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Protein

Ferritin

Gene

FTH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIron storageUniRule annotationSAAS annotation
LigandIron, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
FerritinUniRule annotation
Gene namesi
Name:FTH1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

PeptideAtlasiQ6NZ44

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ6NZ44, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6NZ44
SMRiQ6NZ44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 160Ferritin-like diironInterPro annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
HOVERGENiHBG000410

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NZ44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK
60 70 80 90 100
NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKEPD CDDWESGQNA
110 120 130 140 150
MECALHLEKN VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKAIKELG
160 170 180
DHVTNLRKMG APESGLAEYL FDKHTLGDSD NES
Length:183
Mass (Da):21,242
Last modified:July 5, 2004 - v1
Checksum:i4512E8078A2320B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066341 mRNA Translation: AAH66341.1
UniGeneiHs.524910
Hs.645560

Similar proteinsi

Entry informationi

Entry nameiQ6NZ44_HUMAN
AccessioniPrimary (citable) accession number: Q6NZ44
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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