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Protein

Neurogenic differentiation factor 6-A

Gene

neurod6a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1.1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of neurogenesis Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenic differentiation factor 6-A
Short name:
NeuroD6-A
Alternative name(s):
Protein atonal homolog 2-A
Gene namesi
Name:neurod6aBy similarity
Synonyms:atoh2aImported, ndr1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 24

Organism-specific databases

ZFINiZDB-GENE-010608-1. neurod6a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748151 – 327Neurogenic differentiation factor 6-AAdd BLAST327

Proteomic databases

PaxDbiQ6NYU3.

Expressioni

Tissue specificityi

Embryonic olfactory bulbs. In adult, expressed in brain, eye, intestine, muscle, ovary and skin.1 Publication

Developmental stagei

Embryonic, larval and adult stages. First detected at 22 hours post-fertilization (hpf).1 Publication

Gene expression databases

BgeeiENSDARG00000040008.
ExpressionAtlasiQ6NYU3. baseline and differential.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000089629.

Structurei

3D structure databases

ProteinModelPortaliQ6NYU3.
SMRiQ6NYU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 140bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi74 – 80Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 50Poly-AspSequence analysis4

Phylogenomic databases

eggNOGiENOG410IQ4G. Eukaryota.
ENOG41118Y2. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000049256.
HOVERGENiHBG000250.
InParanoidiQ6NYU3.
KOiK09080.
PhylomeDBiQ6NYU3.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR036638. HLH_DNA-bd_sf.
IPR032650. Neurod6.
IPR022575. Neurogenic_DUF.
IPR016637. TF_bHLH_NeuroD.
PANTHERiPTHR19290:SF9. PTHR19290:SF9. 1 hit.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
PF12533. Neuro_bHLH. 1 hit.
PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6NYU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLPFEDPV IMDTQFGANF PRDCVGDLKG NKQEPFEKEE TLSHVMDDDD
60 70 80 90 100
SEKDEDERED GQDENGLPRR RGPRKKKMTK ARVDRVKVRR MEANARERNR
110 120 130 140 150
MHGLNNALDS LRKVVPCYSK TQKLSKIETL RLAKNYIWAL SEILSTGKRP
160 170 180 190 200
DLLTFVQTLC KGLSQPTTNL VAGCLQLNAR NFIPDQISGE ASFSGRSPYE
210 220 230 240 250
SVYSTYHSPS VVTPSGPSVD AVKPFRSFNY CSSYESFYES VSPECGSPQF
260 270 280 290 300
EGPLSPPINF NGIFSLKHEE PVEYGKSCHY GTRYCAVPPR ASIGQSARGS
310 320
SDLHFPYDIH LRGQFYPVQD ELNTFHN
Length:327
Mass (Da):36,949
Last modified:July 5, 2004 - v1
Checksum:i117D88AB574380FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247S → T in AAD23441 (PubMed:10235116).Curated1
Sequence conflicti285 – 298CAVPP…GQSAR → WRSAAFHRPEPA in AAD23441 (PubMed:10235116).CuratedAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115772 mRNA. Translation: AAD23441.1.
BC066459 mRNA. Translation: AAH66459.1.
RefSeqiNP_571891.3. NM_131816.3.
UniGeneiDr.132085.
Dr.81281.

Genome annotation databases

EnsembliENSDART00000058530; ENSDARP00000096474; ENSDARG00000040008.
GeneIDi114414.
KEGGidre:114414.

Similar proteinsi

Entry informationi

Entry nameiNDF6A_DANRE
AccessioniPrimary (citable) accession number: Q6NYU3
Secondary accession number(s): Q9W6C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome