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Protein

STEAP family member 1B

Gene

STEAP1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Names & Taxonomyi

Protein namesi
Recommended name:
STEAP family member 1B
Gene namesi
Name:STEAP1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105889.14
HGNCiHGNC:41907 STEAP1B
neXtProtiNX_Q6NZ63

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi256227
OpenTargetsiENSG00000105889

Polymorphism and mutation databases

BioMutaiSTEAP1B
DMDMi74737025

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003215121 – 245STEAP family member 1BAdd BLAST245

Proteomic databases

MaxQBiQ6NZ63
PeptideAtlasiQ6NZ63
PRIDEiQ6NZ63

PTM databases

iPTMnetiQ6NZ63
PhosphoSitePlusiQ6NZ63

Expressioni

Gene expression databases

BgeeiENSG00000105889
ExpressionAtlasiQ6NZ63 baseline and differential
GenevisibleiQ6NZ63 HS

Interactioni

Protein-protein interaction databases

BioGridi1291472 interactors.
IntActiQ6NZ63 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6NZ63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STEAP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000008042
HOGENOMiHOG000252937
HOVERGENiHBG062286
OrthoDBiEOG091G0F9X
PhylomeDBiQ6NZ63
TreeFamiTF332031

Family and domain databases

InterProiView protein in InterPro
IPR013130 Fe3_Rdtase_TM_dom
PfamiView protein in Pfam
PF01794 Ferric_reduct, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NZ63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESRKDITNQ EEIWKMKPRR NLEDNDYLQT AHADEFDCPS ELQHAQELFP
60 70 80 90 100
QWHLPIKIAA VMASLTFLYT LLREVIHPLA TSHQQYFYKI PILVINKVLP
110 120 130 140 150
MVSITLLALV YLPGVIAAIV QVHNGTKYKK FPHWLDKWML TRKQFGLLSL
160 170 180 190 200
FFAVLHAIYT LSYAMRRSYR YKLLNWAYQQ VQQNKEDAWI EHDVWRMEIY
210 220 230 240
VSLGIVGLAI LALLAVTSIP SVSDSLTWRE FHYIQVHGRI NFLTL
Length:245
Mass (Da):28,815
Last modified:July 5, 2004 - v1
Checksum:iA9D38F66C3580B7C
GO
Isoform 2 (identifier: Q6NZ63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: L → LHEDTGETSMLKRPVLLHLQ
     235-245: QVHGRINFLTL → QAILTGSLVA...DKLLLIIFQI

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):39,678
Checksum:i48C0E6976DDF7D18
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0393397I → V. Corresponds to variant dbSNP:rs7787814Ensembl.1
Natural variantiVAR_03934029Q → R. Corresponds to variant dbSNP:rs16881810Ensembl.1
Natural variantiVAR_039341166R → M. Corresponds to variant dbSNP:rs16881812Ensembl.1
Natural variantiVAR_039342210I → T. Corresponds to variant dbSNP:rs16881817Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05411628L → LHEDTGETSMLKRPVLLHLQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_054117235 – 245QVHGRINFLTL → QAILTGSLVALCNFQATKLA KTQLVGTPNFWQEQQCGIHF PPPSKTRSYIYFILSAASPS KGNVSSHMFQLHLENLNKKD KLLLIIFQI in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK308991 mRNA No translation available.
AC002480 Genomic DNA No translation available.
AC005061 Genomic DNA No translation available.
AC099759 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24268.1
BC066301 mRNA Translation: AAH66301.1
CCDSiCCDS55094.1 [Q6NZ63-1]
CCDS56469.1 [Q6NZ63-2]
RefSeqiNP_001157932.1, NM_001164460.1 [Q6NZ63-2]
NP_997225.1, NM_207342.2 [Q6NZ63-1]
UniGeneiHs.729825

Genome annotation databases

EnsembliENST00000404369; ENSP00000384370; ENSG00000105889 [Q6NZ63-2]
ENST00000406890; ENSP00000385239; ENSG00000105889 [Q6NZ63-1]
GeneIDi256227
KEGGihsa:256227
UCSCiuc003svh.4 human [Q6NZ63-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTEAL_HUMAN
AccessioniPrimary (citable) accession number: Q6NZ63
Secondary accession number(s): B5MCI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome