNKQR ISVSAASKLL
160 170 180 190 200
SNMMLGYRGM GLSMGSMICG WDKQGPGLYY VDDNGTRLSG RMFSTGCGNS
210 220 230 240 250
YAYGVVDSGY REDMTVEEAY ELGRRGIAHA THRDAYSGGV VNLYHMQEDG
260 270
WIKVCKEDVS ELIHRYKKGM F
Length:271
Mass (Da):30,130
Last modified:July 5, 2004 - v1
Checksum:i97304BDACBE3A003
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066288 mRNA. Translation: AAH66288.1.
UniGeneiDr.7957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066288 mRNA. Translation: AAH66288.1.
UniGeneiDr.7957.

3D structure databases

ProteinModelPortaliQ6NZ73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095608.

Protein family/group databases

MEROPSiT01.012.

Proteomic databases

PaxDbiQ6NZ73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-990415-141. psmb8a.

Phylogenomic databases

eggNOGiKOG0175. Eukaryota.
ENOG410XQRP. LUCA.
HOVERGENiHBG108297.
PhylomeDBiQ6NZ73.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6NZ73_DANRE
AccessioniPrimary (citable) accession number: Q6NZ73
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 15, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.