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Protein

Cyclin-F

Gene

ccnf

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-F
Gene namesi
Name:ccnf
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-021030-2. ccnf.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986361 – 764Cyclin-FAdd BLAST764

Proteomic databases

PaxDbiQ6NYX6.

Expressioni

Gene expression databases

BgeeiENSDARG00000034763.

Interactioni

Subunit structurei

Component of the SCF(CCNF) complex.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043143.

Structurei

3D structure databases

ProteinModelPortaliQ6NYX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 75F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini304 – 404Cyclin N-terminalAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni583 – 738PESTAdd BLAST156

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi19 – 27Nuclear localization signal 1By similarity9
Motifi570 – 575Nuclear localization signal 2By similarity6

Domaini

The nuclear localization signals mediate the localization to the nucleus.By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0654. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00810000125541.
HOGENOMiHOG000285971.
HOVERGENiHBG050838.
InParanoidiQ6NYX6.
KOiK10289.
OMAiLHQKCFH.
OrthoDBiEOG091G0AU2.
PhylomeDBiQ6NYX6.
TreeFamiTF101006.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PANTHERiPTHR10177:SF252. PTHR10177:SF252. 3 hits.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6NYX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAGALHCRC AKCFSLPVRK RVRKRASAVS LLSLPEELLV FVLQCLSAED
60 70 80 90 100
LLSVRAVHSH LCDIIDTNAS IWARVSFKDR WPAPDTVWLF ERAAEKGNFE
110 120 130 140 150
AAVKLGIAYL YNEGPLLSEE GRADLCGRMA SRYLSLSESL RSPQAEPFIW
160 170 180 190 200
LFIRPPWSVS GSCCKAVVFD RLQAECQTSP GRKGTLLYCL ARVLQLFDDE
210 220 230 240 250
EKRDEAELML KESSRCGSLQ SSYLLWAISR ASSTADPGRY LQCMRTLRDY
260 270 280 290 300
AARGCWEAQL AFVKSCGSAN PLGLEPRACS ELVSQFFQTG PSALRYQPHL
310 320 330 340 350
QGQDITTKRY ILVDWLVEVT TTKDFSSQVL HVTISCVDRY LHLRSVPKAQ
360 370 380 390 400
LQLLGIACMV ICTRFISKEI LTIREAVWLT DNTYQYEDLV HMMGEVISVL
410 420 430 440 450
DGKIRTPTVL DYGEVLLSLL PVERRTAHLF SYICELSLLC SPATVPGPAR
460 470 480 490 500
LASAILLLTR ALHNYVPVWP VQLEENTGFS KQDLVSCALT LYIKCFGQDV
510 520 530 540 550
PKDYRHVSLT GVKQRFEDDS YQQISKDTVM GFKELCHVLE VPEVEPQVEV
560 570 580 590 600
SSTSGQITEM HTFLSSPTSS SKRRRADSMQ AHRGAFVATP TAELSNQEET
610 620 630 640 650
LLGDFLDWSL DTSCSGYEGD RESEGEKDGE ISTMEVQMEL PLDCADRQTH
660 670 680 690 700
CCLLSSDDTS LCEEDEQEPP TGGSKPWTRH LSSSSTSSSS SSCGFCTDRH
710 720 730 740 750
SSGYSSIQSF PSPTGSSALV SPQNPPGVPS QRIRRQVKRK NTAAHSAGEA
760
EQEDDAANLA FLSF
Length:764
Mass (Da):84,906
Last modified:July 5, 2004 - v1
Checksum:iA1C5F9B0E29ADC3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066425 mRNA. Translation: AAH66425.1.
RefSeqiNP_996931.1. NM_207048.1.
UniGeneiDr.455.

Genome annotation databases

EnsembliENSDART00000167177; ENSDARP00000141877; ENSDARG00000105046.
GeneIDi266981.
KEGGidre:266981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066425 mRNA. Translation: AAH66425.1.
RefSeqiNP_996931.1. NM_207048.1.
UniGeneiDr.455.

3D structure databases

ProteinModelPortaliQ6NYX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043143.

Proteomic databases

PaxDbiQ6NYX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000167177; ENSDARP00000141877; ENSDARG00000105046.
GeneIDi266981.
KEGGidre:266981.

Organism-specific databases

CTDi899.
ZFINiZDB-GENE-021030-2. ccnf.

Phylogenomic databases

eggNOGiKOG0654. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00810000125541.
HOGENOMiHOG000285971.
HOVERGENiHBG050838.
InParanoidiQ6NYX6.
KOiK10289.
OMAiLHQKCFH.
OrthoDBiEOG091G0AU2.
PhylomeDBiQ6NYX6.
TreeFamiTF101006.

Enzyme and pathway databases

ReactomeiR-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ6NYX6.

Gene expression databases

BgeeiENSDARG00000034763.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR032675. L_dom-like.
[Graphical view]
PANTHERiPTHR10177:SF252. PTHR10177:SF252. 3 hits.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCNF_DANRE
AccessioniPrimary (citable) accession number: Q6NYX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 5, 2004
Last modified: October 5, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.