Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitotic-spindle organizing protein 2B

Gene

MZT2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic-spindle organizing protein 2B
Alternative name(s):
Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B
Gene namesi
Name:MZT2B
Synonyms:FAM128B, MOZART2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25886. MZT2B.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • gamma-tubulin ring complex Source: UniProtKB
  • spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165696943.

Polymorphism and mutation databases

BioMutaiMZT2B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Mitotic-spindle organizing protein 2BPRO_0000338988Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341PhosphoserineCombined sources
Modified residuei152 – 1521PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NZ67.
MaxQBiQ6NZ67.
PaxDbiQ6NZ67.
PRIDEiQ6NZ67.
TopDownProteomicsiQ6NZ67.

PTM databases

iPTMnetiQ6NZ67.
PhosphoSiteiQ6NZ67.

Expressioni

Gene expression databases

BgeeiQ6NZ67.
CleanExiHS_FAM128B.
ExpressionAtlasiQ6NZ67. baseline and differential.
GenevisibleiQ6NZ67. HS.

Organism-specific databases

HPAiHPA052623.

Interactioni

Subunit structurei

Part of the gamma-tubulin complex. Interacts with TUBG1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TUBG1P232582EBI-1052566,EBI-302589

Protein-protein interaction databases

BioGridi123111. 35 interactions.
IntActiQ6NZ67. 19 interactions.
MINTiMINT-8247403.
STRINGi9606.ENSP00000281871.

Structurei

3D structure databases

ProteinModelPortaliQ6NZ67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOZART2 family.Curated

Phylogenomic databases

eggNOGiENOG410IZ6M. Eukaryota.
ENOG410Y69K. LUCA.
GeneTreeiENSGT00390000014845.
HOGENOMiHOG000089967.
HOVERGENiHBG107896.
InParanoidiQ6NZ67.
KOiK16574.
PhylomeDBiQ6NZ67.
TreeFamiTF333013.

Family and domain databases

InterProiIPR024332. MOZART2.
[Graphical view]
PfamiPF12926. MOZART2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NZ67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQGVGPGP GSAAPPGLEA ARQKLALRRK KVLSTEEMEL YELAQAAGGA
60 70 80 90 100
IDPDVFKILV DLLKLNVAPL AVFQMLKSMC AGQRLASEPQ DPAAVSLPTS
110 120 130 140 150
SVPETRGRNK GSAALGGALA LAERSSREGS SQRMPRQPSA TRLPKGGGPG

KSPTRGST
Length:158
Mass (Da):16,226
Last modified:July 5, 2004 - v1
Checksum:i97DE6BDDE2881289
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181A → V.
Corresponds to variant rs1043059 [ dbSNP | Ensembl ].
VAR_043853
Natural varianti155 – 1551R → Q.
Corresponds to variant rs1043152 [ dbSNP | Ensembl ].
VAR_043854

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471263 Genomic DNA. Translation: EAW55603.1.
BC014255 mRNA. Translation: AAH14255.2.
BC066296 mRNA. Translation: AAH66296.1.
CCDSiCCDS2157.1.
RefSeqiNP_079305.2. NM_025029.3.
UniGeneiHs.469925.
Hs.516450.

Genome annotation databases

EnsembliENST00000281871; ENSP00000281871; ENSG00000152082.
GeneIDi80097.
KEGGihsa:80097.
UCSCiuc002tqu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471263 Genomic DNA. Translation: EAW55603.1.
BC014255 mRNA. Translation: AAH14255.2.
BC066296 mRNA. Translation: AAH66296.1.
CCDSiCCDS2157.1.
RefSeqiNP_079305.2. NM_025029.3.
UniGeneiHs.469925.
Hs.516450.

3D structure databases

ProteinModelPortaliQ6NZ67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123111. 35 interactions.
IntActiQ6NZ67. 19 interactions.
MINTiMINT-8247403.
STRINGi9606.ENSP00000281871.

PTM databases

iPTMnetiQ6NZ67.
PhosphoSiteiQ6NZ67.

Polymorphism and mutation databases

BioMutaiMZT2B.

Proteomic databases

EPDiQ6NZ67.
MaxQBiQ6NZ67.
PaxDbiQ6NZ67.
PRIDEiQ6NZ67.
TopDownProteomicsiQ6NZ67.

Protocols and materials databases

DNASUi80097.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281871; ENSP00000281871; ENSG00000152082.
GeneIDi80097.
KEGGihsa:80097.
UCSCiuc002tqu.3. human.

Organism-specific databases

CTDi80097.
GeneCardsiMZT2B.
HGNCiHGNC:25886. MZT2B.
HPAiHPA052623.
MIMi613450. gene.
neXtProtiNX_Q6NZ67.
PharmGKBiPA165696943.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ6M. Eukaryota.
ENOG410Y69K. LUCA.
GeneTreeiENSGT00390000014845.
HOGENOMiHOG000089967.
HOVERGENiHBG107896.
InParanoidiQ6NZ67.
KOiK16574.
PhylomeDBiQ6NZ67.
TreeFamiTF333013.

Miscellaneous databases

ChiTaRSiMZT2B. human.
GenomeRNAii80097.
PROiQ6NZ67.
SOURCEiSearch...

Gene expression databases

BgeeiQ6NZ67.
CleanExiHS_FAM128B.
ExpressionAtlasiQ6NZ67. baseline and differential.
GenevisibleiQ6NZ67. HS.

Family and domain databases

InterProiIPR024332. MOZART2.
[Graphical view]
PfamiPF12926. MOZART2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Eye.
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TUBG1.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMZT2B_HUMAN
AccessioniPrimary (citable) accession number: Q6NZ67
Secondary accession number(s): Q96CG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.