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Protein

STEAP family member 1B

Gene

STEAP1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
STEAP family member 1B
Gene namesi
Name:STEAP1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:41907. STEAP1B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiSTEAP1B.
DMDMi74737025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245STEAP family member 1BPRO_0000321512Add
BLAST

Proteomic databases

MaxQBiQ6NZ63.
PRIDEiQ6NZ63.

Expressioni

Gene expression databases

BgeeiQ6NZ63.
ExpressionAtlasiQ6NZ63. baseline and differential.
GenevisibleiQ6NZ63. HS.

Interactioni

Protein-protein interaction databases

BioGridi129147. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6NZ63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STEAP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000008042.
HOGENOMiHOG000252937.
HOVERGENiHBG062286.
OMAiNDYLHED.
OrthoDBiEOG7Z0JWH.
PhylomeDBiQ6NZ63.
TreeFamiTF332031.

Family and domain databases

InterProiIPR013130. Fe3_Rdtase_TM_dom.
[Graphical view]
PfamiPF01794. Ferric_reduct. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NZ63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESRKDITNQ EEIWKMKPRR NLEDNDYLQT AHADEFDCPS ELQHAQELFP
60 70 80 90 100
QWHLPIKIAA VMASLTFLYT LLREVIHPLA TSHQQYFYKI PILVINKVLP
110 120 130 140 150
MVSITLLALV YLPGVIAAIV QVHNGTKYKK FPHWLDKWML TRKQFGLLSL
160 170 180 190 200
FFAVLHAIYT LSYAMRRSYR YKLLNWAYQQ VQQNKEDAWI EHDVWRMEIY
210 220 230 240
VSLGIVGLAI LALLAVTSIP SVSDSLTWRE FHYIQVHGRI NFLTL
Length:245
Mass (Da):28,815
Last modified:July 5, 2004 - v1
Checksum:iA9D38F66C3580B7C
GO
Isoform 2 (identifier: Q6NZ63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: L → LHEDTGETSMLKRPVLLHLQ
     235-245: QVHGRINFLTL → QAILTGSLVA...DKLLLIIFQI

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):39,678
Checksum:i48C0E6976DDF7D18
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71I → V.
Corresponds to variant rs7787814 [ dbSNP | Ensembl ].
VAR_039339
Natural varianti29 – 291Q → R.
Corresponds to variant rs16881810 [ dbSNP | Ensembl ].
VAR_039340
Natural varianti166 – 1661R → M.
Corresponds to variant rs16881812 [ dbSNP | Ensembl ].
VAR_039341
Natural varianti210 – 2101I → T.
Corresponds to variant rs16881817 [ dbSNP | Ensembl ].
VAR_039342

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei28 – 281L → LHEDTGETSMLKRPVLLHLQ in isoform 2. 1 PublicationVSP_054116
Alternative sequencei235 – 24511QVHGRINFLTL → QAILTGSLVALCNFQATKLA KTQLVGTPNFWQEQQCGIHF PPPSKTRSYIYFILSAASPS KGNVSSHMFQLHLENLNKKD KLLLIIFQI in isoform 2. 1 PublicationVSP_054117Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK308991 mRNA. No translation available.
AC002480 Genomic DNA. No translation available.
AC005061 Genomic DNA. No translation available.
AC099759 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24268.1.
BC066301 mRNA. Translation: AAH66301.1.
CCDSiCCDS55094.1. [Q6NZ63-1]
CCDS56469.1. [Q6NZ63-2]
RefSeqiNP_001157932.1. NM_001164460.1. [Q6NZ63-2]
NP_997225.1. NM_207342.2. [Q6NZ63-1]
UniGeneiHs.729825.

Genome annotation databases

EnsembliENST00000404369; ENSP00000384370; ENSG00000105889. [Q6NZ63-2]
ENST00000406890; ENSP00000385239; ENSG00000105889. [Q6NZ63-1]
GeneIDi256227.
KEGGihsa:256227.
UCSCiuc003svh.4. human. [Q6NZ63-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK308991 mRNA. No translation available.
AC002480 Genomic DNA. No translation available.
AC005061 Genomic DNA. No translation available.
AC099759 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24268.1.
BC066301 mRNA. Translation: AAH66301.1.
CCDSiCCDS55094.1. [Q6NZ63-1]
CCDS56469.1. [Q6NZ63-2]
RefSeqiNP_001157932.1. NM_001164460.1. [Q6NZ63-2]
NP_997225.1. NM_207342.2. [Q6NZ63-1]
UniGeneiHs.729825.

3D structure databases

ProteinModelPortaliQ6NZ63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129147. 1 interaction.

Polymorphism and mutation databases

BioMutaiSTEAP1B.
DMDMi74737025.

Proteomic databases

MaxQBiQ6NZ63.
PRIDEiQ6NZ63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404369; ENSP00000384370; ENSG00000105889. [Q6NZ63-2]
ENST00000406890; ENSP00000385239; ENSG00000105889. [Q6NZ63-1]
GeneIDi256227.
KEGGihsa:256227.
UCSCiuc003svh.4. human. [Q6NZ63-1]

Organism-specific databases

CTDi256227.
GeneCardsiSTEAP1B.
HGNCiHGNC:41907. STEAP1B.
neXtProtiNX_Q6NZ63.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000008042.
HOGENOMiHOG000252937.
HOVERGENiHBG062286.
OMAiNDYLHED.
OrthoDBiEOG7Z0JWH.
PhylomeDBiQ6NZ63.
TreeFamiTF332031.

Miscellaneous databases

GenomeRNAii256227.
NextBioi92751.
PROiQ6NZ63.

Gene expression databases

BgeeiQ6NZ63.
ExpressionAtlasiQ6NZ63. baseline and differential.
GenevisibleiQ6NZ63. HS.

Family and domain databases

InterProiIPR013130. Fe3_Rdtase_TM_dom.
[Graphical view]
PfamiPF01794. Ferric_reduct. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Corpus callosum.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiSTEAL_HUMAN
AccessioniPrimary (citable) accession number: Q6NZ63
Secondary accession number(s): B5MCI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.